2010-2011 IRCM Annual Report
64
1 INSTITUT DE RECHERCHES CLINIQUES DE MONTRÉAL Affiliated with the Université de Montréal 2010-2011 ANNUAL REPORT
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Transcript of 2010-2011 IRCM Annual Report
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INSTITUT DE RECHERCHES CLINIQUES DE MONTRÉAL Affiliated with the Université de Montréal
2010-2011 ANNUAL REPORT
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THE IRCMA LEAdINg bIOMEdICAL REsEARCH INsTITUTE LOCATEd IN THE HEART Of MONTRéAL
Our prioritiesConquering cancer | Living with a healthy heart | Fighting infectious diseases | Understanding embryonic development and the nervous system | Exploring the complexity of biological systems | Accelerating clinical research | Participating in ethical debates
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discovering
researchers – IRCM
research professors
scientific publications
millionin research
funding
$18.8
152
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treating
yearly visits at the IRCM clinic
health professionals
physicians specialized in hypertension,
cholesterol, obesity and
diabetes
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20,000
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innovating
core facilities
specialized services
research platforms
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contributing new
declarations of invention
new patent filings (or applications)
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training
61postdoctoral
fellows
teaching hours
* at the Université de Montréal 316 hours
(25 of our researchers)
at McGill University 92 hours
(13 of our researchers)
408*
113
}61
Master’s and PhD students
57scholarship
holders
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fOUNdEd IN
1967425
researchers, students and employees
A budget of 38 million dollars
Independent non-profit institutionAffiliated with the Université de MontréalAssociated with Mcgill UniversityIRCM Clinic affiliated with the Centre hospitalier de l’Université de Montréal (CHUM)funded by Quebec ministry of Economic development, Innovation and Export Trade (MEdIE)supported by the fonds de recherche du Québec – santé (fRQs)Member of the Université de Montréal’s RUIs (Réseau universitaire intégré de santé)
dr. Jacques genest, founder of the IRCM, surrounded by doctors from Montréal’s Hôtel-dieu
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2011MIssIONTO UNdERsTANd THE CAUsEs Of dIsEAsEs
TO fINd dIAgNOsTIC TOOLs ANd MEANs Of PREvENTION ANd TREATMENT
TO TRAIN A NEw gENERATION Of HIgH-CALIbRE sCIENTIsTs
TO CONTRIbUTE TO QUEbEC’s sOCIO-ECONOMIC dEvELOPMENT by fACILITATINg THE COMMERCIAL dEvELOPMENT Of NEw dIsCOvERIEs
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MEssAgEs fROM MANAgEMENT
Messages from management 19Planning the future 26
discovering Research programs 29
treating IRCM Clinic 45
innovating Core facilities and technology platforms 55
contributing Technology transfer 59
training Tomorrow’s researchers 63
participating Science for all 73Research funding 77Administration 78 IRCM Board of Directors 80 IRCM Management 82 Organizational charts 86 Financial statements 88
IRCM Foundation 90Messages from management 99
supporting Benefit activities 103
volunteering IRCM Foundation Board of Directors 107 Give for Life campaign Board 108
giving The impact of your donations 111 Partners and donors 116 Research Funds and Chairs 123
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Message from the Chairman of the Board
This message will be my last as Chairman of the Institut de recherches cliniques de Montréal’s Board of Directors. After six wonderful years chairing this Board, the time has come for me to pass on the torch.
With Louise Lambert-Lagacé now at the helm, I am confident it is in excellent hands.
During my time on the IRCM’s Board, I have had the pleasure to meet outstanding individuals: passionate researchers, devoted nurses and doctors, promising students and postdoctoral fellows, knowledgeable and hard-working management and staff members. With them, I have shared the pride of belonging to a prestigious institution known the world over for the quality of its research, and one where a stimulating and convivial environment prevails.
My TIME AT THE INsTITUT
I think I can rightly congratulate myself for what we accomplished during my chairmanship: revision of the Institut’s legal status, implementation of a new alliance with Univalor to support the transfer of our technologies, inauguration of
new laboratories and a new clinic, review of our governance rules and revision of our bylaws, in-depth review of our affiliation contract with the Université de Montréal, creation of the ombudsman position and appointment of its first title-holder, establishment of a Communications Committee to improve the Institut’s visibility.
Following the IRCM’s 40th anniversary, which we celebrated in 2007 in the presence of its founder, Dr. Jacques Genest, we launched a major fundraising campaign in collaboration with the IRCM Foundation that will continue until 2015. Finally, I had the pleasure of confirming the renewal of Dr. Tarik Möröy’s term of office as President and Scientific Director. Since his arrival, he has shown remarkable leadership skills that have been evidently reflected in all sectors of activity at the Institut, and which I would hereby like to recognize.
ACKNOwLEdgMENTs
I would like to earnestly thank my colleagues on the Board of Directors for their support. I wish them success in the pursuit of their respective mandates under the chairmanship of Louise Lambert-Lagacé who will, undoubtedly, perform her duties with characteristic effectiveness and enthusiasm. I welcome the arrival of
two new Board members: Monique Jérôme-Forget, an important figure in Quebec’s political scene and currently Special Advisor at Osler, Hoskin & Harcourt, and Michel Lespérance, a lawyer who pursued his career at the Université de Montréal.
On behalf of the entire management team and all Board members, I wish to sincerely thank Claude A. Garcia, who left after serving on the Board for numerous years, for his contributions and continued commitment, particularly on the Audit Committee.
Thank you to everyone and long live the IRCM!
géRARd A. LIMOgEs, C.M., fCA
Message from the President and Scientific Director
The year 2010-2011 was marked by the implementation of the elements required to carry out the projects defined by our 2010-2015 strategic plan.
Before presenting you with a report of this year’s activities, I would like to take this opportunity to sincerely thank Gérard A. Limoges, outgoing Chairman of the IRCM’s Board of Directors.
THANK yOU TO géRARd A. LIMOgEs
For five years, I have had the pleasure of working with Gérard, an energetic man who truly cares for the future of the Institut. In fact, the summary of accomplishments included in his message accurately describes his commitment to our institution. I am very grateful for his warm welcome upon my arrival, as well as for the support he has provided me over the past five years. I would therefore like to thank him personally, and on behalf of everyone at the IRCM. On behalf of us all, on whom Gérard has made a lasting impression, I wish him success in the future and, once again, thank you.
sTRATEgIC PLANNINg
When the Board of Directors adopted our strategic plan, we quickly got to work to set up the elements required for us to complete all measures planned for 2010-2015. It is my pleasure to present to you, in the following pages, the challenges of this strategic plan.
RECRUITMENT
I was honoured to welcome two new researchers this year. Hua Gu, with a PhD in genetics from the University of Cologne in Germany and Professor of immunology at Columbia University before his arrival at the Institut, is now Full IRCM Research Professor, holder of the André-Aisenstadt Chair of Excellence, and Director of the new Molecular Immunology research unit. He is part of the Immunity and Viral Infections research program. Jennifer Estall, who received a PhD in molecular biology from the University of Toronto and who was a postdoctoral fellow at the Dana-Farber Cancer Institute and Harvard Medical School in Boston, is currently Assistant IRCM Research Professor and Director of the Molecular Mechanisms of Diabetes research unit in the Cardiovascular and Metabolic Diseases research program. I also had the pleasure of announcing the recruitment of Benjamin Haibe-Kains, who obtained
a PhD in bioinformatics and who is currently working as a postdoctoral fellow at the Dana-Farber Cancer Institute and Harvard Public School of Health in Boston. He will join the institute in January 2012 as Assistant IRCM Research Professor and Director of the Bioinformatics and Computational Genomics research unit. His laboratory will be part of the IRCM’s Systems Biology and Medicinal Chemistry research program.
INsTITUTIONAL fILEs
websiteOur management team, as well as employees in the Communications and Information Technology departments, persistently worked on the development and launch of our new website. Today, we are very happy to offer a website with a new look and user-friendly appearance: www.ircm.qc.ca.
IRCM’s evaluation by the fRsQFollowing a visit in February 2011 by the Fonds de recherche en santé du Québec (FRSQ), known today as the Fonds de recherche du Québec – Santé (FRQS), we received our research centre’s evaluation report and are extremely proud of its results, the conclusions of which led the evaluation committee’s chairman to qualify the IRCM as a “jewel of Quebec” and recommend the restitution, or even the increase, of the IRCM’s funding. This is excellent
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news, as this financial support is crucial to the proper functioning of our institute.
AgREEMENT wITH MCgILL UNIvERsITy
Historically, the Institut and McGill University have engaged in an informal arrangement, by which IRCM researchers, holding an adjunct professor status in McGill’s Faculty of Medicine, held certain privileges allowing them to supervise graduate students registered at the University. I am pleased to announce that an agreement has now been formalized by way of an official letter, signed by both institutions – McGill University and the IRCM – and now includes the supervision of postdoctoral fellows registered at the University.
INTERNAL APPOINTMENTs
Management changes were made in the Academic Affairs department. Timothy L. Reudelhuber accepted to become the new Executive Director of Academic Affairs. As such, he became a part of the Institut’s administrative management team and a member of the Management Committee. He is also responsible for the academic staff. I wish to thank him, as well as Christian F. Deschepper who held the position over the past few years. Dr. Deschepper took over for Dr. Reudelhuber as Director of
the Cardiovascular and Metabolic Diseases research program. Jean-François Côté was appointed Associate Director of scientific activities in the Academic Affairs office. I thank him for accepting this new challenge and also thank Benoit Coulombe who previously held the title.
REsEARCH PROgRAM CHANgEs
The year 2010-2011 saw numerous changes in the IRCM’s research programs. Some of our researchers retired while others reoriented their scientific careers to hold new positions, either within the Institut or in prestigious research centres abroad. I wish to thank them for their work and accomplishments at the IRCM and for the quality of their research projects.
gIvE fOR LIfE MAJOR fUNdRAIsINg CAMPAIgN
The IRCM Foundation’s major fundraising campaign continues. Many donations have been confirmed. In this respect, I would like to thank everyone who supports the Institut. Your contribution is very important.
MEETINg THE bUsINEss COMMUNITy
I was privileged to meet members of Montréal’s business community when I spoke at a conference held
by the Montreal Council on Foreign Relations (MCFR). It was a great opportunity for me to share my concerns about research funding in general, and particularly in Canada. I would like to thank Pierre Lemonde, MCFR’s President and CEO, for inviting me to this prestigious platform.
In closing, I would like to note that, once again this year, our researchers obtained excellent results in their grant applications, especially those for the Canadian Institutes of Health Research (CIHR) where their success rate was high above the national average.
Finally, I want to thank the entire IRCM community, researchers, students, employees and Board members, for their commitment and dedication. Each in our own way, we are contributing to our institution’s development and success.
TARIK MöRöy, Phd
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CLINICAL REsEARCH bOOsT
Boosting clinical research requires collaboration between basic science researchers and clinical researchers in a synergistic approach. To achieve this, we must better support and accelerate communication between basic and clinical research by exploiting their complementarity.
An ad hoc committee was created in partnership with CHUM to make recommendations for a clinical and translational research model including appropriate performance indicators and conditions for success.
CREATION Of A fORMAL HOsPITAL ALLIANCE wITH CHUM
Successful clinical and translational research at the IRCM must assuredly involve increased access to a hospital environment and clinical researchers. Thus, a formal alliance with the Centre hospitalier de l’Université de Montréal (CHUM) as a main partner in clinical research will give both organisations an important strategic advantage. For the IRCM, CHUM will offer privileged access to a clinical environment and patients with complex medical conditions, as well as a potential pool of clinical researchers. For its part, the IRCM will provide CHUM with its world-renowned expertise in basic science and its modern research equipment.
CONsOLIdATION Of OUR ALLIANCE wITH THE UNIvERsITé dE MONTRéAL ANd TRAININg PRIORITIsATION
The IRCM must consolidate its university affiliation with the Université de Montréal in order to maximize collaboration between the Université and the Institut, and reassert its position as a leading research centre for graduate studies.
A new and innovative training program for international graduate students has been submitted to the Université de Montréal, and planning is underway at the IRCM for its implementation.
sTRATEgIC PROJECTs AdvIsOR
The IRCM created the position of Strategic Projects Advisor, which will be held by Martin Godbout, former President and CEO of Genome Canada. He will assist the Institut in developing projects for extensive strategic grant applications. His services will also enable the IRCM and its scientists to identify new funding possibilities and seize opportunities that might otherwise be lost.
sCIENTIfIC AdvIsORy bOARd
A Scientific Advisory Board, chaired by Alan Bernstein, has been formed. Made up of seven members, this committee’s main objective will be to advise the Institut on its scientific orientation, clinical and translational research, technology transfer strategies and means of forging successful alliances with other research institutions. This committee will also conduct a full institutional and scientific review of the IRCM every five years.
