2015 UPDATE FOR COHG GLOBAL ALLIANCE PARTNERS

NIHR and the Global Alliance have made the Cochrane Oral Health Group

a world leader in evidence-based oral health care.

THANKS TO YOUR SUPPORT OVER THE PAST 4 YEARS, WE HAVE:

PUBLISHED gold standard work

134 publications (52 new protocols, 42 new reviews, and 40 updated reviews) of

internationally renowned quality, across all 8 defined areas of dentistry: periodontology, operative (including endodontics) and prosthodontics, paediatric dentistry, dental

public health, oral and maxillofacial surgery, oral medicine, orthodontics, and cleft lip and/or palate

Podcast production

Evidence summaries for patients on our website

Highly-accessed research*: - Interventions for preventing oral mucositis for patients with cancer receiving treatment (n=

7,479)

- Sealants for preventing dental decay in the permanent teeth (n= 7,026)

- Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia (n= 5,686)

- Manual versus powered toothbrushing for oral health (n= 6,655)

- Fluoride varnishes for preventing dental caries in children and adolescents (n= 6,639)

*2013 access figures

PARTNERED with diverse collaborators

More than 800 authors and 300 referees, in over 40 countries

International expert panels of clinicians and researchers across our 8 areas of

dentistry

IADR’s Global Oral Health Inequalities Research Network (GOHIRA)

World Health Organisation

International guideline developers (ADA, NICE, SIGN, SDCEP)

The public, in an open survey about key oral health concerns

Consumers, through our Consumer Co-ordinator

PRIORITISED within our scope

The most globally important topics within each of our 8 areas of dentistry

A core portfolio of 81 existing review titles that we will actively support the update of

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Identified priority topics for 15 new intervention reviews

Undertaken 2 diagnostic test accuracy (DTA) reviews to enhance our suite of

evidence for oral cancer

Plans to complete stalled reviews

PROMOTED evidence-based care

International conference presentations and training

o IADR workshops;

o Professional societies, including many GA partners

Training for researchers and clinicians

Reviews have been linked to changing practice

Reviews leading to the design of new RCTs

Produced an introductory video about COHG’s research activities (over 1,200 views

to date)

PERFORMED exceptionally well

As measured by:

o the Cochrane Editorial Unit’s quality assurance standards;

o an exponential increase of over 50% in productivity: - Jan 1996-Sep 2010: 167 reviews published (112 new reviews; 55 updated reviews) over

165 months – 1.0 publications p/month;

- Oct 2010-Dec 2014: 82 reviews published (42 new reviews; 40 updated reviews) over 51

months – 1.6 publications p/month

o our Impact Factor (2013: 4.00), which ranks the COHG’s publications alongside

the top 3 dental journals;

o award of NIHR Incentive scheme grant to complete review on Immunotherapy

for the treatment of oral cancer.

Funding from the COHG’s 10 Global Alliance partners has made possible the employment of a senior systematic reviewer and a research coordinator, who have been key to many of these achievements.

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BACKGROUND

COCHRANE ORAL HEALTH GROUP

The Cochrane Oral Health Group (COHG) has an international membership of 1490 members, of which

over 860 are review authors from 42 countries. Our global panel of peer reviewers ensure our reviews

are both of high quality and clinically relevant, and our editorial board’s decision-making processes are

supported by 8 field-specific internationally expert panels of clinicians and researchers (Cleft lip and/or

palate; Dental public health; Operative and prosthodontic dentistry; Oral and maxillofacial surgery; Oral

medicine; Orthodontics; Paediatrics; Periodontology).

As of December 2014, COHG has 153 systematic reviews, 55 review updates and 60 protocols

published on the Cochrane Library, with further reviews and protocols in preparation and an additional

10 registered titles. Reviews on the Cochrane Library have an Impact Factor of 5.939 (2013).

Consequently, it is now ranked 10th of the 150 journals in the Medicine, General & Internal category and

the COHG’s Impact Factor is in the top 3 dental journals.

We have increased our collaboration and partnership working with international guideline

development groups and can demonstrate the impact of COHG reviews in reducing the duplication of

effort.

COHG GLOBAL ALLIANCE

Cochrane reviews are usually undertaken by enthusiastic individuals with some methodological help

from the editorial base. Due to increased commitments on clinicians’ and academics time, and more

complex research methods being introduced centrally by the Cochrane Collaboration, the COHG needed

to fundamentally change the way we support the profession. The Global Alliance was established to

enable an expert methodological and administrative team to support the conduct of priority reviews

ensuring their quality and timeliness.

