11 th BALATON SYMPOSIUM · Balaton Symposium brings together separation scientists and friends from...

Final Program

In memoriam of Ernő Tyihák

on High-Performance Separation Methods

th BALATON SYMPOSIUM


11September 6–8, 2017, Hotel Azúr , Siófok, Hungary

Hungarian Academy of Sciences

Hungarian Society for Separation Sciences

Working Committee on Separation Sciencesof the

and the

Organizers of the Symposium

2

thDear Participants of the 11 Balaton Symposium,

Attila FelingerSymposium Chairman

On behalf of the Organizing Committee, it gives me a great pleasure to thwelcome you at the 11 Balaton Symposium on High-Performance Separation

Methods.

The Hungarian Society for Separation Sciences (HSSS) is happy to continue the well-established series of Balaton Symposia. It is extraordinary that biannually the Balaton Symposium brings together separation scientists and friends from all over the world.

thThe aim of the 11 Balaton Symposium is to bring together experts, users, and scientists of high-performance separation methods to discuss the latest issues, current requirements, and technological challenges we face in the present and future.

Our community has been saddened by the news that Professor Ernő Tyihák passed away on February 13, 2017 at the age of 84. Prof. Ernő Tyihák was one of the Hungarian pioneers of separation sciences. He was the main inventor of overpressured layer chromatography (OPLC). He combined OPLC with direct bioautography and further developed it to the BioArena system which is suitable to study the mechanism of effect of antibiotic compounds. He has been an active scientist until the last minute of his life. He published papers and books and presented lectures until the last day of his life as intensely as before retirement.

thSadly, we dedicate the 11 Balaton Symposium to the memory of Professor

Ernő Tyihák.

The Balaton Symposium traditionally provides a forum to celebrate outstanding separation scientists. The Halász Medal Award and the Csaba Horváth Memorial Award are to be presented at the opening ceremony. For the first time at the symposium, the Ervin sz. Kováts Award for Young Scientists will be presented. The 2017 award honors PhD dissertations accomplished by young researchers, defended or published between January 2015 and December 2016. The award is endowed with an amount of 4000 CHF in addition to a diploma and an

thinvitation to the 11 Balaton Symposium.thThe scientific program of the 11 Balaton Symposium clearly demonstrates

the breadth of separation science; it includes 56 oral lectures from diverse areas. Important scientific results and advances are discussed in the poster sessions with 54 poster presentations. The exhibition includes 12 vendors displaying the latest commercial advances of separation techniques.

Many people need to be thanked for making this Symposium possible. I would like to thank the members of the International Scientific Committee for promoting the Symposium. I also thank our sponsors and exhibitors for providing generous financial support. Special thanks go to all of the people who submitted excellent abstracts from many areas of separation science.

thI wish all participants of the 11 Balaton Symposium an intellectually stimulating and rewarding meeting as well as an enjoyable time in Siófok.

3

Ernő Tyihák (1933–2017)

Professor Ernő Tyihák, former scien-tific adviser at Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences (HAS)

thpassed away on 24 February 2017.

Ernő Tyihák was a highly respected expert in the field of conventional as well as forced-flow planar layer chromato-graphy. He mainly focused on the practical aspects of chromatography that was an important tool for him to better understand biological phenomena. He was a great innovator, passionately developing research methods to expand their applicability as well as improving their efficiency and modelling the life processes.

thProf. Tyihák was born on 29 January 1933 in Tiszaföldvár, Hungary and

spent his childhood there, in his words: “in the Hungarian Provence”. He graduated as a chemical engineer from the Technical University of Budapest in 1958. In that year he chose a job in the Research Institute for Medicinal Plants (Budapest, later Budakalász), because he was interested in the research of medicinal natural substances – an interest that lasted for a lifetime. He examined essential oils, the variability of the constituents of endemic medicinal plants (chemotaxonomy) and started the investigation of the role of formaldehyde in the biological world, mainly by the use of thin-layer chromatography (TLC), thus he pioneered the spread of thin-layer chromatography in Hungary. The “map-chromatography” and the ultramicro chamber (elimination of vapour phase from the TLC system) were introduced by him for the better separation of natural products.

In 1978, he obtained the candidate of chemical science degree of the Hungarian Academy of Sciences in biochemistry and the technical doctor degree at Technical University of Budapest for the isolation of antitumoral substances from plants and mushrooms such as clavicepamines (iso-poly-peptides) from saprophytic Claviceps purpurea.

4

Prof. Tyihák was the leading co-inventor of overpressured layer chromatography (OPLC), one of the forced–flow planar layer chromato-graphic techniques. In 1979, the combination of a pressurized ultramicro chamber and a pump system led to OPLC, the real planar version of HPLC. A series of patent applications in the field of OPLC were announced and the instruments were introduced to the market. In 1994, he obtained the doctor of chemical sciences (DSc) degree of the Hungarian Academy of Sciences in analytical chemistry in the field of OPLC.

Later, his main research fields beyond OPLC were stress- and resistance-biology. In 1983 he was invited to the Plant Protection Institute of HAS (now Plant Protection Institute, Centre for Agricultural Research, HAS) to organize and direct the Department of Resistance-Biology and Bio-chemistry, where he worked till the end of 2011 as a scientific adviser. He examined the role of formaldehyde in disease-resistance, the normal and abnormal cell proliferation and the natural apoptosis. He introduced several new technical terms, among others the formaldehyde cycle, the double and the quadruple immune response. Also, he is the inventor of BioArena, the improvement of direct bioautography that allows the examination of the antimicrobials' action mechanism.

The education of younger generations was very important to him and he was always glad to pass his knowledge on to his colleagues. Although he worked at research institutes, he became a lecturer at Budapest University of Technology and Economics for chromatography, mainly OPLC, he was a titular associate professor at the Semmelweis (Medical) University (Budapest), as well as honorary professor at University of Szeged (Szeged, Hungary) for chromatography and pharmacognosy.

Prof. Tyihák was full of enthusiasm for his scientific investigations and was always ready to co-operate. He published over 200 scientific papers, wrote several book chapters and had 25 patent applications. He received numerous awards as an appreciation for his scientific achievements (Béla Tankó award in 1972, Győző Bruckner award in 2004, Hormesis award in 2007 and Candin Liteanu Medal and Diploma in 2011).

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Symposium Chairman

Honorary Chairman

International Scientific Committee

Attila Felinger, Pécs, Hungary

László Szepesy, Budapest, Hungary

Bezhan Chankvetadze, Tbilisi, GE

Gert Desmet, Brussels, B

Attila Felinger, Pécs, H

Mária Gazdag, Budapest, H

Michal Holčapek, Pardubuce, CZ

Pat Sandra, Kortrijk, B

Peter Schoenmakers, Amsterdam, NL

Gyula Vigh, College Station, TX, USA

Mónika Babják, Budapest

László Drahos, Budapest

Attila Felinger, Pécs

Mária Gazdag, Budapest

Attila Gáspár, Debrecen

Krisztián Horváth, Veszprém

Tamás Janáky, Szeged

Imre Klebovich, Budapest

Ágnes Móricz, Budapest

6

Symposium Secretariat

Diamond Congress Ltd.H-1255 Budapest, P.O.B 48Phone: +36 1 2250210 Fax: +36 1 2012680E-mail: [email protected]

Organizing Committee

†Csaba Horváth (1997) Yale University, New Haven, CT, USAHeinz Engelhardt (1997) Saarland University, Saarbrücken, GermanyAntoine Siouffi (1998) Université Paul Cézanne, Marseille, France†Georges Guiochon (1999) University of Tennessee, Knoxville, TN, USA†Ernst Bayer (2001) University of Tübingen, Tübingen, GermanyBarry L. Karger (2002) Northeastern University, Boston, MA, USAGünther Bonn (2003) Leopold-Franzens University, Innsbruck, Austria†Ervin Sz. Kováts (2004) École Polytechnique Fédérale de Lausanne,

