12. Sachverzeichnis

Acetaldehyd 53 Acetat 13, 14, 54 Acetoacetat 14, 145, 146 Acetoacetyl-CoA 13, 26,

144 Acetylcholin 3, 95, 109, 150 Acetylcholinesterase 125 Acetyl-CoA 13, 19, 26,

144, 147 Acetyl-CoA-Acyltransfe­

rase 13, 14, 26 Acetyl-CoA-Carboxy-

lase 147 Acetyl-CoA-Synthetase 13,

26 N-Acetyldopamin 155 N -Acetyl-dopamin-

chinon 155 Acetylgalactosamin 81 Acetylglucosamin 120, 121 N-Acetyllactosamin-Pep-

tid 120, 121 N-Acetyl-5-methoxytrypt­

amin --+ Melatonin 2-Acetyl-7 -oxo-dodecahydro­

phenanthren 159 Acetylserotonin-Methyltrans-

ferase 95, 125 Acetyltransferase 259 ACTH---> Corticotropin Actin 110 Acyl-CoA-Desaturase 40,

112, 113 Acyl-CoA-Ester 27 Acyl-CoA-Reduktase 113 Addisonsche Krankheit 53 Adenosin-3 ' ,5 '-diphosphat

(pAp) 27 Adenosindiphosphat

(ADP) 77 Adenosin-3 ',5 '-mono­

phosphat (cAMP)" 69, 70, 107-111

-, Biosynthese --+ Adenylcy­clase

-, Gehalt 108, 174 -,- Kompartimente 74,

75, 82, 90,108,109 - , Rezeptorproteine 110,

253

-, Wirkung 25, 73-76, 78-80,82-84,89,108, 111,114,149,216,261, 263, 264

-, - Antagonism us zum cGMP 108-110, 262, 264

-, - Phosphoproteinphos­phatasen 78, 109, 147, 148

-,- Proteinkinasen 76, 78, 79,86,96,107-111, 147,232,253,254

- , - zentral 108 Adenosin-3 ',5' -monophos­

phat-Phosphodieste-rase 86, 107, 110, 111

-, Aktivatorprotein 110 -, Inhibitoren 111, 121,

174,261,262 Adenosin-5 '-phosphosulfat

(APS) 171 Adenosintriphosphat

(ATP) 77,108, 171, 210,245,246,250

Adenosintriphospha-tase 153

Adenylcyclase 107 -, Effektoren 104, 108 -, - Aktivator-

protein 110 -,- ca++ 73, 74, 90,

110 -, - hormonelle Stimula­

tion 69, 73-75, 79, 83, 86,88-91,96,98,104, 107, 108, 11~ 116, 117, 232,254,261,262

-,- Inhibitor 110 Adenylsulfatkinase 171 Adrenal-Ferredoxin 29,

35-37,51 Adrenal-Ferredoxin-Reduk­

tase 29, 35-37, 51 Adrenalin 97, 103, 146, 148 Adrenogenitales Syndrom

(AGS) 52, 57, 267 Adrenosteron 282 Aktiver Sauerstoff 32 Aktives Isopren 16

Akrosin 133 Alanin, Abbau 144, 145,

259 Alaminaminotransfe-

rase 144, 145 Albumin 184, 193, 218,

219,221 Aldehyd-Lyasen 37 Aldose-Reduktase 136 Aldosteron 48 -, Biosynthese 49, 52, 141 -,- Regulation 91-93,

116, 152 -, Gehalt 53, 152 -, Rezeptoren 209, 218,

219 -, Stoffwechsel 189, 190 -, - Halbwertzeit 93,

164, 190 -, Wirkung 141, 142, 151,

241,254 Aldosteron-18-,8-D-glu­

curonid 190 Allergische Symptome 149,

150 Allylalkohole 175, 177,192 Alphaxalon 122 a-Amanitin 235 Ameisensaure 20, 259 Amenorrhoe 94 Aminoacyl-Adenylat 245 Aminoacyl-tRNA 245, 246 Aminoacyl-tRNA-Syntheta-

sen 245, 250, 254 p-Aminoglutathimid 43 6-Aminolavulinsaure 121 ,

122, 140 o-Aminolavulinsauresynthe­

tase 121, 122, 139, 140 a-(p-Aminophenyl)-a-athyl­

glutarimid 43 3,3-bis (p-Aminophenyl)-2-

butanon 43 Aminosauren, Aufnahme

86, 149 -, abbauende Enzyme

144-146 -,Transport 86, 148, 257 Amphenon B 43 Amygdala 102, 209, 215

330

Anabole Wirkung, Andro­gene 134, 135, 138, 139, 212,214,253

-, d~trogene 123, 133 Aniisthetika_ 122, 258 Androgene 134-140 -, Antiandrogene 57, 58,

158-160,163,260 -, Biosynthese 92, 93 -,- 6 4-Weg 53, 54, 56,

83 -,- 6 5-Weg 51, 54-56,

86,172,261 -,- 5a-Weg 56,57 -, - Regulation 56, 83,

86,88 -,- Inhibitor 57, 158 -, Rezeptoren 85, 87, 202,

207,211-214,257,266 -, - Nuclearakzeptoren

202,211 -, - Plasmarezeptoren

193,219-221 -, - andogenbindendes

Protein (ABP) 85, 221 -, Stoffwechsel 41, 43,

164, 167, 17~ 17~ 175, 177, 190-193

-, Struktur, synthetische Androgene 138, 139

-, - Nebennierenrinden­Androgene 49, 53, 57, 59,88,140,221

-, Wirkung 134-140, 158 -,- anabol 134,135,

138,139,212,214,253 -, - Enzym- und Protein­

synthese 58, 59, 136-140, 190

-, - Nucleinsiiure­Synthese 230, 232, 243, 253

-, - Zelldifferenzierung 268-272

-, - ,- Sexualdifferen­zierung 135, 137, 264-266

-,- zentral 59, 135, 137 -,- Zielorgane 134-138 -, -, - Akzessorische Ge-

schlechtsorgane 136, 138,260,262

-,-,-Leber 140,212 -, -,- Niere 59, 136,

138,139,160,212,260, 272

-, -,- Testes 83, 136

1,4-Androstadien-3, 17 -dion 179

Androstan 12 5a-Androstan-3, 17 -dion

56,61, 137,190 5fl-Androstan-3, 17 -dion

190 1,4,6-Androstatrien-3,17-

dion 61 5a-Androst-16-en-3-on 193 Androstendiol-> 3fl,17fl-Di­

hydroxy-5-androsten 4-Androsten-3,17-dion 34,

41,44,47,53,54,62,63, 135-137, 212, 220

-, Gehalt 140 -, Stoffwechsel 41, 51,

55--60, 179, 190 4-Androsten-3,17-dion-3-

sulfat 191, 192 4-Androsten-3-on-17 fl­

carbonsiiure 58 Androsteron (3a-Hydroxy-

5a-androstan-17-on) 49, 56, 135, 136, 140, 187, 190, 191

Angiotensin 91-93 -, Biosynthese 92, 93 -, Gehalt 93 -, Rezeptor 93 -, Stoffwechsel 93 -, Wirkung 52, 70, 91, 93,

108, 152 -,- zentral 91 Angiotensin-Antagonist 93 Angiotensinase 93 Angiotensinogen 92 -, Biosynthese 92, 124,

133, 215 Angulare Methylgruppen 5,

7,8, 10,207 Antiandrogene 158-160 -, 4-Androsten-3-on-17fl-

carbonsiiure 58 -,BOMT 159 -, Corticoide 57, 158 -, Cyproteron 158 -, Cyproteronacetat 57,

158, 159 -, Flutamid 158, 159 -, dstrogene 58, 158, 260 -, Progesteron 58, 158,

260 -, Spirolacton 158, 163 Anticorticoide 162, 163 -, 17a-Methyltesto-

steron 162

Sachverzeichnis

-, dstradiol 162 -, Progesteron 163 -, Testosteron 162 Antigestagene 157 Antihormone 156-163,

200,207 Antiinduktoren 200 Antiinflammatorische Wir­

kung 118, 142, 149-151,257

Antikonzeption 131-134 -, Nebenwirkungen--> Ovu­

lationshemmer Antikorperbildung 148, 149 Antimineralocorticoid 162,

163 -, Progesteron 163 -, Spirolacton 162, 163 -, Spironolacton 162, 163 Antiostrogene 157,

160-162 -, Clomiphen 160, 161 -, Corticoide 63, 162 -, Dihydrotestosteron 162 -, 2-Hydroxyostradiol 103,

162,165,214 -, MER-25 161 -, Nafoxidin 161 -, Progesteron 161, 162 Apocytochrom P-450 42 Aquatoriale Reste 6, 8, 11 Arachidonsiiure 112-116 Area praeoptica -suprachias-

matica 95, 102, 103, 212,215,265-267

Aren-oxid-Hydratase 40 Arginase 138, 147 Argininosuccinat-Lyase

147 Argininosuccinat-Synthe-

tase 147 Aromatase 60-63 -,Inhibitor 61, 162 Arthritis 149 Arylamin-Acetyltransfe-

rase 155 Arylformylamin-Amidohy­

drolase 145 Arylsulfatase 63, 169, 172,

195 -, Inhibitor 172 Ascorbinsiiure 31, 32, 42,

78, 124 Ascorbinsiiure-Cytochrom

b5-Reduktase 31, 42 L-Asparaginsiiure 77, 259 Aspartataminotransferase 145

Sachve rzeichnis

Aspergillus flavus 178 Assoziationskonstante 202,

203 17 a-Athinyl-3,17 tJ-dihydro­

xy-lla-methoxy-1,3,5(10)-ostratrien 161

17a-Athinyl-3,17tJ-dihydro­xy-1 ,3,5(10)-ostratrien --> Athinylostradiol

17a-Athinyl-3tJ,l7tJ-dihydro-xy-4-ostren-3,17-diacetat 13 2

17a-Athinyl-10tJ,l7tJ-dihy­droxy-4-ostren-3-on 17 8

17a-Athinyl-17tJ-hydroxy-4-androsten-3-on 118, 119

17 a-Athinyl-17 P-hydroxy-4-ostren-3-on--> Norethi­steron

17 a-Athinyl-17 tJ-hydroxy-5(10)-ostren-3-on 132

17a-Athinyl-3-methoxy-17tJ­hydroxy-1 ,3,5(1 0)­ostratrien 127

17a-Athinyl-18-methyl-17P­hydroxy-4-ostren-3-on 132

17a-Athinyl-18-methyl-17P-hydroxy-4,9,11-ostratrien-3-on 157

17 a-Athinylostradiol 125-127, 160,178

Athisteron 118, 119 8-Athoxycarbonyl-10, 11-di­

hydroprostaglandin A 117

17a-Athyl-17tJ-hydroxy-4-ostren-3-on 139

Atiocholanolon--> 3a-Hydro-xy-5tJ-androstan-17 -on

Atmungskettenenzyme 74 Autoimmunerkrankung 53 Avidin 119, 120, 124, 268 Axiale Reste 6, 8, 11 Azoospermie 106, 134

Bakterien --> Mikroorga-nismen

Barbiturate 42 Basenpaarung 226 Bastenstapelung 238 Bernsteinsiiure 179, 180 Betamethason 150, 283 Bilirubinglucuronosyltransfe-

rase 122, 261 Bleitetraacetat 38 Blut, Bildung 138, 140

-,Druck 91, 116, 124, 133, 215

-, Steroidabbau 164 -, Volumen 92, 93 Bombyx 154 BOMT 159 Brenztraubensiiure --> Pyruvat 6a-Brom-17tJ-hydroxy-17a-

methyl-4-oxa-5a-an­drostan-3-on 159

Briickenkopfatome 5, 8, 9 Brustdriise, Ostrogenbil­

dung 62 -, Steroidrezeptoren 208,

211,217,218 -, Tumorbildung 62, 88,

127,128,132,196,208, 211

-, - hormonelle Thera­pie 88, 162, 217

-, Wachstum 87, 119, 123, 130

Brutinstinkte 88, 122

Caeruloplasmin 124 Calcitonin 89-91 -, Biosynthese 90 -, Gehalt 91 -, Halbwertszeit 91 -, Membranrezeptor 90 -, Struktur 90 -, Wirkung 89-91, 152,

153 -, - Adenylcyclase 90,

108 Calcium 77, 152, 153 -, Gehalt 89 -, - Aufnahme durch

Zellen 95 -, - bindendes Protein

153 -,- Mobilisierung 89, 90 -, Wirkung 37, 96 -, - Adenylcyclase 73,

74,90 -, - Aktivatorprotein

110 -, - Cholesterin­

transport 28, 3 7 -,- Exocytose 98, 110 -,- !a-Hydroxylase 65,

89 -, - Lutropin 82 -, - Lymphocytentrans-

formation 108 -, - Membranpotential

95, 98, 117

331

-, - Parathormon 90 -, - Sek. Messenger 96 Calliphora 155, 174, 222 cAMP-> Adenosin-3',5'-mo-

nophosphat Carboanhydrase 151 Carotin 129 Casein 87 Catecholamine 3 -, Biosynthese 103 -, Rezeptoren 107 -, Stoffwechsel 103 -, Wirkung 95, 107, 141,