COMMITTEE MEMbERs: Alain Bernstein, Chair; John Aitchison (Institute for Systems Biology, USA); Peter Bruns (Howard Hughes Medical Institute, USA); Gordon Fishell (New York University, USA); Paul Frenette (Albert Einstein College of Medicine, USA); Roderick R. McInnes (Lady Davis Research Institute, Canada); Walter Rosenthal (Max-Delbrück Center for Molecular Medicine, Germany); Alfred Singer (National Cancer Institute,
USA). PLANNINg THE fUTURE
IN RECENT yEARs, THE fIELd Of LIfE sCIENCEs sAw MAJOR TRANsfORMATIONs, As
wELL As A RAPId ANd sUbsTANTIAL ExPANsION IN QUEbEC ANd CANAdA. ANALysIs Of
THE INsTITUT’s RECENT EvOLUTION, IN PARALLEL wITH THAT Of bIOMEdICAL REsEARCH,
ALLOwEd fOR CERTAIN ObsERvATIONs ANd LEd Us TO CONdUCT A sTRATEgIC PLANNINg
ExERCIsE.
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discovering
The Institut de recherches cliniques de Montréal was the first research centre in Quebec to bring together basic science researchers and clinical researchers under one roof, thereby becoming the forerunner for translational research centres.
-- 5 research programs
- 35 research units*152 scientific publications
262 researchers and clinicians***39 laboratories were operational in 2010-2011
** including postdoctoral fellows and students - August 31, 2011
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“In 2010, we published the results of a study in the scientific journal Current Biology, from the Cell Press group, which demonstrates that a key mechanism in the control of cell motility could eventually lead to the development of new cancer-treating drugs that could block the spread of tumours. As many as 90% of cancer patient deaths are attributable to metastasis, which explains the importance of understanding the molecular mechanisms at the basis of this harmful process.”
JEAN-fRANÇOIs CÔTé, PhdAssociate IRCM Research ProfessorDirector of the Cytoskeletal Organization and Cell Migration research unit
Jean-françois Côté, Nadine fradet, research assistant, and Manishha Patel, doctoral student
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Artur Kania and Tzu-Jen Kao, postdoctoral fellow
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CANCER REsEARCH PROgRAM
“The Cancer research program brings together researchers interested in basic cell proliferation and signalling mechanisms, breast cancer and tumor suppressor genes, leukemia and lymphoma, tumour angiogenesis, cell migration and metastasis. The general research objective of our program’s members is to understand the molecular mechanisms governing the neoplastic process, such as normal and pathological hematopoiesis, ciliopathies, cell motility and dissemination, and signalling in normal and cancerous epithelial and endothelial cells. Projects in this research program aim to discover new molecular targets and develop new therapeutic approaches and/or molecules to counter cancer progression.”
MARIE TRUdEL, PhdDirector of the Cancer research programFull IRCM Research ProfessorDirector of the Molecular Genetics and Development research unit
CONQUERINg CANCERREsEARCH UNITs
Jean-François Côté, PhD – Director, Cytoskeletal Organization and Cell Migration – Associate IRCM Research Professor
Jean-Philippe Gratton, PhD – Director, Endothelial Cell Biology – Associate IRCM Research Professor – Canada Research Chair in Endothelial Cell Signalling and Angiogenesis
Tarik Möröy, PhD – Director, Hematopoiesis and Cancer – Full IRCM Research Professor – Canada Research Chair in Hematopoiesis and Immune Cell Differentiation
Katrina Podsypanina, MD, PhD – Director, Breast Cancer Biology – Assistant IRCM Research Professor
Marie Trudel, PhD – Director, Molecular Genetics and Development – Full IRCM Research Professor
William Y. Tsang, PhD – Director, Cell Division and Centrosome Biology – Assistant IRCM Research Professor
Jean Vacher, D.Sc. – Director, Cellular Interactions and Development – Full IRCM Research Professor
7 teams
2 Canada Research Chairs
17 publications by the program’s researchers
1 researcher honoured: Tarik Möröy was selected by Canadians for Health Research (CHR) as Researcher of the Month in January 2011.
CHR is a national organisation dedicated to promoting health research in Canada.
2 scholarship holders from the Fonds de recherche du Québec – Santé (FRQS): Jean-François Côté and William Y. Tsang
1 New Investigator Award from the Canadian Institutes of Health Research (CIHR): William Y. Tsang
6 operating grants from the Canadian Institutes of Health Research (CIHR), 3 recipients, $3.2 million: Jean-Philippe Gratton, Tarik Möröy, William Y. Tsang
2010-2011
MARIE TRUdEL
“PROJECTs IN THIs REsEARCH PROgRAM AIM TO dIsCOvER NEw MOLECULAR TARgETs ANd dEvELOP NEw THERAPEUTIC APPROACHEs ANd/OR MOLECULEs.”
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CARdIOvAsCULAR ANd METAbOLIC dIsEAsEs REsEARCH PROgRAM
“The cardio-metabolic research program groups together researchers working on the biology of cardiovascular diseases and diabetes. Collectively, our projects lead to a better understanding of risk factors for cardiovascular diseases, including genetic factors, hypertension, dyslipidemia, endothelial cell dysfunctions and metabolic disorders. This research is conducted by basic researchers as well as clinical researchers, thereby increasing the clinical relevance of our work. This year, our research program was enriched by the arrival of Dr. Jennifer Estall, allowing us to benefit from her expertise in the molecular pathophysiology of type-2 diabetes.”
CHRIsTIAN f. dEsCHEPPER, MdDirector of the Cardiovascular and Metabolic Diseases research programFull IRCM Research ProfessorDirector of the Experimental Cardiovascular Biology research unit
LIvINg wITH A HEALTHy
HEARTREsEARCH UNITs
Christian F. Deschepper, MD – Director, Experimental Cardiovascular Biology – Full IRCM Research Professor
Louis-Gilles Durand, O.Q., PhD, ing. – Director, Biomedical Engineering (laboratory closed on December 31, 2010)
Jennifer Estall, PhD – Director, Molecular Mechanisms of Diabetes – Assistant IRCM Research Professor
Pierre Larochelle, MD, PhD, FRCPC, FACP, FAHA – Director, Cardiovascular Pharmacology
Claude Lazure, PhD – Director, Neuropeptide Structure and Metabolism – Full IRCM Research Professor
Rémi Rabasa-Lhoret, MD, PhD – Director, Metabolic Diseases – J.A. DeSève Chair of Excellence
Timothy L. Reudelhuber, PhD – Director, Molecular Biochemistry of Hypertension – Full IRCM Research Professor
M. Ram Sairam, PhD – Director, Molecular Endocrinology – Full IRCM Research Professor
Nabil G. Seidah, C.M., O.Q., PhD, MSRC – Director, Biochemical Neuroendocrinology – Full IRCM Research Professor – Canada Research Chair in Precursor Proteolysis
Gaétan Thibault, PhD – Director, Cellular Biology of Hypertension (laboratory closed on January 31, 2011)
10 teams
1 Canada Research Chair
1 IRCM Research Chair
56 publications by the program’s researchers
2 researchers honoured: Pierre Larochelle is appointed Professor Emeritus, a rare honour granted by the Université de Montréal; and Timothy L. Reudelhuber is honoured by the American Heart Association’s Council for High Blood Pressure Research as honorary speaker for the 2010 Arthur C. Corcoran Memorial Lecture
1 grant of $20,000 from Diabetes Québec: Rémi Rabasa-Lhoret
2010-2011
CHRIsTIAN f. dEsCHEPPER
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IMMUNITy ANd vIRAL INfECTIONs REsEARCH PROgRAM
“The Immunity and Viral Infections research program integrates researchers interested not only by the development of immune cells and the regulation of their functions, but also by viral infections, especially those involving viruses that infect immune cells. The scientific mission of our research program is to understand the signalling mechanisms that play an important role in the development, the function and the diseases of the immune system as well as to explore how viral infections, namely HIV/AIDS, lead to immune dysfunctions. Collectively, our studies have led to a better understanding of immune cell regulation in normal and pathological conditions such as during autoimmune diseases, viral infections and immunodeficiency. This year, Dr. Hua Gu, a renowned senior immunologist, joined our research program. Dr. Gu’s work on antitumor immunotherapy will help strengthen our translational research.”
éRIC A. COHEN, PhdDirector of the Immunity and Viral Infections research programDirector of the Human Retrovirology research unitCanada Research Chairholder in Human Retrovirology
fIgHTINg INfECTIOUs
dIsEAsEsREsEARCH UNITs
Éric A. Cohen, PhD – Director, Human Retrovirology – Canada Research Chair in Human Retrovirology
Vibhuti P. Dave, PhD – Director, Lymphocyte Development (laboratory closed on December 31, 2010)
Javier Marcelo Di Noia, PhD – Director, Mechanisms of Genetic Diversity – Associate IRCM Research Professor – Canada Research Chair in Genetic Diversity
Hua Gu, PhD – Director, Molecular Immunology – Full IRCM Research Professor – André-Aisenstadt Chair of Excellence in Immunology
Paul Jolicoeur, MD, PhD, MSRC – Director, Molecular Biology – Full IRCM Research Professor – Canada Research Chair in Studies of Pathogenesis of Retrovirus-Induced Diseases
Woong-Kyung Suh, PhD – Director, Immune Regulation – Assistant IRCM Research Professor
André Veillette, MD, MSRC – Director, Molecular Oncology – Full IRCM Research Professor – Canada Research Chair in Immune System Signalling
7 teams
3 Canada Research Chairs
1 IRCM Research Chair
17 publications by the program’s researchers
1 operating grant from the Canadian Institutes of Health Research (CIHR), $700,000: Éric A. Cohen
2010-2011
éRIC A. COHEN
“OUR sTUdIEs HAvE LEd TO A bETTER UNdERsTANdINg Of IMMUNE CELL REgULATION IN NORMAL ANd PATHOLOgICAL CONdITIONs...”
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NEURObIOLOgy ANd dEvELOPMENT REsEARCH PROgRAMUnderstanding embryonic development and the nervous system Participating in ethical debates
“Researchers in the Neurobiology and Development research program focus their efforts on understanding the cellular and molecular mechanisms that control the development of different organs. Certain groups are interested in mechanisms controlling cell proliferation, differentiation, polarity and death during the development of the nervous system, pituitary gland, limbs, bones, kidneys and epithelial tissues, while others study hormone action mechanisms or guidance mechanisms that allow axons to find their target within a complex neural network. One of our teams also explores ethical questions related to neurosciences. Hence, our researchers’ work is based on simple reasoning: in order to better understand the pathology of diseases and develop effective therapeutic strategies, it is absolutely necessary to know, in detail, the mechanisms that control the normal development of our organs. The knowledge acquired should thereby have a major impact on diagnostic, prevention and treatment strategies.”
MICHEL CAyOUETTE, PhdDirector of the Neurobiology and Development research programAssociate IRCM Research Professor Director of the Cellular Neurobiology research unit
UNdER-sTANdINg
THE NERvOUs sysTEM
REsEARCH UNITs
Michel Cayouette, PhD – Director, Cellular Neurobiology – Associate IRCM Research Professor
Frédéric Charron, PhD – Director, Molecular Biology of Neural Development – Associate IRCM Research Professor
Jacques Drouin, D.Sc., MSRC – Director, Molecular Genetics – Full IRCM Research Professor
David R. Hipfner, PhD – Director, Epithelial Cell Biology – Assistant IRCM Research Professor
Marko Horb, PhD – Director, Molecular Organogenesis (laboratory closed on June 1, 2011)
Artur Kania, PhD – Director, Neural Circuit Development – Associate IRCM Research Professor
Marie Kmita, PhD – Director, Genetics and Development – Assistant IRCM Research Professor – Canada Research Chair in Molecular Embryology and Genetics
Éric Racine, PhD – Director, Neuroethics – Associate IRCM Research Professor
8 teams
1 Canada Research Chair
36 publications by the program’s researchers
1 scholarship holder from the Fonds de recherche du Québec — Santé (FRQS): Michel Cayouette
1 New Investigator Award from the Canadian Institutes of Health Research (CIHR): David R. Hipfner
3 operating grants from the Canadian Institutes of Health Research (CIHR), $1.6 million: Michel Cayouette, Jacques Drouin, Marie Kmita
1 grant of $120,000 from the Cancer Research Society: Frédéric Charron
1 grant of $45,000 from Parkinson Society Canada: Jacques Drouin
2010-2011
MICHEL CAyOUETTE
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sysTEMs bIOLOgy ANd MEdICINAL CHEMIsTRy REsEARCH PROgRAM“The Systems Biology and Medicinal Chemistry research program mainly aims to develop and use mid- and high-throughput analytical methods to map human networks of protein interaction (interactome). Collectively, our researchers are interested in protein-protein interactions, as well as in protein-DNA/chromatin, protein-RNA and protein-metabolite interactions. They also strive to better understand the dynamic regulation of these networks, and their malfunctioning during diseases. Certain members of the research program are developing chemical compounds that can interfere with the interaction or activity of proteins, and cellular and viral enzymes. In addition, our researchers have set up powerful technologies allowing them to maintain the high pace of their discoveries in genomics, proteomics, bioinformatics, synthetic chemistry, screening and imaging for many years to come.”
bENOIT COULOMbE, PhdDirector of the Systems Biology and Medicinal Chemistry research programFull IRCM Research Professor Director of the Gene Transcription and Proteomics research unit
ExPLORINg THE COMPLExITy
Of bIOLOgICAL sysTEMs
REsEARCH UNITs
Jacques Archambault, PhD – Director, Molecular Virology – Associate IRCM Research Professor
Benoit Coulombe, PhD – Director, Gene Transcription and Proteomics – Full IRCM Research Professor
Yvan Guindon, C.M., PhD, MSRC – Director, Bioorganic Chemistry – Full IRCM Research Professor
Éric Lécuyer, PhD – Director, RNA Biology – Assistant IRCM Research Professor
Marlene Oeffinger, PhD – Director, Ribonucleoprotein Biochemistry – Assistant IRCM Research Professor
François Robert, PhD – Director, Chromatin and Genomic Expression – Associate IRCM Research Professor
Peter W. Schiller, O.Q., PhD, MSRC – Director, Chemical Biology and Peptide Research – Full IRCM Research Professor
7 teams
26 publications by the program’s researchers
2 scholarship holders from the Fonds de recherche du Québec – Santé (FRQS): Éric Lécuyer, Marlene Oeffinger
1 New Investigator Award from the Canadian Institutes of Health Research (CIHR): Marlene Oeffinger
1 operating grant from the Canadian Institutes of Health Research (CIHR), $410,109: Éric Lécuyer
2010-2011
bENOIT COULOMbE
“OUR REsEARCHERs HAvE sET UP POwERfUL TECHNOLOgIEs...”