Lausanne, Switzerland†Uwe D. Neue (2005) Waters Corporation, Milford, MA, USAWolfgang Lindner (2007) University of Vienna, Vienna, AustriaLászló Szepesy (2009) Budapest University of Technology and Economics,

Budapest, HungaryGyula Vigh (2011) Texas A&M University, College Station, TX, USANobuo Tanaka (2013) Kyoto Institute of Technology, Kyoto, JapanJanusz Pawliszyn (2015) University of Waterloo, Waterloo, Canada

John Frenz (2004), Alnylam, Cambridge, MA, USAImre Molnár (2005) Molnár-Institute, Berlin, Germany†Szabolcs Nyiredy (2007, posthumous) Research Institute for Medical Plants,

Budakalász, HungaryDanilo Corradini (2009) Institute of Chemical Methodologies of the Italian

Research Council, Rome, ItalyPeter W. Carr (2010) University of Minnesota, Minneapolis, MN, USAGünther Bonn (2011) Leopold-Franzens University, Innsbruck, AustriaFred Regnier (2012) Purdue University, West Lafayette, IN, USAPat Sandra (2013) Ghent University, Ghent, Belgium†Joseph J. Kirkland (2014) Advanced Materials Technology, Wilmington, DE, USAPeter Schoenmakers (2015) University of Amsterdam, Amsterdam,

The NetherlandsJames Jorgenson (2016) University of North Carolina, Chapel Hill, NC, USA

Honored with the Halász Medal Award:

Honored with the Csaba Horváth Memorial Award:

7

Awards

The Halász Medal Award (founded in 1997 by the Hungarian Society for Separation Sciences) as well as the Csaba Horváth Memorial Award (founded in 2004 by the Hungarian Society for Separation Sciences and presented jointly with the Connecticut Separation Science Council since 2010) will be presented during the Symposium.

Gold sponsors

Platinum sponsor

Silver sponsor

Exhibitors

8

ABL&E-JASCO Hungary Ltd.

B&T Service Ltd.

CP-ANALITIKA Ltd.

Gen-Lab Ltd.

Kromat Ltd.

Lab-Comp Ltd.

Merck Ltd.

Molnár-Institute for Applied Chromatography

Per-Form Hungária Ltd.

SIMKON Ltd.

UNICAM Hungary Ltd.

Waters Ltd.

Scope of the Symposium

Venue

Website

Opening hours of the registration

Onsite contact number

Badges

Official language

Key to lectures & posters

thThe focus of the 11 Balaton Symposium on High-Performance Separation Methods will be on the various analytical, preparative, and industrial separation methods and techniques. The symposium will place special emphasis on new developments in pharmaceutical, environmental, biomedical, forensic, life sciences and industrial separation methods. Further, research trends on various stationary phases and column technology, advances in separation techniques, fundamentals of separation science and applications are to be emphasized.

Hotel Azúr 8600 Siófok, Erkel Ferenc utca 2/C.

Tel.: +36 84 501 400

You will find the latest details on the website at www.balaton.mett.hu

Wednesday, September 6, 2017 Thursday, September 7, 2017 Friday, September 8, 2017

08:00 – 18:0008:00 – 18:0008:00 – 13:00

In the lobby ofHotel Azúr:

Attila Varga +36 20 936 2969 Diamond Congress Ltd.

All participants and accompanying persons will receive a personal badge upon registration. You are kindly requested to wear your name badge when attending the meetings or social events.

Official language of the Symposium is English. No translation is available.

LMLP

– Lecture presentation– Manufacturers' lecture– Poster 9

Exhibition

City bus connection

Cultural program

Liability and insurance

Meals

Internet

Social programs

Payment, invoices

In accordance with the conventions of the symposium, parallel to the scientific sessions a professional exhibition is to be organized in the lobby of Hotel Azúr. Please have a look at the exhibition floor plan of the booklet. The exhibition will be open during the whole scientific program.

Every participant will be served breakfast in their hotel. Lunches and dinners will be served in Hotel Azúr. Extra consumption, which is not included in the menus are kindly requested to settle prior to departure.

Wednesday, September 6, 19.00 – 20.00: Entertainment of St. Martin saxophone performer in room Toscana I.

Wednesday, September 6, 20:00 – 24:00: Gala Dinner in the Corinthia Restaurant.Music will be provided by Madarak Music Band.

Thursday, September 7, 20:00 – 24:00: Grill party in the garden of Hotel Azúr.Music will be provided by the Shisha Café Band.

Separate invitation cards will be provided during the registration.

City bus No.1. from the Siófok Railway station to Hotel Azúr.

A free-of-charge wireless service is available in Hotel Azúr.

The organizers cannot accept liability for any personal accidents, loss of belongings or damage to private property of participants and accompanying persons that may occur during the Symposium.

The price of the ordered services will be indicated on the final invoice according to the Hungarian official financial rules. Official final invoices and receipts for fees paid by the participants will be handed over on site at the registration desk. Please forward them to the financial department of your Institution.

10

Oral presentations (L-01 – L-53, ML-1 – ML-3)

Poster Presentations

Poster competition

The length of oral presentations is either 30, 20 or 15 minutes. The organizers suggest leaving 5 minutes for questions and discussion. The organizers kindly ask a strict adherence to the agreed time, as the session chairs will be asked to rigorously maintain the time schedule. During the presentation the lecturer will have a laptop (Windows PC) and a microphone at their disposal. The presentation may be prepared in any available presentation format (MS Office, OpenOffice, LibreOffice, Prezi, pdf, etc.). Please bring your presentation on a USB key. Transferring individual presentations to the laptops will take place before the start of the symposium each day and during coffee or lunch breaks. 30 min. prior to your session at the latest.

Poster session I: P-01 – P-27Wednesday, September 6, 2017, 16:30 – 18:45 Rooms Ibiza I. and Toscana II.

Poster session II: P-28 – P-55

Thursday, September 7, 2017, 17:00 – 19:00 Room Toscana II.

The useful area of the poster board is 90 cm at width and 125 cm at height. The recommended size for your poster is about the standing A0 standard (cca. 84 x 119 cm). Pins will be provided to fix the posters. Posters will be identified by posters numbers, which are printed in the final program. Poster presenters are kindly requested to hang up their poster on Wednesday morning and remove their posters on Friday noon.Authors of posters should stand at their posters and be available to discuss their research during the Poster Sessions on Wednesday or Thursday according to the schedule in the final program.

Posters numbered P-1 – P-16 are located in Room Ibiza I. whereas P-17 – P-55 posters can be found in Toscana II.

A poster Award Committee will evaluate the poster presentations and valuable awards will be conferred at the Poster Award Ceremony preceding the Closing Remarks.

11

Scientific Information

Participants are invited to submit manuscripts based on their oral or poster presentations for possible publication in Chromatographia, with their intention of

thincluding them in a Topical Collection devoted to the 11 Balaton Symposium. Manuscripts will be subject to a regular refereeing procedure. Please consult the journals' homepage for format details. Manuscripts are to be delivered electronically not later than September 30, 2017 via the journal's online submission and reviewing system.

Hotel rooms are booked under the name of the participants. Symposium participants may occupy the rooms from 14:00 on the day of arrival and should arrange the check out until 10:00. The hotel ensures a luggage room. The guarded parking lot of the hotel is available for our participants free of charge. Guests are kindly requested to settle their extra room bills (such as phone calls, drinks and minibar) prior to departure.

The room prices include buffet breakfast, the usage of wellness facilities (pools, jacuzzi, sauna park and steam bath), VAT and city tax.

12

Symposium proceedings

Accommodation

Venue of the

13

on High-Performance Separation Methods



11Hotel Azúr Wellness & Conference Centre

Hote

l Azúr

Hote

l Azúr

Budapest

Budapest

Budapest

14

Scientific Program

15

Plenary Session I. – Room Toscana I.