149 Catecholamin-0-Methyltrans­

ferase 103, 195, 196 Catecholostrogene 102,

103, 162, 195 Centromer 225 Cerebellum 215 Cerebrum 59 Cervixschleim 132, 133 Cervixtumor 128 Chiasma opticum 71 Chiralitiit 4, 13, 14, 31 Chironomus tentans 253 6-Chlor-17a-hydroxy-1,2a-

methylen-4,6-pregnadien-3,20-dion-17 a-acetat --> Cyproteronacetat

6-Chlor-17 a-hydroxy-4-preg­nen-3,20-dion-17-acetat 132

Chlormadinonacetat 132 2,2-bis (2-Chlorphenyl-4-

chlorphenyl)-1, 1-dichlor-iithan 43

6-Chlor-9tJ,lOa-pregna-1,4,6-trien-3,20-dion 120

Cholan 12 Cholecalciferol (Vitamin 0 3)

23,63-65 -, Rezeptor 217,222 8,24-Cholestadien-3-on 21,

26 Cholestan 8, 12 Cholestenol-~-Isomerase

21,26,169 Cholesterin 4, 5 -, Biosynthese 13-27, 66 -, - Regulation 24, 25 -,Carrier 24, 25, 74, 81,

174 -, Gehalt 24, 27 -, Membranwechselwir-

kung 24,25,258 -, Mikrobieller Abbau 179, 273

332

Cholesterin -, Verwertung 13, 27-30,

41,44,47,66,69, 74 -, - Hydroxylierung

29-32,37 -, - Seitenkettenab­

spaltung 37-41,69 Cholesterinacetat 66 Cholesterinacyltransferase

25,27 Cholesterinester 27, 78, 79,

114 -, Biosynthese 25, 27, 28 -,Spaltung 25,27,28,69,

74 Cholesterinesterase 25, 27,

28, 114 -,Regulation 25, 69, 78,

83, 111 Cholesterinlinolsiiureester

174 Cholesterinolsiiureester 27 Cholesterinoxidase 180 Cholesterinsulfat 25, 27, 28,

133, 172, 173 Cholesterinsulfatase 25, 27,

133, 173 Cholinacetyltransferase 215 Cholinerge Rezeptoren 95 Cholinphosphotransferase

147,267 Choriongonadotropin

(hCG) 83-85 -, Biosynthese 84 -, Halbwertszeit 85 -, Membranrezeptor 82,

83 -, Struktur 81, 84 -, Wirkung 42, 70, 71,

83-85,232,267 -, - Adenylcyclase 83,

232 -, - Immunsuppression

85 Chromatin 204, 223-226,

233,234,242 -, Bindefiihigkeit fiir Stero­

idrezeptoren 202, 205 -, Transkriptionsakti-

vitiit 204, 224, 225, 241, 242

-, - EinfluB von Stero-iden 241, 242

Chromomeren 155 Chromosomen 223, 226, 228 -, Gonosomen 213, 223,

256,257,264,265

-, Lampenbiirstenchromo­somen 233

-, Riesenchromosomen 154-156,234,254,258

-, Sequenzen, repetitive 225

-, Transportform 224, 226 Chymotrypsinogen 148 Circadianer Rhythmus 96 -, Aldosteron 53, 93, 152 -,Androgene 59,140 -, Corticoide 53, 152 -,Corticotropin 81 -,DHEA 59 -, Gestagene 183, 184 -, HMG-CoA-Re-

duktase 25 -, Ostrogene 128 -, Prolactin 89 -,Renin 93 Citrat 77, 136 Citronensiiurecyclus 36,

142, 144 Clomiphen 160, 161 Coenzym A 27 Coenzym Q10 58, 169, 175,

191 Collagenase 149 Collagenstoffwechsel 123,

149 Conalbumin 124 Converting enzyme 92 Coprostanol 283 Corney bacterium 150 Corpora allata 156 Corpus luteum 27, 40, 47,

62,70,83,87, 116, 11~ 119, 128-130, 181

Cortexolon (11-Desoxycor­tisol) 41, 48, 49, 51

Cortexon ( 11-Desoxycortico­steron) 34, 48, 49, 51, 57, 151

Corticoide 47-53, 141-152 -, Biosynthese 27, 44,

47-53,69,70 -,- ~4-Weg 49 -,- ~5-Weg 50, 51 -, - Regulation -> Corti-

coliberin und Corticotropin -, Gehalt 53, 152 -, Rezeptoren 203,

206-209,268 -, - Nuclearakzeptor

203,206-208 -,- Plasmarezeptor 219,

220

Sachverzeichnis

-, Stoffwechsel 184-190 -, Struktur 5, 48, 49 -,- Anticorticoide 162,

163 -, - synthetische Cortico­

ide 57, 150, 151, 189, 208,209,219,220

-, Transport 200 -, Wirkung 41-152 -, - Enzym- und Protein-

synthesen 108, 141-149, 207,209,219,244,254, 257,261

-, -, - Gluconeogenese 141-144,147,207,261

-, -,- katabol 141, 144-146,149,208

-, -,- Lipolyse 141, 147-149

-, -,- permissiv 119, 138, 141, 149, 261

-,- an Membranen 257 -, - Nucleinsiiure-

synthese 230, 241, 254, 260

-, - Zelldifferenzierung 141,147,148,207,209, 267,268

-, - Hemmwirkungen 57,62,63,88, 100,106, 141,147-149,205,257, 293

-, -, - Antiinflamma­torisch 142, 149-151, 257,258

-, -, - Antisex­hormon 158

Corticoliberin (CRH) 81, 96, 99, 100

Corticosteron 34, 41, 48, 49, 52, 91, 96, 142, 151, 152,186,209,218,221, 271

Corticosteron-18-monooxyge­nase 37, 40, 41, 49, 52, 74,169,176,269

Corticotrophin (ACTH) 72-81

-, Biosynthese 62, 80, 81 -,- Regulation 81, 141 -, Gehalt 53, 81 -, Halbwertszeit 81 -, Rezeptor 73, 74 -, Struktur 72, 73 -, Wirkung 27, 52, 62,

70-80,91,152 -,- Adenylcyclase 73-75

Sachverzeichnis

-, - Cytochrom P-450 42, 74

-,- DNA-Synthese 74 -,- Guanylcyclase 75,

108 -, - Ornithindecarb­

oxylase 80 -,- Proteinsynthese 74,

75, 80 -,- rRNA-Synthese 75 -,- Steroidsulfatasen 79,

172 -,- zentral 71, 80 Cortisol 48, 150, 151 -, Biosynthese 49, 50, 141 -, Gehalt 53, 152 -, Stoffwechsel 184, 185 -,- Halbwertszeit 164,

184 -, Wirkung --> Corticoide Cortison 48, 141, 142, 150,

169, 185 Cortol 184, 185, 187 /J-Cortol 184 5a-Cortol 184 Cortolon 184, 185, 187 5/J-Cortolon 185 20~-Cortolon 185 Crustecdyson 154 Cumuluszellen 106 Cushing 100, 149, 158 17a-Cyano-3{J-hydroxy-5-an-

drosten-3-acetat 54 16a-Cyano-3/J-hydroxy-

6, 16/J-dimethyl-5-pregnen-20-on 45

2a-Cyano-17/J-hydroxy-17a­methyl-spiro( 5-androsten-4,4' -cyclopropan)-3-on 45

Cyanoketon 45 2a-Cyano-4,4, 17 a-trimethyl-

17 /J-hydroxy-5-androsten-3-on 45

Cyclobutan 16, 18 Cyclohexan 5-7 Cyclooxygenase 113 Cyclopropan 16, 18 Cyclus, weiblicher --> Sexual-

cyclus Cyproteron 158 Cyproteronacetat 158-160 -, Androgenrezeptoren 57,

159,160,212 -, Androgenspiegel 57,

159, 160 -, Corticoide Wirkung 158

-, - EinfluB auf Corticoli­berin 100, 159

-, Gestagene Wirkung 158, 159

-, Leberenzymmuster 160, 272

-, Spermiogenese 134 -, Zelldifferenzierung 159,

160,266 Cytidinaufnahme 125 Cytochrom b5 29, 40, 42,

112, 113 Cytochrom b5-Reduktase

31, 40, 42, 112, 113 Cytochrom c-Reduktase 17,

42, 58, 175, 191 Cytochrom P-450 28-44,

50,61,176 -, Biosynthese 42 -, Halbwertszeit 42, 74 -, Mol.-Gewicht 29,42 -, Reaktionscyclus 32-38 -, Vorkommen 40-42,51 --'-, Wechselwirkung mit Sub-

strat 29-32, 34-36, 39, 43 -, - Bindungstypen

32-34,43 -, - EinfluB von Ascorbin­

siiure 31, 32, 42 -,- EinfluB von Cal-

cium 37 -, - Inhibitoren 43, 44 Cytochrom P-450-Re­

duktase 42 Cytolyse 118

Darm 217,241 -, Calcium-Aufnahme 89 -, Steroidabbau 166, 170 o.p'-DDD 43 Decarboxylierung 19, 20 Dehalogenierung 31, 189 Dehydroascorbinsiiure 78 7-Dehydrocholesterin 23,

24,64-67,169 7-Dehydrocholesterin-Reduk­

tase 22, 23, 26, 67 24-Dehydrocholesterin-Re­

duktase 22 11-Dehydrocorticosteron

48, 186 21-Dehydrocortisol 188 3-Dehydroecdyson 197 Dehydroepiandrosteron

--> DHEA ~ 1-Dehydrogenase 62, 169,

178, 179

333

14-Dehydrosterinreduk-tase 20, 26

1-Dehydrotestosteron 283 Dekalin 7, 8 Demethylierung 19-21, 24 Desaturase 40, 112, 113 Desmosterin 22, 23, 26, 68 11-Desoxycorticosteron

(Cortexon) 34, 48, 49, 51, 57, 141, 151, 152, 209,218

11-Desoxycortisol (Cortexo­lon) 41, 48, 49, 51, 152, 186

21-Desoxycortisol 48, 49, 186

21-Desoxycortison 186 2-Desoxy-a-ecdyson 67 22-Desoxy-a-ecdyson 67 2-Desoxyecdysteron 67 11-Desoxy-17-hydroxycor-

tisteron--> 11-Desoxycor­tisol

Desoxynucleotidkomparti­ment 230

Desoxyribonucleinsiiure ->DNA

21-Desoxytetrahydrocor­tisol 186

Dexamethason 57, 100, 149-151,208,220,254

Dextransulfat 201 DHEA 41, 44, 47, 49, 55,

57,5~62,86, 135, 17~ 187,191,220,258

-, Gehalt 140 -, Hemmwirkungen 260 DHEA-Sulfat 55, 56, 62,

172,173 -, Ostrogenvorliiufer 47,

62,63, 70,172,173 -, Plasmabindung 173 DHEA-Sulfatid 173, 174,

260,262 DHT 53, 56, 135-140, 190,

260, 271 -, Gehalt 140 -, Rezeptor 85, 136,

211-214,220,221 -, Wirkung 57-59, 61,

105,136,137,253,258 Diiithylstilbostrol 127, 128,

158,220 2,22-Didesoxy-a-ecdyson

67 22,25-Didesoxy-a-ecdyson

66,67

334

Dienostrol 128 Dienzephalon 94 Differenzierung--> Zelldiffe-

renzierung 6a,9a-Difluor-

11fj,16a,17a,21-tetrahy­droxy-1 ,4-pregnadien-3,20-dion-16,17-acetonid 151

20P-Dihydrocortisol 184 Dihydrotestosteron--> DHT Dihydroxyacetonphos-

phat 142, 143 3P,17P-Dihydroxy-3,5-

androstadien 192 3a,17a-Dihydroxy-5a­

androstan 136 3a, 17 P-Dihydroxy-5a­

androstan 56, 135, 136, 138,172,190,191,220, 230,271

3{3,17P-Dihydroxy-5a­androstan 135, 190, 191,271

3P,16a-Dihydroxy-5a­androstan 192

3{3, 16{3-Dihydroxy-5a­androstan 192

3a,17{3-Dihydroxy-5P­androstan 190, 191,271

3{3,17{3-Dihydroxy-5{3-androstan 190

3a, 17 {3-Dihydroxy-5a-andro­stan-3, 17 -disulfat 191, 193

3{3, 17 {3-Dihydroxy-5a-andro­stan-3,17-disulfat 193

3P, 17 P-Dihydroxy-5a-andro­stan-17 -sulfat 193

3a, 11{3-Dihydroxy-5a­androstan-17-on 187

3a,11{3-Dihydroxy-5{3-androstan-17 -on 187

3a, 17 {3-Dihydroxy-4-androsten 138, 175, 177, 192

3p, 17 {3-Dihydroxy-4-androsten 138, 177, 192, 193

3P,16a-Dihydroxy-4-androsten 193

3P.17P-Dihydroxy-5-androsten 49, 55-57, 86, 135, 138, 140, 187, 211

3p, 16a-Dihydroxy-5-androsten-17 -on 63, 192

6p, 17 P-Dihydroxy-4-androsten-3-on 193

17 p, 19-Dihydroxy-4-androsten-3-on 60

2P,17 P-Dihydroxy-4-androsten-3-on 193

11p, 17 a-Dihydroxy-4-andro­sten-3-on-17P-car­bonsaure 189

1a,25-Dihydroxy-cholecal­ciferol 41, 63--65, 70, 89-91, 152-154, 197, 217,218,222,240,241