Since 2011, we have received over £200,000 from Global Alliance partners to support this initiative.

This has enabled us to partially fund a senior systematic reviewer and research coordinator to support

the production of priority reviews, and significantly improve their methodological quality.

A consumer perspective is important to making the reviews assessable and the support received by the

GA is enabling the Group to expand its level of patient involvement and develop a strategy to engage

more globally. The COHG launched an evidence summaries section of the website for patients to use to

inform their decision-making. The first section is on tooth decay/caries, with other areas of concern

identified by the international public survey to be added in the near future.

PARTNER ORGANISATIONS

To date, the following organisations have pledged their support of COHG’s production of high quality

and clinically relevant systematic reviews by donating to the GA, either as a one-off sum, or a

commitment of several years:

British Orthodontic Society, UK (2011-2013)

Royal College of Surgeons Edinburgh (RCSEd),

UK (2011-2013)

New York University College of Dentistry, USA

(2011-2013; 2014-2018)

British Society of Paediatric Dentistry, UK

(2011-2013)

National Center for Dental Hygiene Research

& Practice, USA (2012-2015)

Canadian Dental Hygienists Association,

Canada (2012)

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British Association of Oral Surgeons, UK

(2013-2015)

British Society of Periodontology, UK (2013-

2015)

Mayo Clinic, USA (2013-2014)

British Association for the Study of

Community Dentistry, UK (2014 -)

Initially, we asked GA partners for a commitment of 3-year funding to establish this initiative, and we

now realise that this funding is essential to the future success of the COHG. NIHR have committed new

funding from 2015 until 2020 (at the highest tier for UK review groups), which enables us to employ

editorial staff. The GA-funded senior systematic reviewer and research coordinator have contributed

greatly to the quality and productivity of our reviews. We ask, therefore, that GA partner organisations

extend their commitment to allow us to maintain the current review output.

All GA partners have been involved in determining the process and prioritisation of reviews, including

the opportunity to nominate representatives on the international expert panels. The process identifies

the most clinically important reviews in each field of dentistry to ensure editorial base resources are

focused upon regularly maintaining their evidence on the Cochrane Library considered important by a

clinically relevant international experts (to date numbering a total of 133 panel members, across 8

expert panels) and all relevant topic authors.

During 2014, the COHG undertook extensive prioritisation activities (across 6 areas of dentistry:

periodontology, operative (including endodontic) and prosthodontic dentistry, dental public health,

oral and maxillofacial surgery, oral medicine, cleft lip and/or palate) to identify a core portfolio of

priority titles for the editorial base to maintain. The results of this were added to the previous

prioritisation processes (identical in methodology), conducted in 2011 (orthodontics) and 2013

(paediatric dentistry).

Discussions were supplemented by the addition of a small international patient survey to elicit areas of

concern for consumers, and the contribution of representatives from IADR’s Global Oral Health

Inequalities Research Network to ensure appropriate consideration to the global burden of oral disease.

The process identified 81 existing titles across 8 areas of dentistry as being priority for maintenance by

COHG, and a number of additional new priority titles to be developed by clinically and methodologically

experienced teams in due course (see Figure 1).

COHG will repeat the prioritisation process in 2017 to ensure the core portfolio is inclusive of newly

emerging interventions, trials and priority research. In the interim, COHG continues to consult the

expert panels for clinical guidance in registering any newly proposed titles, as and when required.

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Figure 1. Core portfolio of priority titles

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GA IMPACT UPON OUTPUT

At inception of the GA, after 15 years operation of the COHG, there was a total of 217 COHG publications

on The Cochrane Library (Sep 2010: 73 protocols; 111 new reviews; 33 updated reviews).

As of December 2014, an additional 134 publications have been added to The Cochrane Library

as a direct result of GA members’ support of COHG’s research activities.

The contribution of the GA is recognised on each supported publication (under External sources), with

all GA partners individually listed, as per text below:

External sources

- Cochrane Oral Health Group Global Alliance

The production of all our reviews is assisted by funding from our Global Alliance partners

(http://ohg.cochrane.org/): British Association for the Study of Community Dentistry, UK;

British Association of Oral Surgeons, UK; British Orthodontic Society, UK; British Society of

Paediatric Dentistry, UK; British Society of Periodontology, UK; Canadian Dental Hygienists

Association, Canada; Mayo Clinic, USA; National Center for Dental Hygiene Research &

Practice, USA; New York University College of Dentistry, USA; and Royal College of Surgeons of

Edinburgh, UK

This number includes 52 new protocols, 42 new reviews, and 40 updated reviews, demonstrating

considerable impact of partners’ donations.

