11 enolate alkylation

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L11 - FORMATION AND ALKYLATION OF ENOLATES Chemistry 534 Fall 2013 NOTES 1

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Transcript of 11 enolate alkylation

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L11 - FORMATION AND ALKYLATION OF ENOLATES!Chemistry 534! Fall 2013!

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L11 - FORMATION AND ALKYLATION OF ENOLATES!Chemistry 534! Fall 2013!

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L11 - FORMATION AND ALKYLATION OF ENOLATES!Chemistry 534! Fall 2013!

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Alkylation of Aldehydes and Ketones 18-4 Alkylation of enolates can be difficult to control. The alkylation of an aldehyde or ketone enolate is an example.

Alkylation of Aldehydes and Ketones 18-4 Alkylation of enolates can be difficult to control. The alkylation of an aldehyde or ketone enolate is an example.

Alkylation Reactor Design

Alkylation Reactor Design

Direct, enantioselective α-alkylation of aldehydes using ...chemlabs.princeton.edu/.../sites/6/aldehyde-alkylation-S-HAT.pdf · Figure 2 | Proposed mechanism for aldehyde α-alkylation

Direct, enantioselective α-alkylation of aldehydes using ...chemlabs.princeton.edu/.../sites/6/aldehyde-alkylation-S-HAT.pdf · Figure 2 | Proposed mechanism for aldehyde α-alkylation

supernucleophile alkylation

supernucleophile alkylation

anti syn-substituted aminopyrrolidines via lithium amide · 2007-05-11 · General procedure 2 for tandem lithium amide conjugate addition and enolate alkylation BuLi (2.5 M in hexanes,

anti syn-substituted aminopyrrolidines via lithium amide · 2007-05-11 · General procedure 2 for tandem lithium amide conjugate addition and enolate alkylation BuLi (2.5 M in hexanes,

INTRODUCTION TO SULFURIC ACID ALKYLATION … · - 1 - INTRODUCTION TO SULFURIC ACID ALKYLATION UNIT PROCESS DESIGN I. INTRODUCTION Alkylation, first commercialized in 1938, experienced

INTRODUCTION TO SULFURIC ACID ALKYLATION … · - 1 - INTRODUCTION TO SULFURIC ACID ALKYLATION UNIT PROCESS DESIGN I. INTRODUCTION Alkylation, first commercialized in 1938, experienced

ACCOUNT 33 - thieme-connect.de · ACCOUNT 33 accountIntramolecular Enolate Alkylation: From Steroids through Cladiellins to Isolaurallene Intramolecular Enolate AlkylationsDeukjoon

ACCOUNT 33 - thieme-connect.de · ACCOUNT 33 accountIntramolecular Enolate Alkylation: From Steroids through Cladiellins to Isolaurallene Intramolecular Enolate AlkylationsDeukjoon

Enolate Chemistry - UR

Enolate Chemistry - UR

Development of New Reactions Employing Boron-Enolate ...

Development of New Reactions Employing Boron-Enolate ...

Phosphine-Initiated Enolate Transformationsevans.rc.fas.harvard.edu/pdf/smnr_2005_Song_Hyun-Ji.pdf · Phosphine-Initiated Enolate Transformations Hyun-Ji Song ... 62, 1521. c) Kobayashi

Phosphine-Initiated Enolate Transformationsevans.rc.fas.harvard.edu/pdf/smnr_2005_Song_Hyun-Ji.pdf · Phosphine-Initiated Enolate Transformations Hyun-Ji Song ... 62, 1521. c) Kobayashi

HHS Public Access , and Asymmetric Allylic …Construction of Tertiary Chiral Centers by Pd-catalyzed Asymmetric Allylic Alkylation of Prochiral Enolate Equivalents Yusuke Kitaa, Yoshitaka

HHS Public Access , and Asymmetric Allylic …Construction of Tertiary Chiral Centers by Pd-catalyzed Asymmetric Allylic Alkylation of Prochiral Enolate Equivalents Yusuke Kitaa, Yoshitaka

Keywords: enol, enolate, Claisen, Michael Reaction, Stork ...

Keywords: enol, enolate, Claisen, Michael Reaction, Stork ...

Enolate Chemistry - Home - Organische Chemie - UR

Enolate Chemistry - Home - Organische Chemie - UR

ACCOUNT 33 - Thieme · accountIntramolecular Enolate Alkylation: From Steroids through Cladiellins to Isolaurallene Intramolecular Enolate AlkylationsDeukjoon Kim College of Pharmacy,

ACCOUNT 33 - Thieme · accountIntramolecular Enolate Alkylation: From Steroids through Cladiellins to Isolaurallene Intramolecular Enolate AlkylationsDeukjoon Kim College of Pharmacy,

Chapter 6 Formation of Carbon-Carbon σBonds via Enolate ...pnorris/Semesters/6942S2008/Chapter6.pdf6.2 – Direct Alkylation of Simple Enolates – Ester Enolates – From Carboxylic

Chapter 6 Formation of Carbon-Carbon σBonds via Enolate ...pnorris/Semesters/6942S2008/Chapter6.pdf6.2 – Direct Alkylation of Simple Enolates – Ester Enolates – From Carboxylic

III Enolate Chemistry - University of Birminghamchemweb.bham.ac.uk/~coxlr/Teaching/4th_Year/III/Enola… ·  · 2010-02-24III Enolate Chemistry ... form selectively the kinetic enolate.

III Enolate Chemistry - University of Birminghamchemweb.bham.ac.uk/~coxlr/Teaching/4th_Year/III/Enola… ·  · 2010-02-24III Enolate Chemistry ... form selectively the kinetic enolate.

Reactions of Enolate Anions: Enolates + Electrophiles II

Reactions of Enolate Anions: Enolates + Electrophiles II

Sulfuric alkylation

Sulfuric alkylation

Alkylation Unit

Alkylation Unit

ManfredBraun - download.e-bookshelf.de · 2.1 Enolate Formation by Deprotonation 11 2.2 Enolate Formation by Conjugate Addition to α,β-Unsaturated Carbonyl Compounds 51 2.3 AlkaliMetalEnolatesby

ManfredBraun - download.e-bookshelf.de · 2.1 Enolate Formation by Deprotonation 11 2.2 Enolate Formation by Conjugate Addition to α,β-Unsaturated Carbonyl Compounds 51 2.3 AlkaliMetalEnolatesby