erate symptom bother. Nocturia had the greatest negative impact onHRQL, while social interaction was the least affected HRQL domain.Further studies are needed to better understand LUTS in patients withdysautonomia. This understanding might provide critical mechanisticinsight into the global pathophysiology of nocturia and OAB.

Source of Funding: None

1506PREVALENCE OF OVERACTIVE BLADDER (OAB) ANDASSOCIATED RISK FACTORS IN 1,359 PATIENTS WITHTYPE 2 DIABETES

Yao-Chi Chuang*, Min-Shen Chung, Hsueh-Wen Chang, Wei-ChiaLee, Kaohsiung, Taiwan; Michael B. Chancellor, Royal Oak, MI; Rue-Tsuan Liu, Kaohsiung, Taiwan

INTRODUCTION AND OBJECTIVES: The aim of the study wasto evaluate the prevalence of overactive bladder (OAB, dry and wet) andassociated risk factors of OAB wet (with incontinence) in type 2 diabetes.

METHODS: A self administered questionnaire containing over-active bladder symptom score (OABSS, 0–15, indicating increasingseverity of symptoms) was obtained from subjects with type 2 diabetesat a dedicated diabetic center. The association of age, gender, durationof diabetes, body mass index (BMI), waist circumference, glycatedhemoglobin (Hb A1c) level, high sensitive CRP level, and diabetesassociated complications to risk of OAB and OAB wet was evaluated.

RESULTS: Of 1,359 consecutive subjects, 22.5% reportedhaving OAB with 11.7% reporting OAB dry and 10.8% with OAB wet.There were statistically significant difference of symptom severity amongno OAB, OAB dry, and OAB wet (OABSS 2.5�/1.4, 5.9�/1.6 and8.9�/2.6, respectively). The prevalence of OAB and OAB wet were2.4 fold and 4.2 fold greater, respectively, in patients with DM dura-tion � 10 years and age � 50 years. Age, male gender, and age, waistcircumference were independent risk factors for OAB and OAB wet,respectively, after multivariate analysis. Hb A1c and CRP levels weresimilar between DM patients with and without OAB.

CONCLUSIONS: In a dedicated diabetic center where all pa-tients were screened, 22.5% has OAB and 48.0 % of OAB patients hadincontinence. These findings can help guide collaboration betweenurologists and diabetologists to work toward developing screening forand early treatment of urologic complications in higher risk patients.

Independent risk factors associated withOAB

Oddsratio 95% CI

Pvalue

Age 1.033 1.019–1.047 0.007

Gender (male) 1.425 1.083–1.874 0.011

Independent risk factors associated withOAB wet: control vs OAB wet

Age 1.035 1.021–1.049 0.000

Waist circumference 1.018 1.004–1.032 0.013

Source of Funding: Chang Gung Mrmorial Hospital CMRPG860381

1507THE PREVELANCE OF URINARY CATHTERIZATION IN WOMENAND MEN WITH MULTIPLE SCLEROSIS

Sangeeta Mahajan*, Cleveland, OH; Ruth Ann Marrie,Winnipeg, Canada

INTRODUCTION AND OBJECTIVES: To identify the prevalenceof urethral catheterization for voiding dysfunction in women and men withMultiple Sclerosis (MS) and patient traits associated with catheter use.

METHODS: After obtaining IRB exemption, results from the Fall2005 North American Research Committee On Multiple Sclerosis sur-vey were reviewed, including the Urogenital Distress Inventory (UDI-6),the Short Form-12 (SF-12) inventory, the Patient Determined Disease

Steps (PDDS) disability measure, and history of urologic evaluationand treatment. Data were analyzed using descriptive statistics, thechi-square, Student’s t-tests, and analysis of variance.

RESULTS: Of 16,858 surveys mailed, 9702 (25% male and75% female) were returned. Respondents with major bladder surgery(conduit, diversion or augmentation) were excluded, leaving 9676respondents. Of these, 2514 (26%) reported utilizing urinary catheter-ization currently or in the past, including 751 males (32%) and 1763females (25%). When separated by incidence, 1091 (11%) of patientsreported current and 2222 (23%) reported past catheter use. Amongcatheterizing patients, intermittent self-catheterization was most com-mon (ISC, 81%), followed by transurethral foley catheterization (TFC,43%) and suprapubic catheterization (SPC, 8%). When separated bygender, males were significantly more likely to catheterize than females(32% versus 24%, p�0.001) and prefer indwelling catheterizationmethods, with TFC used by 47% of males and 41% of females(p�0.003) and SPC used by 12% of males and 6% of females(p�0.001). Catheter use in any form was significantly associated withlonger disease duration (p�0.001), greater physical disability based ona higher mean PDDS score (4.9 versus 3.1, p�0.001), and reducedquality of life (QoL) in all physical and mental components of the SF-12(p�0.001). Patients who reported catheter use were more likely toreport a history of urine leakage and difficult bladder emptying, antich-olinergic use, and prior urologic evaluation with urodynamic testingand/or post-void residual measurement (all p�0.001).

CONCLUSIONS: Although the use of urinary catheterization forvoiding dysfunction is common among patients with MS, rates of useamong MS patients was previously unknown. This is the first large scalestudy to demonstrate the significant rates of urinary catheterization inpatients with MS and important gender preferences. Despite its necessity,urinary catheterization is associated with reduced QoL, increased physicaldisability and longer disease duration among patients with MS.

Source of Funding: None

1508CLINICAL SURVEY OF OVERACTIVE BLADDER SYMPTOMS INPATIENTS WITH PARKINSON’ DISEASE

Tetsuya Takao*, Akira Tsujimura, Keisuke Yamamoto, ShinichiroFukuhara, Yasuhiro Matsuoka, Yasushi Miyagawa, YoichiYamamoto, Suita, Japan; Saburo Sakoda, Toyonaka, Japan; NorioNonomura, Suita, Japan

INTRODUCTION AND OBJECTIVES: Overactive bladder(OAB) syndrome is defined as a syndrome of urgency, with or withouturge incontinence, usually with frequency and nocturia. OAB symptomsare common in the patients with Parkinson’s disease (PD). However,there are few reports about the relation between the severity of PD andOAB symptoms. The present study investigates the correlation be-tween the clinical symptoms and signs of PD and OAB symptoms.

METHODS: We mailed the OAB symptom score (OABSS) asmeasuring the severity of OAB to the 561 patients registered in the PDdatabase. PD database contains the patients’ age, disease duration, sex,clinical symptoms and signs of PD. We first compared the above variablesbetween the patients with or without OAB by Wilcoxon’s signed rank test.Then, we examined the relation between OABSS and the clinical symp-toms and signs of PD by Wilcoxon’s signed rank test or Jonckheere-Terpstra trend test. Finally, we conducted multiple regression analysis todetect the relation between OABSS and other parameters. This study wasapproved by the ethics committee of our university.

RESULTS: Of the 561 patients, 363 patients (64.7%) returnedthe questionnaire. Three patients were excluded from the analysisbecause of the insufficient data. The total of 167 cases (46.4%) out of360 cases had OAB symptoms and the other 193 cases (53.6%) did nothave OAB symptoms. Patients’ mean age, disease duration, sex dis-tribution were not significantly different in the patients with OAB andwithout OAB. The OABSS was significantly different with or withouterectile dysfunction(ED), severe constipation, syncope/blackout(P�0.05). The variables of finger taps, arising from chair, gait, postureand postural stability are correlated with OABSS (P�0.005). Multiple

e604 THE JOURNAL OF UROLOGY� Vol. 185, No. 4S, Supplement, Tuesday, May 17, 2011