FISIOLOGI PENYEMBUHAN LUKAwoc ec l i n i ca Professional Nurse Lead Service for People with Stomas, Wounds or IncontinenceI j i nNo .1 1 9 6! " #$i n % e s& ' () I I* " " +MOIST WOUND HEALING,eor-e $ Winter .196*/0 proved that wounds that were %ept moist, healed 1etter than those that were e2posed to the air. 345 6'3457 86 98IS3 W8:N$ 45'LIN,Home WORK : Why MOIST ?JUSTIFIKASI1. Fibrinolisis 0 ;1rin cepat hilan- pada suasana lem1a1 oleh netro;l dan sel endotel2. Angiogenesisi 0 proses a%an le1ih teran-san- pada suasana lem1a13. Infeksi 0 le1ih rendah di1andin-%an suasana %erin- . *.6 < vs +.1 < /4. Percepatan pembentukan sel aktif 0 invasi netro; =an- dii%uti olehma%ropha-, monosit dan limfosit %e daerah lu%a a%an 1erfun-sile1ih dini.5. Pembentukan growth factor 0 le1ih cepat pada suasana lem1a1> 5,6, 6,6 dan Interleu%in1 di%eluar%an oleh ma%ropha-untu% proses an-io-enesis dan pem1entu%an str. (orneum> Platelet?derived ,rowth 6actor .P$,6/ dan 3ransformin-,rowth 6actor?1eta .3,6?1eta/ di1entu% oleh platelet untu%proses proliferasi ;1ro1last.3@P5S 86 W8:N$ 45'LIN,1. 4ealin- 1= 6irst Intention*. 4ealin- 1= Second Intention#. 4ealin- 1= 3hird IntentionSchematic Diagram of the Phases of Wound HealingCELLS OF WOUND HEALING.IN6L'99'387@ S3',53anda 0 %emerahan, panas, n=eri dan 1en-%a% Last appro2imatel= A to ! da=sPermulaan terjadin=a proses pen=em1uhan lu%a 0 a%ti;tas platelet untu% S38P perdarahan dantri--ers the immune response*A jam pertama saat terjadi perlu%aan, neutrophils, monoc=tes and macropha-es men-ontrol pertum1uhan 1a%teri dan mem1uan- jarin-an mati . mempersiap%an dasar lu%a /Bharacteristic red color and warmth is caused 1= the capillar= 1lood s=stem increasin- circulation C la=in- foundation for epithelial -rowthP78LI657'3I8N S3',5&e-ins within *A hours of the initial injur= and ma= continue for up to *1 da=sIt is characteriDed 1= three events05pithelialiDation,ranulationBolla-en s=nthesis6ormation of new capillaries that -enerate and feed new tissueGranulation tissue is the 1eef= red tissue that 1leeds easil=P78LI657'3I8N 0 5PI345LI'E'3I8N6ormation of an epithelial la=er that seals and protects the wound from 1acteria and Fuid lossIt is essential to have a moist environment to foster -rowth of this la=erIt is a ver= fra-ile la=er that can 1e easil= destro=ed with a--ressive wound irri-ation or cleansin- of the involved areaP78LI657'3I8N 0 COLLAGEN SYNTHESISBreates a support matri2 for the new tissue that provides it with itsG stren-th82=-en, iron, vitamin B, Dinc, ma-nesium C protein are vital for colla-en s=nthesis3his sta-e is the actual re1uildin- and is inFuenced 1= the overall patient condition of the wound 1ed9'3:7'3I8N6IN'L sta-e of wound healin-&e-ins around da= *1 and ma= continue for up to * =earsBolla-en s=nthesis continues with eventual closure of the wound and increase in tensile stren-th3ensile stren-th reaches onl= a1out H"< of pre?injur= stren-th! 4'7I P'SB' P57L:(''N7566575NB5 Idral $arwis.*""H.Perawatan lu%a dia1et.W8B'75 pu1lishin-. Indonesia'ida S.$. Suriadiredja.*""+. 4istor= of wound healin- and moist wound healin-. Indonesian 53N5P paper.(not publicationBarville (er=lin.199H. Wound care manual. Silver chain foundation.'ustralia&r=ant 7uth.*""+. 'cute and chronic wound. 9os1=.:S'