24,25-Dihydroxy-cholecal­ciferol 89, 197

25,26-Dihydroxy-cholecal­ciferol 197

20a,22R-Dihydroxycho­lesterin 30, 37, 39-41

20a,22R-Dihydroxycholeste­rin-Aldolase 30, 37, 39, 40

4,4-Dihydroxy-7 ,7 '-diathyl­stilben --> Diathylstilb­ostrol

4,4' -Dihydroxy-y,6-diphenyl­n-hexan 127

2,3-Dihydroxy-1,3,5(10)­ostratrien-17-on--> 2-Hy­droxyostron

3,4-Dihydroxyphenylathyl­amin --> Dopamin

{3(3,4-Dihydroxyphenyl)-{J­hydroxyathylamin --> Nor­adrenalin

P(3,4-Dihydroxyphenyl)-P-hydroxy-N-methylathyl­amin --> Adrenalin

17a,21-Dihydroxy-1,4-pregnadien-3,11,20-trion 150, 189

3a,20a-Dihydroxy-5a-pregnan 182

3{J,20a-Dihydroxy-5a­pregnan 182

3a,20P-Dihydroxy-5a­pregnan 182

3P,20P-Dihydroxy-5a­pregnan 182

3a,20a-Dihydroxy-5{3-pregnan 181, 182, 195

3P,20a-Dihydroxy-5{3-pregnan 182

3a,20P-Dihydroxy-5P­pregnan 122,182,261

3{J,20{J-Dihydroxy-5{3-pregnan 182

Sachverzeichnis

3a,21-Dihydroxy-5a­pregnan-11,20-dion 186

3a,21-Dihydroxy-5P­pregnan-11,20-dion 186

3a,20a-Dihydroxy-5p-preg­nan-3-{J-D-glu-curonid 182

3a, 17 a-Dihydroxy-5a­pregnan-20-on 56

3a,6a-Dihydroxy-5a­pregnan-20-on 183

3{J,6a-Dihydroxy-5a­pregnan-20-on 183

3{J,6a-Dihydroxy-5P­pregnan-20-on 182

3a,17a-Dihydroxy-5a­pregnan-20-on 56

3P,20a-Dihydroxy-5-pregnen 172, 183

3{3, 17 a-Dihydroxy-5-pregnen-20-on--> 17a­Hydroxypregnenolon

3P,21-Dihydroxy-5-pregnen-20-on-3,21-disulfat 172

3{J,20a-Dihydrox-5-pregnen-3,20-disulfat 172

11{3, 17 a-Dihydroxy-4-pregnen-3-on--> 21-Des­oxycortisol

11{3,21-Dihydroxy-4-pregnen-3 ,20-dion --> Corticosteron

17 a,21-Dihydroxy-4-pregnen-3,20-dion --> Cortexolon

17 a,21-Dihydroxy-4-pregnen-3,11 ,20-trion --> Cortison

11fj,21-Dihydroxy-4-pregnen-3, 18,20-trion ->Aldosteron

3,4-Dihydroxy-9, 1 0-seco­androsta-1 ,3,5( 1 0)-trien-9,17-dion 179

Dimethylallylpyrophos-phat 15-17,26

Dimethylallyltransferase 16, 17, 26

17 ,21-Dimethyl-19-nor-4, 9-pregnadien-3,20-dion 210

7P,17a-Dimethylte-stosteron 162, 196

Diphenoloxidase 155, 156 2,2-Diphenylvaleriansaure-N­

diathylaminoathylester 44 Dipteren 154, 258

Sachverzeichnis

DNA, Biosynthese (Replika­tion) 226-230, 236

-, - Membranin-itiatoren 223, 226, 227

-, - Okazaki-Stiicke 228 -, - Regulation 223 -, -, - EinfluB von

ACTH 74 -, -, - EinfluB von

cGMP 264 -, -, - EinfluB von Stero­

idhormonen 119, 125, 136,138,148,198,222, 223,229,230

-, - Replikations-komplex 227, 228, 230

-, - Replikon 226-228 -,- RNA-Primer 227 -, Struktur 225, 226 -,- Wechselwirkung mit

Steroid-Rezeptoren 201, 206

DNAasen 223, 233 DNA-Methylasen 233 DNA-Polymerase 223, 229 -, Funktion 227, 230 Dopa 155 Dopa-Decarboxylase 155 Dopamin 155 -, Sekretion 88, 101 -, Struktur 99, 155 -, Wirkung 95, 106, 155 Drosophila 154, 156, 222 Durabolin 139 Dydrogesteron 283

a-Ecdyson 66 -, Biosynthese 66--68 -, Rezeptor 222 -, Stoffwechsel 66--68, 197 -, Wirkung 154-156, 244,

258,262 {J-Ecdyson (Ecdyste-

ron) 66--68, 154-156 Ecdysonoxidase 168, 197 a-Ecdysonphosphat 174 Ecdysonsulfat 68 Ehrlich-Ascites-Tumor-

zellen 260 Eidotterproteine 124, 125 Ei-Entwicklung 129-131 Eicosatetraensaure --+ Arachi-

donsaure Eicosatriensaure 112, 114 Eisen, Elektronenspin 33 -, im Cytochrom P-450

29-36,43

-, im Adrenal-Ferredoxin 35,36

ElektronenfluB 35, 36, 38, 42, 103

Elektronentransportkette 31,34-36

Elipten 43 Eminentia mediana 95, 101,

212,215,261 Endometrium 118-120,

123, 129, 131, 183, 217, 222

Endomitose 154 Enolase 142 Entgiftung 181 Entzugsblutung 131 Enzyme, Wechselwirkung mit

Steroiden 159-262 Enzyminduktion 205, 211,

244,255,293 Enzymmuster, geschlechtsab­

hangige 59, 138, 160, 175-177,190,191,212, 213,266-272

Epiandrosteron 190, 191 Epididymis 136 Epiphyse 96, 125 Epiphysenfuge 123 Epitestosteron --+ 17 a-Hydro-

xy-4-androsten-3-on Epithelkorperchen 89, 90 Epoxidase 17, 40 Epoxidbildung 17, 19, 30,

39,40,61 20,22-Epoxycholesterin 39,

40 Epoxyhydrase 40 Ergocalciferol 64, 153 Ergosterin 64 Erythrocyten 257 Erythropoietin 138 Ethisteron 283 Ethynodioldiacetat 132 Evolution, von Prolactin 88 -, von Steroid-abhangigen

Systemen 273 Exocytose 96, 98, 110, 250

FAD 36 Faktor X 42 -, bei Sexualdifferenzie­

rung 264-266 Farnesylpyrophosphat

15-18,26 Farnesyltransferase 16, 18, 26 Feminisierung, testikulare

213,257

335

Feminisierungsfaktor, hypo-physarer 267, 270

Ferredoxin 29, 35-37, 51 Fetalentwicklung 63, 135 a-Fetoprotein 212, 222,

267 Fettsaureester 25, 27, 79 Fettsauresynthese 123, 141,

147,180,216 Fibroblasten 148 Fiebersenkung 149 Flavinadenindinucleotid 36 Fluocinolonacetonid 151 Fluocortolon 31, 188, 189 9a-Fluorcortisol 189, 209 6a-Fiuor-16a-methyl-llfJ,21-

dihydroxy-1,4-pregna­dien-3,20-dion 31, 188, 189

9a-Fiuor-16a-methyl-ll{J, 17 a,21-trihydroxy-1 ,4-pregnadien-3 ,20-dion --+ Dexamethason

p-Fluorphenylalanin 189 9a-Fluor-11{J,16a,l7a,21-te­

trahydroxy-1 ,4-pregna­dien-3,20-dion--+ Triam­cinolon

Flutamid 160 Follikel 81, 102, 116, 129 Follitropin 85-87 -, Gehalt 87, 130 -, Membranrezeptor 86 -, Sekretion 70, 104-106 -, - Halbwertszeit 86 -, - Regulation 86, 87,

95, 104-106 -, Struktur 81, 85 -, Wirkung 71, 74, 85, 86,

129,221,272 N-Formylkynurenin 145 Fructose 136 Fructose-1,6-di-

phosphat 142-144, 147 Fructose-1,6-diphosphat-D­

Giycerinaldehyd-3-phos­phat-Lyase 142, 143

Fructose- I ,6-diphosphat-1-Phosphohydrolase 142-144

Fructose-6-phosphat 142-144, 147

FSH --+ Follitropin Fucose 81 Fumarsaure 146 4-Fumaryl-acetoessig­

saure 146

336

4-Fumaryl-acetoessigsiiure­Fumarylhydrolase 146

Fusidansaure 10

Galactose 81 Galactosyltransferase 120,

121 Gallenblasenerkran-

kungen 131 Gallensauren 24 Ganglioside 84 Genom 224-226 Geranylpyrophosphat 16,

17, 26 Gerinnungsfaktoren 215 Geschlechtsanlagen 265, 266 Gestagene ---> Progesteron Gewebshormone 3, 117 Globin-mRNA 253 a2.-Globulin 138, 272 Glucagon 149, 273 Glucocorticoide ---> Corticoide Gluconeogenese 141-144,

147,207,261 Glucose 142, 146, 216 -, Transport 148 Glucoseeffekt 108 Glucosefaktor 77 Glucoseoxydation 127, 141,

216 Glucose-1-phosphat 76, 77,

166 Glucose-6-phosphat 76, 77,

111,142-146,174,262 Glucose-6-phosphat-Dehy­

drogenase 125, 174, 215,260,262

Glucose-6-phosphat-Ketol­Isomerase 142, 143

Glucose-6-phosphat-Phos­phohydrolase 142-144

Glucose-1-phosphat-U ridylyl-transferase 166

Glucoside 164, 170 Glucosyltransferasen 168 J3-Glucuronidase 124, 138,

160, 169, 170, 190 Glucuronidierung 122, 164,

166- 170, 184 Glucuronosyltransfera-

sen 165, 167, 168, 195, 271

L-Glutamat-Dehydroge­nase 259

Glutamin 259 L-Glutaminsiiure 77, 145,

259

Glutaminsynthetase 148, 207,209,268

Glycerinaldehyd 4 D-Glycerinaldehyd-3-phos­

phat 142, 143 D-Glycerinaldehyd-3-phos­

phat-Dehydrogenase 142, 143

a-Glycerinphosphat 77, 141 Glycerinphosphat-Dehydro­

genase 148 Glycerinphosphat-Phosphat­

idyltransferase 14 7, 268 Glycerinsiiure-1 ,3-di­

phosphat 142, 143 D-Glycerinsaure-2-phos­

phat 142, 143 D-Glycerinsiiure-3-phos-

phat 142, 143 Glycoside 170 Glykogen 76, 141, 146 Glykogenphosphorylase 76,

111,259 Glykogensynthetase 146,

147 Glykolyse 142 - , hormonelle Stimula­

tion 83, 86, 136 Glykoproteinsialyltransfe-

rase 133 Golgi-Apparat 250 Gonaden---> Ovar bzw. Testes - , LH-Rezeptoren 82 - , Steroidabbau 164 -, Steroidsynthese 83 Gonadoliberin (Gn-RH)

99-106 -, Abbau 101, 105 -, Rezeptor 104 -, Sekretion 96 -, - Kernbereiche 94, 95 -,- Regulation 88, 95,

96, 102,212 -, Struktur 101 -,- Antagonisten 104 -,-Depot-

priiparate 105, 106 -, Wirkung 83, 87, 104,

105, 116 Gonadotropine 81 -, FSH ---> Follitropin -, LH ---> Lutropin -, hCG ---> Choriongonado-

tropin -, PRL---> Prolactin -, Bildung in Neo-

plasmen 63

Sachverzeichnis

-, Sekretion 97, 100-106, 130, 131

-, - Regulation 97, 98, 106

-, Membranrezeptoren 57 Gonosomen 213, 223, 256,

257,264,265 Graafsche Follikel 85, 129 Granulocyten 148, 257 Granulosa-Zellen 86, 129 Guanosindiphosphat

(GOP) 108 Guanosin-3',5' -mono­

phosphat (cGMP) 70, 75,107-111,123,254, 262,264

Guanosin-3' ,5 '-monophos­phat-Phosphodieste-rase 111

Guanosinpolyphos-phate 181

Guanosintetraphosphat 181, 232

Guanosintriphosphat (GTP) 104, 108, 245-250

Guanylcyclase 1 07 -, hormonelle Stimula-

tion 75, 87, 91, 107, 108

Haarwuchs 135, 138 Halbsesselform 6 Halbwertszeit, biologi-

sche 166 Hiim ---> Protoporphyrin IX Hiimoglobin 29, 140 Hiimoproteine 29 Harnstoffcyclus 14 7 Haut, Vitamin-03-Bil-

dung 65 - , Zielorgan der Andro­

gene 57 -, Zielorgan der Corti-

coide 141 hCG ---> Choriongonadotropin Hefe 177,180 HeLa-Zellen 85, 148, 238 Herzgifte 10 Hexahydroaldosteron 189 2J3,3J3, 14a,20J3,22R,25-He-

xahydroxy-5/'1-cholesta-7-en-6-on ---> Ecdysteron

Hexokinase 136 Hierarchie der Hormondrii­

sen 98,99, 104,105 Hippocampus 209 Hirnpeptide 98

Sachverzeichnis

Hirsutismus 57, 88, 159, 160,221

Histamin 123, 149 Histone 206, 223-225, 241,

242 -, Modifizierung 111, 223,

224,233,234,242,250 -, Synthese 125, 223, 230 HMG-CoA 13, 14, 25, 26 HMG-CoA-Reduktase 14,