11:10 –11:4011:10 –11:4011:10 –11:4011:40 –12:1011:40 –12:1011:40 –12:1012:10 –12:3012:10 –12:3012:10 –12:30

12:30 –12:4512:30 –12:4512:30 –12:45 12:30 –12:5012:30 –12:5012:30 –12:50

14:30 –15:0014:30 –15:0014:30 –15:0015:00 –15:3015:00 –15:3015:00 –15:3015:30 –15:5015:30 –15:5015:30 –15:5015:50 –16:1015:50 –16:1015:50 –16:10

16:10 –16:3516:10 –16:3516:10 –16:35

MorlockVovkMóriczLorántfyKanakaki

JungbauerGrittiBroeckhovenBorowiak

MolnárGuillarmeHorváthde ZeeuwCross

HopfgartnerHolčapekTuriákSteppertTóth

VértesUrbaniDrahosBobály

OtsukaKutterGáspárDe Vos

L-01L-02L-03L-04

L-05L-06L-07L-08L-09

L-15L-16L-17L-18L-19

L-25L-26L-27ML-1

L-32L-33L-34L-35ML-2

L-20L-21L-22L-23L-24

L-28L-29L-30L-31

L-36L-37L-38L-39

No.

No.

No.

No.

No.

No.

No.

No.

No.

ChankvetadzeNolvachaiSchoenmakersDesmetS

peakers

McCalleyCavazziniIliszCataniSepseyS

peakers

Speakers

Speakers

Speakers

Speakers

Spea

kers

Speakers

Speakers

Speakers

Opening CeremonyOpening CeremonyOpening Ceremony10:00 –10:1010:00 –10:1010:00 –10:10

Presentation of the Halász Medal Award,Presentation of the Halász Medal Award,Csaba Horváth Memorial Award andCsaba Horváth Memorial Award andErvin sz.Kováts Award for Young ScientistsErvin sz.Kováts Award for Young Scientists

Presentation of the Halász Medal Award,Csaba Horváth Memorial Award andErvin sz.Kováts Award for Young Scientists

10:10 –10:3010:10 –10:3010:10 –10:30

12:30 –14:00 12:30 –14:00 12:30 –14:00

15:55 –16:30 15:55 –16:30 15:55 –16:30

Poster Session I.Poster Session I. – Rooms Ibiza I.Poster Session I. – Rooms Ibiza I. and Toscana II.

16:30 –18:4516:30 –18:4516:30 –18:45

19:00 Cultural Program19:00 Cultural Program19:00 Cultural Program

20:00 Gala Dinner20:00 Gala Dinner20:00 Gala Dinner

Parallel Session I. – Room Toscana I.

Coffee Break & ExhibitionCoffee Break & ExhibitionCoffee Break & Exhibition


Lunch & ExhibitionLunch & ExhibitionLunch & Exhibition



10:25 –11:1010:25 –11:1010:25 –11:10

Parallel Session III. – Room Toscana I. Parallel Session IV. – Room Marbella I.-II.

Lunch & Exhibitio n Lunch & Exhibitio n Lunch & Exhibitio n 12:50 –14:3012:50 –14:3012:50 –14:30

Parallel Session V. – Room Toscana I. Parallel Session VI. – Room Marbella I.-II.

16:35 –17:0016:35 –17:0016:35 –17:00Poster Session II.Poster Session II. – Room Toscana II.Poster Session II. – Room Toscana II. 17:00–19:0017:00–19:0017:00–19:00

20:00 Grill Party20:00 Grill Party20:00 Grill Party

Parallel Session VII. – Room Toscana I.

Parallel Session IX. – Room Toscana I.

Parallel Session VIII. – Room Marbella I.-II.

Parallel Session X. – Room Marbella I.-II.

10:25 –11:1010:25 –11:1010:25 –11:10

8:30 – 9:00 8:30 – 9:00 8:30 – 9:00 9:00 – 9:20 9:00 – 9:20 9:00 – 9:20 9:20 – 9:40 9:20 – 9:40 9:20 – 9:40 9:40 – 9:55 9:40 – 9:55 9:40 – 9:55

9:55 –10:109:55 –10:109:55 –10:1010:10 –10:2510:10 –10:2510:10 –10:25

BonnCorradiniEkeBartosińskaÁcs

TarafderSallayLambertBenkovicsHorváthTimmerman

L-40L-41L-42L-43L-44ML-3

L-45L-46L-47L-48L-49

Plenary Session II. – Room Toscana I.

No.

Spea

kers 11:10 –11:4011:10 –11:40

11:40 –12:1011:40 –12:1012:10 –12:4012:10 –12:4012:40 –13:1012:40 –13:10

11:10 –11:4011:40 –12:1012:10 –12:4012:40 –13:10

Marko-VargaVighMarriottSandra

L-50L-51L-52L-53

10:30 –11:0010:30 –11:0011:00 –11:3011:00 –11:3011:30 –12:0011:30 –12:0012:00 –12:3012:00 –12:30

10:30 –11:0011:00 –11:3011:30 –12:0012:00 –12:30

8:30 – 9:00 8:30 – 9:00 9:00 – 9:30 9:00 – 9:30 9:30 – 9:50 9:30 – 9:50 9:50 –10:10 9:50 –10:1010:10 –10:2510:10 –10:25

8:30 – 9:00 9:00 – 9:30 9:30 – 9:50 9:50 –10:1010:10 –10:25

14:00 –14:3014:00 –14:3014:30 –15:0014:30 –15:0015:00 –15:2015:00 –15:2015:20 –15:4015:20 –15:4015:40–15:5515:40–15:55

14:00 –14:3014:30 –15:0015:00 –15:2015:20 –15:4015:40–15:55

Septe

mber

6,

Wednesday

Poster Award Ceremony Poster Award Ceremony – Room Toscana I.– Room Toscana I.Poster Award Ceremony – Room Toscana I. 13:10 –13:2013:10 –13:2013:10 –13:20Closing RemarksClosing RemarksClosing Remarks 13:20 –13:3013:20 –13:3013:20 –13:30

Septe

mber

7,

Thurs

day

Septe

mber

8,

Fri

day

13: 3013: 3013: 30 LunchLunchLunch16

Parallel Session II. – Room Marbella I.-II.

BuszewskiLämmerhoferPastiPernyesziSimon

L-10L-11L-12L-13L-14

No.

Speakers

Timetable

L – lectureML – manufacturers' lecture

Codes

– Room Toscana I.

September 6, Wednesday

Plenary Session I.

10:10–10:30 Presentation of the Halász Medal AwardPresentation of the Csaba Horváth Memorial AwardPresentation of the Ervin sz. Kováts Award for Young Scientists

10:00–10:10

Opening Ceremony

L-01

10:30–11:00

Recent Developments in Liquid-Phase Separation of Enantiomers by Using Polysaccharide Derivatives as Chiral Selectors

Chankvetadze, B.

Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Tbilisi, Georgia

L-02

11:00–11:30

Computational Strategies for Stationary Phase Selection and Experimental Design in Multidimensional Gas Chromatography

Nolvachai, Y.*, Kulsing, C. and Marriott, P.J.

Australian Centre for Research on Separation Science, School of Chemistry, Monash University, Clayton, Australia

L-04

12:00–12:30

On the Advantage of Ordered Separation Media

Desmet, G.

Department of Chemical Engineering, Vrije Universiteit Brussels, Brussels, Belgium

12:30 – 14:00 Lunch & Exhibition

L-03

11:30–12:00

LC LC – Unconventional Interfacing in Comprehensive Two-Dimensional Liquid Chromatography

1 2 1,3 1,3Schoenmakers, P. *, Gargano, A. , Pirok, B. , Wouters, B. , 1,4Peters, R.

1 Van 't Hoff Institute for Molecular Science (HIMS), University of Amsterdam, Amsterdam, The Netherlands 2 Centre of Analytical Sciences Amsterdam (CASA), Amsterdam, The Netherlands3 TI-COAST, Amsterdam, The Netherlands4 DSM Coating Resins, Waalwijk, The Netherlands

17

Chair: Attila Felinger and Gyula Vigh

Parallel Session I.

