6Research Profile:UnlockingBiological Secrets

Faculty Profile:DiscoveringFresh Ways toSolve RetinalProblems

1112

Patients’ Pointof View:TheophilusBrown & Paul Wonner7

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A P E E K I N S I D E :

Envision the Future

Hope for World VisionUCSF Ophthalmology’s Global Programs

Dear Friends,

Our fall issue

of Visions

and our

Annual

Report are

dedicated to international

ophthalmology. The World

Health Organization (WHO)

estimates that more than 42

million people in the world are

currently blind. The longer we

live, the greater the chance of

becoming victims of cataracts.

The longer we live, the greater

our chance of encountering

macular degeneration. For

people in developing nations,

the risk of blindness is even

greater. And yet, technological

advancements and bright minds

make it possible to imagine a

world without blindness.

We celebrate the involvement

of our UCSF ophthalmologists

with global health initiatives.

You will find stories here on the

work of our faculty in Africa,

India, China, Vietnam, Latin

America, and Monterrey,

Mexico. Closer to home, our

ground-breaking American

Chinese Eye Study benefits the

residents of Chinatown with

research and treatment that will

resonate around the world.

Our work is possible because

of your support through That

Man May See. Thank you for

inspiring us with your

contributions to research,

service, and patient care.

Sincerely,

Creig Hoyt, MD

Jean Kelly Stock

Distinguished Professor

Chairman

UCSF Department of

Ophthalmology

We are committed tointernational ophthal-

mology because we recognizethat we can have tremendousimpact in the developing world,where 90% of all blindnessoccurs,” says Senior Vice Chair of Ophthalmology,AssociateProfessor Stephen McLeod, MD.

With research and training thatprovides new treatments for

blinding eye disease, and setsstandards for ophthalmicpractice throughout the world,the influence of UCSFOphthalmology and the FrancisI. Proctor Foundation forResearch in Ophthalmologyextends around the globe.

International Collaboration

“We collaborate with localleaders and eye professionals

around the world, so that theycan define local needs and makeself-sustaining changes,” saysJohn Whitcher, MD, MPH,Professor of Ophthalmology,who has been a ProctorFoundation faculty membersince 1974. Dr.Whitcher has led major research studies incataract prevention in India, andcorneal ulcer prevention inNepal, India, Bhutan, and

Eye Mobile to Chinatown apartmentbuildings, where they provide free eyeexams and specialized tests, and gatherinformation about their patients’history of eye disease.The exams formthe basis of a population-based studyin Chinatown, designed to determinethe rate of glaucoma, cataract andother eye diseases in the Chinese-American community.

Continued on page 2

Continued on page 2

Focal Point

Annual Report Issue Fall 2005Koret Vision Institute + Beckman Vision Center + Department of Ophthalmology

V I S I O N S

Burma. He has also workedwith Associate Professor TomLietman, MD, on the infectiouseye disease, trachoma, in Nepaland Ethiopia.

In 1991, Dr.Whitcher andcolleagues at UCSF formedone of the first research teamsto collaborate with Aravind Eye

Our goal is to determine themajor causes of blindness in the

Chinese-American community,” saysglaucoma specialist,Assistant ProfessorShan Lin, MD, who takes the UCSFEye Mobile and a group of healthprofessionals to San Francisco’sChinatown on weekends, for the

American Chinese Eye Study.

Working with Chinatown leadersand volunteers, Dr. Lin brings the

University of California San Francisco + That Man May See

Ophthalmology InsightSaving Vision in ChinatownAmerican Chinese Eye Study & Care

Led by Dr. Shan Lin

04-05A R

Annual Report

5HearstFellowsImproveEye Care

2 V I S I O N S Fall 2005

Hope for World VisionContinued from page 1

“This is a population that hasnot been studied well, althoughit is the third-largest ethnicpopulation group and one ofthe fastest-growing populationsin the U.S.,” says Dr. Lin.“Fifteen years ago, the BaltimoreEye Study discovered that theincidence of glaucoma inAfrican-American patients was four times the rate forCaucasians. In Los Angeles, theLatino Eye Study found highrates of glaucoma amongHispanics.With the Eye Mobile, funded largely by theCongressional GlaucomaCaucus and That Man May See, Dr. Lin has been able toconduct a pilot study in theChinese-American communityof Chinatown.

Specialized Testing

“Our preliminary data indicatethat cataracts are a major causeof blindness in Chinatown.Cultural barriers and pooraccess to health care maycontribute to foregoing of thenecessary cataract surgery,”Dr. Lin notes.

“Studies from Singaporeindicate that glaucoma may bethe leading cause of blindnessin the Chinese population. Butwe do not yet know if regionaldifferences or environmentalfactors play significant roles inclosed-angle glaucoma.” saysDr. Lin. High-risk patients are

of the WHO CollaboratingCenter at the ProctorFoundation. In 1947, Proctorfaculty conducted the first U.S.trachoma studies, and in theearly 1970s, Professor-EmeritusChandler Dawson, MD,initiated trachoma research inTunisia and Egypt.

Our current trachoma clinicaltrials in Ethiopia, Nepal, andEgypt are part of a WHOeradication effort, usingmathematical models to designtreatment strategies. Dr.Lietman, Dr.Whitcher,AssistantClinical Professor BruceGaynor, MD, of Santa Rosa,and their collaborators atORBIS have treated andmonitored 100,000 children in 40 villages. New studies are evaluating the geneticprevalence of trachoma andtreatment alternatives.

consultants on the SICCA(Sjögren’s InternationalCollaborative Clinical Alliance)Study based at UCSF, whichcoordinates the investigation of the Sjögren’s Syndromeautoimmune disorder atcollaborating centers in China,Japan, Denmark and Argentina.The study will create aninternational Sjögren’s registry,for future study. Phase I isfunded by NIH for five years.

