20 petiveria alliacea l
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Transcript of 20 petiveria alliacea l
Petiveria alliacea L. Extract for the Treatment of
Gastroesophageal Reflux Disease
Edwin J. Alvarado
Petiveria alliacea L.
• Petiveria alliacea L., also known as Anamú or garlic weed, is a very influential plant in traditional medicine.
• Proved to possess antibacterial1 and analgesic2 properties, among others.
• Both contribute to the plant’s reputation for calming GERD symptoms.
Question/Problem
• Can the extract from the Petiveria alliacea L. affect the stomach’s pH or, more ideally, the stomach’s acid irrigation?
Hypothesis
• If the contents of the stomach are irrigated with the plant’s extract, the pH levels of the acid will increase, inhibiting the stomach’s acid irrigation over a long term exposition, sparing damage to the organs involved.
Chemical Experiment
• Prepare a solution of HCl, KCl and NaCl, among others, add consecutive doses of extract and record pH.
• To determine if extract acts as a buffer solution.
• If true, determine buffer region.
In Vivo Experiment
• Organism: Mice / Rats
• Quantity: 20 per group (80 in total)
• Variables: Presence of extract in ingestion
Presence of acid promoters
Prowess over time
• Period: 4 weeks
Experimental Groups
• Group A
• P. alliacea extract
• No acid promoter foods
Group B
P. alliacea extract
Acid promoter foods
Group C
No P. alliacea extract
Acid promoter foods
Control Group
• Group D (NEGATIVE CONTROL)
• No P. alliacea extract
• No acid promoter foods
Methodology
• Strict, standardized diets, varying only aforementioned factors.
• After each week, collect five specimens from each group and extract stomach contents.
• Analyze pH, acid concentration, gastric component concentration.
• Interpret results.
Objectives
• To determine if the extract “neutralizes” the stomach’s pH and in what capacity.
• To determine if the extract affects the stomach’s acid irrigation and in what capacity.
• To determine efficiency, if any, in abnormal stomach conditions.
• To determine the efficiency, if any, of short term treatment versus long term.
Goal
• Provide those afflicted with GERD an alternative treatment that both relieves pain and controls the disease
References
1. Kim S, Kubic R, Musah RA. Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria Alliacea L. 2005. Available from: http://www.sciencedirect.com. Accessed: 2012 June 21.
2. Lopes-Martins RAB, Pegoraro DH, Woisky R, Penna SC, Sertié JAA. The anti-Inflammatory and analgesic effects of a crude extract of Petiveria Alliacea L. (Phytolaccaceae). 2004. Available from: http://www.sciencedirect.com. Accessed: 2012 June 21.