L-05

14:00–14:30

Investigation of the Retention of Acidic Solutes in Hydrophilic Interaction Chromatography

McCalley, D.

Department of Applied Sciences, University of the West of England, Bristol, UK

L-06

14:30–15:00

Ultrafast Chiral Separations in Liquid Chromatography through Superficially Porous and Sub-2-Micron Fully Porous Particles

1 1 1 2 2Cavazzini, A. *, Catani, M. , Pasti, L. , Gasparrini, F. , Ismail, O.1 University of Ferrara, Ferrara, Italy2 University of Rome, Rome, Italy

L-07

15:00–15:20

Enantiomeric Separations by Ion Exchanger-Based Chiral Stationary Phases

1 1 1 1 1,2Ilisz, I. *, Péter, A. , Orosz, T. , Bajtai, A. , Lajkó, G.1 Department of Inorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary2 Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary

L-08

15:20–15:40

Investigation of Mass Transfer Phenomena in Zwitterionic Chiral Stationary Phases

1 2 1 3 2,4Catani, M. *, Bacskay, I. , Cavazzini, A. , Lindner, W. , Felinger, A.1 Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy2 MTA–PTE Molecular Interactions in Separation Science Research Group, Pécs, Hungary3 Department of Analytical Chemistry, University of Vienna, Vienna, Austria4 Department of Analytical and Environmental Chemistry and Szentágothai Research Center, University of Pécs, Pécs, Hungary

L-09

15:40–15:55

Rate Constant Determination from Chromatograms Using the Stochastic Theory of Batman Peaks

1 1,2Sepsey, A. *, Felinger, A.1 Department of Analytical and Environmental Chemistry and Szentágothai Research Center, University of Pécs, Pécs, Hungary2 MTA-PTE Molecular Interactions in Separation Sciences Research Group, Pécs, Hungary


18

Chair: Jörg Kutter and Pat Sandra

L-10

14:00–14:30

Metabolomics In vitro and In vivo Clinical Studies by Coupled Separation and Mass Spectrometry Techniques

1,2 1,2Buszewski, B. *, Szultka-Młyńska, M.1 Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Torun, Poland2 Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, Torun, Poland

L-11

14:30–15:00

Sample Preparation Strategies by Functionalized Nanoparticles

Lämmerhofer, M.

Pharmaceutical (Bio-)Analysis, Institute of Pharmaceutical Sciences, University of Tübingen, Tübingen, Germany

L-12

15:00–15:20

Zeolites for Pharmaceuticals Removal from Water1 1 1 2Pasti, L. *, Cavazzini, A. , Marchetti, N. , Martucci, A.

1 Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy2 Department of Physics and Earth Sciences, University of Ferrara, Ferrara, Italy

L-13

15:20–15:40

Bioadsorption Processes1,2 1,2 3,5 2,4Pernyeszi, T. *, Honfi, K. , Kőnig-Péter, A. , Nagy, L. ,

1,2Csudai, Cs.1 Department of Analytical and Environmental Chemistry Faculty of Sciences, University of Pécs, Pécs, Hungary2 Department of General and Physical Chemistry Faculty of Sciences, University of Pécs, Pécs, Hungary3 Environmental Analysis and Geoanalytical Research Group Szentágothai Research Centre, University of Pécs, Pécs, Hungary4 Green Chemistry Research Group Szentágothai Research Centre University of Pécs, Pécs, Hungary5 Institute of Bioanalysis Faculty of Medicine University of Pécs, Pécs, Hungary

L-14

15:40–15:55

Correlation Analysis on a Series of 1D and 2D Chromatograms1 1,2Simon, J. *, Felinger, A.

1 MTA-PTE Molecular Interactions in Separation Science Research Group, Pécs, Hungary2 Department of Analytical and Environmental Chemistry and Szentágothai Research Center, University of Pécs, Pécs, Hungary


Parallel Session II.

15:55 – 16:30 Coffee Break & Exhibition

16:30 – 18:45 Poster Session I. – Detailed list on the next four pages

19:00 Cultural Program

20:00 Gala Dinner 19

Chair: Danilo Corradini and Michal Holčapek

P-01

Investigation of a Multiplex Sampling System with the Use of a Barrier Ionization Discharge Detector for Gas Chromatography

Antoniadou, M.*, Rosenberg, E.

Institute of Chemical Technologies and Analytics, Vienna University of Technology, Vienna, Austria

P-02

Determination of Fatty Acids from Different Cell Cultures by Gas Chromatography

2 1 1 2 3 3Gór-Nagy, Zs. *, Mátyási, J. , Balla, J. , Tóth, B. , Sarnyai, F. , Zámbó, V. , 3Csala, M.

1 B&B Analytics Ltd., Érd, Hungary

2 Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Hungary

3 Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary

P-03

Experiments to Decrease the PAH Content of Bone Oil

1 1 1 2 2Matók, Zs. *, Gura, B. , Kalauz, A. , Mátyási, J. , Balla, J.

1 Department of Inorganic and Analytical Chemistry,Budapest University of Technology and Economics, Budapest, Hungary


P-04

Analysis of Trans Fatty Acids - Development and Validation of a Gas Chromatographic Method

1 2 2Szabó, R. *, Mátyási, J. , Balla, J.



P-05

Noninvasive Investigation on the State of the Column During CIP

Meckel-Yoneyama, B.

DAISO Fine Chem GmbH., Duesseldorf, Germany

Poster Session I.September 6, Wednesday 16:30–18:45

P-06

Characterization of Stable-Bond Reversed Phase/Weak Anion-Exchange Mixed-Mode Stationary Phases and the Benefit of Strong Acidic Co-Ligands

Bäurer, S.*, Zimmermann, A., Horak, J., Lämmerhofer, M.

Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-) Analysis, University of Tübingen, Tübingen, Germany

20

P-07

Renewal of an Old European Pharmacopoeia Method for Terazosin Using Modeling with Mass Spectrometric Peak Tracking

1 2Kormány, R. *, Molnár, I.

1 Egis Pharmaceuticals Plc., Budapest, Hungary

2 Molnár-Institute for Applied Chromatography, Berlin, Germany

P-08

De Gustibus Non Est Disputandum…, but in Matters of Columns There Is(In Matters of Taste There Can Be No Disputes, but in Matters of Columns There Is)

Győrffy, P.Á.

Analytical Laboratory of Formulation Development, Gedeon Richter Plc., Budapest, Hungary

P-09

UPLC-DAD and HPLC-DPPH Methods for Profiling the Accumulation of Lysimachia Flavonoids and their Participation to the Antioxidant Capacity

Tóth, A.*, Riethmüller, E., Alberti, Á., Kéry, Á.

Department of Pharmacognosy, Semmelweis University, Budapest, Hungary

P-10

High-Performance Separation of Aliphatic and Aromatic Carboxylic Acids with Macrocycle-Based Anion Chromatography

Lukács D.*, Horváth K., Hajós P.

Department of Analytical Chemistry, University of Pannonia, Veszprém, Hungary

P-11

Profiling Plasma Phospholipids by HILIC Chromatography Coupled to High-Resolution Mass Spectrometry

1 1 2 2 1Tömösi, F. *, Berkecz, R. , Lantos, I. , Endrész, V. , Janáky, T.

1 Department of Medical Chemistry, University of Szeged, Szeged, Hungary

2 Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary

P-12

Development and Application of a Novel Comprehensive Online Two-Dimensional Liquid Chromatography Coupled with High-Resolution Mass Spectrometry Method in Lipidomics

Berkecz, R.*, Tömösi, F., Körmöczi, T., Janáky, T.

Department of Medical Chemistry, University of Szeged, Szeged, Hungary

P-13

LC-MS/MS Method Development for Quantitative Analysis of Tryptophan Metabolites

Kecskeméti, G.*, Tömösi, F., Berkecz, R., Szabó, Z., Janáky, T.