24-26, 111 Hoden -> Testes Hohlweg-Effekt 97, 102,

103, 120, 122, 123, 129, 162,195,266

Homogentisinsaure 145, 146

Homogentisinsaure-1,2-Di-oxygenase 146

Homosexualitat 266, 267 Hormon-Begriff 3 HTC-Zellen 148, 162, 200,

208,254,255,270 17 a-H ydroperoxyproge­

steron 54, 55 2a-Hydroxyandrogene 43,

272 2(J-Hydroxyandrogene 41 3-Hydroxy-androsta-1 ,4-

dien-17-on 191, 192 9a-Hydroxy-1,4-androsta­

dien-3,17-dion 179 3a-Hydroxy-5(J-androstan-

11,17-dion 187 3a-Hydroxy-5a-androstan-

17 -on -> Androsteron 3a-Hydroxy-5(J-androstan-

17-on 186, 187, 190, 191

3(J-Hydroxy-5a-androstan-17-on 190, 191

3(J-Hydroxy-5(J-androstan-17-on 190

3(J-Hydroxy-5a-androstan-16-on 192

17a-Hydroxy-5a-androstan-3-on 138, 271

17(J-Hydroxy-5a-androstan-3-on-> DHT

17{J-Hydroxy-5(J-androstan-3-on 190, 271

3a-Hydroxy-5a-androst-16-en 193

3(J-Hydroxy-5a-androst-16-en 193

2a-Hydroxy-4-androsten-3,17-dion 272

6(J-Hydroxy-4-androsten-3,17-dion 272

7 a-Hydroxy-4-androsten-3,17-dion 272

19-Hydroxy-4-androsten-3,17-dion 41, 60

ll(J-Hydroxy-4-androsten-3,17-dion 49

16a-Hydroxy-4-androsten-3,17-dion 63

l?(J-Hydroxy-4-androsten-3,19-dion 60

17a-Hydroxy-4-androsten-3-on (Epitestosteron) 13 7, 192,193,271

17 P-Hydroxy-4-androsten-3-on -> Testosteron

3P-Hydroxy-5-androsten-17-on-> DHEA

3-Hydroxyanthranil-saure 145

17(J-Hydroxy-17a-athinyl-18-methyl-4,9,11-ostratrien-3-on 157

3(J-Hydroxy-24-athyl-5-cholesten 66, 68

25-Hydroxycholecalciferol 41, 64, 65, 89, 153

-, Rezeptor 217,218,222 -, Stoffwechsel 197 5,6-trans-25-Hydroxychole­

calciferol 153, 154 25-Hydroxycholecalciferol-1-

monooxygenase ->!a-Hy­droxylase

3(J-Hydroxy-5, 7 -cholestadien (7-Dehydrocholesterin) 23,24,64-67,169

3(J-Hydroxy-5,20(22)­cholestadien 40

3(J-Hydroxy-5 ,24-cho­lestadien -> Desmosterin

3(J-Hydroxy-5a-cholesta-7,24-dien 22, 23, 26

3(J-Hydroxy-5a-cholesta-8,24-dien -> Zymosterin

Jp-Hydroxy-5-cholesten -> Cholesterin

3{J-Hydroxy-5,7 ,24-cholestatrien 22, 26

3(J-Hydroxy-9, 1 0-seco-cho­lesta-5, 7 ,9(10)-trien -> Vitamin 0 3

20a-Hydroxycholesterin 30, 37,41

22R-Hydroxycholesterin 30,41

337

18-Hydroxycorticosteron 41,48,51

16a-Hydroxydehydroepian­drosteron 192

16a-Hydroxydehydroepian-drosteronsulfat 63

26-Hydroxy-ecdyson 197 26-Hydroxy-ecdysteron 67 25a-Hydroxy-ergocal-

ciferol 64, 65 3-Hydroxy-L-kynu-

renin 145 Hydroxylierungen 30-32,

41,50,51, 165,166,176 -, bakterielle ->Mikroorga­

nismen -, geschlechtsabhangige Hy­

droxylasen 176, 272 -, H-Donator 31, 32, 35,

40,42 -, hydroxylierte Positionen

(Spezifitat) 30, 31, 41, 51

-,- !a-Hydroxylase 41, 64,65, 89-91,154,169, 176-178

-,- 2-Hydroxylase 103, 165, 195, 196

-,- 2a-Hydroxylase 43, 176,272

-,- 2(J-Hydroxylase 41, 169,177,178,272

-,- 3a-Hydroxylase -, - 3(J-Hydroxylase -,- 4-Hydroxylase -,- 4a-Hydroxylase

178 178

179 178

-,- 6a-Hydroxylase 41, 178, 182, 196

-,- 6(J-Hydroxylase 41, 169, 177, 178, 185, 189, 192,269,272

-,- ?a-Hydroxylase 169,178,269,272

-,- 7(J-Hydroxylase 178 -,- 8(J-Hydroxylase 178 -,- 9a-Hydroxylase

178, 179 -,- lla-Hydroxylase

41, 169, 178 -,- ll(J-Hydroxylase

29,34,35,39-41,50,51, 57, 74, 169, 176-178

-, -,- Inhibitoren 43, 44 -,- 12a-Hydroxylase

41,178 -,- 12(J-Hydroxylase

41, 178

338

Hydroxylierungen -,- 14a-Hydroxylase

177, 178 -,- 14{3-Hydroxylase

177, 178 -,- 15a-Hydroxylase

20,26,41, 169,177,178 -,- 16a-Hydroxylase

41,62,63, 169,178,182, 196,269,272

-, -,- Inhibitoren 162, 196

-,- 16{3-Hydroxylase 178, 196

-,- 17a-Hydroxylase 41,49-51,54-56,74,82, 86, 169, 178

-, -, - Inhibitoren 44, 51

-,- IS-Hydroxylase 37, 40,41,49,52, 74,169, 176,269

-, -, - Inhibitoren 43 -,- 19-Hydroxylase 41 ,

60, 169, 178 -, -, - Inhibitoren 43 -,- 20a-Hydroxylase

30,41,43 -, -, - Inhibitoren 43 -,- 21-Hydroxylase 41,

49, 50,52,57, 74,169, 178

-, -,- Inhibitoren 43, 52, 121

-,- 22R-Hydroxylase 30,41

-,- 24-Hydroxylase 89, 154, 197

-,- 25-Hydroxylase 42, 64,65

-, -, - Inhibitoren 65 -,- 26-Hydroxylase 66,

169 -, Mechanismus --+ Cyto­

chrom P-450 3{3-Hydroxy-24-methyl-

5, 7 ,22-cholestatrien 64 2-Hydroxymethylen-17 a -me­

thyl-17{3-hydroxy-5a­androstan-3-on 139

Hydroxymethylglutaryl-CoA 13, 14, 25, 26

Hydroxymethylglutaryl-CoA­Lyase 14

Hydroxymethylglutaryl-CoA­Reduktase 14, 24--26, 111

H ydroxymethylglutaryl-CoA­Synthase 14, 26

2-Hydroxyostradiol 103, 137, 162, 165, 195, 196, 214

6a-Hydroxyostradiol 196 6/J-Hydroxyostradiol 196 11a-Hydroxyostradiol 61 17 a-Hydroxyostradiol --+ 17 a-

Ostradiol 17/J-Hydroxy-4-ostren-3-on-

17-phenylpropionat 139 2-Hydroxyostriol 196 6/J-Hydroxyostrogene 196 2-Hydroxyostron 103, 137,

194--196 2-Hydroxyostron-Glutathion-

iither 196 6a-Hydroxyostron 196 6/J-Hydroxyostron 196 16a-Hydroxyostron 196 16/J-Hydroxyostron 196 8( 1-Hydroxy-3-oxopropyl)-

9,12-dihydroxy-5,10-hep­tadecadien-carbon-siiure 115

p-Hydroxyphenylbrenztrau­bensiiure 145, 146

p-Hydroxyphenylbrenztrau­bensiiure-Dioxyge-nase 146

3a-Hydroxy-5a-pregnan-16-en-11,20-dion 122

2/J-Hydroxypregnane 41 17a-Hydroxypregnane 41 3/J-Hydroxy-5a-pregnan-20-

on 182, 183 3/J-Hydroxy-5/J-pregnan-20-

on 182, 183 3a-Hydroxy-5a-pregnan-20-

on 56, 119, 182, 183, 210 3a-Hydroxy-5{3-pregnan-20-

on 121, 182 20a-Hydroxy-5a-pregnan-3-

on 183 17a-Hydroxy-5a-pregnan-

3,20-dion 56 3a-Hydroxy-5{3-pregnan-

6,20-dion 182 16a-Hydroxy-4-pregnen-

3,20-dion 182 17a-Hydi:oxy-4-pregnen-

3,20-dion --+17a-Hydro­xyprogesteron

21-Hydroxy-4-pregnen-3 ,20-dion --+ 11-Desoxycortico­steron

Sachverzeichnis

17a-Hydroxypregne-nolon 41, 44, 47, 50, 51, 54--57,86

17 a-Hydroxypregnenolon­sulfat 172, 173

21-Hydroxypregnenolon 44 20a-Hydroxy-4-pregnen-3-

on 47, 125, 182, 183 20/J-Hydroxy-4-pregnen-3-

on 182, 183 3a-H ydroxy-5 -pregnen-20-

on 44 3/J-Hydroxy-5-pregnen-20-on

--+ Pregnenolon 17 a-Hydroxy-4-pregnen-

3,11,20-trion--+ 21-Des­oxycortison

21-Hydroxy-4-pregnen-3,11,20-trion--+ 11-Dehy­drocorticosteron

11a-Hydroxyproge-steron 177

11/J-Hydroxyprogesteron 49 17a-Hydroxyproge-

steron 41, 44, 47, 49, 51,53,54,56, 57, 157

17a-Hydroxyprogesteron-Al­dolase--+ C-17,20-Lyase

17a-Hydroxyprogesteron-17-capronat 119

3-Hydroxy-9, 1 0-seco-andro­sta-1,3,5(10)-trien-9,17-dion 179

3a-Hydroxysteroid-Dehydro­genase 56, 135, 165, 168, 175-177, 182, 185, 186,190,269-271

3/J-Hydroxysteroid-Dehydro­genase 26, 165, 168, 176,177, 182, 190, 269-271

3/J-Hydroxy-A 5 -Steroid-De­hydrogenase 44-47, 50, 54-57,63, 168, 173,180, 183

- , Struktur 4 7, 54 -, Vorkommen 44, 47, 54,

62, 172,213 - , Wirkung 47, 168 -, - EinfluB von LH 83 -,- Inhibitoren 45, 46,

56, 157, 158, 160 6a-Hydroxysteroid-Dehydro­

genase 182, 196 6{3-Hydroxysteroid-Dehydro­

genase 196

Sachverzeichnis

11#3-Hydroxysteroid-Dehy­drogenase 168, 177, 185,269

16a-Hydroxysteroid-Dehy­drogenase 168, 196

16P-Hydroxysteroid-Dehy­drogenase 196

17a-Hydroxysteroid-Dehy­drogenase 168, 192, 193,269,271

17j3-Hydroxysteroid-Dehy­drogenase 54-56, 60, 120, 130, 136, 160, 162, 168,177,190,196,213, 220,244,262, 269,270

20a-Hydroxysteroid-Dehy­drogenase 125, 168, 177, 182, 183, 185, 186, 270

20j3-Hydroxysteroid-Dehy­drogenase 168, 182, 185,211,244

21-Hydroxysteroid-Dehydro­genase 168, 188

3j3-Hydroxysteroid-Sulfo-transferase 27, 171

2j3-Hydroxytestosteron 272 6P-Hydroxytestosteron 61,2 72 lla-Hydroxytestosteron 61 11#3-Hydroxytestosteron 61 16a-Hydroxytesto-

steron 272 19-Hydroxytestosteron 60 17 P-Hydroxy-4,4,17 a-trime­

thyl-5-androsten­(2,3d)isoxazol 45

3j3-Hydroxy-4,4,14a-trime-thyl-8,24-cholestadien --> Lanosterin

5-Hydroxytryptamin--> Sero-tonin

Hyperandrogenismus 52, 57 Hyperprolactinamie 88 Hypoglykamie 106 Hypogonadismus 105, 158 Hypophyse 70, 71, 94, 95,

230 -, glandotrope Hormone

70,80,81,94,95 -, 5a-Reduktase 58, 59 -, Steroidrezeptoren 96,

105,209,210,215 -, Tripeptidasen 96 Hypophysektomie 58, 74,

80-83,271 Hypophysenstiel 71, 94, 95,

101,261

-, Steroidrezeptoren 96 Hypothalamus 94, 95, 266,

271 -, Androgene 138 -, Kernbereiche--> Nucleus -, Liberine 94-96 -, Neurohormone 94, 95 -, Ostrogenbildung 59, 62,