These publications are in the following areas of dentistry:

Periodontology: 19 publications - 14%: 8 protocols; 6 new reviews; 5 updated reviews

Operative (including endodontic)/prosthodontic surgery: 33 publications - 25%: 16

protocols; 6 new reviews; 11 updated reviews

Paediatric dentistry: 14 publications - 10%: 5 protocols; 5 new reviews; 4 updated reviews

Dental public health: 7 publications - 5%: 4 protocols; 1 new review; 2 updated review

Oral/maxillofacial surgery: 19 publications - 14%: 3 protocols; 9 new reviews; 7 updated

reviews

Oral medicine: 17 publications - 13%: 7 protocols; 8 new reviews; 2 updated reviews

Orthodontics: 21 publications - 16%: 7 protocols; 6 new reviews; 8 updated reviews

Cleft lip and/or palate: 4 publications - 3%: 2 protocols; 1 new review; 1 updated review

A full list of the GA-supported publications to date follows (priority titles in bold).

As a consequence of GA support, the Cochrane Oral Health Group has:

PUBLISHED gold standard reviews;

PARTNERED diverse collaborators (both individual and organisations);

PRIORITISED globally important topics for dentistry;

PROMOTED evidence based care though presentations and informing new research; and

PERFORMED exceptionally well according to formal Cochrane standards.

We hope our existing partners will continue to support our research activities through

Global Alliance donations in the future, and we look forward to new partners

joining the GA to strengthen COHG’s gold standard research output.

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Area of Dentistry Protocols Reviews Updates Periodontology (19 publications: 8 protocols; 6 reviews; 5 updated reviews)

1. Flossing for the management of periodontal diseases and dental caries (Nov 2010)

2. Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis (Jul 2011)

3. Interventions for the maintenance of the dentition in patients treated for periodontal disease (Oct 2011)

4. Interdental brushing for the management of periodontal diseases and dental caries in adults (May 2012)

5. Enamel matrix derivative for periodontal regeneration in teeth with furcation involvement (Mar 2013)

6. Triclosan/copolymer containing toothpastes for oral health (May 2013)

7. Topical herbal interventions for gingivitis (Jun 2013)

8. Autologous platelet concentrates for treatment of periodontal defects (Dec 2014)

9. Different powered toothbrushes for plaque control and gingival health (Dec 2010)

10. Flossing for the management of periodontal diseases and dental caries in adults (Dec 2011)

11. Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia (Aug 2013)

12. Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults (Dec 2013)

13. Triclosan/copolymer containing toothpastes for oral health (Dec 2013)

14. Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis (Aug 2014)

15. Interventions for replacing missing teeth: treatment of peri-implantitis (Jan 2012)

16. Interventions for replacing missing teeth: management of soft tissues for dental implants (Feb 2012)

17. Routine scale and polish for periodontal health in adults (Nov 2013)

18. Recall intervals for oral health in primary care patients (Dec 2013)

19. Powered versus manual toothbrushing for oral health (Jun 2014)

Operative/ prosthodontic surgery (33 publications: 16 protocols; 6 reviews; 11 updated reviews)

1. Irrigants for non-surgical root canal treatment in mature permanent teeth (Jan 2011)

2. Single crowns versus conventional fillings for the restoration of root filled teeth (May 2011)

3. Laser therapy for dentinal hypersensitivity (Nov 2011)

4. Metal-free materials for fixed prosthodontic restorations (Feb 2012)

5. Gingival retraction for fixed prosthodontic treatment (Apr 2012)

6. Rubber dam isolation for restorative treatment in dental patients (May 2012)

7. Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (Oct 2012)

8. Interventions for replacing missing teeth: alveolar ridge preservation techniques for oral implant site development (Nov 2012)

9. Lasers for caries removal in deciduous and permanent teeth (Nov 2012)

10. Professionally-applied chemically-induced

17. Interventions for replacing missing teeth: partially absent dentition (Feb 2012)

18. One-to-one dietary interventions undertaken in a dental setting to change dietary behaviour (Mar 2012)

19. Single crowns versus conventional fillings for the restoration of root filled teeth (May 2012)

20. Irrigants for non-surgical root canal treatment in mature permanent teeth (Sep 2012)

21. Direct composite resin fillings versus amalgam fillings for permanent or adult posterior teeth (Mar 2014)

22. Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults (Jun 2014)