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treating
HyPERTENsIONdIAbETEsObEsITyHyPERCHOLEsTEROLEMIANUTRITION
Multidisciplinary team
Doctors, nutritionists, kinesiologists, nurses
3 specialized research clinics
Hypertension clinic
Nutrition, metabolism and atherosclerosis clinic
Obesity, metabolism and diabetes clinic
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ACCELERATINg CLINICAL
REsEARCHIRCM CLINIC
The IRCM’s outpatient linic handles over 20,000 patient visits a year. The IRCM offers its clinical researchers the unique opportunity to follow their patients’ progress on site thanks to its external consultation services. The Institut’s infrastructure and distinctive conceptual model allows for clinical and translational research, within the framework of an institution devoted to basic research.
The IRCM Clinic boasts three clinics specialized in the fields of hypertension, cholesterol, diabetes and obesity. Clinical research protocols are regularly developed, contributing to the development of new diagnostic approaches, the identification of new biochemical or genetic markers for cardiovascular risk and the evaluation of new therapeutic approaches. This research bridges the gap between fundamental laboratory research and its applications in patients.
PERMANENT sTAff – MEdICAL PERsONNEL
Directors: Pierre Larochelle, Robert Dufour, Rémi Rabasa-LhoretNutritionists: Chantal Blais, Émilie Raymond, Sonia Fortin, Catherine LerouxNurses: Martine Gauthier (Head Nurse), Sylvie Blaquière, Lucienne Bourque, Maryse Dallaire, Joanie Houle, Hélène Larchevêque, Jennifer Levasseur, Annabelle MathieuKinesiologists: Philippe Briand, Corinne SuppereResearch assistant: Virginie MessierTechnicians: Annie Tardif, Diane Mignault
The clinic is funded directly by the Institut de recherches cliniques de Montréal and through funding from private sources, such as the pharmaceutical industry, government agencies and the Canadian Institutes of Health Research.
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Robert dufour, Café scientifique on cholesterol
NUTRITION, METAbOLIsM ANd ATHEROsCLEROsIs CLINIC
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“The Hypertension clinic assesses and treats patients referred for their high blood pressure. Our research protocols study new hypertension diagnostic methods and treatments. Studies are also conducted to improve our understanding of the role of the autonomic nervous system in hypertension and its effects on the vascular function. In addition, following the promising results obtained from the Éducoeur and Éducoeur-en-route research projects, the Agence de la santé et des services sociaux de Montréal developed an additional research project to evaluate the interdisciplinary interventions of kinesiologists, nutritionists and nurses with a diabetic and hypertensive population in six health and social services centres in the Montréal region. Another 3,000 patients will be recruited and their progress will be followed for two years following an interdisciplinary intervention. Also, the results obtained in the Éducoeur-en-route research protocol with patients in family medicine groups led to the implementation of a new program by the Société québécoise d’hypertension artérielle. All information pertaining to this program is also available at the IRCM Clinic and on our website.”
PIERRE LAROCHELLE, Md, Phd, fRCPC, fAHA, fACPDirector
Pierre Larochelle, Café scientifique on hypertension
HyPERTENsION CLINIC
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“The endocrinology clinic allows us to follow the progress of patients suffering from various metabolic disorders, obesity, and, more particularly, type-1 and type-2 diabetes. Patients can benefit from the support of our multidisciplinary team. We have numerous ongoing research projects. Among them, two projects have the potential of significantly improving patient care in the coming years. Diabetes secondary to cystic fibrosis. In recent years, the life expectancy of people with cystic fibrosis has gradually improved and now exceeds 40 years. As a result, new major complications have emerged, such as diabetes secondary to cystic fibrosis. With our colleagues at CHUM, we are attempting to shed light on the mechanisms involved in the development of this type of diabetes, and the correlation between elevated blood-sugar levels and changes in weight and pulmonary function. Development of an artificial external pancreas. Type-1 diabetes is treated by administering insulin by injection or with an insulin pump. In recent years, the development of systems continually measuring blood-sugar levels under the skin has allowed patients to have a better overview of their diabetic profile. With our study, we want to develop data processing tools that will link this profile to an insulin pump in order to automatically manage blood-sugar levels, thereby making treatment easier. In addition, Dr. May Faraj, visiting scientist at the IRCM, is working to identify new relationships between hypercholesterolemia and the risk of developing type-2 diabetes.” RéMI RAbAsA-LHORET, Md, Phd Director
Rémi Rabasa-Lhoret, Chantal blais, véronique Perrault, Café scientifique on diabetes
ObEsITy, METAbOLIsM ANd dIAbETEs CLINIC
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innovating
7 core facilitiesAnimal facilities and animal experimentationChemical biologyFlow cytometryHistologyMicroscopyMolecular biology and functional genomicsTransgenesis and microinjection
3 ultra-specialized research platformsNational platform on protein interactionProteomics discovery platform (mass spectrometry and proteomics – bioinformatics)Research platform on obesity, metabolism and diabetes (PROMD)
5 specialized services Electrophysiology, molecular modelling, nuclear magnetic resonance, protein sequencer, specialized equipment
50 people serving research
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REsEARCH sERvICEs
Executive Director: Louis-Gilles DurandAssistant Director: Judith Cotton-Montpetit
CORE fACILITIEsAnimal facilities and animal experimentation:Director: Ion-Ovidiu Jumanca
Animal facilitiesHead: Julie D’amoursAnimal physiologyHead: Manon Laprise
Chemical biologyContact person: David GagnonExpert advisor: Jacques ArchambaultFlow cytometryHead: Éric MassicotteContact person: André VeilletteHistologyHead: Dominique LauzierMicroscopyHead: Dominic FilionMolecular biology and functional genomics Head: Odile NeyretExpert advisor: François RobertTransgenesis and microinjectionDirector: Qinzhang Zhu Supervisor: André Veillette
TECHNOLOgy PLATfORMsNational platform on protein interaction Director: Benoit CoulombeProteomics discovery platformDirector: Benoit Coulombe
Mass spectrometry and proteomicsHead: Denis FaubertBioinformaticsContact person: Johanne Duhaime
Research platform on obesity, metabolism and diabetes (PROMD)Director: Rémi Rabasa-LhoretContact person: Diane Mignault
OTHER sPECIALIzEd sERvICEsElectrophysiologyContact persons: Artur Kania, Michel PaquetMolecular modellingContact persons: Peter W. Schiller, Brian WilkesNuclear magnetic resonanceContact persons: Yvan Guindon, Michel PrévostProtein sequencerContact person: Claude LazureSpecialized equipmentHead: Richard Cimon
sTRENgTHENINg OUR TECHNOLOgICAL
AdvANTAgECORE fACILITIEs ANd TECHNOLOgy PLATfORMs
Innovation is at heart of a society’s development, and to conduct research is to continually innovate. The IRCM’s core facilities therefore allow researchers to remain at the forefront of modern science, achieve important scientific breakthroughs, and offer cutting-edge training to tomorrow’s scientists.
To facilitate innovation, the IRCM ensures that it provides its researchers with the best technologies. Over the years, its core facilities and technology platforms have proven to be extremely useful and effective. Certain discoveries may not have been possible without these state-of-the-art resources.
Our facilities support projects in molecular biology and functional genomics with possibilities of high-throughput sequencing, as well as in cellular biology, chemical biology and animal biology. We also make a microinjection service and a proteomics discovery platform available to our researchers. We have also created a research platform on obesity, metabolism and diabetes, and are continuing our efforts to install a new bioinformatics platform.
In 2010, thanks to funding from the Canada Foundation for Innovation (CFI), we acquired new high-performance scientific instruments: a high-throughput sequencer (HiSeq 2000), a high-throughput microscopy system (imageXpress Micro), a high-density microarray scanner (InnoScan 900), and an instrument for the transfection of cells in 96-well plates. These devices once again help strengthen our technological advantage, and allow us to offer our researchers the most powerful tools.
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contributing
$1.5 million in revenue for the Institut, its laboratories, and its researchers accumulated over the past five years
73 % of IRCM researchers shared their discoveries with the Technology Transfer Office
32 patents duly issued for major discoveries in the past 25 years
11 new patent filings (applications) in 2010-2011 7 new declarations of invention in 2010-2011
The IRCM’s mission states that the institute must contribute to Quebec’s socio-economic development by facilitating the commercial development of new discoveries. To carry out this mission, the Institut’s Technology Transfer Office collaborates with Univalor, a limited partnership whose goal is to accelerate the transfer to industry of research results. In 2010-2011, the Office’s efforts led to the implementation of three research collaborations and to the negotiation of two contracts with biotechnology companies and pharmaceutical partners locally and internationally. The Technology Transfer Office also participated in funding applications for the commercial development of new promising technologies.
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PROMOTINg THE COMMERCIALIzATION Of OUR dIsCOvERIEsTECHNOLOgy TRANsfER OffICE
Director: Stéphane Létourneau, L.L.B., M.Litt.Technology Transfer Officer: Dominique Bergeron, PhD
THERAPEUTIC REPROfILINg / NEw THERAPEUTIC APPLICATIONsDrug reprofiling is a well-known process by which old drugs learn to perform new therapeutic tricks. The use of known drugs to treat additional diseases can prove to be very cost effective, since the drug has already been tested in animals and humans.
“My team and I accomplished an extremely promising drug reprofiling, thanks to the discovery that the cellular enzyme called AID (Activity-Induced Cytidine Deaminase) is a substrate, or “client”, of another cellular protein called Hsp90. The AID protein is a target that had already been shown, or was suspected to be involved in, a variety of human diseases, but for which no drug is presently available. Now we know that Hsp90 inhibitors can also downregulate AID.”
JAvIER MARCELO dI NOIA, PhdAssociate IRCM Research ProfessorDirector of the Mechanisms of Genetic Diversity research unitCanada Research Chairholder in Genetic Diversity
This discovery will dramatically increase the number of diseases that known Hsp90 inhibitors can target. In fact, Hsp90 inhibitor drugs could be reprofiled for treating diseases where AID is overexpressed. The most likely applications would be for chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL), and could also include other cancers, as well as inflammatory and autoimmune diseases (colitis, allergies).
Javier M. di Noia and Alexandre Orthwein, doctoral student
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training
2010-2011 sTUdENTs ANd POsTdOCTORAL fELLOws61 postdoctoral fellows74 doctoral students39 Master’s students57 scholarship holders
COMPLETEd fELLOwsHIPs ANd AwARdEd dEgREEs13 postdoctoral fellowships12 doctorate degrees (PhD)13 Master’s degrees63 undergraduate internships
ALUMNI AssOCIATIONMembers: 1,188New members in 2010-2011: 45Postdoctoral fellows: 19Doctoral students: 13Master’s students: 13
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sTUdENTs fROM AROUNd THE gLObE
“Training the next generation of scientists is a key element in the IRCM’s mission statement. Each year, we welcome nearly 150 Master’s and doctoral students, and approximately 50 postdoctoral fellows. The students are generally registered at the Université de Montréal or McGill University. In addition, we have about 60 undergraduate students pursuing research internships. These students and postdoctoral fellows come from all over the world, making the IRCM a very cosmopolitan institute whose diversity reflects that of the city of Montréal.
