Nichino America Inc.Jim Adams, Manager, Product Development

Marie Maks-Regulatory Affairs ManagerPhone: (302) 636-9001

Web site: www.nichino.net

2008 IR-4 Food Use WorkshopSacramento, CA

NAI-2302 15ECNAI-2303 15SC

Tolfenpyrad

Chemical Details on TolfenpyradChemical Name: 4-chloro-3-ethyl-1-

methyl-N-[4-p-tolyloxy)benzyl] pyrazole -5-carboxamide

Empirical Formula: C21H22Cl N3O2Molecular Weight: 283.9Code Number: NAI-2302

Insects ControlledHemiptera, Coleoptera, Diptera,

Lepidoptera, Thysanoptera, and AcarinaPoisoning by ingestion; contact activity;

anti-feeding activity against lepsTarget Crops:

Vegetables, Cucurbits, Cole CropsFruits & NutsSelected row cropsOrnamentals

Efficacy Trials

Use rate 0.137 to 0.274 lb. a.i/acre (153-307 grams ai / hectare)

14 – 27 oz/a (15% EC and 15% SC formulations)

Alternative mode of action useful against numerous vegetable and fruit/nut pests

U.S. Registration Timeline

Submit non-crop indoor greenhouse use mid 2008 as reduced risk candidate

Submit crop uses with residue chemistry data by 2010 as reduced risk candidate

NNI-0771NNI-0772NNI-0776

Flubendiamide-Based Insecticides

CF3

CF3F

I

ONH

OCH3

HN

CH3CH3SCH3

OO

NAI-2310 (FLUBENDIAMIDE)

New generation of chemistry active against Lepidoptera at low rates

Discovered by NNC and marketed by NNC and Bayer

Registered in Japan as Phoenix

FLUBENDIAMIDEProduct Characteristics

Flubendiamide (NAI-2310) Target Mkts: TNV, Vegetables, Cotton Chemistry: Substituted phtallic acid diamide MOA: Ryanodine receptor modulator Ingestion by insect results in immediate cessation

of feeding Contact (not systemic in plants and has only

limited translaminar movement) Rates: 15-140 gms ai/hectare

2009 IntroductionsNNI-0772 (Tourismo™)

Tree Nuts, Pome, Stone, Vines, CottonNNI-0871 (Vetica™)

Vegetables, Cucurbits, Cole Crops

US Registration TimelineSubmission to EPA 2008Commercial Launch 2009

NNI-0101

Pyrifluquinazon

NNI-0101(Pyrifluquinazon)

Chemistry: Quinazolinone Chemistry MOA: Insect Behavior Modifier

Rapid cessation of feeding Insects remain but starve to death

Target Mkts: TNV, Vegetables, Cotton, Cucurbits

Pyrifluquinazon (NNI-0101)Hemiptera / Homptera

Rates: 12.5-50 grams ai/hectareWhitefly, Aphids

Rates: 50-125 grams ai/hectareMealybug, thrips, leafhopper

Higher Rates:ScaleTrue bugs

Biological mode of action on aphids

0

20

40

60

80

100

0 20 40 60 80 100

Mortality

％ of dispersion

Mortality of starvedinsects

Hours after treatment

Percent of dispersal

insects (stop feeding) &

mortality

Abnormal behavior Death by starvation

Appearance of activity/Green peach aphid

Figure 1. Mortality and percent of insect dispersal from treated plants of green peach aphid, Myzus persicae, after treatment with NNI-0101 at a dose rate of 50ppm.

(insects may appear normal)

of NNI-0101 treated insects

of NNI-0101 treated insects

NNI-0101 shows two distinct effects on aphids; 1. Rapid response of abnormal behavior (insect dispersion, feeding cessation)2. Slow lethal action

Possible IR-4 InterestsOnion thrips (PCR submitted)Aphid, Thrip, Whitefly, Mealybug and Scale control on ornamentals

Rapid cessation of whitefly and aphid feeding reduces transmission of viruses vectored by these pests on important fruit and vegetable crops

US Registration Timeline

Submit for food crop uses early 2010