23. Interventions for replacing missing teeth: different times for loading dental implants (Mar 2013)

24. Operative caries management in adults and children (Mar 2013)

25. Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications (Jul 2013)

26. Interventions for replacing missing teeth: dental implants in zygomatic bone for the rehabilitation of the severely deficient edentulous maxilla (Sep 2013)

27. Interventions for replacing missing teeth: hyperbaric oxygen therapy for irradiated patients who require dental implants (Sep 2013)

28. Antibacterial agents in composite restorations for the prevention of dental caries (Dec 2013)

29. Antibiotic use for irreversible pulpitis (Dec 2013)

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whitening of teeth in adults (Feb 2013) 11. Proximal sealing for managing dental decay in

primary and permanent teeth (Mar 2013) 12. Dental cavity liners for Class I and Class II resin-

based composite restorations (May 2013) 13. Hypnosis for alleviation of anxiety in adults

undergoing dental treatment (Aug 2013) 14. Home-use whitening toothpastes for whitening

teeth in adults (Jan 2014) 15. Management of gag reflex for patients

undergoing dental treatment (May 2014) 16. Adhesive restorations for the treatment of dental

non-carious cervical lesions (Dec 2014)

30. Replacement versus repair of defective restorations in adults: amalgam (Feb 2014)

31. Replacement versus repair of defective restorations in adults: resin composite (Feb 2014)

32. Interventions for replacing missing teeth: different types of dental implants (Jul 2014)

33. Slow-release fluoride devices for the control of dental decay (Nov 2014)

Paediatric dentistry (14 publications: 5 protocols; 5 reviews; 4 updated reviews)

1. Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental treatment in children and adolescents (Mar 2012)

2. Non-fluoride topical remineralising agents containing calcium and/or phosphate for controlling dental caries (Mar 2012)

3. Chlorhexidine versus topical fluoride treatment for the prevention and management of dental caries in children and adolescents (Jul 2012)

4. Xylitol-containing products for preventing dental caries in children and adolescents (Sep 2013)

5. Interventions for increasing acceptance of local anaesthetic in children having dental treatment (Mar 2014)

6. Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children (Dec 2011)

7. Preoperative analgesics for additional pain relief in children and adolescents having dental treatment (Sep 2012)

8. Interventions for treating traumatised permanent front teeth: luxated (dislodged) teeth (Apr 2013)

9. Interventions for the restorative care of amelogenesis imperfecta in children and adolescents (Jun 2013)

10. Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental treatment in children and adolescents (Dec 2014)

11. Sedation of children undergoing dental treatment (Mar 2012)

12. Sealants for preventing dental decay in the permanent teeth (Mar 2013)

13. Fluoride varnishes for preventing dental caries in children and adolescents (Jul 2013)

14. Pulp treatment for extensive decay in primary teeth (Aug 2014)

Dental public health (7 publications: 4 protocols; 1 review; 2 updated reviews)

1. Primary school-based behavioural interventions for preventing caries (Oct 2011)

2. Maternal consumption of xylitol for preventing dental decay in children (Nov 2012)

3. Oral health educational interventions for nursing home staff and residents (May 2013)

4. Water fluoridation for the prevention of dental caries (Dec 2013)

5. Primary school-based behavioural interventions for preventing caries (May 2013)

6. Screening programmes for the early detection and prevention of oral cancer (Nov 2010)

7. Screening programmes for the early detection and prevention of oral cancer (Nov 2013)

Oral/ maxillofacial surgery (19 publications: 3 protocols;

1. Dental extractions prior to radiotherapy to the jaws for reducing post-radiotherapy dental complications (Dec 2010)

2. Interventions for the management of dry mouth: non-systemic therapies (Jan 2011)

4. Pharmacological interventions for pain in patients with temporomandibular disorders (Oct 2010)

5. Interventions for the treatment of oral cavity and oropharyngeal cancer:

13. Domestic violence screening and intervention programmes for adults with dental or facial injury (Dec 2010)

14. Interventions for the treatment of oral cavity and oropharyngeal cancer:

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9 reviews; 7 updated reviews)

3. Interventions for the treatment of oral and oropharyngeal cancers: targeted therapy and immunotherapy (Feb 2013)

radiotherapy (Dec 2010) 6. Arthroscopy for temporomandibular

disorders (May 2011) 7. Interventions for the management of dry

mouth: topical therapies (Dec 2011) 8. Interventions for the management of

temporomandibular joint osteoarthritis (Apr 2012)

9. Dental extractions prior to radiotherapy to the jaws for reducing post-radiotherapy dental complications (Feb 2013)

10. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth (Dec 2013)