The Institut also contributes to raising young people’s awareness of the benefits of choosing a research career in biomedical sciences. Therefore, we regularly invite high school, CEGEP and university students to visit our laboratories and meet our researchers.
Our students and postdoctoral fellows particularly excelled this year in different scholarship competitions. For example, two of our students received the prestigious Vanier Canada Graduate Scholarship.”
TIMOTHy L. REUdELHUbER, PhdExecutive Director, Academic AffairsFull IRCM Research ProfessorDirector of the Molecular Biochemisty of Hypertension research unit
TRAININg TOMORROw’s
REsEARCHERsACAdEMIC AffAIRs dEPARTMENT
Executive Director: Timothy L. Reudelhuber, PhDAssociate Director, scientific activities: Jean-François Côté, PhDAssociate Director, student affairs: Jean-Philippe Gratton, PhDAdvisor: Johanne LangevinAgent: Virginie LeducChief, Documentation centre: Nicole Campeau
TIMOTHy L. REUdELHUbER
IRCM REsEARCH dAy
The IRCM Research Day offers students and postdoctoral fellows the opportunity to present their work to their peers. A true forum for scientific exchanges, this event allows them to showcase the quality of their research projects and their communication skills. Once again this year, the day was a great success. Thanks to the generosity of our partners, we granted 16 awards for the best posters and oral presentations.
For more information on scholarship holders, refer to the IRCM’s academic report. In 2010-2011, 49 nominal scholarships and 11 internal scholarships were granted to the IRCM’s graduate students and postdoctoral fellows.
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RECIPIENT Of A 2011 vANIER CANAdA gRAdUATE sCHOLARsHIP
“Through the Developmental Biology program at McGill University, to which I am registered, I was able to rotate between three laboratories during my doctoral studies, and have been at the IRCM for almost one year, where I will complete my PhD. I was drawn here by the cutting-edge methods used in Dr. Frédéric Charron’s research unit, such as novel axon guidance techniques. I am proud to have received this scholarship and represent Canada on an international stage. It will undoubtedly offer me many opportunities to broaden my scientific horizons, and will also free up laboratory funds, which could then be used to develop further innovative methods.”
JIMMy PENgRecipient of a Vanier Canada Graduate ScholarshipDoctoral student in the Molecular Biology of Neural Development research unit, directed by Dr. Frédéric Charron
REsEARCH PROJECT – INvEsTIgATINg AxON gUIdANCE by sHH AT THE MIdLINE Of THE vIsUAL sysTEM ANd sPINAL CORd
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RECIPIENT Of A 2011 vANIER CANAdA gRAdUATE sCHOLARsHIP
“After completing my bachelor’s degree in Benin, I received a scholarship from the Canadian International Development Agency, allowing me to pursue my Master’s studies at the Université de Moncton. I wanted to work on diabetes and obesity for my doctorate, and chose the IRCM due to Dr. Rémi Rabasa-Lhoret’s excellent reputation. In fact, as my supervisor, he has since inspired me to become an endo-crinologist, through his work and commitment. In our extremely competitive field, receiving a scholarship like this one will set me apart from others and open many doors for me in the future.”
bELINdA ELIsHARecipient of a Vanier Canada Graduate ScholarshipDoctoral student in the Metabolic Diseases research unit, directed by Dr. Rémi Rabasa-Lhoret
REsEARCH PROJECT – CARdIAC AdIPOsITy ANd CARdIO-METAbOLIC RIsK fACTORs AssOCIATEd wITH ObEsITy OR TyPE 2 dIAbETEs: ROLE Of EPICARdIAL fAT
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IRCM sTUdENT AssOCIATION
The IRCM Student Association brings together the institute’s students and postdoctoral fellows. It also fosters their relationships with other members of the internal community and represents them in dealings with governing bodies. The Association acts as a liaison between students and postdoctoral fellows and scientific management, in order to facilitate interaction and cooperation, thereby positively contributing to the IRCM’s development. Moreover, the Asso-ciation maintains ties with other student bodies at the Université de Montréal and McGill University.
“I have been a student at the Institut for five years now, and continue to be satisfied with my decision to pursue my graduate studies at the IRCM. In fact, over the years, I noticed the broad scope of the science conducted here, both by the researchers’ excellence and by the students’ work. In order to promote the warm atmosphere that reigns in the internal community, I became President of the Student Association. Choosing a work environment to pursue one’s graduate studies is very important, and the Association can make a difference by bringing students together on social and academic levels. So I confirm my choice in the IRCM by ensuring that I am among the front runners for the years to come. ”
fRANÇOIs gOdINPresident, IRCM Student Association 2010-2011Doctoral student in the Bioorganic Chemistry research unit, directed by Dr. Yvan Guindon
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participating_4 international symposiums and public conferences
_3 cafés scientifiques
_3 social networks
14 appearances on radio and television shows and public forums
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INTERNATIONAL syMPOsIUMs
Each year, the Institut’s researchers organize international symposiums in order to share with their colleagues in the scientific community the knowledge acquired in their respective fields. This year, three events were organized by our researchers, including two held at the IRCM and a third in a different Canadian province.
AT THE IRCM3rd meeting on systems biology: molecular networksExperimental and computational studies of molecular networksOrganized by Benoit Coulombe, Éric Lécuyer and François RobertOver 170 participants
2nd international neuroethics conference: Brain Matters 2Ethics in the translation of neuroscience research to psychiatric and neurological careOrganized by Éric RacineOver 150 participants
IN bANff9th conference on signalling in normal and cancer cellsMetabolism and CancerOrganized by André VeilletteOver 220 participants
PUbLIC CONfERENCE
As part of the Brain Matters 2 international conference, a public event was organized to discuss the challenges of transferring the knowledge acquired from neurosciences.
Proven and unproven therapies: the challenges of translating neuroscience to patient care
Organizer: Éric RacineThis engaging panel discussion welcomed nearly 100 participants in the IRCM’s Jacques-Genest Auditorium.
CAfés sCIENTIfIQUEs
The Institut held its second season of cafés scientifiques in 2010-2011. Three events took place. The IRCM’s experts shared with the public the results of their research projects, as well as the new developments in their field of expertise.
Premenopause and the risk of diabetes (Préménopause et le risque de diabète)Experts: Rémi Rabasa-Lhoret, Sonia Fortin, Philippe BriandHost: Louise Lambert-Lagacé
My blood pressure and I (Ma pression et moi)Experts: Pierre Larochelle, Jean-Philippe Gratton, Chantal Blais, Philippe BriandHost: Véronique Perrault
2011: A new cholesterol odyssey (2011 : la nouvelle odyssée du cholestérol)Experts: Robert Dufour, Nabil G. Seidah, Chantal Blais, Philippe BriandHost: Véronique Perrault
brain Matters 2
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sOCIAL NETwORKs
The IRCM is present on Facebook and now has its own address on the social network at www.facebook.com/IRCM.Montreal. The Institut also has a YouTube channel for its videos, and a SlideShare site, where different presentations about the IRCM are made available.
PUbLIC ExHIbITION
Through its research platform on obesity, metabolism and diabetes (PROMD), the IRCM hosted a booth at the 2011 Salon Ma Santé held at Complexe Desjardins. Hundreds of visitors took the opportunity to learn about what takes place at the Institut, from prevention and intervention to the new molecule targeted for diabetes treatment.
PUbLIC fORUM
The IRCM’s President and Scientific Director had the opportunity, when speaking at the Montreal Council on Foreign Relations (MCFR), to share with the city’s business community his thoughts on the different facets of research funding and the importance of providing appropriate financial support to basic research.
PUbLIC AffAIRs PROgRAMMEs
Researchers, physicians and other professionals from the Institut and the IRCM Clinic are often approached by various media searching for experts for an article or programmes. Their participation as experts contribute to increasing the IRCM’s visibility and inform the general public of hot topics related to health and health research.
REsEARCH fUNdINg April 1, 2010 to March 31, 2011
Government agencies and departments provide essential funding for the Institut’s research activities. In most cases, funds are granted based on the recommendations of peer-review committees. Researchers, as well as the students and postdoctoral fellows on their team, benefit from this funding. Following is a list of the IRCM’s major funding partners for 2010-2011:
PEER-REvIEwEd gRANTINg AgENCIEs
Association française contre les myopathies – Canada Foundation for Innovation – Canada Research Chairs – Canadian Blood Services – Canadian Cancer Society – Canadian Diabetes Association – Canadian Foundation for AIDS Research – Canadian Institutes of Health Research – Cancer Research Society – Cystic Fibrosis Canada – Diabetes Québec – Fonds de recherche du Québec - Santé – Heart and Stroke Foundation of Canada – Héma Québec – Howard Hughes Medical Institute – Muscular Dystrophy Association – National Institutes of Health – Natural Sciences and Engineering Research Council of Canada – Neurodevelopment Network – Parkinson Society Canada – Quebec Consortium for Drug Discovery – Quebec ministry of Economic Development, Innovation and Export Trade – Quebec Transgenic Research Network – Roche Foundation for Anemia Research – Social Sciences and Humanities Research Council of Canada – Terry Fox Research InstituteTOTAL: $13,116,384
bIOPHARMACEUTICAL INdUsTRy
AstraZeneca Canada – Boehringer Ingelheim (Canada) Ltd – Bristol-Myers Squibb Canada – Danone Research – Eli Lilly Canada Inc. – Immunotec Inc. – Isis Pharmaceutical – Merck – Novartis Pharma Canada inc. – Novo Nordisk – Pfizer Canada Inc. – Sanofi-aventis Canada Inc. – Stealth Peptides International Inc. TOTAL: $726,951
PEER-REvIEwEd gRANTINg AgENCIEs: 85.1%dONATIONs fROM THE IRCM fOUNdATION: 7.8%bIOPHARMACEUTICAL INdUsTRy: 3.9%OTHERs sOURCEs: 3.3% $18.8 MILLION:100 %
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AdMINIsTRATION
THANK yOU TO géRARd A. LIMOgEs
“On behalf of all IRCM Board members, I sincerely thank Gérard A. Limoges for his devotion and commitment to the Institut de recherches cliniques de Montréal. We also wish to thank him for his numerous contributions and for his active participation in the Institut’s development and success.
A man of action and conviction, Gérard A. Limoges never counted the hours he dedicated to the IRCM. He attended all meetings and participated in several of the Institut’s and the Foundation’s events, whether they were public or internal. Always ready to listen, he constantly made himself available to meet people working at the IRCM.
Under his chairmanship, the Board of Directors gained influential members from the Montréal community. In fact, he recruited Raymond Chrétien, Hélène Desmarais, W. Robert Laurier, Christine Le Jeune, Camille Limoges and Yvon Turcot. He also actively participated in the IRCM Foundation’s major fundraising campaign.
During all these years, with his characteristic smile, Gérard A. Limoges performed his duties with assurance and astonishing calmness.
He has well prepared the Board for the future and I now have the opportunity of following in his footsteps while surrounded by extraordinary people.
Thank you Gérard Limoges!”
LOUIsE LAMbERT-LAgACéChair-elect of the IRCM Board of Directors
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IRCM bOARd Of dIRECTORs
The IRCM relies on the council and volunteer support of its Board member for help in achieving its mission. In 2010-2011, five regular meetings were held. The Board member’s attendance rate was of 77.2%.
MEMbERs Of THE IRCM bOARd Of dIRECTORsMembers appointed from June 2010 to June 2011 CHAIRMANGérard A. LimogesCorporate Director
vICE-CHAIRLouise Lambert-LagacéPresidentLa clinique de nutrition Louise Lambert-Lagacé et associées
PREsIdENT ANd sCIENTIfIC dIRECTOR Tarik Möröy
MEMbERsGuy BretonRector, Université de Montréal
Raymond ChrétienPartner and Strategic AdvisorFasken Martineau DuMoulin LLP
Hélène DesmaraisChairwoman of the Board of Directors, HEC Montréal
Claude A. GarciaCorporate Director
W. Robert LaurierCorporate Director
Paule LeducCorporate Director
Christine Le JeuneCMA, FCA
Camille LimogesCorporate Director
Alain MayrandCorporate DirectorPresident of the IRCM Foundation
Pierre ShoonerCorporate Director
Yvon TurcotStrategic Communications ConsultantCorporate Director
Michael L. TurcotteChairman of the Board of Directors, Hydro-Québec
sECRETARyStéphane LétourneauExecutive Director, Corporate and Legal Affairs, IRCM
TREAsURERLouis-Gilles DurandExecutive Director, Administration and research services, IRCM
ObsERvERLuc CastonguayMinistry of Economic Development, Innovation and Export Trade (MDEIE)
The IRCM’s directors are individuals who are committed to the Institut, and to society in general. In this regard, they are often honoured by various prestigious organizations for their contributions to the community. In 2010-2011, two Board members were awarded.