266 -, 5a-Reduktase 59 -, Steroidrezeptoren 96,

209,210,212,215,266

lkterus 122, 261 Immunsuppressor 85, 149 Induced protein (IP) 123,

124, 126 Informoferen 237,238 Informosomen 238, 247,

251,253 Inhibierungsfaktor, hypotha­

lamischer 267, 270 Inhibin 87, 99, 106 Insektenhormone 66-68,

154-156 Insulin 87, 119, 144 Interphase 226, 229 lntersexe 266 Interstitiell-Zellen 82 Isoandrosteron--> 3a-Hydro-

xy-5j3-androstan-17 -on Isocapronaldehyd 30, 37, 40 Isocapronylalkohol 38, 39 Isohexylalkoholdehydro-

genase 39 Isomerase --> Steroidisome­

rase Isopentenylpyrophos-

phat 16,17,26 Isopentenylpyrophosphat-Iso­

merase 16, 26 Isopren, aktives 16 Isoprenoide 13

Juvenilhormon 66, 156

Kalium 52, 151 -, K+/Na+-Quotient 155,

204,258,259 Kapazitation 133 Kastration 59, 119, 136,

160,230,241,253,254 Katabole Wirkung 118,

141, 144-146, 149 Keimepithel 106, 134 Kernbereiche --> Nucleus Ketogenese 14

339

a-Ketoglutarsaure 77, 145, 259

2-Keto-4-hexensaure 180 Ketosauren 14 17-Ketosteroide 53, 165,

186, 187 P-Ketothiolase 13 Kininase II 92 KIP 124,232,243 Knochen, Bildung 128, 153 -, Calcium-Mobili-

sierung 89, 90, 153 Knochenmark 138, 212,

242 Kobalt 42 Kohlenmonoxid 29 Konformationsbeschrei-

bung 5-11 Konjugatbildung 164-174 Kontrazeptiva--> Ovulations-

hemmer Korpertemperatur 122, 128 Krotengifte 10 Kryptorchismus 106 Kynurenin 145 Kynurenin-Hydrolase 145 K ynurenin-Oxidoreduk-

tase 145

Lac-Operon 205 a-Lactalbumin 121 Lactat 142 Lactatdehydrogenase , 125 Lactose-Synthese 121 -,Regulation 87, 121 Lactosesynthetase 121, 133 Lanosterin 17, 19-21,24,

26 Lampenbiirstenchro­

mosom 233 · Larvenhautungen 156 Lathosterinoxidase 21, 22,

26, 169 Lathosterol 284 Laurinsaureester 174 Liivulinsaure 179, 180· Leber, Adenylcyclase 89 -, Angiotensinogen-

Bildung 92, 124 -, Cholesterinbildm'lg 27 -, Enzymmuster, ge-

schlechtsabhangige 138, 160,175-177,190,212, 213,267-272

-, Plasmaproteinbil­dung 124,219

-, Regeneration 148

340

Leber -, Steroidabbau 164, 170,

175, 176, 190, 192, 196 -, Steroidrezeptoren fiir -,- Androgene 212, 213 -,- Corticoide 208,215 -,- Ostrogene 216,222 -, Tumoren 132, 142,208,

222 -, Zielorgan fiir -,- Androgene 140, 212 -,- Corticoide 142,

144-147,207,208,219 -,- Ostrogene 124,

220-243,254 -, - Proteohormone 88,

89 Lecithin 14 7 Lecithinacyltransferase 27 Leucin 144 -,Transport 121,257 Leukiimie, myeloische 148,

257 Leukocyten 148 Leydigsche Zwischenzel-

len 53, 82, 85, 87, 221 LH -> Lutropin Liberine (RH) 94-106 -, Abbau 96,261 -, Biosynthese 98 -, - Kernbereiche 94, 95 -, Rezeptoren 98, 107 -, Sekretion 95, 96, 102 -, - Regulation 94-96,

118 -, Struktur -> Corticoliberin,

Gonadoliberin bzw. Pro­lactoliberin

-, Wirkung 94-98, 107 Limbische Hirnbereiche 59,

137 Linolensiiure 112 Linolsiiure 112, 174 Lipid-Granulae 27,79 Lipidphasenbeweglichkeit

-> Membran Lipocyten 148 Lipolyse 133, 139, 141,

147-149 Lipoproteine, LDL 24, 25,

27, 174 -, HDL 25, 27, 174 Liposomen 122 Lipotropin 73 Lipovitellin 120, 124, 125 Lipoxygenase 113 Lumisterin 65

Lunge, Steroidabbau 164, 170

Lungensurfactant 148, 209, 267

Lutealphase 131, 181, 195, 207,214

Luteinisierendes Hormon -> Lutropin

Luteolyse 130, 134 Luteotropes Hormon -> Pro-

lactin Lutropin (LH) 81-83 -, Gehalt 83, 87, 130 -, Halbwertszeit 83 -, Membranrezeptor 82,

85 -, - Hemmpeptid 82 -, Sekretion 83, 104, 105 -,- Regulation 83, 94,

102, 104, 105 -, Struktur 81, 98 -, Wirkung 28, 47, 59, 63,

70,71,81-83,87,101, 129

-, - EinfluB von Cal-cium 82

C-5,10-Lyase 179 C-10,19-Lyase 41, 60,61 C-17,20-Lyase 41, 44,

53-56,83,166,186 -, Inhibitoren 44, 46, 53,

160,260 C-20,22-Lyase 30, 37, 40,

41,54,83 Lymphatisches System 141,

148,149,208,209,293 Lymphoblasten 148, 257 Lymphocyten 230 -, Calcitonin-Rezeptor 90 -,Transformation 108,

230,264 Lymphopenie 148 Lynestrol 284 Lysophosphatidylcholin 27 Lysosomen 198, 204, 258 -, Labilisierung 108, 123,

158,204,257,258,262 -, Stabilisierung 141, 149,

158,205 -, Steroidrezeptoren 199,

204,217 -, Wirkung 129,204,205,

234,242 Lysozym 124, 268

~akrophagen 148,257 Malat 77

Sachverzeichnis

Malat-Dehydrogenase 77, 125,215

Malat-Pyruvat-Shuttle 77 4-Maleyl-acetoessig-

siiure 146 4-Maleyl-acetoessigsiiure-Iso-

merase 146 Mannose 81, 84 Medrogeston 284 Medroxyprogesteronace-

tat 267, 284 Megestrolacetat 132 Meiose 83 Melanocyten 73 Melanotropin (MSH) 53,

73, 100 Melatonin 95-97, 125 Membrane 24, 198, 252 -, Depolarisierung 98, 116 -, Hormonrezeptoren

-> Plasmamembranre-zeptoren

-, Lipidphasenbeweglich­keit 25, 122, 205, 258

-, Potential 95 -, Steroidpassage 200,

205 -, Struktur, Proteine 71,

111, 148, 257 -,- Labilisierung 118,

257 -,- Stabilisierung 133,

141,149,257 -, - Steroidwirkung 252,

257-259,274 -, - EinfluB auf DNA­

Synthese 223, 226, 227 Membransyndrom, hya-

lines 148 MER-25 161 Mesenchym 148 Mesterolon 139 Mestranol 127 Metadrenalin 97, 103 Metanephrin 97, 103 Methandrostenolon 139 P(3-Methoxy-4-hydroxyphe-

nyl)-P-hydroxy-N-me­thyliithylamin -> Metadre­nalin

2-Methoxy&tradiol 103, 137, 196

2-Methoxy&triol 103, 196 2-Methoxyostron 103, 137,

196 2-Methoxyostron-3-sulfat

195

Sachverzeichnis

2-Methoxyostron-3-glucu­ronid 195

Methylasen, DNA-Methy­lasen 223

-, Proteinmethylasen 98 -, tRNA-Methylasen 125,

243,254 2-Methyl-1 ,2-bis(3-pyridyl)-

1-propanon 43 4a-Methyl-5a-cholesta-8,24-

dien-3-on 23 Methylgruppe, angulare 5,

7,8, 10,207 17a-Methyl-17/)-hydroxy-

1 ,4-androstadien-3-on 139

la-Methyl-17 /)-hydroxy-5a­androstan-3-on 139

1-Methyl-17/)-hydroxy-5a­androsta-1-en-3-on-17-acetat 139

7 a-Methyl-17 {3-hydroxy-5-androsten-3-on 157

3-Methyl-2-hydroxy­ostradiol 103

17a-Methyl-17 {3-hydroxy-4, 9, 11-ostratrien-3-on 213

7a-Methyl-17{3-hydroxy-5-ostren-3-on 157

7 a-Methyl-17/)-hydroxy-4-ostren-3-on-17 -ace tat 157

6-Methyl-17 a-hydroxy-4-pregnen-3, 20-dion-17-acetat 132

Methylmalonyi-CoA 144 8-Methyl-perhydroindan-1, 5-

dion-4a-carbonsiiure 180

8-Methyl-perhydroindan-1, 5-dion-4a-propionsiiure 180

15-Methylprostaglandin F2a 134

Methylsterinmonooxy-genase 19, 20, 26

17a-Methyltestosteron 162 Methyltrienolon 212, 213 Metopirone (Metyrapon) 43 Mevalonatkinase 15, 26 Mevalonsiiure 13-15 Mevalonsiiurepyrophos-

phat 15,26 Mevalonsiiurepyrophosphat­

Kinase 15, 26 Mikrofilamente 110

Mikroorganismen 177-181 -, Cytochrom P-450 29 -, Dehydrogenasen 177,

178 -, Hydroxylasen 177, 178 -, 5a-Reduktase 59, 165,

176, 178 -, Sterine 181, 273 -, Steroidrezeptoren 211,

213,214 Mikrosomen 168-170, 196 -, Cytochrom P-450 31,

40-43,54,62 -, HMG-CoA-Re-

duktase 14 -, Hydroxylasen 40, 41,

51,52,62, 169,176 -, Hydroxysteroid-Dehydro­

genasen 168, 176, 177, 269, 270

-, 5a-Reduktase 169, 175, 183, 191

-, Steroidrezeptoren 211 -, Sulfatasen 169, 172 -, UDP-Glucuronosyltrans-

ferasen 167, 168 Mikrotubuli 110, 111 Milchbildung 87, 121, 123 Mineralocorticoide 49, 52,

70, 141, 142, 151, 152 Minipille 132, 133 Mitochondrien 74, 169, 234 -, Cytochrom P-450 28,

30-32,34-36,39-41,54, 65, 74

-, DHEA-Sulfatid-Bildung 173

-, Glucuronosyltransferase 167

-, H-Transfer 77, 78, 262 -, Hydroxylasen 41,176 -, Membran 37, 51, 77 -, NADPH-Kompar-

timent 33, 77 -,Steroid-Transfer 47, 51 Mitose 86, 108, 116,

224-226,230,262,263 Mitoseindex 139 Monodehydroascorbin­

siiure 31 Monodehydroascorbinsiiure­

Reduktase 78 Monooxygenasen, mischfunk-

tionelle -> Hydroxy Jasen Morbus Addison 53 Miillersche Gange 267 Muskeln, Abbau 141, 149

341

-, Steroidrezeptoren 208, 212

-, Wachstum 137-139 Muskulatur, glatte 116 Myoblasten 139 Myometrium 124, 183 Myopathie 149

Na +, Riickresorption, renale 93, 151

-, Transportsystem 116, 117,141,151,259

-, Wirkung 52, 91, 152 -, - Na + IK +-Quotient

155,204,258,259 NAD+ 20, 21, 45, 47, 166,

167 NADH 18, 59, 77, 78 -, H-Donator fiir Arachi­

donsiiurebildung 112, 113

-, - fiir Dehydrogena­sen 21, 168, 176, 177, 270

-, - fiir Hydroxylierun­gen 31,40,42

-,- fiir Reduktasen 169, 175

NADPH 18, 36-40, 76-78 -, H-Donator fiir Choleste­

rinsynthese 16-23 -, - fiir Dehydrogena­

sen 168, 176, 177, 196, 270

-, - fiir Hydroxylierungen 17, 19, 20, 29, 31, 32, 35-37,39,40,76,169

-, - fiir Peroxidasen 22, 38

-,- fiir Reduktasen 14, 1~22,23,58, 16~ 175

NADPH-Cytochrom c-Re­duktase 17, 42, 58, 175, 191

Nafoxidin 161 Nebennierenmark 80, 148 Nebennierenrinde (NNR)

47-49,74,79,80,87,271 -, Adenome und Carci­

nome 57 -, Morbus Addison 53 -, Steroidsynthese 27, 28,

47,49,51-53,62,63, 70, 71, 122, 141, 172

-, Oberfunktion 187 Nebenschilddriise 89, 90,

218

342

Neonuclearrezeptor 201, 205,206,216,231

Neoplasmen --+ Tumoren Nervensystem 3 Neugeborenen-Ikterus 122,

261 Neuraminidase 73, 84, 85, 200 Neuraminsiiure 84 Neurohormone 94, 99 Neurotransmitter 3, 95, 96,

115 Nichthistonproteine (NHP)

111,124,156,223,224, 230,233,241,242,250

-, Rolle als Nuclearakzepto­ren 201-203,206,225

Nicotinamiddinucleotid --+ NAD+ bzw. NADH

Nicotinamiddinucleotidphos-phat --+ NADPH

Nidation 119, 133, 157 Niere 70, 87,89-93, 160 -, Steroidabbau 164, 170 -, Zielorgan der Andro-

gene 59, 136, 138, 139, 160,212,260,272

-, Zielorgan der Cortico­ide 148,151,208,209

4 '-Nitro-3 '-trifluormethyliso­buttersiiureanilid 160

Nocardia restrictus 176 Non-heme-iron-Protein

(NHI) 29, 35, 36 Noradrenalin 95, 97, 100,

103, 107, 109, 148 Norethynodrel 132 Norethisteron (Noriithin­

dron) 132,267,284 Norgestrel 132 24-Nor-25-hydroxy-chole­

calciferol 65, 153 19-Nortestosteron 61 Nuclearakzeptoren 201,

203-206,216,231 Nuclease--+ DNAase bzw. Ri­

bonuclease Nucleinsiiuren--+ DNA bzw.