Training International

Practitioners

“Training the world’s futureleaders in health care, we offerresearch and clinical fellowshipsand observerships at UCSF,”says Professor Todd Margolis,MD, PhD, Director of theProctor Foundation.“Theseresearchers make significantcontributions to ophthalmologyat UCSF, and bring new skillsand techniques back to their

Hospital in South India. Ourfaculty works closely with M.Srinivasan, MD, Director ofAravind, now the world’s largesteye hospital, to conduct eyestudies and help developresearch infrastructure.

Cornea Studies

Our corneal ulcer studies haveled to new guidelines forcorneal ulcer treatmentthroughout Southeast Asia.“The corneal ulcer studies westarted in Nepal with Dr.Madan Upadhyay in 1985, andcontinued in India with Dr.Srinivasan in 1991, show thatmore than 90% of blindingulcers can be prevented bydiagnosis of corneal abrasionsand simple antibiotic treatmentby village health workers,” saysDr.Whitcher.“These findingswere confirmed by our studies,

supported by the World HealthOrganization (WHO), inBhutan and Burma.”

The recent SCUT (Steroids for Corneal Ulcer Treatment)Study conducted in India byDr. Lietman with the assistanceof Drs.Whitcher, McLeod,Srinivasan, Gilbert Smolin, andothers, seeks to determinewhether steroids with antibiotictreatment improve the finalvisual outcome for resistantbacterial corneal ulcers.

Research Overseas

Once the second leading causeof blindness in the world,trachoma is now the sixthmajor cause, and it may soon be eliminated.“Our studiesindicate that we could eradicatetrachoma in the next 20 years,using community-widetreatment with the simpleantibiotic, azithromycin,” saysDr. Lietman, who is Director

Cataract Studies

Cataracts are the number onecause of blindness in thedeveloping world. In a recentlong-term study we evaluatedthe effect of antioxidants oncataracts in rural India. Dr.Whitcher, Dr. Lietman, andProctor Foundation associates,including principal investigatorand clinical faculty memberDavid Gritz, MD, of Kaiser,Oakland, examined 800patients annually for five years.“Although the results wereunequivocally negative, welearned a great deal about theepidemiology of eye diseases inthis defined population, and weestablished a model for futureclinical research in villagepopulations where mostblindness occurs,” reports Dr.Whitcher.

Dr.Whitcher and AssistantProfessor Erich Strauss, MD,are principal ophthalmic

MatchingChallenge SupportsGlaucoma ResearchR. Jean & James D. Taylor Foundation

The R. Jean & James D. Taylor Foundation has made a challenge

gift of $50,000 to fund the clinical and laboratory research of

pioneering glaucoma investigator, Shan Lin, MD. Our success

depends upon your support.

The accompanying Visions article (Saving Vision in Chinatown)

describes Dr. Lin’s population-based eye study, the results of which

will have an impact around the world. Jean and Jim Taylor hope

this support will create awareness of the need for glaucoma

research and the value of Dr. Lin’s study. They hope to see their

gift equally matched by January 2006.

Glaucoma is recognized as the leading cause of irreversible

blindness. It affects over 3 million people in the U.S. alone, and

nearly 70 million worldwide. Because it usually does not cause pain

or central vision loss until the advanced stages, glaucoma is called

the “silent” blinding disease.

Please help us reach our goal by sending your check to

That Man May See, Shan Lin Glaucoma Research, 10 Koret Way,

San Francisco, CA 94143, or call Kathleen Rydar, President of

That Man May See, 415-476-4016 for further information about

this matching challenge and the scope of Dr. Lin’s research.

Thank you for helping achieve this support! •

Saving Vision in ChinatownContinued from page 1

3V I S I O N S Fall 2005

brought in to UCSF foradditional testing with aspecialized UltrasoundBiomicroscope (UBM).

“If we discover that closed-angleglaucoma is a major cause ofblindness, it can usually betreated by a simple laserprocedure,” Dr. Lin explains.“These study results couldlead ophthalmologists to use additional tests morefrequently, to look for thistype of glaucoma inChinese patients.”

The examiningphysician provides

each Chinatownpatient with

information about his or hereye diseases, and doctors andclinics for follow-up. Patientswith active eye disease are alsocalled to see if they have seen a clinician.

Community Volunteers

Felix Chu of the ChinatownLion’s Club is one of theChinatown leaders who hasmade this study and treatmentprogram possible.The EyeMobile is supervised by Stuart Seiff, MD, Director of Ophthalmology at SanFrancisco General Hospital,and the Eye Study iscoordinated by May Lin.

High school students andvolunteers from the Chinatowncommunity are joined byUCSF Ophthalmology staff,residents and faculty whovolunteer for the project,including David Hwang, MD,Jennifer Diehn, MD, Scott Lee,MD, Diamond Tam, MD, JulieChen, MD, Gloria Wang, MD,and Selena Lee, OD.

Over 200 people have beenscreened in the initial phase of this study, which began in

November 2004. Dr. Linanticipates that the target of300-500 patients for the pilotstudy should be met in 2006.

Broader Study Planned

“This is a pilot study ofselected apartment buildings,”says Dr. Lin. Ultimately hewould like to reach all thepeople 40 years and older inChinatown community.

“When we apply for NIHfunding, we plan to compareChinese-Americans inChinatown and those in themiddle-income Sunset District,to determine if one group hasless preventable eye disease,”he says.