Department of Medical Chemistry, University of Szeged, Szeged, Hungary

21


P-14

Utilizaton of Microbore Size-Exclusion Chromatography for the Characterization of Macromolecules

Góra, R.*, Beňo, E., Hutta, M.

Faculty of Natural Sciences, Department of Analytical Chemistry, Comenius University in Bratislava, Bratislava, Slovak Republic

P-15

Combined New Approaches for Improved Quantitative and Qualitative LC-MS

Altmaier, S., Griesinger, H., Schulz, M., Appelblad, P.*

Instrumental Analytics R&D, Merck Life Science, Darmstadt, Germany

P-16

Recent Advances in Microextraction – Biocompatible Solid Phase Microextraction

Bell, D.S.*, Barrey, E., Lu, X.

MilliporeSigma/Supelco, Bellefonte, PA, USA

P-17

Analysis of Minor Substances in Isoindoline Yellow Pigment P.Y. 139

1 1 2 2Fischer, J. *, Landsmanová, M. , Šimková, K. , Vyňuchal J.

1 Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic

2 Synthesia a.s., Pardubice, Czech Republic

P-19

TLC-MS: Coupling Thin Layer Chromatography with Mass Spectrometry - a Practical Approach for Matrix-Loaded Samples

1 1 2 1Oberle, M. , Griesinger, H. , Matus, I. *, Schulz, M.

1 Instrumental Analytics R&D, Merck KGaA, Darmstadt, Germany2 Life Science Technical Marketing, Merck KGaA, Darmstadt, Germany

P-20

Straightforward Process for the Identification and Isolation of Natural Products Using Thin-Layer and Preparative Chromatography

1 1 2 2 2Sixt, M. , Strube, J. , Oberle, M. , Schulte, M. , Matus, I. *

1 Institute for Separation and Process Technology, Technical University Clausthal, Clausthal-Zellerfeld, Germany2 Merck Life Science, Darmstadt, Germany,

P-18

Optimization of HPLC Separation of Amino Acids Presented in Mead

Klikarová, J.

Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic


22

P-21

Beyond HPLC-MS: Profiling of High Molecular Weight Impurities during Drug Synthesis

Bauer, H., Matheis, K., Oberle, M., Griesinger, G., Michalski, A., Matus, I.*

Merck KGaA, Darmstadt, Germany

P-23

Retention Modeling of DryLab Software in an Extended Design Space

Rácz, N.*, Kormány, R.

Egis Pharmaceuticals Plc., Budapest, Hungary

P-24

Comparison of Hysteretical Behaviour on Amylosic and Cellulosic Columns

Horváth, S.*, Dancsó, A., Németh, G.

Egis Pharmaceuticals Plc., Budapest, Hungary

P-25

Identification of Natural Dyestuff in Historical and Archeological Textiles by HPLC-MS/MS

1 2Békési-Gardánfalvi, M. *, Hofmann, T.

1 Hungarian National Museum, Budapest, Hungary

2 Institute of Chemistry, University of West Hungary, Sopron, Hungary

P-22

Cave Air Analysis with Gas Chromatography Mass Spectrometry

1 2 1 2Nyerges, Gy. *, Mátyási, J. *, Szieberth D. , Balla, J.



P-26

Determination of Opioids in Human Urine with LC/MS, Using Deuterated Standard

Fábián, P.A.*, Kemenes, K., Somogyi, G.P.

Department of Toxicology, Hungarian Institute for Forensic Sciences, Budapest, Hungary

P-27

Simulated Moving Bed Enantiomer Separation of a Chiral Intermediate

Temesvári, K.

Synthetic Development Laboratory, Gedeon Richter Plc., Budapest, Hungary


23

September 7, Thursday


Parallel Session III.

24

Chair: Imre Klebovich and Imre Molnár

L-15

8:30–9:00

Office Chromatography – an Open-Source Based System

Fichou, D., Häbe, T., Morlock, G.*

Chair of Food Science, Institute of Nutritional Science, Justus Liebig University Giessen, Giessen, Germany

L-16

9:00–9:30

Challenges in Chromatographic Analyses of Secondary Metabolites of Physalis alkekengi L.

1 1 1 1 1Vovk, I. *, Kranjc, E. , Albreht, A. , Simonovska, B. , Glavnik, V. , 1 1 2Naumoska, K. , Križman, M. , Ferant, N.

1 Department of Food Chemistry, National Institute of Chemistry, Ljubljana, Slovenia2 Slovenian Institute for Hop Research and Brewing, Žalec, Slovenia

L-17

9:30–9:50

Applicability of Layer Chromatography Based Platform in Drug Discovery

Móricz, Á.

Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary

L-18

9:50–10:10

Significant Hungarian Contributions, Opportunities, and Challenges in Cannabinoid Research & Development

1 1,2 1,2 1,2Lorántfy, L. *, Rutterschmid, D. , Guan, Y.H. , Czirok, M.1 RotaCrom Technologiai Kft., Dabas, Hungary2 Budapest University of Technology and Economics, Budapest, Hungary

L-19

10:10–10:25

Innovative Screening Methods for the Determination of Non-Intentionally Added Substances in Food Contact Materials

1 1 2 2Kanakaki, C. *, Piniella, V.O. , Steiner-Reischütz, N. , Pyerin, M.1 OFI GmbH., Wiener Neustadt, Austria2 OFI GmbH., Vienna, Austria



L-24

10:10–10:25

Development of Self-Packed Columns for (Phospho)Proteomics1 2 2 1 1Tóth, G. *, Tóth, E. , Ozohanics, O. , Borsos, K. Turiák, L. ,

1,2Drahos, L. 1 MTA TTK MS Proteomics Research Group, Hungarian Academy of Sciences, Budapest, Hungary2 MTA TTK NAP B MS Neuroproteomics Group, Hungarian Academy of Sciences, Budapest, Hungary

L-20

8:30–9:00

The Application of Liquid and Supercritical Chromatography with High Resolution SWATH Mass Spectrometry for Metabolomics

Hopfgartner, G.

Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva, Geneva, Switzerland

L-21

9:00–9:30

Dysregulated Lipids in Kidney Cancer Determined by UHPSFC/MS, UHPLC/MS and MALDI-MS

1 1 1 1 1Holčapek, M. *, Khalikova, M. , Lísa, M. , Jirásko, R. , Cífková, E. , 1,2 1 3 3Berkecz, R. , Hájek, R. , Vrána, D. , Melichar, B.

1 Department of Analytical Chemistry, University of Pardubice, Pardubice, Czech Republic2 Department of Medical Chemistry, University of Szeged, Szeged, Hungary3 Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic

L-22

9:30–9:50

Integrated Proteomics and Glycomics of Prostate Cancer Tissue Microarrays

1 1 1 1 1Turiák, L. *, Tóth, G. , Ács, A. , Révész, Á. , Vékey, K. , 1,2Drahos, L.

1 MTA TTK MS Proteomics Research Group, Hungarian Academy of Sciences, Budapest, Hungary2 MTA TTK NAP B MS Neuroproteomics Group, Hungarian Academy of Sciences, Budapest, Hungary

L-23

9:50–10:10

Quantification of Virus-Like Particles by High-Performance Size-Exclusion Chromatography and Nanoparticle Tracking Analysis

1 1 2 1,2Steppert, P. *, Burgstaller, D. , Klausberger, M. , Jungbauer, A. 1 Department of Biotechnology, University of Natural Resources and Life Sciences Vienna, Vienna, Austria2 ACIB GmbH, Vienna, Austria

Parallel Session IV.

25

Chair: László Drahos and Alois Jungbauer


L-25

11:10–11:40

Fluid Dynamics Simulation and Nano Computer Tomography to Predict 3D Pore Structure, Flow Pattern and Resolution of Macro Porous Monoliths and Packed Beds

1,2 2 2Jungbauer, A. *, Tscheliessnig, R. , Schweiger, S. , 2Jungreutmayer, C.

