1st Lecture on Lymphoid Histology by Dr. Roomi
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Transcript of 1st Lecture on Lymphoid Histology by Dr. Roomi
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Click to edit Master subtitle styleHISTOLOGY OF LYMPHOID
SYSTEMBY
DR. MUDASSAR ALI ROOMI (MBBS,M. PHIL)
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Components of lymphatictissue
lymphatic tissue consists of two maincomponents:
1. Reticular tissue (reticular cells andreticular fibers)
2. Free or motile cells (lymphocytes,
macrophages and plasma cells)
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LYMPHOID SYSTEM
Synonym: Alsocalled as immune
systemDefinition:
Consists of cells ,
tissues andorgans designedto protect thebody from
invasion and 4/23/12 4
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Types of immunity
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distribution of lymphatictissue
Diffuse lymphatic tissue
Nodular lymphatic tissue
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Diffuse lymphatic tissue
Does not exhibitany special
organizationLocation: occurs
chiefly as aninfiltration of thelamina propria ofmucusmembranes,
particularly those 4/23/12 7
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Nodular lymphatic tissue
The cells are densely aggregated toform spherical structures calledlymphatic nodules (lymphoidfollicles).
Examples of lymphoid organs are:lymph nodes, spleen, tonsils, and
thymus.
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Structure of lymphaticnoduleDiameter: 200
um- 1mm.
TWO ZONES:
PERIPHERALZONE: stainsdarkly and
contains closelypacked smalllymphocytes.
GERMINAL 4/23/12 9
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LYMPH NODE
Oval or beanshaped bodiesfound along thecourse oflymphatic vessels
Usually occur ingroups.
Diameter: 1-25
mm 4/23/12 10
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Stroma (supporting framework) ofthe lymph node
Capsule: covers the whole lymphnode and is mainly composed of typeI collagen.
Trabeculae (septa): arise fromcapsule and extend into the interiorof the node.
Network of reticular fibers andcells: extend throughout thesubstance of the lymph node and
entraps the lymphocytes. 4/23/12 11
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Zones or regions of lymphnode
Cortex: outer zone, situated beneaththe capsule.
Medulla: inner zone, occupies centreof the L. node and its hilum.
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Cortex of the lymph node
It has incomplete compartments.
Lymphatic nodules (closely packed
lymphocytes) are present here.**B-lymphocytes are present here.***
Lymphatic nodules often contain
germinal centres (secondarynodules).*****
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Paracortex of lymph nodes
Inner to the maincortex
Devoid of lymphnodules
Composed ofsmalllymphocytes
T- Lymphocytesare present
here**** 4/23/12 14
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MEDULLA OF LYPM NODE
Medullary cords: composed oflymphocytes and
plasma cells.
No lymphaticnodules
Medullarysinusoids also arealso present here.
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IDENTIFICATION POINTS OFLYMPH NODE
Connective tissue capsule is present
Cortex and medulla is present
Lymph nodules are only situated inthe cortex and have no central
arterioles medulla contains Med. cords and
Med. sinuses
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FUNCTIONS OF LYMPHNODES
Filter lymph
Maintain and produce lymphocytes
Produce antibodies
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CLINICAL NOTE
Lymphadenitis: inflammation of thelymph nodes.
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CLINICAL NOTE
Lymphangitis:Inflammation oflymph vessels.
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CLINICAL NOTE
Metastasis to lymph nodes:spread of cancer from primary site tolymph nodes.
e.g. spread of breast cancer toaxillary lymph nodes
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