An interdisciplinary groupstudying disease in the Chinesepopulations is now meeting todiscuss an Asian Studies Centerat UCSF, including Dr. Lin, andProfessor of Neurology, DavidBonovich, MD, in collaborationwith the Chinese communityof San Francisco and HongKong.They would coordinatestudies of eye disease, stroke, andAlzheimer’s disease—conditionsthat may be more prevalent inthe Chinese community. •

Dr. Shan Lin

own countries.” (See HearstFellows on page 5.)

Developing a nationwide planin Vietnam to preventRetinopathy of Prematurity(ROP), an emerging cause ofchildhood blindness indeveloping countries, Directorof Pediatric Ophthalmology,Associate Professor DougFredrick, MD, works closelywith Vietnamese medicalprofessionals. Small groups ofphysicians from Vietnam cometo UCSF for two months eachyear, training with Dr. Fredrickand UCSF neonatologist ColinPartridge, MD. Dr. Fredrickalso travels to Vietnam, Burmaand Trinidad, to teach advancedsurgical techniques.Theseprograms are sponsored by thenonprofit ORBIS.

International Standards

“We live in a globalcommunity, and most of us

think globally, says ProfessorRichard Abbott, MD, anesteemed corneal surgeon,explaining why so many atUCSF develop programsbeyond our borders.

Dr.Abbott is President–Elect ofthe Pan American Associationof Ophthalmology, withmembers from 27 North andSouth American nations.“Morethan 60% of our faculty willattend the WorldOphthalmology Congress inBrazil,” says Dr.Abbott.“Co-sponsored by the Pan AmericanAssociation and theInternational Council ofOphthalmology (ICO), thiswill be a unique exchange.”Dr.Abbott is also President of the Pan AmericanOphthalmological Foundation,supporting research andeducation in the Americas.

In China, Dr.Abbott directs apilot project to establishophthalmic treatmentguidelines in a developingnation, as Chair of the ICOClinical GuidelinesCommittee. He works with the Chinese Ministry ofHealth, ICO, NEI, and WHO.Professionals throughout China have reviewed the newtreatment guidelines, whichwill set eye care standards forall physicians in China.

“Our research and trainingprograms, and the work of our faculty, have changed the outlook in science andhealth internationally,” says Dr. Margolis. •

From left to right: Dr. John Whitcher; Dr. Whitcher in India; Dr. Tom Lietman; Dr. Lietman in India; Dr. RichardAbbott (right, with Professor Jialiang Zhao, President, Chinese Ophthalmological Association) in China; Dr. StephenMcLeod in India.

Thanks to our generous donors to these international programs:

The Bernard Osher Foundation, which has provided essential

leverage to secure National Institutes of Health funding; That

Man May See; ORBIS International; The Carter Center;

International Trachoma Initiative; the South Asia Research Fund;

The Bodri Foundation; Research to Prevent Blindness; World

Health Organization; the National Institutes of Health and the

National Eye Institute.

Thanks to our generous donors:

The American Chinese Eye Study is supported by funds from the Congressional Glaucoma Caucus, the

Theodore and Doris Lee Foundation, Santen Pharmaceuticals, and That Man May See. Dr. Lin’s work is also

supported by the R. Jean & James D. Taylor Foundation (see Matching Challenge, page 2).

4 V I S I O N S Fall 2005

The UCSF – JapanConnectionDr. Shigeaki Ohno Now Heads UCSF – Japan Eye Society

Former Proctor Fellow

This interview is part of the ongoing Cordes Connection, which features

UCSF Ophthalmology alumni.

When he was a youngphysician in Sapporo,

Hokkaido, Japan, in 1972,Shigeaki Ohno, MD, wasinspired to study at UCSF after a special lecture by theOphthalmology DepartmentChair, the late Michael J.Hogan, MD, at the JapaneseOphthalmological Society. In1974, he came to UCSF as aHearst Fellow to study ocularimmunology, microbiology and uveitis. He returned toUCSF in 1982, as a JapaneseGovernment PostdoctoralFellow at the ProctorFoundation.

Today, Dr. Ohno is animportant academic andophthalmic researcher in Japan, and he maintains hisUCSF connection as Presidentof the UCSF-Japan Eye Societyin Japan. He is Chair of theDepartment of Ophthalmology

and Visual Sciences atHokkaido University GraduateSchool of Medicine;VicePresident and Head of theDepartment of Ophthalmologyat Hokkaido UniversityHospital; and ExecutiveDirector of Eye Ambitious,Inc., in Japan.

Learning from World Experts

“Studying at UCSF, I wasexposed to many new ideas and a broad perspective ondevelopments in ophthalmologythroughout the world,” Dr.Ohno recalls.“I was very luckyto study with world-famousauthorities in ophthalmology,who taught me the importanceof basic scientific investigation,daily practice, and carefulobservation of my patients.”

One of Dr. Ohno’s mentors atUCSF was the late SamuelKimura, MD, who was world-

renowned for research andclinical care of inflammatorydiseases of the eye.“Dr. Kimurawas a great teacher of clinicalophthalmology,” he recollects,“and he was also a great teacherof fishing.”

Dr. Ohno’s teachers includedProfessor-Emeritus, neuro-ophthalmologist William Hoyt, MD; Professor-Emeritus,uveitis specialist G. RichardO’Connor, MD; andophthalmic infectious diseasespecialists, Gilbert Smolin, MD,Robert Nozik, MD, and John P.Whitcher, MD, MPH.

Continuing to pursue moleculargenetic epidemiological studies,this October Dr. Ohno willhost the 4th InternationalConference on Ocular Infections atHokkaido University. His

recent studies are the first toshow that uveitis occurs inpatients who are geneticallysusceptible.