11. Interventions for iatrogenic inferior alveolar and lingual nerve injury (Apr 2014)

12. Surgical techniques for the removal of mandibular wisdom teeth (Jul 2014)

chemotherapy (Apr 2011) 15. Interventions for the treatment of oral

and oropharyngeal cancers: surgical treatment (Sep 2011)

16. Surgical removal versus retention for the management of asymptomatic impacted wisdom teeth (Jun 2012)

17. Interventions for the management of mandibular fractures (Jul 2013)

18. Antibiotics for the prophylaxis of bacterial endocarditis in dentistry (Oct 2013)

19. Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus (May 2014)

Oral medicine (17 publications: 7 protocols; 8 reviews; 2 updated reviews)

1. Interventions for myogenous temporomandibular disorder (TMD) patients (Nov 2010)

2. Interventions for the management of dry mouth: non-pharmacological interventions (Feb 2012)

3. Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults (Nov 2012)

4. Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions (Dec 2012)

5. Interventions for the management of taste disturbances (Apr 2013)

6. Topical interventions for recurrent aphthous stomatitis (mouth ulcers) (Dec 2013)

7. Interventions for the management of oral ulcers in Behçet's disease (Mar 2014)

8. Psychosocial interventions for the management of chronic orofacial pain (Nov 2011)

9. Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) (Sep 2012)

10. Antibiotics to prevent complications following tooth extractions (Nov 2012)

11. Local interventions for the management of alveolar osteitis (dry socket) (Dec 2012)

12. Interventions for the management of dry mouth: non-pharmacological interventions (Sep 2013)

13. Clinical assessment to screen for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults (Nov 2013)

14. Interventions for the management of oral ulcers in Behçet's disease (Sep 2014)

15. Interventions for the management of taste disturbances (Nov 2014)

16. Interventions for preventing oral mucositis for patients with cancer receiving treatment (Apr 2011)

17. Interventions for treating oral lichen planus (Jul 2011)

Orthodontics (21 publications: 7 protocols; 6 reviews;

1. Interventions for correcting relapse of the lower front teeth after orthodontic treatment (Oct 2010)

2. Direct versus indirect bonding for bracket

20. Adhesives for bonded molar tubes during fixed brace treatment (Jun 2011)

21. Treatments for adults with prominent lower front teeth (May 2012)

26. Orthodontic treatment for deep bite and retroclined upper front teeth in children (Jan 2012)

27. Extraction of primary (baby) teeth for

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8 updated reviews) placement in orthodontic patients (Jul 2012) 3. Laceback ligatures for controlling anchorage in

patients undergoing fixed orthodontic treatment (Aug 2012)

4. Orthodontic treatment for bimaxillary proclination in children and adults (Nov 2012; withdrawn Mar 2014 - link unavailable)

5. Non-pharmacological interventions for alleviating pain during orthodontic treatment (Dec 2012)

6. Adjunctive surgical procedures for accelerating tooth movement in patients undergoing orthodontic treatment (Jun 2013)

7. Non-surgical adjunctive interventions for accelerating tooth movement in patients undergoing fixed orthodontic treatment (Dec 2013)

22. Interventions for managing relapse of the lower front teeth after orthodontic treatment (Sep 2013)

23. Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children (Sep 2013)

24. Orthodontic treatment for distalising upper first molars in children and adolescents (Oct 2013)

25. Enamel etching for bonding fixed orthodontic braces (Nov 2013)

unerupted palatally displaced permanent canine teeth in children (Dec 2012)

28. Initial arch wires for tooth alignment during orthodontic treatment with fixed appliances (Apr 2013)

29. Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children (Nov 2013)

30. Fluorides for the prevention of early tooth decay (demineralised white lesions) during fixed brace treatment (Dec 2013)

31. Orthodontic treatment for posterior crossbites (Aug 2014)

32. Reinforcement of anchorage during orthodontic brace treatment with implants or other surgical methods (Aug 2014)

33. Orthodontic and orthopaedic treatment for anterior open bite in children (Sep 2014)

Cleft lip and/or palate (4 publications: 2 protocols; 1 review; 1 updated review)

1. Pre-surgical orthopaedics (PSO) for infants with complete cleft lip and palate (Dec 2010)

2. Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients (Feb 2013)

3. Secondary bone grafting for alveolar cleft in children with cleft lip or cleft lip and palate (Jun 2011)

4. Feeding interventions for growth and development in infants with cleft lip, cleft palate or cleft lip and palate (Feb 2011)