Hélène Desmarais was honoured by the Board of Trade of Metropolitan Montreal by being inducted into the Academy of Great Montrealers for her contribution to the city’s economic sector.
Camille Limoges became Member of the Order of Canada for his contributions to the development and direction of research in Canada as a science and technology historian.
bOARd COMMITTEEs
ExECUTIvE COMMITTEEClaude A. GarciaLouise Lambert-LagacéGérard A. Limoges, ChairAlain MayrandTarik Möröy
COMMUNICATIONs COMMITTEERaymond ChrétienLouise Lambert-LagacéPierre ShoonerYvon Turcot, Chair
gOvERNANCE COMMITTEE Claude A. GarciaW. Robert LaurierCamille LimogesMichael L. Turcotte, Chair
HUMAN REsOURCEs COMMITTEERaymond ChrétienLouise Lambert-Lagacé, ChairPaule LeducAlain Mayrand
AUdIT COMMITTEEClaude A. Garcia, ChairW. Robert Laurier Christine Le JeunePierre Shooner
Hélène desmarais, Camille Limoges
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IRCM MANAgEMENT
As President and Scientific Director, Tarik Möröy oversees both the IRCM’s administrative and scientific operations. In this respect, he receives support from other scientists who share administrative responsibilities and also manage their own research unit. Dr. Möröy chairs the Management Committee and the Scientific Management Committee, and supervises his own research unit at the IRCM.
MANAgEMENT COMMITTEE
The Management Committee is responsible for supporting the President and Scientific Director in his administrative and scientific management functions. To accomplish the IRCM’s fundamental missions of excellence in research and training the next generation of scientists, this committee coordinates the departments and personnel supervised by Executive Directors.
Committee members(As of July 1, 2011)Louis-Gilles DurandPierre LarochelleStéphane LétourneauTarik MöröyTimothy L. Reudelhuber
sCIENTIfIC MANAgEMENT COMMITTEE
The Scientific Management Committee includes all research program Directors. This committee’s primary role is to advise the President and Scientific Director on the recruitment of new research unit directors, the Institut’s strategic planning, and the mandate and relevance of various core facilities.
Committee members(Appointed in 2010-2011)Michel Cayouette (March 2011 - ) Éric A. CohenBenoit CoulombeChristian F. Deschepper (since July 2011)David R. Hipfner (July 2010 to October 2010)Artur Kania (November 2010 to February 2011)Tarik MöröyTimothy L. Reudelhuber (until June 2011)Marie Trudel
from left to right: Tarik Möröy, Pierre Larochelle, Carole vincent, committee secretary, Louis-gilles durand, stéphane Létourneau, Timothy L. Reudelhuber
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TRIbUTE TO PIERRE bOIs
“Pierre Bois was a Scientific Advisor for the IRCM’s management for nearly 15 years, during which time he also edited a book on the institute’s history, A Vision in Progress. A graduate in medicine from the Université de Montréal, Dr. Bois held several professorial positions at the same university, and was Dean of the Faculty of Medicine from 1970 to 1981.
Pierre Bois was known worldwide. He was a member of many scientific societies in Canada, the United States and France. He is the author and co-author of over 130 publications in the field of biomedical research. Throughout his career, Dr. Bois received numerous awards for his excellent work and the significance of his accomplishments.
Many of us knew Pierre Bois. He was an honest and incredibly intelligent man with a wonderful sense of humour, who was well-respected by the scientific and medical community.
The entire IRCM internal community, which includes many of his friends, salute and thank him.”
TARIK MöRöy, PhdPresident and Scientific Director
Pierre Bois passed away on September 30, 2011.
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Louise Lambert-Lagacé, Chair
Tarik Möröy
Timothy L. Reudelhuber
Timothy L. Reudelhuber
Nicole Campeau
Jean-François Côté Benoit Papineau
Richard Tanguay
Judith Cotton-Montpetit
Jean-Philippe Gratton
Louis-Gilles Durand Stéphane Létourneau Pierre Larochelle
Robert Dufour
Martine Gauthier
Michel Gaudreau
Marcel Leclerc
Michel Charest
Ion-Ovidiu Jumanca
Marielle Gascon-BarréAdvisor
Lucette Thériault
Hélène Véronneau
Jacqueline Turgeon
Stéphane Létourneau
Board of Directors
Executive DirectorAcademic Affairs
Associate DirectorScientific Activities
DirectorFinances
DirectorHuman Resources
Associate Director
Head NurseDirector Information System Technology
DirectorTechnology Transfer
Assistant Director Research Services
Director Animal Facilities and Animal Experimentation
Director Communications
Director Foundation
Director Engineering Services
and Physical Plant
Assistant Director Engineering Services
CoordinatorSecurity
Associate DirectorStudent Affairs
Academic Staff
ChiefDocumentation Center
Executive DirectorAdministration and Research Services
Executive DirectorCorporate and Legal Affairs
Executive DirectorClinic and Clinical Research
President and Scientific Director
Louise Lambert-Lagacé, Chair
Tarik Möröy
Research Program DirectorSystems Biology and Medicinal Chemistry
Benoit Coulombe
Research Program DirectorImmunity and Viral Infections
Éric A. Cohen
Research Program DirectorCardiovascular and Metabolic Diseases
Christian F. Deschepper
Research Program DirectorCancer
Marie Trudel
Molecular Biochemistry of Hypertension
Timothy L. Reudelhuber
Molecular BiologyPaul Jolicoeur
Endothelial Cell BiologyJean-Philippe Gratton
Molecular OncologyAndré Veillette
Immune RegulationWoong-Kyung Suh
Human RetrovirologyÉric A. Cohen
Biochemical Neuroendocrinology
Nabil G. Seidah
Molecular ImmunologyHua Gu
Experimental Cardiovascular BiologyChristian F. Deschepper
Mechanisms of Genetic Diversity
Javier Marcelo Di Noia
Research Program DirectorNeurobiology and
DevelopmentMichel Cayouette
Epithelial Cell BiologyDavid R. Hipfner
Molecular Genetics-Jacques Drouin
Cellular NeurobiologyMichel Cayouette
NeuroethicsÉric Racine
Molecular Biology of Neural Development
Frédéric Charron
Neural Circuit DevelopmentArtur Kania
Genetics and DevelopmentMarie Kmita
Cardiovascular Pharmacology
Pierre Larochelle
Neuropeptide Structure and MetabolismClaude Lazure
Molecular Mechanisms of Diabetes
Jennifer Estall
Board of Directors
President and Scientific Director
Chemical Biology and Peptide ReseachPeter W. Schiller
Gene Transcription and Proteomics
Benoit Coulombe
Molecular VirologyJacques Archambault
Ribonucleoprotein Biochemistry
Marlene Oeffinger
Bioorganic ChemistryYvan Guindon
RNA BiologyÉric Lécuyer
Chromatin and Genomic Expression
François Robert
Cytoskeletal Organization and Cell Migration
Jean-François Côté
Molecular Genetics and DevelopmentMarie Trudel
Breast Cancer BiologyKatrina Podsypanina
Hematopoiesis and Cancer
Tarik Möröy
Cellular Interactions and DevelopmentJean Vacher
Cell Division and Centrosome Biology
William Y. Tsang
Molecular EndocrinologyM. Ram Sairam
Metabolic DiseasesRémi Rabasa-Lhoret
THEsE REsEARCHERs ARE MEMbERs Of THE IRCM’s sCIENTIfIC COMMITTEE
Also members: Jean Davignon, Robert Dufour, Louis-Gilles Durand, Zaher S. Hanna, Maxime Lamarre-Cliche, Annik Prat
AdMINIsTRATIvEORgANIzATIONJULy 2011
sCIENTIfICORgANIzATIONJULy 2011
OperatingFund
ResearchFund
Capital AssetFund Total
OperatingFund
ResearchFund
Capital AssetFund Total
AssetsCurrent assets:
Cash and cash equivalents $ 2,278,847 $ 3,020,426 $ - $ 5,299,273 $ 1,355,924 $ 8,206,843 $ - $ 9,562,767
Grants receivable and other receivables 224,439 2,718,103 - 2,942,542 313,792 2,231,141 - 2,544,933 Current portion of grants receivable - - 3,403,706 3,403,706 - - 4,111,164 4,111,164 Prepaid expenses 205,758 34,546 - 240,304 200,612 49,182 - 249,794 Interfund advances (1) - 266,644 - - 746,748 - - - Advances receivable from the Foundation 29,555 169,068 - 198,623 - 444,315 - 444,315
2,738,599 6,208,787 3,403,706 12,084,448 2,617,076 10,931,481 4,111,164 16,912,973
Investments 277,137 500,000 - 777,137 - - - - Investment in a subsidiary - 136,213 - 136,213 - 93,420 - 93,420 Grants receivable - 29,808,354 29,808,354 - - 32,743,141 32,743,141 Capital assets - 47,144,096 47,144,096 - - 44,124,428 44,124,428
$ 3,015,736 6,845,000 $ 80,356,156 $ 89,950,248 - $ 2,617,076 $ 11,024,901 $ 80,978,733 $ 93,873,962
LiabilitiesCurrent liabilities:
Accounts payable and accrued liabilities $ 447,764 $ 2,331,142 $ 470,475 $ 3,249,381 $ 552,693 $ 849,802 $ 516,314 $ 1,918,809
Accrued remuneration and salaries payable 1,909,933 493,114 - 2,403,047 2,042,113 539,456 - 2,581,569 Deferred grants 307,938 - - 307,938 - - - - Current portion of notes payable - - 3,100,688 3,100,688 - - 4,013,404 4,013,404 Interfund advances (1) 266,644 - - - - 746,748 - - Advances payable to the Foundation - - - - 20,736 - - 20,736
2,932,279 2,824,256 3,571,163 9,061,054 2,615,542 2,136,006 4,529,718 8,534,518
Notes payable 29,808,354 29,808,354 33,192,299 33,192,299
Fund Balances (Deficiencies)Invested in capital assets - - 46,978,194 46,978,194 - - 43,260,317 43,260,317 Externally restricted - 7,316,209 7,316,209 - 11,471,476 - 11,471,476 Deficiency on internally restricted balances - (3,295,465) (3,295,465) - (2,582,581) - (2,582,581) Unrestricted net assets (deficiency) 83,457 - (1,555) 81,902 1,534 - (3,601) (2,067)
83,457 4,020,744 46,976,639 51,080,840 1,534 8,888,895 43,256,716 52,147,145
$ 3,015,736 6,845,000 $ 80,356,156 $ 89,950,248 $ 2,617,076 $ 11,024,901 $ 80,978,733 $ 93,873,962
(1) For presentation purposes, the interfund advances were eliminated from the total column.
Restricted Funds Restricted Funds
20102011
Revenues:Peer review grant program $ - $ - $ 16,020,980 $ 17,389,295 $ - $ - Grants - interest and management fees portion - - - - 1,754,701 1,757,712 Other grants - - 1,216,443 1,704,945 - - Restricted donations - - 98,603 66,580 - - Grant from ministère du Développement économique, de l'Innovation et de l'Exportation 14,631,534 14,253,500 - - - - Grant from Fonds de la recherche en santé du Québec 2,923,514 3,217,065 - - - - Grant from Fonds de la recherche en santé du Québec - Soutien à la recherche 96,423 - - - - - Grant from federal councils for indirect costs 1,111,464 1,025,248 - - - - Donations from Fondation de l'Institut de recherches cliniques de Montréal - - 1,461,389 1,698,750 - - Contribution from Université de Montréal 650,000 650,000 - - - - Other revenues 149,350 47,871 - - - - Investment income 4,677 - 23,750 - - - Change in fair value of investments 27,449 - - - - -
$ 19,594,411 $ 19,193,684 $ 18,821,165 $ 20,859,570 $ 1,754,701 $ 1,757,712
Expenses:Research Fund expenses for the year $ - $ - $ 15,682,413 $ 16,610,320 $ - $ - Operating Fund expenses for the year 18,704,270 18,320,601 - - - - Depreciation of capital assets - - - - 4,904,130 4,567,622 Interest on notes payable - - 7,925 152,035 1,770,313 1,797,597 Share in the loss of the subsidiary - - 167,532 160,257 - -
$ 18,704,270 $ 18,320,601 $ 15,857,870 $ 16,922,612 $ 6,674,443 $ 6,365,219
Excess (deficiency) of revenues over expenses $ 890,141 $ 873,083 $ 2,963,295 $ 3,936,958 $ (4,919,742) $ (4,607,507)
Fund balances, beginning of year $ 1,534 $ 996 $ 8,888,895 $ 7,387,900 $ 43,256,716 $ 44,555,715
Excess (deficiency) of revenues over expenses 890,141 873,083 2,963,295 3,936,958 (4,919,742) (4,607,507)
Interfund transfers (808,218) (872,545) (7,831,446) (2,435,963) 8,639,665 3,308,508
Fund balances, end of year $ 83,457 $ 1,534 $ 4,020,744 $ 8,888,895 $ 46,976,639 $ 43,256,716
Operating Fund Research Fund Capital Asset Fund
Restricted FundsOperating Fund Research Fund Capital Asset Fund
Restricted Funds
2011 2011 20112010 2010 2010
2011 2011 20112010 2010 2010
fINANCIAL sTATEMENTssUMMARIzEd sTATEMENT Of fINANCIAL POsITIONMarch 31, 2011 with comparative figures for 2010
TOTAL TOTAL
sUMMARIzEd sTATEMENT Of OPERATIONsyear ended March 31, 2011, with comparative figures for 2010
sUMMARIzEd sTATEMENT Of CHANgEs IN fUNd bALANCEsyear ended March 31, 2011, with comparative figures for 2010
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IRCM fOUNdATION
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92 93supporting
1 major fundraising campaign:
$8,255,811 3 annual benefit activities:
$223,5371 annual direct mail campaign:
$73,501204 in memoriam donations:
$20,565*in commitments and donations
*
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94 95volunteering
Board members
fundraising campaign Board members
honorary chairpersons, patrons, volunteers and
organizers for the benefit activities
36
16
13
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96 97giving
$1,461,389donated to the IRCM
$12,7millions capitalized
6 Research Chairs
24 personalized funds
14 scholarships and Excellence Awards
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MEssAgEs fROM MANAgEMENT
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Message from the President The IRCM Foundation supports the Institut de recherches cliniques de Montréal by raising funds for the researchers’ scientific projects and for training activities, by means of scholarships for deserving graduate students and postdoctoral fellows.