Left His Heart in San Francisco

Dr. Ohno delivered an invitedlecture at UCSF OphthalmologyGrand Rounds in 1998, as the Samuel Kimura VisitingProfessor.At the CordesSociety’s 1985 scientificmeeting, Dr. Ohno deliveredthe keynote Hearst Lecture.

He also brought down thehouse with a rendition of “I Left My Heart in SanFrancisco.”

“We have many brilliantophthalmologists and academicsin Japan who studiedophthalmology at UCSF,” saysDr. Ohno.“I am pleased thatmy former fellow, Ms.YumiImai, DVM, PhD, is currently aProctor Fellow, studying withDr.Todd Margolis.At UCSF,

you can learn everything aboutophthalmic science withoutgoing around the world.”

Generous Funding for Japan –

UCSF Eye Society

Dr. Sam Kimura and Dr.Michael Hogan founded ThatMan May See, Inc. in 1971 to provide a new source offunding for a comprehensivevision center at UCSF.

Dr. Kimura’s widow, PearlKimura, has worked vigorouslyto support the goals of TMMS.Last year she helped launch thePacific Rim Center for Vision.She has also supported theUCSF-Japan Eye Society Fundand the Kimura Lecture Series,as well as an endowment, alaboratory, the Samuel J. KimuraOphthalmology Chair,designated for promising youngscientists, and the KimuraOcular Immunology Laboratoryat the Proctor Foundation. •

Building Bridges InternationallyOphthalmology Faculty & Alumni Restore Sight Abroad

In developing countries, where

eye care is limited, UCSF faculty

and alumni work with local

partners to expand eye care

capabilities and provide

advanced skills and training.

“We are very proud of our

faculty and alumni who lecture

extensively overseas and help

develop educational curricula.

Many also demonstrate clinical and surgical techniques, and

provide medical care to patients throughout the world,” says

Senior Vice Chair of Ophthalmology, Associate Professor Stephen

McLeod, MD. (Also see Faculty News on page 14.) Examples of

UCSF faculty making a difference internationally include:

Department Chair, Creig Hoyt, MD, Professor of Ophthalmology,

is the first American editor of the internationally oriented British

Journal of Ophthalmology. Retina specialist, Robert Bhisitkul, MD,

PhD, Assistant Professor of Ophthalmology, is Web Editor for the

British Journal.

UCSF Clinical Professors Marc Lieberman, MD, and Melvyn D. Bert,

MD, FACS, spend two months each year training Tibetan surgeons

to restore sight to impoverished Tibetans blinded by cataracts on

the ‘rooftop of the world.’ The goal of the Tibet Vision Project is

to eliminate preventable blindness throughout Tibet, with local

resources only, by the year 2020. Dr. Lieberman founded the Tibet

Vision Project in 1995, and is Director of Rural Eye Programs; Dr.

Bert is Director of the Lhasa Eye Program. They have trained 20

Tibetan ophthalmologists in modern eye surgery, who have done

over 2000 cataract surgeries with lens implants free of charge. A

documentary about their work, Visioning Tibet, is slated for

national PBS broadcast in 2006. A Cordes Alumnus (1980), Dr.

Lieberman is a glaucoma specialist with offices in northern

California; Dr. Bert is a San Francisco ophthalmologist.

www.tibetvisionproject.org

William Good, MD, World View Editor for the British Journal of

Ophthalmology, is a volunteer clinician/surgeon at the Tilganga

Eye Centre in Kathmandu, Nepal, a country where nearly 70% of

blindness is due to cataracts. Tilganga has no pediatric specialist,

and Dr. Good has treated children with a wide range of eye

problems. He has also worked as a volunteer at the Regional

Institute for Ophthalmology in Chennai, India, with the support of

ORBIS International. A Cordes Alumnus (1985-88) and former UCSF

faculty member, Dr. Good is Pediatric Ophthalmology Clinician-

Researcher at Smith-Kettlewell in San Francisco.

Research scientist, Jennifer LaVail, PhD, Professor of Anatomy and

Ophthalmology, is an advisor to the Neuroscience Program at the

Universidad Autónoma de Nuevo León in Monterrey, Mexico,

south of the Texas border. Working with a team from UCSF,

Harvard and NIH, she consults with the school in establishing

the neurovirology division of their new Biomedical Center

for Translational Medicine, advising on courses, syllabus and

admissions. She also lectures and leads Grand Rounds at

the school.

Glaucoma specialist Jorge Alvarado, MD, Professor of

Ophthalmology and Physiology, has taught glaucoma surgical

and diagnostic techniques, and consults on glaucoma curriculum

in Argentina, Columbia, Brazil, Uruguay, Costa Rica, Mexico and

Venezuela. He has provided surgery to children suffering from

congenital glaucoma throughout Central and Latin America.

Director of Ophthalmic Clinical Pharmacology at the VA Hospital,

Professor Allan Flach, MD, PharmD, has taught residents and

medical students in Lima, Peru, and Pretoria, South Africa, and

directed pharmacological research in Pretoria. He led U.S.

ophthalmologists on an interactive 6-week pharmacology

continuing education program in China. •

Proctor PerspectiveInternationalVision CenterPreventing Blindness In the

Developing World

This fall, the International Vision Center opensnew offices at the Proctor Foundation, to support

investigators who have dedicated their careers topreventing blindness in the developing world.

Spearheaded by Professor John Whitcher, MD,MPH,Associate Professor Tom Lietman, MD, andcolleagues from UCSF Ophthalmology and theProctor Foundation, the Center will coordinate thefaculty’s diverse research on prevention of blindnessin the developing world.This Center will be one of three international eye research centersworldwide, including the Dana Center at JohnsHopkins University, and the Institute for TropicalMedicine and Hygiene at Moorefields Eye Hospitalin London.