1 Department of Biotechnology, University of Natural Resources and Life Sciences Vienna, Vienna, Austria2 ACIB GmbH., Vienna, Austria

L-26

11:40–12:10

Vacuum-Jacketed Chromatographic Columns. An Exciting Journey from Fundamentals to Applications

Gritti, F.*, Fogwill, M., Gilar, M., Jarell, J.A.

Core Research / Instrument / Fundamental Group, Waters Corporation, Milford, MA, USA

L-27

12:10–12:30

Elucidating the Contribution of Injection and Detection to Dispersion in Liquid Chromatography Using Light-Induced Fluorescence Measurements

Broeckhoven, K.*, Vanderlinden, K., Deridder, S., Desmet, G.

Department of Chemical Engineering, Vrije Universiteit Brussel, Brussel, Belgium

ML-1

12:30–12:45

Feed Injection - a Novel Injection Principle that Opens New Application Spaces in SFC

Borowiak, A.

Agilent Technologies, Waldbronn, Germany


Parallel Session V.

26

Chair: David McCalley and Krisztián Horváth


27

L-28

11:10–11:40

Ion Mobility Separation and Mass Spectrometry in Single Cell Analysis

Vértes, Á.

Department of Chemistry, The George Washington University,Washington, DC, USA

L-29

11:40–12:10

Perspectives of the Human Proteome Project in Laboratory Medicine1,2Urbani, A.

1 Istitute of Biochemistry and Clinical Biochemistry, Catholic University of the “Sacred Heart”, Rome, Italy2 IRCCS-Fondazione St. Lucia, Rome, Italy

L-30

12:10–12:30

Proteomic and Phosphoproteomic Analysis of the Synaptosome1 1 1 2 2Ozohanics, O. , Tóth, E. , Gulyássy, P. , Tóth, G. , Borsos, K. ,

1,3 3 1 1,3 1Tóth, V. , Kékesi, K.A. , Vékey, K. , Juhász, G. , Drahos, L. *1 MTA-TTK NAP B MS Neuroproteomics Group, Hungarian Academy of Sciences, Budapest, Hungary2 MTA TTK MS Proteomics Laboratory, Hungarian Academy of Sciences, Budapest, Hungary3 Proteomics Group, ELTE Biology Institute, Budapest, Hungary

L-31

12:30–12:50

A Generic Method Development Approach for the Analysis of Monoclonal Antibody Glycovariants in HILIC

1 1 2 1 1Bobály, B. *, D'Atri, V. , Beck, A. , Guillarme, D. , Fekete, Sz.1 School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Centre Médical Universitaire (CMU), Geneva, Switzerland2 Institut de Recherche Pierre Fabre, Centre d'Immunologie, Saint-Julien-en-Genevois, France

Parallel Session VI.


Chair: Gerard Hopfgartner and Tamás Janáky


L-32

14:30–15:00

Relationship between Gradient Shape and Critical Resolution in HPLC Method Development

Rieger, H-J., Molnár, I.*

Molnár-Institute for Applied Chromatography, Berlin, Germany

L-33

15:00–15:30

Combining Chromatographic and Mass Spectrometric Information for the Analytical Characterization of Biopharmaceuticals

Guillarme, D.*, D'Atri, V., Bobály, B., Goyon, A., Veuthey, J-L., Fekete, Sz.

School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, CMU, Geneva, Switzerland

L-34

15:30–15:50

Unbiased Determination of Adsorption Isotherms by Inverse Method in Liquid Chromatography

Horváth, K.

Department of Analytical Chemistry, Institute of Chemistry, University of Pannonia, Veszprém, Hungary

L-35

15:50–16:10

Using Free, High-Performance, Computer Modeling Software to Simulate Gas Chromatographic Separations

de Zeeuw, J.

Restek Corporation, Middelburg, The Netherlands

ML-2

16:10–16:35

Enchancements for Improved Routine Impurity Analysis

Cross, T.

Thermo Fisher Scientific, Hemel Hempstead, UK


Parallel Session VII.

28

Chair: Günther Bonn and Alberto Cavazzini


29

L-36

14:30–15:00

The Use of Specific Interactions in Liquid-Phase Microscale Separations

Kubo, T., Kanao, E., Kubota, K., Naito, T., Otsuka, K.*

Graduate School of Engineering, Kyoto University, Kyoto, Japan

L-37

15:00–15:30

The Potential of Unmodified and Modified Thiolene-Based Monoliths for On-Chip Sample Preparation and Separation

Jönsson, A., Lafleur, J.P., Sticker, D., Kutter, J.P.*

Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark

L-38

15:30–15:50

Chromatographic Packings in Microchips

Nagy, A., Kecskeméti, Á., Gáspár, A.*

Department of Inorganic and Analytical Chemistry, University of Debrecen,

Debrecen, Hungary

L-39

15:50–16:10

Development of Spatial Three-Dimensional Liquid Chromatography

De Vos, J.*, Eeltink, S.

Department of Chemical Engineering, Vrije Universiteit Brussel, Brussels, Belgium


Parallel Session VIII.

17:00 – 19:00 Poster Session II. – Detailed list on the next five pages

20:00 Grill Party

Chair: Gert Desmet and Michael Lämmerhofer

Poster Session II.September 7, Thursday 17:00–19:00

30

P-28

HPLC-DAD-ESI-MS/MS for the Quality Control of Plant Extracts in Dietary Supplements

Riethmüller, E.*, Sztefanyuk, O., Végh, K., Tóth, A., Béni, Sz., Kéry, Á.


P-31

Characterization of a Poly(dimethylsiloxane) Microfluidic Chip Containing Adsorbed Trypsin for Rapid Protein Digestion

Kecskeméti, Á.*, Nagy, N.C., Gáspár, A

Department of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen, Hungary

P-29

Isolation and Structural Identification of Diarylheptanoids from Morus alba

Alberti, Á.*, Mészáros, A., Pénzes, R., Darcsi, A., Béni, Sz


P-30

Quantitative Determination of Isoflavonoids in Ononis spinosa L. Roots and In Vitro Cultures by LC-ESI-MS/MS

Gampe, N.*, Nagy, E., Kursinszki, L., Béni, Sz.


P-32

A Novel Structure Elucidation Strategy of Monophosphorylated Lipid A Variants Applying HPLC-MS/MS

1 2 1 1,2 3Dörnyei, Á. *, Sándor, V. , Kilár, A. , Kilár, F. , Kocsis, B.

1 Department of Analytical and Environmental Chemistry, Faculty of Sciences, University of Pécs, Pécs, Hungary

2 Institute of Bioanalysis and Szentágothai Research Centre, University of Pécs, Pécs, Hungary

3 Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Pécs, Hungary

P-33

Overloading Study on Chincona Alkaloid-Based Chiral Zwitterionic Stationary Phase

1 2 3 1, 2Bacskay, I. *, Varga, B. , Lindner, W. , Felinger, A.

1 MTA–PTE Molecular Interactions in Separation Science Research Group, Pécs, Hungary

2 Department of Analytical and Environmental Chemistry and Szentágothai Research Center, University of Pécs, Pécs, Hungary

3 Institute of Analytical Chemistry, University of Vienna, Vienna, Austria

P-34

Persistent Organic Pollutants in Human Breast Milk

Kőnig-Péter, A.*, Poór, V., Dergez, T.

Institute of Bioanalysis, University of Pécs, Pécs, Hungary

P-35

Measuring of Endocannabinoids and Related Compounds with SFC-MS/MS in Human Plasma Using Different Analgesic Methods

1 2 2 3Mayer, M. , Kőnig-Péter, A. , Poór, V. *, Almási, R.