In 2010-2011, the Foundation gave $1,461,389 to the IRCM. In addition to the research projects and training activities, this contribution was used to upgrade the Institut’s animal facilities and to consolidate the research chair’s capitalized funds.
Part of our mandate, as the Foundation’s Board of Directors, is to ensure the proper and accurate management of the funds we collect. We must also make sure the portfolio returns, overseen by our fund managers, offer the best possible results. Another priority for us is to attract businesses, private foundations and individuals so they can become our partners in supporting the outstanding clinical and biomedical research conducted at the IRCM.
MAJOR fUNdRAIsINg CAMPAIgN
Along with the volunteer members of the Campaign Board, we continued our efforts within the business and philanthropic circles. Many donations
have been confirmed, while several others requests are still pending. I wish to thank everyone who has granted us their support thus far. I also thank our volunteers for the time they devoted to our various meetings.
AUdIT COMMITTEE
This year, with the arrival of six new Board members, we were able to officially form an Audit Committee, which has been mandated to make recommendations to the Board of Directors on all matters related to accounting procedures, the review of financial statements, internal control and risk management.
The committee is chaired by Corporate Director Edmée Métivier. I thank her for accepting to take on this role.
OUR vOLUNTEERs ARE HONOUREd
I would like to take this opportunity to congratulate our volunteers who received prestigious honours in 2010-2011. First, our colleague on the Board of Directors, Jean-Pierre Desrosiers, received the Prix Art-Affaires Montréal from the Conseil des arts de Montréal for his outstanding support of the city’s artistic and cultural development. He is also the recipient of the 2010-2011 Prix Hermès de carrière from the Université Laval’s Faculty of Business Administration. In addition, Nathalie Bernier, Board member for
the Give for Life major fundraising campaign, was named one of Canada’s Most Powerful Women (Top 100) in 2010. This honour is awarded each year to particularly influential Canadian women.
In closing, I would like to call attention to the remarkable work done by Hélène Véronneau, Director of the Foundation. I also want to thank the Institut’s personnel who work with us on our different projects, from finance and communications to corporate and legal affairs. Of course, I also want to thank the IRCM’s President and Scientific Director, Tarik Möröy, for his active participation in the Foundation’s activities and in the major fundraising campaign.
Finally, my most sincere thanks go to my colleagues on the Board of Directors for their support and cooperation.
ALAIN MAyRANd
Message from the Director The year 2010-2011 was, in large part, dedicated to the major fundraising campaign, Give for Life. In fact, we were eager to publicly launch our campaign before the end of 2011. We are very satisfied with our results and are confident that we will achieve our goal.
A CAMPAIgN IN THREE sTAgEs
The first stage began with our in-house fundraising campaign and, last year, we celebrated the fact that we exceeded our target of one million dollars. This extraordinary support allowed us to enter the campaign’s second phase, which consisted of approaching large businesses, private foundations and individuals. Several significant donation commitments were confirmed during this silent phase and, despite tough economic times, we obtained exceptional results: to date, we have collected nearly nine million dollars. These results will, in turn, allow us to launch the third and final stage of this campaign.
THE fOUNdATION’s vIsIbILITy
In order to increase the Foundation’s visibility with various publics, we first wanted to learn how it was perceived. We therefore conducted a perception study with patients, researchers and
IRCM employees. The results of this study revealed, among other things, that patients are proud to come to a clinic that also houses scientific research, and are aware that their donations are being dedicated to this research.
bENEfIT ACTIvITIEs
The success of our benefit activities cannot be denied and, once again this year, we achieved great results. I wish to thank all volunteers who contributed to this success.
IN-HOUsE fUNd fOR ExCELLENCE
This year, the Foundation granted its first awards from the In-House Fund for Excellence. Created as part of the in-house fundraising campaign, (L’IRCM la vie. J’y crois, je participe!), this fund is used to recognize the commitment of members of the internal community towards the Institut. Three awards are given each year to a researcher, a student or postdoctoral fellow, and an employee.
Finally, I would like to thank everyone who supports the IRCM Foundation and the Institut for their donations or their participation in our activities. Your generosity and dedication are truly appreciated. I also want to note the outstanding work of my IRCM colleagues, in particular that of the Finance and Communications departments, Academic Affairs, and Corporate and Legal Affairs.
To successfully work for a foundation like the IRCM Foundation, one needs support and trust. In this regard, I am thankful for the assistance I receive from the Foundation’s President, Alain Mayrand, and his Board of Directors, as well as from the Institut’s President and Scientific Director, Tarik Möröy.
Last but not least, I want to especially thank Laura-Emmanuelle Gagné, Assistant to the Foundation, who helped me carry out all our projects.
HéLèNE véRONNEAU
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102 103supportinggIvE fOR LIfE MAJOR fUNdRAIsINg CAMPAIgN
$ 8,255,811*Co-chairs: Sophie Brochu and Emmanuel Triassi7 exceptional donors (donation of over $500,000)More than 1,000 donors
bENEfIT ACTIvITIEs
ANNUAL dINNER
$170,200 350 guestsHonorary chairman: Jean-Pierre Desrosiers, FCA, Partner at Fasken Martineau DuMoulinRecipient of the 2010 Merit Award: Justice Jacques Chamberland11 major partners10 important partners
bILAN dE sANTé – gOLf TOURNAMENT
$50,000136 golfers76 health checksHonorary chairwoman: Nathalie Brisson, CEO and General Manager of Confab Laboratories6 partners
IRCM CHALLENgE – RUN fOR LIfE
130 runners25 partnersOne Master’s scholarship awarded
ANNUAL dIRECT MAIL CAMPAIgN
$73,501931 donors315 Friends12 Builders7 Great Builders
The major Give for Life fundraising campaign, the benefit activities and the direct mail campaign all directly help the Institut to set up new research units and grant scholarships to tomorrow’s researchers. In turn, thanks to your support, the Foundation support the IRCM: $1,461,389 were donated to the Institut in 2010-2011.
*in commitments and donations
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bILAN dE sANTé – gOLf TOURNAMENT
“It was a great honour for me to chair the IRCM Foundation’s 2011 golf tournament. I have known the institute for several years, and all the people I met at the IRCM further convinced me of the necessity of supporting this prestigious research centre, for Montrealers and for our entire society.”
NATHALIE bRIssON, CEO and General Manager of Confab Laboratories
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106 107volunteeringIRCM fOUNdATION bOARd Of dIRECTORs (Members appointed from June 2010 to June 2011)In 2010-2011, four regular Board meetings were held.
PREsIdENTAlain Mayrand Corporate Director
MEMbERsSerge A. BoileauPresident – Commission des services électriques de Montréal
Normand BrathwaiteHost
André J. P. CouillardVice-president – Executive SearchOptimum Talent
Jean-Pierre DesrosiersPartner – Fasken Martineau Dumoulin LLP
Marinella ErmacoraSenior Vice President – Business SolutionsFujitsu Canada Inc.
Jacques GauthierCorporate Director
Gérard A. LimogesChairman of the IRCM Board of DirectorsCorporate Director
Reford MacDougallSpecial Advisor to the President – Montreal Economic Institute
Edmée MétivierCorporate Director
Tarik MöröyPresident and Scientific Director – IRCM
J.-Robert OuimetChairman of the Board of Directors and CEOHolding O.C.B. Inc.; Cordon Bleu International Ltd; & Ouimet Tomasso Inc.
Joseph P. PaulinPresident – Preston Phipps
dIRECTORHélène Véronneau
sECRETARyStéphane LétourneauExecutive Director – Corporate and Legal Affairs – IRCM
TREAsURERLouis-Gilles DurandExecutive Director – Administration and Research services – IRCM
AUdIT COMMITTEEAndré J. P. CouillardJean-Pierre DesrosiersEdmée Métivier, ChairJoseph P. Paulin
The IRCM Foundation is privileged to be able to rely on people who value the mission and growth of the Institut de recherches cliniques de Montréal. These individuals are members of the Board of Directors, members of the major fundraising campaign’s Board, or honorary patrons and volunteer organizers for our benefit activities.
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gIvE fOR LIfE CAMPAIgN bOARd
Members of the major fundraising campaign’s Board were once again very involved this year. They supported the Foundation in numerous donation and partnership requests and obtained excellent results.
CO-CHAIRsSophie BrochuPresident and CEO – Gaz Métro
Emmanuel TriassiPresident – Groupe TEQ
MEMbERsNathalie BernierAssociate Director – KPMG
Françoise BertrandPresident and Executive Director – Fédération des chambres de commerce du Québec
Jean-Guy Desjardins
Desjardins-Moreau Foundation
Claude A. GarciaCorporate Director
Jacques GauthierCorporate Director
Norman E. Hébert Jr.
President and CEO – Groupe Park Avenue Inc.
W. Robert LaurierCorporate Director
Reford MacDougallSpecial Advisor to the President – Montreal Economic Institute
Alain MayrandCorporate Director and President of the IRCM Foundation
L. Jacques MénardChairman of the Board of Directors – BMO
Yvon TurcotCommunications Consultant and Corporate Director
Michael L. TurcotteChairman of the Board of Directors – Hydro-Québec
Louis VachonPresident and CEO – National Bank
René VézinaColumnist and Senior Reporter – Les Affaires
bENEfIT ACTIvITIEs
The IRCM Foundation relies on numerous volunteers to help with the organization of its activities.
2010 ANNUAL dINNERHonorary ChairmanJean-Pierre Desrosiers
Honorary patronsNathalie Bernier – Serge A. Boileau – Michel GaudreauJacques Gauthier – Odette Jobin-LabergePierre Larochelle – Nabil G. Seidah
2011 bILAN dE sANTé – gOLf TOURNAMENTHonorary ChairwomanNathalie Brisson
Organizing committeeJacques Gauthier, co-chairSerge A. Boileau, co-chairRobert Dufour, MDGuy LamarreMarcel Leclerc
Bilan de santé committeeDiane Bergevin-LachapelleChantal BlaisRobert Dufour, MDMartine GauthierJoanie HouleFrançois Larivière, MDDiane MénardValérie Vincent
2011 IRCM CHALLENgE – RUN fOR LIfESteves Morin, organizer and race founderFanny Bergeron-LabrecqueJoël BoninPhilippe BriandBelinda ElishaSonia FortinNadine JosephJean-François LauzonAnnabelle MathieuVirginie MessierElena PalmesinoHuda SalemHanny WassefAsheley Ziai
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$1,461,389 dONATEd TO THE IRCM IN 2010-2011
IN 2010-2011, TwO RECRUITs bENEfITTEd fROM PART Of THE fUNdINg.
Jennifer Estall, Assistant IRCM Research Professor and Director of the Molecular Mechanisms of Diabetes research unit.
Hua Gu, Full IRCM Research Professor, Director of the Molecular Immunology research unit, and holder of the André-Aisenstadt Chair of Excellence in immunology.