“In developing countries, adults and children havepreventable and curable eye diseases that often leadto blindness, if left untreated,” says Dr.Whitcher.“Our research is aimed at preserving their sighttoday, and for generations to come.

“The International Vision Center will make itpossible to expand and coordinate vision research that could have a tremendous impact throughoutthe world.” •

5V I S I O N S Fall 2005

Hearst Fellows Improve Eye CareIn 27 Locations Around The World

Ajay Singh, MD, arrived at UCSF early this year from Amritsar,

India, as the current recipient of the prestigious Hearst

Fellowship in International Ophthalmology. The fellowship

provides valuable advanced training for promising young

ophthalmologists from abroad.

Dr. Singh’s father, Rajbir Singh, MD, was also a Hearst Fellow at

UCSF, in 1978. In the US for one year, the young Dr. Singh and

his wife, Mandira, recently gave birth to their baby daughter,

Jiya, providing potential to extend the legacy even further.

Generous Hearst Gift Established

International Program

Hearst Fellowships began in the mid 1960s with a gift from

George and Rosalie Hearst, inspired by the couple’s friend and

personal physician, Kenneth A. Grow, MD. The William

Randolph Hearst Foundation continued to provide annual

support and established an endowment to ensure the

continuation of Hearst Fellows in perpetuity.

Velasco FamilySupportsExchange withPhilippines

As part of the Pacific Rim Center for Vision,UCSF Ophthalmology is building bridges of

medical exchange with the Philippines.Thanks to thegenerosity of the Geronimo Velasco family,VelascoFellows will come to UCSF for specialized clinicaltraining and research, and UCSF faculty will travel tothe Philippines to share expertise and to learn moreabout needs in that country.

The program is designed to advance ophthalmicmedicine in both countries – and to demonstratepartnership results that can have global impact.Fellows will be recruited from the Philippines fortraining as basic or clinical researchers or clinicians,and will return to the Philippines and other parts of Asia to set up research laboratories.

“This type of exchange is critical,” says ProfessorRobert Stamper, MD, Director of the UCSFGlaucoma Service.“Reciprocal learning, academicinterchange, and collaborative teaching add to thevitality of the Department, and to the individual livesthat are changed.The result is better care for patients,and better teachers and role models to elevate thediagnosis and practice of eye disease.

“As a glaucoma specialist,” continues Dr. Stamper,“Iview this exchange as an important bridge to enhanceresearch, education, and treatment of glaucoma andother eye problems in the Philippines, and nurturing a collaborative partnership between the U.S., thePhilippines, and greater Asia.”

“On a personal note,” says Dr. Stamper,“thegenerosity of the Velasco family demonstrates a legacyof concern and care for the people of the Philippines,and for all who suffer from glaucoma.” •

Bringing New Perspectives HomeStories of Some Former Hearst Fellows

Daniel Pereira, MD, the 2004 Hearst Fellow, is from Goiana,

Brazil, where he trains residents and fellows at Santa Casa de

Sao Paulo. “The exposure to research through the Hearst

Fellowship changed my thinking about the physiopathology of

disease, and allows me to treat patients in new and different

ways,” he says. His mentors at UCSF were Robert Bhisitkul, MD,

Phd, and Daniel Schwartz, MD.

Former Hearst Fellow, Marita Uusitalo, MD, was mentored in

1999 by Joan M. O’Brien, MD. She returned to Helsinki

University Central Hospital, where she is Chief of Oculoplastics.

She continues to do collaborative research with Dr. O’Brien in

retinoblastoma, a childhood eye tumor. “The time I spent at

UCSF was extremely useful and important, and I continue to

draw from lessons learned there.”

Fabian Lerner, MD, developed new expertise in glaucoma

treatment under the mentorship of Jorge Alvarado, MD, and

David Hwang, MD. Dr. Lerner, a 1990 Hearst Fellow, returned to

Buenos Aires to focus his practice on glaucoma. “The Hearst

Fellowship provided a superb professional and human

environment. I continue to share this experience with

colleagues and fellows in Argentina,” he says. Dr. Lerner

recently established a foundation to assist people with

glaucoma.

Across the globe in Japan, Shiroaki Shirato, MD, PhD, has

opened a specialty eye clinic in central Tokyo. Dr. Shirato was

a Hearst Fellow in 1986, guided by Jorge Alvarado, MD. In

1994, he became Vice Chair of Ophthalmology at the

University of Tokyo; in 1999, he was named Professor and

Director of Ophthalmology at Tokyo Medical University.

Today, he is Clinical Professor at Tokyo Medical University and

Tokyo Medical-Dental University. Dr. Shirato feels his UCSF

training at was invaluable, and continues to collaborate with

Dr. Alvarado.

Antii Vannas, MD, arrived from Helsinki, Finland in 1973. He

has been Head Ophthalmologist for the Finnish Armed Forces

since 1985. UCSF ophthalmic pioneers Michael Hogan, MD,

and Samuel Kimura, MD, had a special influence, giving him

access to new avenues in ophthalmic surgery. He learned

vitreous surgery with Alexander Irvine, MD, at UCSF, just as it

was being introduced in Finland. Dr. Vannas does ophthalmic

research in Finland and at the University of South Wales in

Australia. •

Dr. Ajay Singh (left) withhis mentor, Dr. Alex Irvine

Now, 27 locations throughout the world link to UCSF

Ophthalmology through Hearst Fellows, who complete specialty

training, and return to their countries to make a difference in

research and patient care. UCSF Hearst Fellows have hailed from

China, Finland, Brazil, Switzerland, Japan, Australia, India,

Mexico, Argentina, New Zealand, Germany, Italy, Spain, Chile,

Peru, and Venezuela.