RNA Nucleolus 234, 235, 243 Nucleosidtriphosphatase 27 Nucleosomen 224 Nucleotide, cyclische --+ Ade-

nosin-3', 5' -monophos­phat bzw. Guanosin-3', 5'-monophosphat

Nucleotidkompartiment 125,234,259

Nucleus dorsomedialis 94 - hypothalamicus ante-

rior 265 - paraventricularis 95 - praemamillaris 94 - suprachiasmaticus 96 - supraopticus 95 - tuberis infundibularis 94 - ventromedialis 94, 102,

265

Ohnos Modell 256 Oocytreifung 83, 124, 129,

264 Orientierung 6, 11 Omithinaminotransfe-

rase 147 Ornithindecarboxylase 232,

243 -, hormonelle Regula­

tion 80, 88, 124, 125, 148

Orosomucoid 184, 219 Osteoblasten 148 Osteoide 90 tlstradiol 122-131, 194 -, Biosynthese 41, 44,

59-63, 195 -, - Regulation 63, 267 -, Gehalt 128, 129 -, Rezeptor 160, 200-205,

207,214-217,239,240, 257,261

-, - EinfluB von cAMP 111,261

-, - EinfluB von Prolac­tin 87,88

-, - EinfluB von Stero­iden 120, 125, 127, 129, 207,210,216

-, - Nuclearakzeptor 201,203-205,216,240

-, - Plasmarezeptor 219-222

-, -,- a-Fetoprotein 212,222

-, Stoffwechsel 41, 62, 103, 120, 137, 164

-, - Halbwertszeit 197 -,- Konjugate 167, 169,

171 -, Struktur, synthetische

tlstrogene 125-128 -,- Antiootrogene 157,

160-162 -, Wirkungen, Enzym- und

Sachverzeichnis

Proteinsynthesen 92, 95, 123-126,183,207,210, 215,220,242,244,254, 268

-, - Hemmwirkungen 58,87,97, 101,117,119, 122,123,157,160,175, 258,260

-, - Nucleinsiiure­synthesen 87, 125, 126, 204,230,238-243,251, 254,268

-,- Lysosomen-Labi­lisierung 123, 204, 257, 258

-, - Prostaglandine 102, 123

-, - Triglycerid-Gehalt 133

-, - Zelldifferen­zierung 268

-, Zielorgane, Brust­driise 119

-, - Hypophyse 88, 97, 101-106, 122, 123

-,- Tumoren 128 -,- Uterus 118,

122-125,207,216,259, 261,268

17a-tlstradiol 170, 192 17 ,8-tlstradioldehydroge­

nase 177,195 17 a-tlstradiol-1 7-,8-D­

glucosid 170 17 a-tlstradiol-3-,8-D-glucu­

ronid-17 -,8-D-glucosid 170

17 ,8-tlstradiolsulfat 195 tlstriol 62, 63, 126, 127,

129, 194-197 -, Brusttumoren 127, 162 -, uterotrophe Wir-

kung 126,216 tlstriol-3,16-disulfat 172,

194 tlstriol-16-,8-D-glucosid

170 tlstriol-16-glucuronid 194,

197 tlstriol-3-glucuronid 194,

197 tlstriol-16-sulfat 62, 194 tlstriol-3-sulfat-16-glu­

curonid 194 tlstrogene 122-134 -, Biosynthese 60-63,69,

70

Sachverzeichnis

-, Stoffwechsel 62, 164, 165, 167, 177, 178, 194-197

-, Struktur 5, 9 -,- Antiostrogene 157,

160-162 -, Wirkung 122-136 Ostrogenkonjugate 123 Ostron 60, 62, 63, 120, 126,

127, 129, 130, 137, 194-196,220

Ostronglucuronid 167, 194 Ostron-3-glucuronosyltransfe­

rase 167 Ostron-3-sulfat 169, 171,

172, 194, 195 Ostronsulfotransferase 171 Ostruscyclus 131 Ovalbumin 120, 124, 240,

268 -, mRNA 239, 240, 244,

253 Ovar, 27, 40, 53, 59, 70,

119,122,123,211,243 -, Cumuluszellen 106 -, Gonadotropin-Rezep-

toren 82, 86 -, Insuffizienz 88 -, Theka-Zellen 62, 86,

129 -,Tumor 57 Ovidukt 119, 120, 124, 138,

209-211,214,216,239, 254,268

Ovomucoid 268 Ovulation 83, 102, 116,

119, 120, 122, 129-131, 160

-, reflektorische 94, 130 Ovulationshemmer 83, 127,

131-134 -, beschleunigter Abbau

176 -, Nebenwirkungen 121,

124,131-133,215 Oxalacetat 77, 142-144 7 -Oxaprostaglandine 117 7-0xaprosta-13-insaure 117 Oxidasen 38 -, Steroid-18-oxidase

49,52 -, Steroid-19-oxidase 60 4{),5{)-0xido-19-oxo­

testosteron 61 9{),11{)-0xidopregnan 39,

40 Oxidoreduktasen 166

Oxido-squalen 17, 19,26 Oxido-squalen-Lanosterincy­

clase 19, 26 19-0xoandrostendion 60 18-0xocorticosteron---> Aldo­

steron 2-0xoglutarsaure 77, 145,

259 6-0xoostradiol 196 16-0xo6stradiol 196 6-0xoostron 196 16-0xo6stron 196 3-0xosteroid-d 1- Dehydro-

genase 62, 169, 178, 179

3-0xosteroid-d 4 -d 5-

Isomerase---> Steroid-d­Isomerase

3-0xosteroid-d 4-0xidore-duktasen ---> Reduktasen

19-0xotestosteron 41, 60, 61

3,4-bis(p-Oxyphenyl)-2,4-hexadien 128

3,4-bis(p-Oxyphenyl)-3-hexen ---> Diathylstiloostrol

Pankreas 3, 148,212,268 Parachor 149 Parathormon 89-91 -, Abbau 88, 89 -, Biosynthese 89, 90 -,- Regulation 89-91 -, Gehalt 91 -, Struktur 89 -, Wirkung 65, 70, 71,

89-91, 108, 152, 197 Pentagastrin 116 2(J,3(J,14a,22R,25-Pentahy­

droxy-5{J-cholesta-7 -en-6-on---> a-Ecdyson

3a, 11{), 17 a,20a,21-Pentahydroxy-5a­pregnan 184

3a,11{J,17a,20a,21-Pentahydroxy-S{J­pregnan 184, 185, 187

3a,11{J,17a,20{J,21-Pentahydroxy-5{J­pregnan 184

Pentosephosphatcyclus 76, 77,260

Peptidasen 99, 101 -, hormonelle Aktivie­

rung 96,101,106,261 Peptidhormone 107 -,Angiotensin 91-93

343

-, Liberine 94-106 Peptidyl-Dipeptidase 92, 93 Peptidylprolylaminosaure-

carboxypeptidase 93 Peptidyltrimsferase

248-250 Perhydrocyclopentanophen­

anthren 4, 7, 10, 16 17a-Perhydroxyproge-

steron 54, 55 Peroxid 32, 33, 38 Peroxidase 22, 26, 38, 40 -, IS-Peroxidase 113 Pfortadersystem 94, 95, 98 Phagocyten 134, 149 Phenobarbital 176 Phenylalaninabbau 145 Phenylalaninhydroxylase

145, 189 Phenylathanolamin-N-Me­

thyltransferase 148 Phosphat 89-91 Phosphatase, alkalische 90,

148,174 -, saure 136, 174 3' -Phosphoadenosin-5' -phos­

phosulfat 27, 168, 170, 171

Phosphodiesterase ---> Adeno­sin-3' ,5' -monophosphat­Phosphodiesterase

Phosphoenolpyruvat 142, 143, 147

Phosphoenolpyruvatcarboxy­kinase 142-144, 149

Phosphofructokinase 13 7, 147

Phosphoglucomutase 77 3-Phospho-D-glycerat-1-

Phosphotransferase 142, 143

Phospholipasen 116, 117 -,Phospholipase A1 114 -, Phospholipase A2 200 Phospholipide 27, 37, 114 Phosphomevalonat-Kinase

15,26 5-Phosphomevalonsaure 15, 26 3-Phosphomevalonsaure-py­

rophosphat 15, 16, 26 Phosphoproteinphosphatase

78, 109, 120, 147, 148, 151,253

Phosphoribosylpyrophos-phat 260

Phosphoribosylpyrophosphat­Aminotransferase 259

344

Phosphoribosyltransfera-sen 259,260

Phosphorylase 76, 111, 259 Phosphorylase-Kinase 76 Phosphorylase-Phospha-

tase 76 Phosphoserinphospha-

tase 149 Phosvitin 120, 124, 125 Phytohamagglutinin 230 Phytosterine 66 PIF --> Prolactostatin Pinocytose --> Exocytose Placenta 27, 40, 47, 62, 63,

70,80,83,84,87, 119, 122

Plasmamembran 24, 123, 258

-, Rezeptoren 24, 57, 69, 71, 72,80-82,87,90, 199,217

Plasmaproteine Plasmavolumen Plasmarezeptoren

218-222

124 93

166,

Pleiotypische Regula-tion 111

Polaritatsregel 219 Polyadenylsaure-Polymerase

237,251 Polysomen 239, 252, 255 Porphyrinsynthese 121, 122 Porphyrie, intermittierende

121, 122, 140 Portalgefiillsystem 94, 95, 98 Potenzstorungen 94 Pracalciferol 65 Praputialdriise 59, 137 Prasqualenpyrophosphat 16,

18,26 Prednisolon 148, 150, 151,

158,189,257 Prednison 150, 189 9{J,10a-Pregna-4,6-dien-3,20-

dion 120 Pregnan 10, 12 Pregnandiol-> 3a,20a-Dihy­

droxy-5{J-pregnan 5a-Pregnan-3,20-dion 47,

53,56, 119,182,210,271 5{3-Pregnan-3,20-dion 182 4-Pregnen-3,20-dion --> Pro­

gesteron 5-Pregnen-3,20-dion 45, 46 Pregnenolon, Biosynthese

27-30,37-41,69,79,81, 82

-, Verwertung zur Steroid­synthese 44, 47, 50, 53-55,69,86,183

Pregnenolon-3-sulfat 28, 172, 173

Pregnenolonsynthetase 28-30,36,37,74,78

-, Inhibitoren 43 -, Phosphorylierung 80,

111 -, ungewohnliche Substrate

39, 79 Prenylpyrophosphat --> Dime-

thylallylpyrophosphat Pressinonsaure 100 Primobolan 139 Primordialfollikel 129 PRL --> Prolactin Proandrogene 191 Proangiotensin 92 Progesteron 118-122 -, Biosynthese 27,44-47,

69, 70, 122, 141, 183 -,- Regulation 47, 83,

87 -, Gehalt 122, 130 -, Rezeptoren 125, 201,

203,205,207,209-211, 217,264

-, - Nuclearakzeptoren 203

-, - Plasmarezeptoren 184,219,220,222

-, -, - Uteroglobin 119, 120, 130

-, Stoffwechsel 121, 122, 181-184,210

-,- Halbwertszeit 184 -, Struktur, Antigesta-

gene 157 -, - synthetische Gesta­

gene 120-122,132,210, 219

-, -, - androgene Neben­wirkung 267

-, Wirkung 119-122 -, - aniisthetische Wir-

kung 122 -, - Brustdriisenent­

wicklung 119 -,- DNA-Synthese 119 -, - Enzym- und Protein-

synthese 119, 120, 222, 268

-, - Hemmwirkungen 53,56, 58, 87,100,101, 117, 119-121, 123, 129,

Sachverzeichnis

132, 133, 157, 161, 162, 207,216,257,258,260, 261

-, - Hypophysen­hormone 103, 119

-,- Oocyt-Reifung 121, 264

-,- Ovulation 120 -,- RNA-Synthese 205,

241 -,- Uterus-Entwicklung

119 -,- Verwertung zur Stero­

idsynthese 41, 49-51, 54,56,57

-,- zentral 103, 122 Progesteronmonooxygenase

41,54 Prolactin (PRL) 87-89 -, Gehalt 89, 106 -, Rezeptoren 87 -, Sekretion 88, 106 -, - Regulation 88, 96,

106, 119 -, Struktur 87, 98 -, Wirkung 87, 88, 107,

211 -, - Enzym- und Protein­

synthese 87, 88, 120 -, - Hemmwirkungen

88, 120 -, - Steroidrezeptor­

Bildung 87, 88, 211, 215 -,- Steroidsynthese 47,

59, 70, 71,83,87,88 -, Zielorgane, Leber 271 -,-Mamma 88 -, - Nebennierenrinde

271 -, - Prostata 87 -,- Vesikulardriise 87 -,- ZNS 71, 88 Prolactoliberin 88, 97, 99,

106 Prolactostatin (PIF) 88, 96,

97,99,106 Prolinhydroxylase 149 Propionaldehyd 180 Propionsaure 31, 180 Propionyi-CoA 144 Prostaglandine 3, 112-117 -, Abbau 114, 117, 134 -, Biosynthese 112-115,

117 -, - Regulation 82, 88,

91,95, 117,123,141,149 -, Rezeptor 116, 117,258

Sachverzeichnis

-, Struktur, Antagonisten 117

-,- PG AI 52, 114, 115, 117, 152

-,- PG B 114, 115 -,- PG C 114, 115 -,- PG 0 2 113, 115 -,- PG E1 114-116,258 -, - PG E2 82, 83, 88,

91, 96, 101, 102, 113, 115, 116

-,- PG F2a 88, 91, 102, 107,113,115,116,258

-,- PG G2 113-115 -,- PG H 2 113-115,

117 -,- 15-Methyl­

prostaglandin F2a 134 -, Wirkung 112, 115-117 -, - Adenylcyclase 88,

112, 114, 116, 117 -, - Guanylcyclase 88,

107 -,- Luteolyse 116, 134 -,- Muskulatur 116 -, - Oocytreifung 83 -,- Ovulation 116 -, - Proteohormonse-

kretion 88, 96, 101, 112, 116

-, - Steroidsynthese 70, 82, 116

-,- Synapsen 95,112 Prostaglandinisomerase

113,114 Prostaglandinsynthetase 113 Prostata 136, 190, 241 -, Steroidrezeptoren 211,