1 Department of Forensic Medicine, Faculty of Medicine, University of Pécs, Pécs, Hungary

2 Institute of Bioanalysis, Faculty of Medicine, University of Pécs, Pécs, Hungary

3 Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Pécs, Pécs, Hungary

P-36

A Novel Structure Elucidation Strategy of Non-Phosphorylated Lipid A Variants Applying HPLC-MS/MS

1 2 2 1,2 3Sándor, V. *, Dörnyei, Á. , Kilár, A. , Kilár, F. , Kocsis, B.1 Institute of Bioanalysis and Szentágothai Research Centre, University of Pécs, Pécs, Hungary 2 Department of Analytical and Environmental Chemistry, Faculty of Sciences, University of Pécs, Pécs, Hungary3 Department of Medical Microbiology and Immunology, Faculty of Medicine, University of Pécs, Pécs, Hungary

P-373

Study of the Effects of Structural Characteristics on the Elution Order of Cyclic β -Amino Acid

Enantiomers on Anion-Exchanger-Type Chiral Stationary Phases by High-performance Liquid Chromatography

1 1 2 3 1Orosz, T. *, Péter, A. , Fülöp, F. , Lindner, W. , Ilisz, I.1 Department of Inorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary2 Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary3 Department of Analytical Chemistry, University of Vienna, Vienna, Austria


P-38

Application of Cinchona Alkaloid-Based Chiral Zwitterionic Stationary Phases for the

Enantioseparation of Cyclic β-Aminohydroxamic Acids

1 2 2 2 3 1 1Bajtai, A. *, Fekete, B. , Palkó, M. , Fülöp, F. , Lindner, W. , Péter, A. , Ilisz, I.1 Department of Inorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary2 Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary3 Department of Analytical Chemistry, University of Vienna, Vienna, Austria

31

P-39

3Liquid Chromatographic Enantioseparation of Limonene-Based Carbocyclic β -Amino Acids on

Quinine and Quinidine-Based Chiral Stationary Phases1,2 1 2 2 3 1 1Lajkó, Gy. *, Orosz, T. , Szakonyi, Zs. , Fülöp, F. , Lindner, W. , Ilisz, I. , Péter, A.

1 Department of Inorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary2 Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary3 Department of Analytical Chemistry, University of Vienna, Vienna, Austria

P-40

Determination of Glutathione and Glutathione Disulfide in Bovine Blood Samples by Capillary Isotachophoresis in Coupled Columns

1 2 2 1Bodor, R. *, Nečasová, A. , Pechová, A. , Masár, M.1 Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovak Republic2 Department of Animal Protection, Welfare and Behaviour, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic

P-41

A New Alternative Method for Impurity Profiling of Olmesartan Medoxomil Using LC-MS/MS

Piper, A.*, Altmaier, S., Appelblad, P.

Merck Life Science, Instrumental Analytics R&D, Darmstadt, Germany

P-42

Verification and Validation of HPLC Methods from European Pharmacopoeia Monographs Using Different HPLC Base Materials

Piper, A.*, Altmaier, S., Appelblad, P.


P-43

The Effect of Linear Velocity on the Sensitivity of Temperature Programmed Gas Chromatographic Separation

1 2 2 1Mátyási, J. *, Somogyvári, K. , Uhrin, Cs. , Balla, J.1 B&B Analytics Ltd., Érd, Hungary2 Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Hungary

32


P-44

Investigation of the Retention Behavior of Alkylbenzenes on a C Stationary Phase in 18

Supercritical Fluid Chromatography 1 1, 2Rédei, Cs. *, Felinger, A.

1 MTA-PTE Molecular Interactions in Separation Science Research Group, Pécs, Hungary2 Department of Analytical and Environmental Chemistry, University of Pécs, Pécs, Hungary

P-45

Separation of Proteins by Capillary Zone Electrophoresis Using Ionic Liquids as Dynamic Coating and Running Electrolyte

Mező, E., Páger, Cs.*, Makszin, L., Kilár, F.

Institute of Bioanalysis, Faculty of Medicine and Szentágothai Research Center, University of Pécs, Pécs, Hungary

P-46

Comparison of Various Reversed Phase Stationary Phases by Flow-Reversal Method1 1 1,2Mester, A. *, Zelenyánszki, D. *, Felinger, A.

1 Department of Analytical and Environmental Chemistry and Szentágothai Research Center, University of Pécs, Pécs, Hungary2 MTA-PTE Molecular Interactions in Separation Science Research Group, Pécs, Hungary

P-48

Examination of Degradation of Zearalenone (F2-Toxin) and Deoxynivalenol Mycotoxins and Degradation Products with Ozone-Enriched Medium by GC-MS Technique

B. Tóth, Sz.

Department of Chemistry, Eszterházy Károly University, Eger, Hungary

P-47

Straightforward Tips and Tricks and Troubleshooting for Improved HPLC Performance

Altmaier, S., Piper, A., Schulz, M., Appelblad, P.*


P-49

Determination of Antioxidants of Fungi with Different DPPH Based Scavenging Assay1 2 1 1Krüzselyi, D. *, Vetter, J. , Ott, P.G. , Móricz, Á.M.

1 Plant Protection Institute, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary2 Department of Botany, Faculty of Veterinary Science, Szent István University, Budapest, Hungary


33

P-50

Electrophoretic Analyses of Perchloric Acid Soluble Serum Proteins of Patients1,2 1,2 1 3 3 3 2,3Makszin, L. *, Páger, Cs. , Mező, E. , Kustán, P. , Szirmay, B. , Györgyi, E. , Kőszegi, T. ,

3 1,2Ludány, A. , Kilár, F.1 Institute of Bioanalysis, Faculty of Medicine, University of Pécs, Pécs, Hungary2 Szentágothai Research Centre, University of Pécs, Pécs, Hungary3 Department of Laboratory Medicine, University of Pécs, Pécs, Hungary

P-51

Fatty Acid Composition of Grape Seed Oils from South-West Hungary1 2 2Marosvölgyi, T. *, Szabó, É. , Márk, L.

1 Clinical Centre, Department of Pediatrics, University of Pécs, Pécs, Hungary 2 Medical School, Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary

P-52

Different Normalization Strategies in LC-MS and GC-MS Based Urine Metabolic Fingerprinting1 1 1 2Jacyna, J.* , Wawrzyniak, R. , Kordalewska, M. , Markuszewski, M. ,

2 1 1Matuszewski, M. , Kaliszan, R. , Markuszewski, M.J.1 Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland2 Department of Urology, Medical University of Gdańsk, Gdańsk, Poland

P-54

Determination of TCA Metabolites by Ion Chromatography HR/AM Mass Spectrometry1 2 1 1 1Christison, T.T. *, Hu, S. , Tautenhahn, R. , Kiyonami, R. , Rohrer, J.S.

1 Thermo Fisher Scientific, San Jose, CA, USA2 University of California, Los Angeles, CA, USA

P-55

Charged Derivatization and On-Line Solid Phase Extraction to Measure Extremely Low Cortisol and Cortisone Levels in Human Saliva with Liquid Chromatography – Tandem Mass Spectrometry

1 1 2 3,4 5 1 1 Magda, B. *, Márta, Z. , Dobi, Z. , Mészáros, K. , Szabó, É. , Imre, T. , Szabó, P.T. 1 MTA TTK MS Metabolomics Laboratory, Hungarian Academy of Sciences, Budapest, Hungary 2 MTA TTK Institute of Organic Chemistry, Hungarian Academy of Sciences, Budapest, Hungary 3 Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary 4 MTA-SE "Lendület" Hereditary Endocrine Tumours Research Group, Budapest, Hungary 5 Egis Pharmaceuticals Plc., Budapest, Hungary

P-53

Novel Capillary Flow LC HRAM MS Platform for Fast Targeted Analysis and Robust Profiling of Complex Samples

1 2 1 1 3 1 4Boychenko, A. *, Bults, P. , Ruehl, M. , Meding, S. , Baynham, M. , Decrop, W. , Harder, A. , 2 2 1van de Merbel, N. , Bischoff, R. , Swart, R.