Singh Family in Medicine – Also a Legacy

In addition to its Hearst legacy, the Singh family has a long

association with vision care. In 1939, Ajay’s great-grandfather,

Sohan Singh, MD, an eminent eye surgeon and professor at the

Amritsar Medical College, treated thousands of patients free of

charge at a rural eye service. The Singh ophthalmologists—

grandfather Ranbir, and his father, Rajbir—continue this

tradition. The Singh family also runs an advanced retinal

hospital, where surgeons from all over India are trained in

retinal disease.

Selective Fellowships

Hearst Fellows are selected after careful review by a senior

clinical faculty committee: Robert N. Shaffer, MD, Stacy Mettier,

MD, and Ariah Schwartz, MD.

On the tenth anniversary of their fellowship, Hearst Fellows are

eligible to give the annual George and Rosalie Hearst Lecture at

the Annual Meeting of the Cordes Society, which is the UCSF

Faculty and Alumni Association. •

6 V I S I O N S Spring 2005

ResearchP R O F I L E

may lead to new treatments for blinding eye disorders,especially those of children.

A distinguished neurobiologist,Dr. Beggs has established an impressive array ofcollaborations with top researchteams at UCSF and around the world to study defects incellular signaling pathways.As a postdoctoral fellow, sheworked on understanding

factors controlling braindevelopment with investigatorLouis Reichardt, PhD, at theUCSF Howard HughesMedical Institute.

In her current studies, Dr.Beggs is investigating theunderlying causes formicrophthalmia (small eye syndrome), retinaldysplasia/degeneration, andcongenital cataracts.“All three of these ocular disordersare found in children withCongenital MuscularDystrophy,” she says.“Exploringthe unknown link betweenthem may help explain whythey occur in the first place.”

Mechanisms of Eye Disease

The ways in which cells respond to theirmicroenvironment is a crucial factor in visual system development.“Anymiscommunication ordisconnect between cells andtheir surroundings can result indisease,” Dr. Beggs explains.“Ifyou imagine cell signaling as agame of ‘telephone,’ then we are interested in identifyingwhere the signal goes awry.”

Dr. Beggs’ lab is investigating a major signaling relay stationin the cell, called FAK (focaladhesion kinase). FAK is critically involved intransforming instructions from the outside of a cell intoappropriate responses, such as

whether to move or stop, or to survive or die. Disruptingthis activity brings about severepathological consequences andproduces developmental defectsthat resemble severe congenital eye and brain disorders.

By carefully analyzing thepathways activated by FAK and related enzymes, Dr.Beggs hopes to uncover newcellular mechanisms of eyedevelopment and disease, thatcould well lead her to newtherapeutic targets.“If we can understand how FAK isuniquely regulated in specificcells, we might learn how to correct some of theseblinding disorders.”

Love of Basic Science

Hilary Beggs grew up in amedical family in Princeton,New Jersey. Her father was awidely respected neurosurgeon,and her mother began hercareer as an inorganic chemist.Naturally, science was alwaysencouraged, and often discussedaround the dining room table.Starting as an English major atWashington and Lee Universityin Virginia, she found herselfdrawn increasingly toward thelaboratory. Eventually shegraduated cum laude with a BS in Biology, and went on toearn a PhD in Neurobiology at the University of NorthCarolina in Chapel Hill.

UCSF is a hotbed ofneuroscience research, withgreat strength in basic science,

Dr. Beggs believes, addingthat basic scientific researchrequires long-termunderstanding.“With theseresources in developmentalbiology, biochemistry,neuroscience and imaging,we can ‘knock out’ specificgenes and cell types withtemporal and spatial controlwe never thought waspossible, to study theactivities that make cells go‘haywire,’ and consider howto repair them.”

Dr. Beggs’ research issupported by an award from That Man May See to collect data that couldsupport a larger NIH grantin the coming year. She has also received a CareerDevelopment Award fromResearch to PreventBlindness (see story on page 13), and a KnightsTemplar Eye FoundationAward for research inpediatric ophthalmology, aswell as receiving supportfrom the Sandler FamilySupporting Foundation toestablish her new laboratory.

Bay Area Living

Dr. Beggs and her husband,novelist Tom Barbash, live in Mill Valley. Barbash’s firstnovel, The Last Good Chance,won the California BookAward, and his nonfictionbook, On Top of the World,was a New York TimesBestseller. •

Unlocking BiologicalSecretsDr. Hilary Beggs Investigates Molecular Mechanisms of

Eye Disease

Dr. Hilary Beggs

‘‘What excites me most in my work is the

chance to unlock a biologicalmystery,” says research scientistHilary Beggs, PhD,AssistantProfessor of Ophthalmologyand Physiology.“If we canunderstand how the eyedevelops normally, then we’ll be one step closer to figuringout what goes wrong in diseasestates.”The research Dr. Beggsis conducting here at UCSF

Dr. Jonathan C. Horton WinsAlcon Award

Drs. Sretavan & Chang inSeoul, KoreaMicrotechnology-Assisted Nerve Repair

UCSF Ophthalmologist andNeuroscientist, Professor Jonathan

C. Horton, MD, PhD, has been named a2005 Alcon Research Institute awardrecipient. Founded in 1982, the AlconResearch Institute bestows prizes eachyear upon a handful of vision scientists.“The Alcon Award is one of the mostprestigious international awards inophthalmic research,” says Senior ViceChair of Ophthalmology,AssociateProfessor Stephen McLeod, MD.“TheAlcon Award is a prize for which onecannot apply,” he explains.“The AlconResearch Institute makes its selectionbased on the quality and significance ofone’s work.”