212,215,220 -, Tumoren 134, 136, 158 -, Wachstum 87, 128, 135,

136,230 Prostatahypertrophie 158,

160 Proteinasen 149, 198, 234,

242,252 Proteinkinasen 76, 78, 79,

86,96,107- 111,147, 232,253,254

Proteinmethyltransfe-rasen 98

Proteinreifung 250-252 Proteinsynthese 238,

244-257,259 -, Elongationsfak­

toren 248, 250, 254 - , EinfluB von Hormo-

nen 74, 118, 125, 141, 198,239,250-257

-, Startfaktoren 125, 245, 246,250,252,253

-, Terminationsfak-toren 249, 250

-, Translationsre-pressor 253, 256

Proteohormone ---+ Gonado­tropine

-, Gehalt 3, 81, 83, 87, 89, 91

-, Rezeptoren 57, 69, 72, 107

-, Wirkung 24, 69-93, 107 Prothoraxdriise 66, 68, 154 Protocollagenhydroxy-

lase 123 Protolanosterin 17, 19 Protoporphyrin IX 29-31 -, Biosynthese 42 -, EinfluB auf 11-Aminolavu-

linsauresynthetase 121, 140

-,- auf Globin-Mes­senger 253

Proviron 139 Pseudohermaphroditis­

mus 206,213,264 Pseudomonas testostero-

ni 211, 213, 244 Pupertat 104 Puffing 155, 156, 234, 253 Purinnucleosidtriphos-

phate 181 Purinnucleotidbiosynthese

259,260 Pyknose 148 Pyrogalloostrogene 196 Pyroglutaminsaure 101 Pyrophosphat-Phosphohydro-

lase 171 Pyrophosphomevalonat-De­

carboxylase 16, 26 Pyruvat 77, 142-145, 180,

259 Pyruvatcarboxylase 142-144 Pyruvatkinase 147

Rebound-Effekt 97 Redox-Potentiale 36 Reduktasen 169, 175, 176 -, bakterielle 59, 165, 169,

175, 176 -, 5a-Reduktase 58, 59,

61, 166, 169, 174-176, 185

345

-, - Wirkung, Rolle von Coenzym 0 10 58, 169, 175,191

-,- H-Donatoren ---+ NADH bzw. NADPH

-, - Geschlechts-abhangig 59, 175, 191, 266,269-271

-,- Inhibitoren 47, 58, 119,158,160,175,260

-,- Regulation 58, 59, 83

-,- bei Porphyrie 121, 139

-, - bei Progesteronreduk­tion 47, 56, 119, 183, 271

-, - bei Testosteronreduk­tion 58, 136, 160, 190-'192, 213, 266

-, 5~-Reduktase 58, 164, 166, 169,174-176,182, 185, 186, 190, 191

-, - Geschlechts­abhiingig 190, 269, 271, 272

-,- Inhibitoren 158, 175,189

Relaxin 128 Releasing Hormone ---+ Libe-

rine Renin 52, 91-93 -, Biosynthese 91, 92 -, Gehalt 93 -, Halbwertszeit 93 Replikation-+ DNA-Syn­

these Replikon-+ DNA-Synthese Reticulum, endoplasmati­

sches 252 Retinal-Differenzie-

rung 148,207,209,268 Retrodifferenzierung 70, 80 Retroprogesteron 120 Retro-Steroide 7, 120 Rezeptoren -+ Steroidrezep-

toren, Proteohormonre­zeptoren, Plasmarezepto­ren, Plasmembranrezep­toren

Rheuma 149, 150 Rhizopus arrhizus 177 Rhythmus, circadianer---+ Cir-

cadianer Rhythmus Ribonuclease 181, 204,

237,241,242,251 Ribonucleinsaure-+ RNA

346

Ribonucleoproteine 201, 206,211,216,238,251

Ribosephosphatpyrophos­phatkinase 260

Ribosomen 231, 240, 243, 245,246-250,254

-, ribosomale Proteine 111, 250, 254

Riesenchromosomen 154-156,234,254,258

Rifamycin 176 Ringkonformation 5-11 Ringverkniifgung 7-10, 12 RNA 236 -, Biosynthese 224,

227-238,241 -, - Regulation durch

Hormone 86, 89, 111, 138, 141, 148, 155, 156, 198, 205, 230-234, 238-244

-, - Transkriptions­einheit 236

-, Messenger-RNA 238-244,246-250

-, - Biosynthese 234, 237,251

-, -, - Regulation durch Hormone 125, 239, 241-243,251

-,- Struktur, Cap-Se­quenz 238,247

-, -, - Informosomen 238,247,251,253

-, -,- Poly A-Seg-ment 237, 238,240,251

-, -, - Stabilitat 238, 244,253-255

-,Nuclear-RNA 223, 237, 251

-, - Biosynthese 234, 235,237

-, -, - Regulation durch Hormone 86, 126, 199, 205,240,242,253

-,- Reifung 198,204, 237, 238,243,251,253

-, Ribosomale RNA 250 - , - Biosynthese 156,

204,231 , 232, 234,235, 243,256

-,- Reifung 237,243, 251

-, Transfer-RNA 236, 245-254

-, - Biosynthese 234, 235,237,243,252,254

-,- Methylierung 125, 243,252,254

RNase --> Ribonuclease RNA-Polymerase I 214, 215,

231,232,234-236,243 -, Hormonrezeptor 214,

243,256 -, Inhibitorproteine 156 -, Regulation durch Hormo-

ne 232,240,243,256 - II 126, 225, 227, 231,

234-236 -, EiweiBfaktoren 232 -, Phosphorylierung 111,

232 -, Regulation durch Hormo-

ne 126,153,240 -III 234,235 -, mitochondriale 234 Riickkopplung 99, 102 -, kurze 99 -,negative 94, 96, 123,

131,261 -,positive--> Hohlweg-Ef­

fekt -, ultrakurze 96, 99

Salvage-Pathway 111, 260 Samenblase --> Vesikulardriise Samenkanalchen 85 Sauerstoff, aktiver 3 2 Schilddriise 96 Schilddriisenzellen, parafolli-

kulare 90 Schmerz 116 Schwangerschaft 119, 123,

128,267 -, Abbruch 133, 134 -, Serumproteine 133,

218,220,221 -, Steroidstoffwechsel 122,

181, 182, 196 Second-Messenger-Hypothe-

se 72,76 Sekretin 3 Seminalplasma 106 Serin-Pyruvat-Aminotransfe-

rase 149 Serotonin 95-97, 106, 148 Sertolizellen 62, 85, 221 Sesselform 5-8 Sexhormon-bindendes Globu-

lin (SBG) 124, 136, 158, 193,213,219-221

Sexprotein 138, 272 Sexualcyclus 102, 104, 119,

122, 129- 131

Sachverzeichnis

-, EinfluB auf Korpertempe­ratur 122, 128

-, - auf Membranrezep­toren 82

-, - auf Plasmahormon­spiegel 83, 119, 120, 122, 129, 130, 183

-, - auf Steroidausschei­dung 181

-, - auf Uterusproteine 120,171,183,207

-, Phasen --> Lutealphase Sexualhormone 3, 69 -, --> Androgene bzw. Ge-

stagene bzw. dstrogene Sexualtrieb 134, 160 Sexualverhalten--> Verhalten Sexualzentrum, Differenzie-

rung 53, 135, 137, 264-267

-, Erotisierungszentrum 265

- , Organisationsgesetz 265 Sialinsaure 73, 81, 82,

84-86 Sichelzellenanamie 257 Sitosterin 66, 68 SKF-525A 44 Sklerotisierung 155 Sofa-Konformation 6 Somatomedin 88, 123 Somatotropin--> Wachstums-

hormon Sorbitdehydrogenase 136 Spermatozoen-Entwick­

lung 106 Spermatozyten-Oberflachen-

antigene 134 Spermidin 232 Spermien, kapazitierte 133 Spermiogenese 85, 87,

134-137,263 Spin der Einzelelek-

tronen 33 Spinnbarkeit --> Cervixschleim Spirolacton 158, 162, 163 Spironolacton 162 Squalen 16-19, 23, 24, 26,

68 Squalen-Epoxidase (Squalen-

Monooxygenase) 17,26 Stammzellen 263, 268 Statine 95, 96, 107, 118 Stearinsaureester 17 4 Stein-Leventhal-Syn-

drom 57 Steran 4-7, 9, 12

Sachverzeichnis

Sterilitat 105 Sterin 4-7, 9, 10, 13, 19,

23,181,273 Sterincarbonsaure-Decarb­

oxylase 19-21, 26 Sterin-Carrier-Proteine

(SCP) 24 A5-Sterin-A24-Reduktase 26 Sterinsulfatase 25, 56, 169,

172, 173 -, EinfluB von Corticotro­

pin 79, 172 -, Inhibitoren 172, 260,

261 Steroide, Biosynthese

13-68, 172 -,- Regulation 69-117 -, - ektopisch ~ Tumoren -, Rezeptoren 96, 157,

199-218,231 -, - Plasmare-

zeptoren 218-222 -, Stoffwechsel 164-197 -,- Halbwertszeit 218 -, Struktur 4-12 -, Transport 200, 205 -, Wirkung, biologisch 3,

118-163, 264-272 -, - molekularbio­

logisch 198-262 Steroidacetate 164 Steroiddehydrogenasen ~ Hydroxysteroid-Dehy­drogenasen

Steroid-4,5-Dioxy-genase 179

Steroidglucoside 164 Steroidglucuronide 164,

167, 170, 184, 187, 190, 192,194,219

Steroidhydroxylierung ~ Hy­droxylierung

Steroid-A-Isomerase 46, 50, 53,55,56,63, 160,169, 172, 173, 183, 213

Steroidkonjugate ~ Konju-gate

Steroidmonooxygenasen ~ Hydroxylasen

Steroidoxidasen ~ Oxidasen Steroidphosphate 164, 174 Steroidreduktasen ~ Reduk-

tasen Steroidresistenz 206 Steroidrezeptoren ~ Steroide Steroidsulfatasen --+ Sterinsul-

fatasen

Steroidsulfate 164, 171-173,184,219,271

Steroidsulfatide 164 Streptomyces spec. 177 - hydrogenans 181, 211,

214,244 Stress 81, 100 Stroma 62, 125 Strophantidin 10 Strukturgen 225, 226, 236 Succinat 77 Succinyl-CoA 144 Sulfat-Adenylyl-Transfe-

rase 171 Sulfatbildung 164, 170-173,

271 Sulfatasen ~ Sterinsulfatasen

bzw. Arylsulfatase Sulfatide 164 Sulfotransferasen (Sulfokina­

sen) 27, 165, 168, 170, 171, 191, 195

Superinduktion 255, 256 Superoxid-Anion 32 Synaptosomen 96, 215

Tachysterin 65 Testes 27, 40, 53, 57, 59,

62, 70,82,99, 106,136, 173,221,264

-, EinfluB von Follitro­pin 85, 86, 138, 221

Testosteron 134-140 -, Biosynthese 41, 44, 49,

53-59,63,140,177 -,- Regulation 59,83 -, Gehalt 59, 140 -, Rezeptoren 136, 211,

212 -, - Nuclearakzeptoren

211 -, - Plasmarezeptoren

193,219-221 -, Stoffwechsel 137, 190 -, - Halbwertszeit 193 -,- Ring A-Reduktion

-+DHT -, - Aromatisierung

59-62, 105, 123, 128, 137,139,193,212,266

-, Struktur synthetischer Androgene 138, 139

-, Wirkung 105, 134-140, 258,265

-,- anabol 135, 137-139 -,- DNA-Synthese 136,

230

347

-, - Enzym- und Protein-synthese 136-139

-,- Glykolyse 136 -,- Membranen 257 -,- RNA-Synthese

241-243,257 -,- zentral 59, 135, 137 -, Zielorgane, akzessorische

Geschlechtsorgane 136, 138,260,262

-,-Leber 140,212 -,- Muskeln 208, 212 -,- Niere 59, 136, 138,

139,160,212,260,272 -,- Testes 83, 136 Testosteronacetat 41, 54 Testosteron-17 P-Dehydro-

genase~ 17(3-Hydroxy­steroid-Dehydrogenase

Testosteronfettsaure-ester 174

Testosteron-17 (3-glucu-ronid 58, 191, 271

Testosteronsulfat 173 . Tetrahydroaldosteron . 189 Tetrahydrocortico-

steron 186 Tetrahydrocortisol 184 Tetrahydro-11-dehydrocorti­

costeron 186 Tetrahydro-11-desoxycor­

tisol 186 Tetrahydropteridine 31 3a, 11(3,20(3,21-Tetrahydroxy-

5a-pregnan 186 3a, 17a,20a,21-Tetrahydroxy-

5{3-pregnan 186 3a, 11(3,20(3,21-Tetrahydroxy-

5{3-pregnan-18-on 189, 190

3a,17a,20a,21-Tetrahydroxy-5(3-pregnan-11-on 184, 185, 187

3a, 17 a,20{3,21-Tetrahydroxy-5(3-pregnan-11-on 185

3a, 11(3, 17 a,21-Tetrahydroxy-5{3-pregnan-20-on 184, 185

11{3,17a,20(3,21-Tetra­hydroxy-4-pregnen-3-on 184

3(3,11{3,17a,21-Tetrahydroxy-5-pregnen-20-on 50

tfm-Syndrom 213, 257 Thekaluteinzellen 62 Thekazellen 62 Theophyllin 111

348

Thermosensitive Neuro-nen 122, 128

Thromboembolische Erkran-kungen 131, 215

Thromboxan B2 115 Thymidineinbau 229 Thymidinkinase 111, 149,

230,259 Thymocyten 148 Thymus 208, 209, 257 Thyreotropin 81, 85, 106 Thyroliberin 88, 106 Thyroxin 87, 96 Thyroxin-bindendes Glo-

bulin 124 Tomkins' Modell 254-256 Transcalciferin 222 Transcortin 124, 184, 189,

193,210,219-221 Transfer-Ribonucleinsiiure

-->RNA Transhydrogenase, energieab­

hiingige 77, 78 Transkription--> RNA-Syn­

these Translation --> Proteinsyn-

these Transportprozesse 77 -, Aminosiiuren 86, 148, 257 -, Glucose 148, 257 -,Natrium 116, 117, 141,

