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  • 1. . 2014, , . ;CLSI & EUCAST. ,. .&.

2. CLSI Clinical Laboratory Standard Institute, :EUCAST European Committee on Antimicrobial Susceptibility Testing 3. CLSI - www.clsi.org 15 1968 31 2000 , 1800 69 116 ( , , ) ( , ) 4. Committee membership9 Consensus CommitteesConsensus Committee on MicrobiologyGovernment agencies, Industry, Laboratory health care professionalsSubcommittees on Antimicrobial ST Antifungal ST Veterinary ST Standards, Guidelines, Reports / 5Working Groups (WGs) Text and Table Quality Work, Staphylococci, Enterobacteria ceae 5. Subcommittee on Antimicrobial Susceptibility Testing .. (FDA, CDC.) ASM, ATCC , 6. CLSI Performance Standards for Antimicrobial Susceptibility Testing (AST), M100-S24 Performance Standards for Antimicrobial Disk Susceptibility Tests, M02-A11 Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that grow Aerobically, M07-A9 Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolates or Fastidious Bacteria, M45 Methods for AST for Anaerobic Bacteria, M11-A48 Principles and Procedures for Detection of Fungi in Clinical Specimens. Direct examination and Culture, M54 Methods for AST for Human Mycoplasmas, M43 32 7. / 8. Cefepime 201430g25mm S19-2418mm R2mg/L SSusceptible-Dose Dependent (SDD)4-816mg/L R 9. 1997ISC FESCI 10. ECA / (CLI ) ( ) cut-off (ECOFFs) 11. (Epidemiological cut-off, ECOFF) MIC W , Wild Type (WT) Wild Type (NWT) W: NWT: Non 12. (Epidemiological cut-off, ECOFF) / / MICs WXmg/L ECOFF: 13. K S (clinical breakpoint) K : MICs PK PD M R 14. K S (clinical breakpoint) (R) R MIC: X, R>Y mg/L : SX, R