2 pt
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DEFINITIONS NAME THAT ANTIGEN
DISEASE ASSOCIATION
KELL SYSTEM ENZYMES
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This is the ability of an antigen to stimulate an antibody
response.
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Immunogenicity
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This is the term for antigens that are present in
less than 10% of the general population.
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Low prevalence
Low frequency
Low incidence
Familial
Private
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DAILY DOUBLE
This is a known failure of an antigen-antibody reaction to
yield a positive test result as a consequence of antibody excess.
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Prozone
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This is the term for a reaction in which one cell population is agglutinated,
but a second cell population remains free.
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Mixed-field
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What term has been used to denote those antibodies which react weakly both
when diluted or undiluted, but are present in high
concentration.
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HTLA
(High Titer, Low Avidity)
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After the ABO and Rh antigens, this antigen is the
most immunogenic.
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Kell
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Name an antigen in the Kell system that is high prevalence.
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k (Cellano)
Kpb ( Rautenberg)
Jsb (Matthews)
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This antigen is formed by a non-secretor who has
inherited the genes lele.
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Lec
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Anti-Tja is associated with this blood group system.
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P
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Name one antigen that is part of the C4 molecule of complement,
and therefore not an intrinsic part of the RBC membrane.
(An example of an HTLA antibody)
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Chido or Rodgers
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This relatively uncommon antibody is found in up to 80% of
patients with infectious mononucleosis.
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Anti-i
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This antigen, related to the Kell system, is associated with Chronic Granulomatous
Disease.
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Kx
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The erythrocytes of individuals with this
phenotype appear to resist invasion by
Plasmodium vivax.
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Fy (a-b-)
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The Donath-Landsteiner antibody that is present in the
serum of patients with paroxysmal cold
hemoglobinuria (PCH) has this specificity.
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Anti-P
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A patient with a Mycoplasma pneumoniae infection will most
likely develop a cold autoantibody with this specificity.
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Anti-I
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Antibodies of the Kell system generally react at this phase of
testing.
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AHG
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Give two reasons a patient who had anti-K two years ago now appears to be compatible with two random donor units
of red blood cells.
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1.Both units are K negative.
2.The anti-K titer is too low to be detected.
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Name three pairs of antithetical antigens at the Kell locus.
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1.K and k (Kell and Cellano)
2.Kpa and Kpb (Penny and Rautenberg)
3.Jsa and Jsb (Sutter and Matthews)
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Individuals of the Kell null phenotype may only be
transfused with RBCs from other Kell null individuals
because their plasma contains this antibody.
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Anti-Ku
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A person with anti-K will be compatible with approximately this many random donors out of
ten.
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9
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This enzyme is the most commonly used in routine Blood
Banking.
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Ficin
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Papain is derived from this plant.
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Papaya
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Name 5 blood group antigens that are enhanced by enzymes.
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Kidd, Lewis , Rh, Ii, P, ABO
(Kidd Lewis has Ripples In his Pecs and Abs.)
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DAILY DOUBLE
Name 5 blood group antigens that are adversely affected by proteolytic substances.
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MNS, Fy, Xga
(Many New Soldiers are destroyed in the Field by eXplosions.)
Note: Sometimes Kell (Many New Soldiers are Killed in the Field by
eXplosions)
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These antigens of the Duffy system are enzyme
resistant.
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Fy3, Fy5 (and Fy4)