1.Surrounded by selectively permeable membrane –Composed of proteins and lipids –Selectively...
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Transcript of 1.Surrounded by selectively permeable membrane –Composed of proteins and lipids –Selectively...
1. Surrounded by selectively permeable membrane– Composed of proteins and lipids– Selectively Permeable Membranes…
• Allow lipid soluble substances to pass easily• Allow small uncharged molecules to pass easily• Allow ions to pass only through protein channels
2. Contains Cytosol3. Contains Organelles with each having
specific functions4. Inclusions5. Exhibit Contact Inhibition6. Differentiated
1. Each has specialized function
The Typical Cell
Cellular CommunicationCellular Communication
Hormone interactions, Foreign Invaders Recognition and
destruction
Electrochemical GradientElectrochemical Gradient
Facilitates intra/extracellular fluids through the membrane via membrane potential
Selective PermeabilitySelective Permeability Regulates entry and exits of cellular materials & Fluids
Permeability depends of four (4) factors
1. Lipid Solubility 2. Size 3. Charge 4. Channels & Transporters
Passive Active (Energy Required) Osmosis Sodium/Potassium Pump Diffusion Vesicular Phagocytosis
Pinocytosis
Osmosis & DiffusionOsmosis & Diffusion
Osmosis DiffusionMovement of water from an
area of high concentration to a low concentration
Movement ions from a high concentration to a low
concentration
Energy Required
ATP
Sodium-Potassium Pump• Ejects 3 Na+ from inside the cell and takes in 2
K +
– Acts as an enzyme to break down ATP for energy required to transport ions across concentration gradients and through the membrane
Integral Protein+ PO4
-
Why is the Sodium Potassium Pump so
Important?
• Maintaining Electrochemcial Gradient and Concentration gradient– Action potential of nerve and muscle
cells– Glucose and Amino Acids into the cell– Movement of Na+ creates a osmotic
gradient that drives the cell’s absorption of water
Exocytosis Exocytosis &&
Endocytosis EndocytosisAnimation
Pseudopods
Phagocytes – Cells designed to perform phagocytosis against invaders and bacterial spores
Examples: Neutrophils (WBC) and Macrophages (Tissues)
• Nucleus – Largest organelle, contains genetic information (chromosomes)
• Ribosomes – Protein synthesis, attached to Rough ER• Rough ER – Storage for new materials to be sent to the Golgi
Complex, responsible for forming glycoproteins. • Smooth ER – Steroid, fatty acid, and phospholipid synthesis• Golgi Complex – Processes, packs, and delivers proteins and
lipids to plasma membrane• Lysosomes – Digestive enzymes which form in the Golgi
Complex• Peroxisomes – Enzymes which oxidize and detoxify many
chemicals in the body primarily the liver and kidney• Mitochondria – Synthesis of ATP (Cellular Respiration
w/glucose)• Cytoskeleton – Filamentous proteins which are responsible for
cellular movement– Microfilaments– Microtubules– Intermediate filaments
• Flagella & Cilia - Movement• Centrioles – Important for forming mitotic spindle during
cellular division
Inclusions
• Melanin– Pigment in hair, skin,
eyes– Screens out harmful
UV rays, can alter appearance AKA suntan
• Glycogen– Quick breakdown for
required energy
• Triglycerides– Stored adipocytes,
broken down to synthesize ATP
I DONT WANT TO GET OLD!
Aging• Progressive degeneration of the body’s homeostatic adaptive
responses– Temperature, Diet, Oxygen Supply
• Geriatrics – Medical field of Elderly care• Signs of Aging
– Gray Hair– Tooth Loss– Wrinkled Skin (Collagen Denaturation)– Decrease in muscle mass– Decrease in osteocyte production
• Osteoperosis• Osteopenia
– Increased Fat deposits– Inability to move
• Due to glucose additions to proteins thus losing the elasticity of body
Cancer Cancer – Severe failure in the regulation of genes (Mutations) that code for cell division
Mutation CausesMutation Causes
Habits
• Alcohol
• Drugs
• Smoking
• Sexual Irresponsibility
Environment• Chemicals (Pesticide, Asbestos,
Benzene)• Second Hand Smoke• UV rays (Sunlight)
Family History• Inherited DNA mutation
Cancer Characteristics• Lack Differentiation
– “Immortal” due to repeated division, normal cells do not repair the mutation
– Not Specialized = No purpose to any body part, does use nutrients from the body
• Have Abnormal Nuclei– - Genes are mutated and contain excessive number of
chromosomes• Form Tumors
– Abnormal mass of cells that invade surrounding tissues and disrupt normal cellular mitosis
Cancer• Cells divide uncontrollably and produce an excess of
tissue– Benign Tumors
• NOT cancerous. • Does not spread to other parts of the body or invade and
destroy nearby tissue. • Benign tumors usually grow slowly.• Generally, not harmful. However, this is not always the case.
If a benign tumor is big enough, its size and weight can press on nearby blood vessels, nerves, or organs, or otherwise cause problems
– Malignant tumor can be fatal• Cancer cells compete with normal cells for nutrients, blood,
and energy eventually causing normal cells to atrophy• The spreading of cancer is known as Metastasis which allows
cells to spread to other parts of the body Cancer cells usually spread via the bloodstream or the lymph system
MelanomaDestruction melanocytes
LymphomaDestruction of lymph nodes
CarcinomaMalignant tumor hat arises from epithelial cells
SarcomaMuscle or connective tissue cancer
LeukemiaDestruction of Leukacytes (WBC)
Necrosis – Death of a cell or a group of cells
Atrophy – Decrease in cellular size and corresponding organs or tissuesNeoplasm – Abnormal formation or
growth
Common Cancer Terms
Biopsy – Removal and microscopic examination of tissues from the body
Viral Associations
Common Viral Diseases• HTLV-1
– Attacks killer T-cells in leukacytes and impairs Lymphatic system
• HIV– Directly attacks Helper T cells which are responsible
for stimulating B Lymphocytes antibody productionEpstein Barr (EBV)– Mononucleosis (Kissing Disease) can attack white
blood cells and lymphatic system (Hodgkin’s Disease)
• Hepatitis B (HBV)– Affects the flow of fluids (bile) through the liver
• Herpes Simplex 2– Cancer of the cervix