“Dr. Horton is one of the nation’s topneuro-ophthalmologists, dedicated tocuring neurovisual disorders and findingout how visual perception occurs in thehuman brain,” says Dr. McLeod. Hisresearch focuses on amblyopia (“lazyeye”) and strabismus (“crossed eyes”)and seeks to uncover pathways vital fornormal perception.

“What is most gratifying, and so like Dr.Horton,” continues Dr. McLeod,“is thathe has directed the prize to That ManMay See to support eye research atUCSF.” Dr. Horton and his team ofcommitted researchers conduct theirstudies in the state-of-the-art Laboratoryfor Visual Neuroscience at UCSF,completed in 2002 with generoussupport from friends of That Man MaySee. Basic scientific research is the key toUCSF Ophthalmology’s mission to findnew treatments and cures for blindingeye diseases. •

With a report on a novel methodof nerve repair at the cellular

level,“Microdevice Components for aCellular Microsurgery Suite,” ProfessorDavid Sretavan, MD, PhD, and Post-Doctoral Fellow Wesley Chang, PhD,were invited to describe their work atthe world’s leading conference devotedto the advancement of microsystemtechnologies, in Seoul, Korea. For thefirst time, a conference track at theInternational Conference on Solid StateSensors,Actuators and Microsystems was

devoted to biomedical applications.Following their conference presentation,Drs. Sretavan and Chang were invited to publish their research in a scientificjournal dedicated to microsystemtechnologies.

Recognized as an expert indevelopmental neuroscience, Dr.Sretavan is investigating the intersectionof biology and micro/nanotechnologyto develop new surgical tools. Dr. Changis a Postdoctoral Fellow at UCSFOphthalmology and a graduate of theUC Berkeley School of Engineering,working with Dr. Sretavan to developnew microtools for nerve repair. •

Dr. David Sretavan

7V I S I O N S Fall 2005

2004-2005A N N U A L R E P O R T

Dear Friends of That Man May See,

Directors & OfficersStephen S. Smith*ChairmanKathleen Rydar*PresidentDaniel Benatar*Vice PresidentCreig Hoyt, MD*Vice PresidentAnn Golson*TreasurerW. Scott Thomas*SecretaryRichard L.Abbott, MDThomas J. BirdJackson BuschEdward B. CollinsJ. Brooks Crawford, MD*Bruce E. Crocker*John F. de Benedetti Janet L. DinsmoreEmily H. FineAllan J. Flach, MD, PharmD Françoise G. FleishhackerTom FollettPaul L. Gomory, Jr.William H. Green Larry HaimovitchJohn E. HallPaige HutsonSteven G. Kramer, MD, PhD*James P. Livingston *Angus L. MacLean, Jr. *Gerry MarshallThomas R. Mazzocco, MDStacy R. Mettier, Jr., MD

Rosanne OglesRichard J. Olsen *Marilyn Pratt*J. Frederick Riedel, MDPatricia L. Robinson Albert R. SchreckIsabel P. SchuchardtRobert L. Stamper, MDR. M.Terry ThomasDavid T.TraitelJohn P.Whitcher, MD, MPHA. Sydney Williams, MDAndrew Yau

Director EmeritusPearl T. Kimura

Distinguished Honorary Board Theresa M. Caygill

Honorary Board Members Brook H. ByersAnn Jones CarlsonRoger S. CarlsonJ. Hallam DawsonMargaret DuflockReed FreyermuthMaurice Galante, MDArthur O. HarperCharles W. HomerH. Dunbar Hoskins, MDThomas F. Kostic William C. KuehneJack LinkletterPeter H. MattsonNan Tucker McEvoy

Herbert P. Moore, Jr.J. Fraser Muirhead, MDAllen S. MusikantowWalter S. NewmanJames R. Powell, MDStanley Powell, Jr.Stephen S. Seiff, MDRobert N. Shaffer, MDJon B. ShastidSteven P. Shearing, MDDavid P. SinaiJohn P. StockJames B. SwinertonDexter C.TightAlejandro Zaffaroni, MD

Past ChairmenPeter H. MattsonAngus L. MacLean, Jr.Dexter C.TightRichard J. OlsenBrook H. ByersStacy R. Mettier, Jr., MDJames P. LivingstonWilliam H. Green

Past PresidentsWalter S. NewmanStacy R. Mettier, Jr., MDCrowell Beard, MDSamuel J. Kimura, MD

* Executive Committee

Board of DirectorsThat Man May See, Inc.2004-2005

Clinical/Research FacultyCreig S. Hoyt, MD

Chair

Richard L.Abbott, MDJorge A.Alvarado, MDRobert B. Bhisitkul, MD, PhDKimberly P. Cockerham, MDJ. Brooks Crawford, MDMichael V. Drake, MDJacque L. Duncan, MDAllan J. Flach, MD, PharmDDouglas R. Fredrick, MDJonathan C. Horton, MD, PhDEdward L. Howes, MDDavid G. Hwang, MDAlexander R. Irvine, MDMarsha C. Kavanagh, MDThomas M. Lietman, MDShan C. Lin, MDTodd P. Margolis, MD, PhDStephen D. McLeod, MDJoan M. O’Brien, MDDaniel M. Schwartz, MDStuart R. Seiff, MDRobert L. Stamper, MDJohn A. Stanley, MDJay M. Stewart, MD

