2012 02-22 rittweger orlando ipmc

Folie 1

The Space LaboratoryPast Experience and Future Perspectives

Jörn Rittweger

German Aerospace Center (DLR)

Folie 2Vortrag > Autor > Dokumentname > Datum

STS-9

First SpaceLab Payload (28th Nov to 8th Dec 1983)

Preparing Spacelab 1 at KSC

So

urc

e:

ES

A/N

AS

A

So

urc

e:

NA

SA

Launch of STS-9

Folie 3

Spacelab: German Astronauts

Ulf Merbold

Reinhard FurrerErnst Messerschmid

Ulrich WalterHans Schlegel

D1

D2

STS-9

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Life Science Experiments on STS-9

PI Experiment Discipline Country Publication

A Scano Ballistocardiography in weightlessness

Cardio-vascular Physiology

Italy

RJ von Baumgarten

Effects of Rectilinear Acceleration, Optokinetic and Caloric Stimulation on Human Vestibular Reactions and Sensations

Vestibular Physiology

Germany Science 225:208-12 (1984)

O Quadens Eye movements during sleep Neuroscience Belgium Science 225:221-222 (1984)

A Cogoli Effects of weightlessness on lymphocyte proliferation

Cell and Molecular Biology

Switzerland Science 225:228-230 (1984)

HE Ross Mass discrimination during weightlessness

Neuroscience United Kingdom

Science 225:219-221 (1984)

KA Kirsch Measurement of central venous pressure and hormones in blood serum during weightlessness

Cardio-vascular Physiology

Germany Science 225:218-219 (1984)

Folie 5

Caloric Nystagmus:a standard test in medicine

• Warm fluid evokes typical sequence of

rapid and slow eye movements

• Explained by density-related fluid flow by

Robert Bárány (Nobel prize in 1915)

• However, caloric nystagmus can also be

elicited in the absence of gravity

• So, the mechanisms are still unclear….

after 100 years of research on Earth!

3D-ETDClarke & Scherer (1988)


Salt & blood pressure:Space Medicine fosters Medicine on Earth

Excess sodium is stored in the skin!

Macrophages are salt-sensitive

Lymphatic vessel formation in response to salty diet

Machnik et al., Nature Medicine, 15:545-552 (2009)

Folie 7

MARS500

24h Diastolic Blood Pressure

BDC ISO-1 ISO-2 ISO-3 R+6 R+13

p (m

mH

g)

0

60

65

70

75

80

85

‡ ‡

*

*: p < 0.05‡: p < 0.001

Renin, mineralocorticoids, glucocorticoids, androgens, and sodium excretion can explain 80% of long-term blood pressure variance during confinement.

Folie 8

Flight experiment SOLO:

SOdium LOad in Microgravity

PI: Petra Frings-Meuthen

Astro 1 Astro 224

24.5

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28.5

Low NaCl High NaCl

Bicarbonate mmol/L

Hypothesis

Salt Intake

Acidosis

Bone Loss


Lessons learnt

Life Science in Space is possible and often fruitful

More experiments, and greater samples are

desirable

Solution: International Space Station

Complicated mechanisms often difficult to unravel

in Space

Solution: Ground based parallel research

Folie 10

Gerzer Passing the Torch 110421 10

:envihabA new DLR facility for ground-based

parallel research into the human organism

Partners: Space Community+Acad. Industry Health Insurers Hospital Chains Military„Green Industry“ Outreach Stakeholders


:enviGeneration – Matrix organisation

Genetics / omics

Gender

Age

Prevention & Rehabilitation

e.g.

Cen

trifu

ge T

rain

ing

e.g.

Pha

rmac

olog

ical

C

ount

erm

easu

res

e.g.

Eye

pro

blem

s in

ast

rona

uts

…

Musculoskeletal, cardiovascular, psychological well-being

Topics

The

mes


Thank you for your attention !

:envihab - Current status (functional in 2013)

2012 02-22 rittweger orlando ipmc

Technology

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