IN 2011, 11 NOMINAL sCHOLARsHIPs wERE AwARdEd TO MAsTER’s ANd dOCTORAL sTUdENTs, ANd POsTdOCTORAL fELLOws:Angelo-Pizzagalli postdoctoral scholarship (Carole Iampietro)Jean-Coutu postdoctoral scholarship (Justine Rousseau)Industrial Alliance doctoral scholarship (Adèle Coriati)Jean-H.-Lafleur doctoral scholarship (Marie Mutabaruka)Michel-F.-Bélanger doctoral scholarship (Sophie Ziai)André-Caillé doctoral scholarship (François Godin)Joseph-Paulin Master’s scholarship (Tyler Sloan)Métro Master’s scholarship (Fanny Bergeron-Labrecque)IRCM – Run for Life Master’s scholarship (Clémence Meunier)IRCM – Wisent Master’s scholarship (Karen Cholmondeley)IRCM – Invitrogen Master’s scholarship (Qi Yang)
THREE ExCELLENCE AwARds wERE gRANTEd TO A REsEARCHER, AN EMPLOyEE, ANd A sTUdENT:Pierre-Bois Excellence Award (Frédéric Charron)Vincent-Castellucci Excellence Award (Steves Morin)André-Barbeau Excellence Award (Cynthia Forlini)
Many businesses, foundations, and individuals support the IRCM each year, either through its benefit activities, its direct mail campaign or by creating personalized funds. Other donors choose to support the Foundation by donating shares or making bequests. A sincere thank you to all our donors.
THE IMPACT Of yOUR dONATIONs
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MARINELLA ERMACORA CHOsE THE dONATION Of sHAREs
“I am proud to support the Foundation. I transferred shares directly into the Foundation’s account, and was thereby able to take advantage of making such a donation: the capital gain is not taxable and I received a tax receipt in the amount of my charitable donation. Donating shares is easy and quick: all it takes is an electronic transfer.”
MARINELLA ERMACORA, Senior Vice President – Business Solutions, Fujitsu Canada Inc.
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gIvE fOR LIfE MAJOR fUNdRAIsINg CAMPAIgN dONORs
The major fundraising campaign we are conducting with businesses and private foundations has allowed us to raise $8,255,811 to date. The Foundation thanks all donors who contributed to this campaign.
OvER $1,000,000 Marcelle and Jean Coutu Foundation
$500,000 to $999,999Desjardins-Moreau FoundationGaétane Beauchemin EstateGosselin Family FoundationIRCM internal communityNational BankPower Corporation of Canada
$100,000 to $499,999 BMO Financial Group Cogeco Inc. Gaz Métro Hydro-Québec Jeanne-Mance FoundationMirella and Lino Saputo FoundationQuebecor RBC Foundation Samcon Scotia BankSociété des alcools du Québec TD Bank Group
$25,000 to $99,999Aon Hewitt / Aon ParizeauHélène Desmarais Louis-Gilles Durand Groupe Park Avenue Inc.Groupe TEQ Industrial Alliance Gérard A. Limoges
Luigi Liberatore Foundation Métro Richelieu Inc. Petra Ltd Placements Borsa Inc. André Toupin
$10,000 to $24,999Anonymous (1)CIBC Éric A. CohenRobert Dufour Claude A. Garcia Mrs Estelle and Dr. Jacques Genest Italian Chamber of Commerce in CanadaPierre Larochelle Tarik Möröy Monique and Robert Parizeau Paul A. Fournier FoundationJoseph P. Paulin Guylaine Saucier
$5,000 to $9,999Anonymous (2)Serge A. Boileau Jacques Archambault Jacques de Champlain Christian F. DeschepperJacques Gauthier Paul Jolicoeur Paule LeducStéphane Létourneau Camille Limoges Gaétan Lussier Alain Mayrand Michael A. Meighen Guy Saint-Pierre M. Ram Sairam Peter W. Schiller Cécile and Pierre Shooner Richard Tanguay Michael L. Turcotte Jacqueline Turgeon Hélène Véronneau
OUR PARTNERs ANd dONORs
*total donations
2010-2011 dIsTRIbUTION Of dONATIONs
$1,261,090*Major fundraising campaign $935,394 74.2%benefit activities $252,195 20.0%direct mail campaign $73,501 5.8%
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AN ExCEPTIONAL COMMITMENT by THE gOssELIN fAMILy fOUNdATION
“For several years already, I have supported the IRCM Foundation and the Institut through annual contributions to the benefit activities. It is therefore with great pleasure that my Foundation decided to participate in the major Give for Life fundraising campaign. My family and I believe in this world-renowned institution, whose contribution to the improvement of our society’s health is immeasurable.”
LéON gOssELIN
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dONORs – IN-HOUsE fUNdRAIsINg CAMPAIgN, L’IRCM LA vIE. J’y CROIs, JE PARTICIPE
257 donors (46 anonymous)
Jaime Agudelo – Richard Alain – Robert Alain – Jeannine Amyot – Geneviève Archambault – Émélie Aucoin – Aurélio Balsalobre – Gaétan Baril – Alain Roger Bataille – Catherine Beauregard – Dorothée Bégin – Mohammed Bencheqroum – Ines Lilia Benzaghou – Iréna Berezowska – Dominique Bergeron – Lise Bernier – Monique Bernier – René Bibeau – Julie Binette – Chantal Blais – Serge A. Boileau – Pierre Bois – François Bordeleau – Annie Bouchard – Lucie Boulet – Frédéric Bourque – Daniel Bouthillier – Isabelle Brisson – Nicole Campeau – Michel Cayouette – Michel Chamberland – Michel Charest – Frédéric Charron – Marcel A. Chartrand – Radu Chiriac – France Chrétien Desmarais – Michel Chrétien – Raymond Chrétien – Richard Cimon – Éric A. Cohen – Marc Cool – Jean-François Côté – Richard Côté –Judith Cotton-Montpetit – André J.P. Couillard – Dominique Davidson – Jean Davignon – Jacques de Champlain – Sébastien Decelles – Chantal Delisle – Christian F. Deschepper –Desjardins-Moreau Foundation – Hélène Desmarais – Javier Di Noia – Dimitrios Jimmy Dikeakos – Céline Domecq – Jacques Drouin – Simon Drouin – Patrick Du Souich – Caroline Dubé – Robert Dufour – Pierre Dupont – Louis-Gilles Durand – Jean-Marie Ekoé – Denis Faubert – Claudia Fiorentino – Clara Forestier – Diane Forget – Jocelyne Fouquette – Nadine Fradet – L. G. Serge Gadbois – Marc Gagnon – Sergio Galeno – Claude A. Garcia – Michel Gaudreau – Dany Gauthier – Jacques Gauthier – Yves Gauthier – Estelle and Jacques Genest – Alexandra Gervais – Francisco Gomes – Raphaël Gottardo – Lysanne R. Goyer – Jean-Philippe Gratton – Michel Greenshield – Pierre Guiot-Guillain – Anne Haché – Josée Hamelin – Dagmar Hipfner – Alice Tania Hobeika – Jean Huet – IRCM Student Association – Natacha Jackson – Claude Jacques – Hélène Jacques – Pierre-Étienne Jacques – Christine Jolicoeur – Louise Joly – Claudia Jones –
Artur Kania – KCI Ketchum – Samer Jacques Khaouam – Marie Kmita – Dayana Krawchuk – Christine L’Abbé – Benoît Laganière – Olivier Lagueux – Maxime Lamarre-Cliche – Louise Lambert-Lagacé – Josette-René Landry – Johanne Langevin – Dominique Laniel – Julie Lapointe – Mathieu Lapointe – Manon Laprise – Louise Laramée – François Larivière – Lise Laroche – Pierre Larochelle – Tommy Larouche – W. Robert Laurier – Mélanie Laurin – Christine Le Jeune – Marcel Leclerc – Éric Lécuyer – Paule Leduc – Gino Lefebvre – Stéphanie Lemay – Félix-Antoine Lessard-Ouellet – Stéphane Létourneau – Danielle Lévesque – Martin Lévesque – Camille Limoges – Gérard A. Limoges – Bastien Llamas – Gaétan Lussier – Martine Maheu – Andrew P. Makrigiannis – Carole Marcotte – Gérard Marcoux – Cleiton Martins de Souza – Ginette Massé – Éric Massicotte – Alain Mayrand – Michael A. Meighen – Johanne Mercier – Chantal Mercure – Philippe Mochirian – Yves Morin – Tarik Möröy – Gina Muccigrosso – Benoit Papineau – Mario Paquet – Robert Parizeau – Manishha Patel – Lise Patenaude – Ariane Pelletier – Stéphane Perras – Jessica My Tram Pham – Sylvie Picard – Christian Poitras – Annik Prat – Amanda Prioletta – Jessica Prioletta – Mike Prioletta – Éric Racine – Vasanth Ramamurthy – Émilie Raymond – Inmoo Rhee – Rina Riberdy – Jonathan Richard – François Robert – Michel Robillard – Ghislaine Roederer – Nicole Rougeau – Raymond Roy – Odile Royer – Alexis Sabourin – Guy Saint-Pierre – Ram M. Sairam – Guylaine Saucier – Giuseppe Schiavone – Peter W. Schiller – Carole Schmidt – Nabil G. Seidah – Hélène Sénéchal – Jijun Shang – Pierre Shooner – Sardar Sindhu – Sodexo – Lise St-Germain – Julie St-Jean – Lyne St-Pierre – Catherine Strifas – Woong-Kyung Suh – Jean-René Sylvestre – Gaétan Thibault – Carole Tremblay – Jocelyn Tremblay – Michel Tremblay – Marie Trudel – Yvon Turcot – Jean Vacher – Annie Vallée – Hélène Véronneau – Luc Vinet – Grazyna Weltrowska – Ewa B. Wesolowska – Zeina Yared – Shaohua Zhang – Ming-Chao Zhong – Qinzhang Zhu
fRIENds, bUILdERs ANd gREAT bUILdERs
The IRCM and its foundation thanks the donors who gave generously to its annual fundraising campaign.
dONORs – 2010-2011dIRECT MAIL CAMPAIgN
gREAT bUILdERs(OvER $1,000)Anonymous (1)Gertrude BernardMarinella ErmacoraInvestissements ElmagDiane JacquesMigertinMonique and Robert ParizeauPeerless Clothing and Alvin Ségal André Toupin
bUILdERs($500 TO $999)Anonymous (1)A. Pizzagalli Family Foundation Serge ArchambaultMihai BalabanLine BrissonKay and Raymond ChrétienPhilippe DalphondSébastien DecellesLouis DeumiéJanet-Louise ElyFerreira FernandesLanglois & CieMatériaux de plomberie PMF Inc.Nelco Inc.