151,259 -, Nucleoside 257 -, Steroide 200, 205 -, Thymidin 230 Trengeston 120 Triamcinolon 150 Triamcinolonacetonid 151 Tricarbonsiiurecyclus 36,

142, 144 2,22,25-Tridesoxy-a­

ecdyson 67 Triglyceridfreisetzung --> Li­

polyse 3a,16a,17{3-Trihydroxy-5a­

androstan 192 3a,16a,17{3-Trihydroxy-5{3-

androstan 192 3a, 17 {3, 18-Trihydroxy-5a­

androstan-3-on 193 3{3,16a,17{3-Trihydroxy-5-

androsten 192 3{3,5, 14-Trihydroxy-(5{3, 14{3)­

card-20(22)-enolid-19-on 10

2{3,3{3,14a-Trihydroxy-5{3-cholesta-7-en-6-on 67

3,16a,17{3-Trihydroxy-1 ,3,5(10)-ostratrien --> Ostriol

1a,3{3,25-Trihydroxy-9,10-se­co-cholesta-5,7 ,10(19)­trien -->1a,25-Dihydroxy­cholecalciferol

11{3,17a,21-Trihydroxy-1,4-pregnadien-3,20-dion --> Prednisolon

3a,6a,20a-Trihydroxy-5{3-pregnan 182

3{3,16a,20a-Trihydroxy-5{3-pregnan 182

3{3,16a,20a-Trihydroxy-5a­pregnan 183

3a,11{3,21-Trihydroxy-5a­pregnan-20-on 186

3a,11{3,21-Trihydroxy-5{3-pregnan-20-on 186

3a,11{3,17a-Trihydroxy-5{3-pregnan-20-on 186

3a, 17 a,20a-Trihydroxy-5{3-pregnan-11-on 186

3a, 17 a,21-Trihydroxy-5{3-pregnan-20-on 186

3a, 17 a,21-Trihydroxy-5{3-pregnan-11 ,20-dion 185

3a, 11{3,21-Trihydroxy-5{3-pregnan-18,20-dion 189, 190

3{3, 11{3,21-Trihydroxy-5{3-pregnan-18,20-dion 190

3a, 11{3,21-Trihydroxy-5a­pregnan-18,20-dion 190

3{3,17a,21-Trihydroxy-5-pregnen-20-on 50

11{3,17a,21-Trihydroxy-4-pregnen-3,20-dion --> Cortisol

11{3,18,21-Trihydroxy-4-pregnen-3,20-dion 52

2,2, 17 a,-Trimethyl-17 -hydro­xy-4,9,11-ostratrien-3-on 159

Triosephosphatisomerase 142, 143

Tropine --> Proteohormone Tryptophanabbau 144, 145 Tryptophan-2,3-dioxy-

genase 144, 145 Tryptophan-5-monooxyge-

nase 148 Tubulin 110 Tubulus-Apparat 85, 86 Tumoren 70, 217, 251, 260 -, Membranrezeptoren 57,80

Sachverzeichnis

-, Proteohormon-bil-dende 63, 70,80,84,85

-, Steroid-bildende 27, 57, 62,80

Tyrosin 155 -, Abbau 145, 146 -, Bildung 145 Tyrosinaminotransferase

145, 146, 149, 162, 254-256,261

Tyrosin-3-monooxyge-nase 150, 155

UDP-Galactose 146 UDP-Giucose 166-168 UDP-Giucose-Dehydro-

genase 166, 167 UDP-Giucosyltransfe­

rase 168 UDP-Giucuronosyltrans­

ferase 167, 168 UDP-Giucuronsiiure

166-168 UDP-Xylose Urocortisol Urocortison Uteroglobin

222

170 184, 185 185 119, 120, 130,

Uterus, Muskulatur 116 -,RNA 240 -, Schleimhaut 119, 122,

129 -, Steroidmetabolite 177,

183 -, Steroidrezeptoren 207,

210,214-216,222 -, Wachstum 123, 138, 212 Utilisationstherorie 164

Vagina, Schleimhaut 125, 126, 138, 212

-, Steroidrezeptoren 211 -, Tumoren 128 Valinverwertung zur Gluco-

neogenese 144 Vasodilatation 116, 123 Vasokonstriktion 116 Vasopressin 100 Verhalten, EinfluB von An-

drogenen 137,138,212 -, EinfluB von Cortico-

iden 141, 151, 152 -,- von Ostradiol 128,215 -, - von Peptiden 80 -,- von Progesteron 122 -, sexuelles 137, 212, 215,

264,265

Sachverzeichnis

Vermeideverhalten, ak­tives 80

Vesikulardriise 59, 115, 133,137,260,262

-, Testosteronbindung 212 -, tRNA-Synthese 243 -, Wachstum 87, 128, 135,

136, 138 Virilisierung 193, 221 -, Adrenogenitales Syn-

drom 52, 57, 267 -, p-Aminoglutiithimid 43 -, Anabolika 139 -, synthetische Gesta-

gene 267 Vitamin C -> Ascorbinsiiure Vitamin 0 2 -> Ergocalciferol Vitamin 0 3 -> Cholecalciferol

·vitellogenin 124, 156

Wachstumshormon 87, 88, 106, 138

Wannenform 5-8, 10 Wasserstoffbriicken-Bin­

dung 226,238

Xyloside 170 Xylosyltransferase 170

Zellcyclus 108, 139, 229, 230,255,264

Zelldifferenzierung 3, 70, 82, 85, 108, 118, 135, 141,209,263-272

Zellteilung 264 Zellwachstum 108 Zentrales Nervensystem

(ZNS) 94

349

-, Steroidrezeptoren 96 -, Wirkung, Corticotro-

pin 71,80 -, - cyclische Nucleo-

tide 108 -, - Peptide 80 -,- Prolactin 71, 88 -,- Prostaglandine 95,

112 -, - Proteohormone 71 -,- Steroide 118, 152 Zink 59,92 Zona fasciculata 48, 49, 51,

74 - functionalis 123 - glomerulosa 48, 49, 51,

74,93 - reticularis 48, 49, 51, 74 Zymosterin 21, 26

P. v. Sengbusch Einfiihrung in die Allgemeine Biologie Hochschultext 221 Abbildungen und 64 Schemata. VI, 475 Seiten. 1974 DM 29,80; US$ 12.30 ISBN 3-540-06810-4 Inhaltsiibersicht: Organisationsebenc: Zelle. - Organisationsebene: Vielzeller. - Organisationsebene: Gesellschaften. -Evolution.

Biologie Ein Lehrbuch ftir Studenten der Biologie Gemeinschaftlich verfaBt von zahlreichen Fachwissenschaftlem Herausgeber: G. Czihak, H. Langer,H. Ziegler 957 Abbildungen, 2 Falttafeln. XXIII, 837 Seiten. 1976 Gebunden DM 58,- ; US S 23.80 ISBN 3-540-05727-7 Jnhaltsiibersicht: Bau und Leistungen der Zellen: Cytologie. - Strukturen und Funktionen derOrganismen: Genetik. F ortpflanzung und Sexualitiit. Entwicklung. Bau und Funktion pflanzlicher und tierischer Organe. Strukturelle und funktionelle Integration im Gesamtorganismus. Verhalten. - Die Organismen in Population en: Okologie. Biogeographie: Verbreitung der Pflanzen und Tiere. Evolution. Grundlagen und Ziele der biologischen Systematik. Stammbaume der Pflanzen und Tiere. Sachverzeichnis

Physiologische Chemie Eine Einft.ihrung in die medizinische Biochemie ft.ir Studierende der Medizin und A.rzte Von H. A. Harper, G. Li:iffier, P. E. Petrides, L. Weiss. 644 Abbildungen, 189 Tabellen. XI, 940 Seiten. 1975 DM 88,-; US$ 36.10 ISBN 3-540-07490-2 Inhaltsiibersicht: Teil A: Stoffe und Stoffwechsel der Zelle. Stoffe: Bausteine der Zelle: Wasser- und Bioelemente. Kohlenhydrate. Lipide. Nucleotide und Polynucleotide (Nucleinsauren). Aminosauren und Polyaminosauren (Proteine). Stoffwechsel: Energie- und Materieum­satz der Zelle: Mechanismus und Regulation der Proteinbiosynthese. Enzyme. Bioenergetik und biologische Oxidation. Citratcyclus. Stoff­wechsel der Kohlenhydrate. Stoffwechsel der Lipide. Stoffwechsel der Aminosauren. Stoffwechsel der Purine und pyrimidine. - Por­phyrine und Gallenfarbstoffe. Grundlagen der Emahrung. Wasser­und Elektrolyt-Haushalt. Spurenelemente und Vitamine. - Teil B: Struktur und Stoffwechsel der Gewebe: Hormone. Gastrointestinal­trakt. Leber. Blut. Muskelgewebe. Binde- und Stiitzgewebe. Nerven­gewebe. Immunsystem. Nieren und Urin. - Hinweisindex zum Gegen­standskatalog Physiologische Chernie. - Sachverzeichnis.

C. Bresch, R. Hausmann Klassische und Molekulare Genetik 3. erweiterte Auflage. Zahlreiche Abbildungen, 32 Tafeln. XI, 415 Seiten. 1972 DM 42,- ; US$ 17.30 ISBN 3-540-05802-8

Springer-Verlag Berlin Heidelberg New York

Grundrill der Sinnesphysiologie Herausgeber: R. F. Schmidt Mit Beitragen von H. Altner et al. 2. Auflage. 122 Abbildungen, 109 Testfragen zur Selbstkontrolle. X, 249 Seiten. 1976. (Heidelberger Taschenbi.icher, 136. Band. Basistext Medizin) DM 18,80; US S 7.80 ISBN 3-540-07587-9 Inha/tsiibersicht: Allgemeine Sinnesphysiologie. - Somato-viscerale Sensibilitat. - Physiologie des Sehens. - Physiologie des Horens. -Physiologie des Gleichgewichtssinnes.- Physiologie des Geschmacks.­Physiologie des Geruchs. - Durst und Hunger: Allgemeinempfindun­gen. - Antwortschli.issel. - Sachverzeichnis.

W. F. Ganong Lehrbuch der Medizinischen Physiologie P.ie Physiologie des Mensch en ftir Studierende der Medizin und A.rzte. Ubersetzt, bearbeitet und erganzt von W. Auerswald in Zusammen­arbeit mit B. Binder, A. Haidenthaler, J. Mleczoch 3., vollig neu bearbeitete und erweiterte Auflage. 545 Abbildungen, 150 Tabellen, 1 Anhang, XVIII, 811 Seiten. 1974 DM 48,-; US S 19.70 ISBN 3-540-06440-0 Inhaltsiibersicht: Physiologie der Nerven- und Muskelzellen. Funktio­nen des Nervensystems. Endokrinologie und Zwischenstoffwechsel. Gastrointestinale Funktionen. Zirkulation. Atmung. Nierenfuktion, Wasser- und Elektrolyt-Haushalt.

J. van Lancker Molecular and CeUular Mechanisms in Disease 411 figures, 68 tables. XX, 1168 pages. 1976 Cloth DM 362,-; US S 148.50 (in 2 parts, not available separately) ISBN 3-540-06932-1 Contents: Cellular Sources of Energy. - Determination of Cellular Specificity. -Inborn Errors of Metabolism. -Malnutrition. -Calcium and Phosphorus Metabolism. - Iron and Bile Pigment Metabolism. -Blood Coagulation. - Hormones. - Alterations of Body Fluids and Electrolyte Metabolism. - Cellular Death and Degeneration. - Blood Lipids in Arteriosclerosis and Hyperlipidemia. - Radiation. - Inflam­mation. -Immunopathology. -Regeneration, Hypertrophy, and Wound Healing.- Cancer.

E. Gurpide Tracer Methods in Hormone Research 35 figures. XI, 188 pages. 1975 Cloth DM 72,-; US$ 29.60 ISBN 3-540-07039-7 Contents: Rates in Open System in the Steady State: Definitions and Relations. -Infusion of Tracers at a Constant Rate. -Rapid Injection of Tracers. - Tracer Kinetics in Compartmental Models. - Interpretation of Isotopic Data from Blood-Borne Compounds. - Rates of Secretion and Metabolism of Hormones Estimated from Specific Activities of Urinary Metabolites. - In vitro Tracer Superfusion Experiments.

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