1 Thermo Fisher Scientific, Germering, Germany2 University of Groningen, Groningen, The Netherlands3 Thermo Fisher Scientific, Runcorn, UK4 Thermo Fisher Scientific, Bremen, Germany

34


September 8, Friday

L-40

8:30–9:00

Visualizing Method Conditions Experienced by Analytes in SFC - Effects of Composition and Pressure Variations

Tarafder, A.

Waters Corporation, Milford, MA, USA

L-41

9:00–9:20

Novel Application of Standard Analytical Tests in Process Scale HPLC

Sallay, I.

DAISOGEL, Osaka, Japan

L-42

9:20–9:40

Characterization of Stationary Phases for Fast Liquid Chromatography

Lambert, N.*, Zelenyánszki, D., Felinger, A.

Department of Analytical and Environmental Chemistry, University of Pécs,Pécs, Hungary

L-43

9:40–9:55

Characterization and Application of Single-Isomer Cyclodextrin Derivatives

1,2 3 3 1 3Benkovics, G. *, Darcsi, A. , Fejős, I. , Varga, E. , Béni, Sz. , 1 1 1 1Malanga, M. , Sohajda, T. , Szemán, J. , Fenyvesi, É.

1 CycloLab, Cyclodextrin R&D Ltd, Budapest, Hungary,2 Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Prague, Czech Republic,3 Department of Pharmacognosy, Semmelweis University, Budapest, Hungary

L-44

9:55–10:10

Characterization of Hysteretical Behaviour on Amylosic Columns

Horváth, S.*, Dancsó, A., Németh, G.

Egis Pharmaceuticals PLC, Budapest, Hungary

ML-3

10:10–10:25

Managing Data Integrity and Compliance Confidence

Timmerman, A.

Waters Chromatography B.V., Etten-Leur, The Netherlands


Parallel Session IX.

36

Chair: Bezhan Chankvetadze and Davy Guillarme

September 8, Friday

L-45

8:30–9:00

New Enrichment and Separation Technologies for Natural Product Research in Phyto-Pharmacy, Phyto-Cosmetics and Phyto-Nutrition

1,2Bonn, G.K.1 Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University of Innsbruck, Innsbruck, Austria2 ADSI - Austrian Drug Screening Institute, Innsbruck, Austria

L-46

9:00–9:20

High-Performance Separation Techniques for Plant Secondary Metabolites: Fundamental and Practical Aspects

Corradini, D.

CNR, Institute of Chemical Methodologies, Rome, Italy

L-47

9:20–9:40

Solid State Urea Clathrate Formation Based Sample Preparation Method for the Determination of Polycyclic Aromatic Hydrocarbons in Infant Formula

1 1,2Nyiri, Z. , Eke, Zs. *1 Joint Research and Training Laboratory on Separation Techniques, Institute of Chemistry, Eötvös Loránd University, Budapest, Hungary2 Wessling International Research and Educational Center, Budapest, Hungary

L-48

9:40–9:55

Quantitative Determination of Tocopherols and Tocotrienols in Human Breast Adipose Tissue with the Use of RP-LC-MS/MSand RP-HPLC-FLD Methods

1 1 1 2Bartosińska, E. *, Jacyna, J. , Borsuk-De Moor, A. , Kaliszan, M. , 3,4 2 1Kruszewski, W.J. , Jankowski, Z. , Siluk, D.

1 Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland 2 Department of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland 3 Department of Oncological Surgery, Gdynia Centre of Oncology, Maritime Hospital in Gdynia, Gdynia, Poland4 Division of Propedeutics of Oncology, Medical University of Gdańsk, Gdynia, Poland


Parallel Session X.

L-49

9:55–10:10

Emerging Role of Glycosylation: Structural Analysis of PSA (Prostate Specific Antigen)

1,2 1 1 3Ács, A. *, Turiák, L. , Ozohanics, O. , Navarro-Calderon, D. , 3 4 1 1,5de Frutos, M. , Telekes, A. , Vékey, K. , Drahos, L.

1 MTA TTK MS Proteomics Laboratory, Hungarian Academy of Sciences, Budapest, Hungary2 Semmelweis University, Budapest, Hungary3 Institute of Organic Chemistry (IQOG-CSIC), Madrid, Spain.4 Department of Oncology, Bajcsy-Zsilinszky Hospital, Budapest, Hungary5 MTA-TTK NAP B MS Neuroproteomics Group, Hungarian Academy of Sciences, Budapest, Hungary

37

Chair: Gertrud Morlock and Ákos Vértes

September 8, Friday

13:30 Lunch

Plenary Session II.

L-50

11:10–11:40

Malignant Melanoma: A Cancer Moonshot Lund Program

Marko-Varga, Gy.1 Clinical Protein Science & Imaging Group, BioMedical Center, University of Lund, Lund, Sweden2 Department of Surgery, Tokyo Medical University, Tokyo, Japan

L-51

11:40–12:10

In-Silico Analysis of Oligoethylene Oligoamine - Acrylic Acid-Based pI > 7 Carrier Ampholytes

Vigh, Gy.

Texas A&M University, College Station, TX, USA

L-52

12:10–12:40

Innovative Method Development by Employing Multiple Sequential (3 or more) Capillary GC Columns

Marriott, P.J.

Australian Centre for Research on Separation Science, School of Chemistry, Monash University, Victoria, Australia

L-53

12:40–13:10On-line Comprehensive and Multiple Heart-Cutting LC for Analysis of Challenging (bio)Pharmaceutical Applications

Sandra, P.

Research Institute for Chromatography, Kortrijk, Belgium

13:10 – 13:20 Poster Award Ceremony

13:20–13:30 Closing Remarks

38

Chair: Attila Felinger and Peter Schoenmakers

Sponsor and Exhibitor Information

39

40

ABL&E-JASCO Hungary Ltd.H-1116 Budapest, Fehérvári út 132-144., HungaryPhone: +36 1 209 3538Fax: +36 1 279 0472E-mail: [email protected]

B&T Service Ltd. – EDWARDS Vacuum official distributorH-1142 Budapest, Dorozsmai u. 211-213. 4/451., HungaryPhone: +36 30 4585 480Fax: +421 233 204 579E-mail:[email protected]

CP-Analitika Ltd.H-1145 Budapest, Amerikai út 98., HungaryPhone: +36 1 460 1090Fax: +36 1 460 1099E-mail: [email protected]

Gen-Lab Ltd.H-1119 Budapest, Hadak útja 41., HungaryPhone: +36 1 206 2455Fax: +36 1 206 2451E-mail: [email protected]

Kromat Ltd.H-1112 Budapest, Péterhegyi út 98., HungaryPhone: +36 1 248 2110Fax: +36 1 319 8547E-mail: [email protected]

Lab-Comp Ltd.H-1142 Budapest, Rákos tér 23/aTel: +36 1 347 6090Fax: +36 1 280 6358E-mail: [email protected]

Merck Ltd.H-1117 Budapest, Október huszonharmadikautca 6-10., HungaryPhone: +36 1 463 8133Fax: +36 1 463 8101E-mail: [email protected]

Molnár-Institute for Applied ChromatographyD-10407 Berlin, Schneeglöckchenstr. 47, GermanyPhone: +49 30 421 559 99 E-mail: [email protected]

Per-Form Hungária Ltd.H-1142 Budapest, Ungvár u. 43., HungaryPhone: +36 1 251 1116Fax: +36 1 251 1461E-mail: [email protected]

Simkon Ltd.H-1163 Budapest, Színjátszó u. 30., HungaryPhone: +36 1 403 4420Fax: +36 1 403 4430E-mail: [email protected] www.simkon.hu

Unicam Hungary Ltd.H-1144 Budapest, Kőszeg u. 29., HungaryPhone: +36 1 221 5536Fax: +36 1 221 5543E-mail: [email protected]

Waters Ltd.H-1031 Budapest, Záhony u. 7., HungaryPhone: 36-1-350-5086Fax: 36-1-350-5087E-mail: [email protected]

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11 th BALATON SYMPOSIUM · Balaton Symposium brings together separation scientists and friends from...

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