Pierre E. PaquetteIrène StrycharMarika F. Teakle
fRIENds($100 TO $499)Anonymous (54)Norma AdubRobert AllenMaria AndradeMoïse AmselemEbrahim AssadiP. André AubinJean AuboirouxCamille AudetJean AugerJacques AurayLucie and Olivier AuriolEmma Balestard Ste-MarieMonique BaribeauMoise BassalMoussa BassalAndré BastienBernard BaudyNormand BeauchampPauline BeaucheminSylvain BeaulieuMonique Beaulieu GagnonGilles N. BeauregardMarie Beauregard DucharmeAndrée BédardJean BédardJean-Louis BéginMichel BehamdouniLouis BélandLouis-P. BélangerPierre BelhumeurNormand BenoîtRichard BernècheDenis BernierJean-Serge Bienvenu
Marc BouthilletteFernand BoilyJacqueline BoisjoliPierre BonnaudJohanne BonneauRobert BoucherPierre BoulayL. Jean BourgaultHélène BourgeoisJacques BourgeoisEstelle BourretClaude BoyerMary and Carl BrennanRené BrièreClaude BrosseauGilbert BrosseauClaude BruneauGilbert BureauGérard CaisseGisèle CaronVito CarosielliMarie-Lucette CasseusJean M. CastonguayBenoit ChaputFrançois CharbonneauRichard CharruauJean ChartonJean-Paul ChartrandMichel ChartrandJean-Marc ChatelJean-Marie ChauretChristian ChoquetMichel ChrétienRossana Cininni CollettiPaul CobettoRaphael CohenPhilippe CollBernard ComtoisAnne Marie ConnesNathalie and Philippe CorbinGérard P. Cordebas
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José CostaLangevin CôtéMichel CoudercJanine CoutuYves CoutureGilles CouturierPierre CouvretteJ.V. Raymond CyrMichelle Dalpé-WiggsJacques D’AmourThi-Muon DangAboubekr Daoud-BrixiRaymond DavidFrançois DazéClaude De LaunièreAndrée DelisleLéo-Claude DelmaireEdgard DelvinGilles DemersLouis DemersRolland DemersAlain DeromeJacques DeschênesLouise Desjardins JoubertLouis R. DesmaraisGérald DesrochersSerge DesrochersFernand DesrochersRodrigue DesrosiersRenée Di Gregorio CastonguayJacques Di muroRené DiamondLouise B. DionneRobert DoloreuxPaul DominiqueSolange DoucetOdette DrouinMichel DubucGérald DufourJean DufourMichel DufourPierrette Dufresne
Lucia Dujmovic HorvatClaudette DuvalChristiane ÉlieBenoît EmeryJean GagnonMario EscobedoYolande FahndrichBernard FaribaultWilliam H. FeindelJean FiolaColette FontaineChristiane ForestNormand FortinAndré FournierFournier-Simard FamilyAlain FrenetteRobert GalardoCéline D. GariépyJérome GariépyNessim GarzonFernand GaudreaultNormand GaulinGilles J. GauthierGuy-Alain GauthierSolange GauthierArthur GauvinGisèle and Jacques GebelStephan GeorgievGaston GermainAlbert GiguèreMonique GiguèrePierre GiguèrePierre H. GirardPierrette GirouardJules GirouxMichel GirouxMariette GonthierGilles GouletDenis GoyetteJuliette Gratton St-CyrJohn GrayHélène Grégoire
Philippe GrenteJacques GressetGroupe LacasseClaudette Guay-CloutierSerge GuéretteLouise Guérin BourbonnaisMarcelle GuertinJacqueline GuilbaudAnna HareHenri HarlandPierre HarveyGeorges HauspyDaniel HébertMonique HébertRolande HenrichonJulie HérouxIsabelle HervetPierrette HervieuxSandra IrvingMarc-Odile-Simone Isch-WallGaétan JodoinMichèle JodoinRosee JompheCécile JulienAndré JutrasAlbert KassabJohn KayemRobert KeatonGinette Khalil LerouxJo-Anne L’Heureux-GiguèreLionel LabontéJosée LabossièreOdette LacasseLoyal LachapelleCarmen Lacombe CastonguayFrancine LacroixRichard LacroixRaymond LafontaineSylvain LafontaineRobert LagardeThe Honourable Marc LalondeJean Lamarre
Michel LamarreSuzanne LamarreRené LanevilleSuzanne Langevin LavoieJean-Louis LangloisCéline Laporte-JulienDenise LaraméeYvon LarinMario LarochelleAntonio LaroucheMadeleine LatulippeLisette LaurentGilles-Albert LavignePierre LavigneThérèse Lavigne PetitclercClaude LavoieCharles Le BorgnePierre LebeauPierre LebelClaude LeblancPauline LeblondRichard LecavalierDaniel LeclairMonique LeclairHélène LeclercPierre LeducYves LefebvreRichard LégerRaymond LegrosRené LemireMonique Le PageLouis-Bernard LépineSimone LerouxAndré LesageFélix-Antoine Lessard-OuelletPierre LessardJacques LetendreMurielle LizeJocelyne Lussier LeducJ.H. Guy LordKamal MaariNormande M. Mailloux Casgrain
Bernard MainvilleMarie Louis MalloukManulife FinancialIleana MaraJean-Claude MareuilGilles MarinRenée MartelNormand MartinYvon MartinPaul-André MasséMichael MattocksLouis J. MiquelonMarielle Miron LeducVictoria Elias MoghrabiPierre MonahanFrançois MoquinHubert Morel ChevilletJean-Pierre MorinSerge MorinFrançoise Morin DumontSylvie NadeauGuy NadonNational Bank Financial GroupJosé NavarroRoxana Nemes BratisHoang Long NguyenPaul NoiseuxGilles NormandinIrene O’BrienCécile Lachance OlivierAgathe OuelletElaine OuelletLyne and Clément PagetSylvie PalardyJeannette Papavasil ZellicLaurent PaquetteJacques ParéMonique ParentJocelyne PellandNormand PelletierFrancine PépinJean-Yves Pépin
Jacques PériardJean-Paul PhilieAlain PicardMichael PilleyRaynald PineaultJean-Jacques PlaisanceDiane PlourdeDiane PoirierAndrée Cossette PoitevinNathalie PoullainAlix PrentkiStéphane PrimeauDenis R. RoyLydie Rabasa-LhoretMs Rabasa-LhoretSerge RacetteLaurent RadenSuzanne RangerRecochem Inc.Claude RichardDanielle RicherHuguette RiouxMartine RivardLouise Robert-GasconGuy RobillardMarc RochefortNicole Janin RochefortRolande Rompré LeducVictor RosaBéatrix Ross BhatiaLéo RosshandlerRichard RowlandFrançoise RoyYves RoyÉlie SalehMichèle SandersonMarie SaucierCharles L. SausmanDenis R. SéguinRichard SerriAmina and Hussein F. ShaarawiClaude-Armand Sheppard
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Société en commandite Gestion Heenan BlaikieChiu Sang SouFrançois SpainMartin St-GeorgesLuc St-JacquesJules St-MichelJean St-PierreElissaveta StanchevaJuliette TeasdaleRobert TessierNoëlla TétreaultThe Hermitage ClubClaudia ThériaultMonique ThisdaleLouise ThoburnPascal TissotHoward TomPhilip TousignantFleurette Tremblay DeslongchampsGilles TremblayAndré TrempeYves TrépanierLise Trudeau BarbeauMicheline TurcotGilles TurcotteJean-Claude TurcotteMichael L. TurcotteMarc-André UlysseLucien ViarguesDanie VidoudezThérèse Vien ClermontJosée VigeantMonique VermetteMaurice VernerJacques VézinaPierre VilliardJean VincentJuanita Westmoreland-TraoreAndré WilkinGuy Wolfe
“IN MEMORIAM” dONATIONs
In 2010-2011, donors supported the IRCM with a donation in the memory of the following people. donors also become friends or builders, depending on the amount of their donation.
Marthe Barbeau DauphinRaymond BarretteMonique BastienMarguerite BeaulieuClaude BeauregardLorenzo BédardAlain BélangerMarie-Paule BélangerPierre BissonneaultPierre BonnierAlonzo BoudreaultFrancine BrièreMarc BrièreLéopold BrochuClaire BrunelleCamille C.-L. D’AmourGeorgette Drolet CarbonneauMarcel H. CaronMarcel CaronRobert CharbonneauGilles ChenierBrigitte ComeauJacques CossetteJean-Louis CoutuJean-Clovis CrevierLouise CrevierJ. Paul DaigneaultLouis DamianiPhilippe DaoustGisèle Demers Charlebois
Jean DeserresNinon DesjardinsLouise DeslauriersGertrude DesranleauGabrielle DesrochersCatherine DeyglunClaude DubucJean-Claude DubucDr. Yves DupréDenyse FortinGilberte Fortin GuindonYvonne FrappierLouise GagnonÉmile GarciaAnnette GariépyAngela GhezziGilberte GirouxRéal GravelFrancine GuilbertMaurice HannequartClaude HébertDr. G. HowleAndrée B. JolicoeurPierre LacombeJean H. LafleurRéal LafrenièreThérèse Lajoie AllenOctavie LalliéLucille LambertMaurice LandryMaurice LangloisPierre LangloisMaurice LapierrePierre-Aimé LatraverseAnnette Lauzon-GuindonCécile Lavallée-RobertClaire LefaivreAndré LemayLucile LemieuxDiane LongpréJeanne Labonté Maher
Pierre MartinElisabetta Masselli GasparoMarc MéthéWilfrid MondouxAndré PichéJ. Yves PilonHélène PlourdeMadeleine PoirierNicole PoupartAndrée ProulxRenée B. Prud’hommeRichard Rabasa-LhoretRita Racette CadieuxSeverio RagozzinoPierre RainvilleNoëlla Raymond-BouletGermaine Rheault PigeonLucille Rhéaume-AudetJeanne RiouxCéline RobillardYves RollandJacques RompréThérèse Rochon SaindonNicole Rozon JoyleMadeleine Shuick ParéYvonne ServantThérèse SomersClaude St-CyrBernard St-OngeRené Ste-MarieMarcel TellierGaétan ThibaultMarthe ThibodeauJean-François ToutantMarcel TrahanPierre TremblayClaude TrudelMarcel TrudelLola Vinditti
PARTNERs Of OUR bENEfIT ACTIvITIEs
In 2010-2011, our partners contributed $130,000 to our benefit activities.
Agir – Air Canada – BD – Bio Basic Inc. – Bio-Rad – Boehringer Ingelheim (Canada) Ltd – BPR – Brian Mulroney – Business development Bank of Canada – Confab Laboratories– Demco – Dessau – EMD Millipore – Fasken Martineau DuMoulin – Feldan Bio – Fisher Scientific – Gaz Métro – GDI Distinction – GE Healthcare – Gosselin Family Foundation – Grandma Emily’s – Groupe Biron – HVAC inc. Ventilation-plomberie – Hydro-Québec – Inter Medico – KPMG – Lafleur Portes de garage industrielles – Life Technologies – Merck – Metler-Toledo – MP Bio – National Bank – Naya – Oasis – Ogilvy Renault – Peprotech – Pfizer – Power Corporation of Canada – Promotour Marketing – Qiagen – Research platform on obesity, metabolism and diabetes (PROMD) at the IRCM – Saputo – SAQ – Sarstedt – Sodexo – Ultident Scientific – Versalab – Ville de Montréal – VWR International – Wisent Bioproducts
THE IRCM fOUNdATION’s REsEARCH fUNds ANd CHAIRs
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since the IRCM foundation’s beginnings, donor contributions have enabled the creation of several personalized funds and research chairs.
The IRCM foundation’s research funds and chairs(In chronological order of creation, from the oldest to the most recent)
Marcel and Béatrice Piché Fund*Rosario and Annette Genest Fund*Marie and Willie Chrétien Fund*Jacques Genest – Royal Bank Chair*J.A. DeSève Research Chair of Excellence*Canadian Pacific Research Chair in pain*Georges Lachapelle Fund*John Low-Beer Chair*Michel-F.-Bélanger Cancer Research Chair*Angelo-Pizzagalli Postdoctoral Scholarship Fund*Jean Coutu Postdoctoral Scholarship Fund*Bell-Bombardier Chair in Cardiovascular Diseases*Sainte-Thérèse de l’Enfant-Jésus Fund in memory of Mable and Lucien ToupinIRCM In-House Fund for Excellence*National Bank Fund for Cancer ResearchRBC Royal Bank Fund for Research on Infectious DiseasesBMO Fund for Priority ResearchLucille, Rollande and Gaétane Côté FundJean-Guy Desjardins Fund for Priority Research*Mirella and Lino Saputo Fund for Clinical ResearchHydro-Québec Fund for Priority ResearchGaz Métro Fund for Priority ResearchQuebecor Fund for Neurology ResearchPower Corporation Fund for Priority ResearchDiana and Sam Scalia Fund for Research on Cardiovascular and Metabolic DiseasesGosselin Family Foundation FundScotia Bank Fund for Diabetes ResearchSAQ Fund for Priority ResearchCogeco Fund for Cancer Research
*Capitalized funds
THE ANNUAL REPORT Is A REvIEw Of THE yEAR’s HIgHLIgHTs ANd sUMMARIzEs THE MAIN sCIENTIfIC ANd ACAdEMIC ACTIvITIEs fOR THE PERIOd Of sEPTEMbER 1, 2010 TO AUgUsT 31, 2011. THE REPORT ALsO INCLUdEs A sUMMARy Of THE IRCM fOUNdATION’s ACTIvITIEs fOR THE sAME PERIOd. THE fINANCIAL fIgUREs COvER THE PERIOd Of APRIL 1, 2010 TO MARCH 31, 2011.
fOR MORE INfORMATION ON THE IRCM’s ANd THE IRCM fOUNdATION’s ACTIvITIEs, REfER TO THE ACAdEMIC REPORT ANd THE INsITUT’s wEbsITE.
PROdUCTIONIRCM – COMMUNICATIONs dEPARTMENT
COORdINATIONLUCETTE THéRIAULT
REsEARCH, wRITINg, TRANsLATIONLUCETTE THéRIAULT, JULIE LANgELIER
ART dIRECTION, gRAPHIC dEsIgNHéLèNE LAMbIN
PHOTOgRAPHyHéLèNE LAMbIN, CHRIsTIAN gUAy, fOTOLIA
EdITORIAL COMMITTEEJUdITH COTTON-MONTPETIT, dAvId R. HIPfNER, HéLèNE LAMbIN, JULIE LANgELIER, JOHANNE LANgEvIN, sTéPHANE LéTOURNEAU, LUCETTE THéRIAULT, HéLèNE véRONNEAU
dECEMbER 2011IsbN-978-2-924029-01-5LEgAL dEPOsIT – bIbLIOTHèQUE ET ARCHIvEs NATIONALEs dU QUébEC, 2011
wE THANK EvERyONE wHO CONTRIbUTEd TO THE PROdUCTION Of THIs ANNUAL REPORT.
INsTITUT dE RECHERCHEs CLINIQUEs dE MONTRéAL (IRCM)110 AvENUE dEs PINs OUEsTMONTRéAL (QUEbEC) H2w [email protected] | www.IRCM.QC.CA
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