Erich C. Strauss, MDJohn P.Whitcher, MD, MPHIra G.Wong, MD

Research ScientistsDaniel L.Adams, PhDHilary E. Beggs, PhDDavid R. Copenhagen, PhDKeith G. Duncan, PhDDavid Krizaj, PhDJennifer H. LaVail, PhDMatthew M. LaVail, PhDJulie L. Schnapf, PhDDavid W. Sretavan, MD, PhDErik M. Ullian, PhD

Emeritus FacultySteven G. Kramer, MD, PhD(Chairman, Ophthalmology

1975-2003)Chandler R. Dawson, MDWilliam F. Hoyt, MDG. Richard O’Connor, MD

FacultyUCSF Department ofOphthalmologyKoret Vision InstituteBeckman Vision Center

Thanks to you, support for That Man May See is increasing. We generated

over $10 million, including bequests, for the UCSF Department of

Ophthalmology this past fiscal year. The $500,000 challenge made by Mr.

Bernie Newcomb to launch the Chairman’s Forum was fully met. And, we

were able to provide over $1 million directly to our faculty for immediate

research projects. With these seed funds, the department leveraged our

private support to attract funds from government sources. This year,

$3,170,784 from agencies such as the National Institutes of Health and the

National Eye Institute was provided in revenues.

Bequests continue to play a large role in our achievement, and we invite

you to consider That Man May See in your estate plans while you continue

to support us during your lifetime. We hope you enjoy this year’s Annual

Report of progress. Please join us in celebration of the difference we

make when we work together.

Sincerely,

Stephen S. Smith

Chairman, That Man May See, Inc.

This Annual Report 2004 – 2005 demonstrates a vibrant

year that sets the stage for even greater accomplishment

ahead. The vision of That Man May See parallels the

growth and continuing pursuit of excellence of UCSF’s

Department of Ophthalmology.

We are building an international community of individuals, foundations,

and companies whose support can reduce the burden of blindness and

cure eye disease through research, teaching, and patient care. We seek

financial support for faculty research and collaborative projects with other

departments and with other researchers beyond UCSF.

You – our contributors – are the greatest hope for expanding resources of

the department to extend its leadership position. Breakthroughs in

research bring about results for vision care unheard of only a few years

ago. And, these innovative projects require support commensurate with

the quality of the ideas.

Opportunities for partnership will increase as the department continues to

attract the brightest and the best new faculty. We also want to reward

with distinction those faculty members who make this university great.

8 V I S I O N S Fall 2005

The following exceptionalcontributors have madecumulative gifts of$1,000,000 or moreArnold and Mabel Beckman

Foundation*Theresa M. and Wayne M.

Caygill, MDPaul L. and Lois M. Fahrney

TrustsThe Foundation Fighting

Blindness*Mrs. Pearl T. KimuraKoret Foundation*Dr.Thomas and Mrs.Yvonne

MazzoccoBernard A. Newcomb Fund

at Peninsula CommunityFoundation

Helen Pritchard EstateResearch to Prevent

Blindness*Mr. and Mrs.Walter

RosenbergRobert Henry Sanborn

Estate*Mr. and Mrs. Marshall Steel, Jr.Wayne and Gladys Valley

Foundation

Benefactors - ($500,000 + )Bernard A. Newcomb Fund

at Peninsula CommunityFoundation

Visionaries - ($100,000 + )

Alcon Research InstituteHelen Hall Boothman EstateTheresa M. CaygillThe Glaucoma Foundation*The Thomas J. Long

FoundationJoanne M. Pochobradsky

Estate

Entrepreneurs - ($50,000 + )Eleanore Compagno EstateBurnham and Nina Enersen

EstateMr. and Mrs. Charles W.

HomerKnights Templar Eye

Foundation*Research to Prevent

Blindness*

Investors - ($25,000 + )American Glaucoma Society*Françoise G. FleishhackerMrs. Pearl T. KimuraDr.Thomas and Mrs.Yvonne

MazzoccoThe Dorothy & Edward

Muschner Charitable Fundat the PeninsulaCommunity Foundation

The Sandler FamilySupporting Foundation

Alfred P. Sloan Foundation*Stephen S. Smith and Paula

K. Smith FamilyFoundation

Joan and David TraitelGeronimo Z.Velasco

Director’s Council -($10,000 + )

The Bellini FoundationDaniel and Jeanne BenatarDagmar Bengtson-Olson

EstateRichard H. Chartrand Eye

Research FoundationMr. Robert J. DrabkinDoris and Donald FisherThe Joan Leidy Foundation,

Inc.Mrs. Jeannik M. LittlefieldMr. and Mrs. James P.

LivingstonLumenisThe Mattson Family

Conservation FoundationInc.

MellonDavid and Marilyn PrattJeanne and Sanford

Robertson FundJohn and Patricia RobinsonSanten Holding Company,

Inc.Dr. and Mrs. Steven P.

ShearingW. Scott Thomas

Luminaries - ($5,000 + )Tom, Jan,Tommie &

Christopher BirdSuzanne and Bruce Crockerde Benedetti Pass-Through

FundDenise B. Evans*James S. Feehan and

Geraldine F. Feehan Estate*Mary Ellen and Michael E.

Fox Family FoundationMr. and Mrs. Milo S. GatesAnn and Charles GolsonJohn Hall and Rebecca

DerringtonWilliam K. Hamilton, MDClare & Gordon Johnson

Charitable TrustJean-Claude KaminsKoret FoundationAngus L. MacLean, Jr.Dr. and Mrs. Stacy R.

Mettier, Jr.Richard and Candace OlsenLisa and John PritzkerThe Thomas K. and Martha

A. Procter EstateFrank & Denise Quattrone

Foundation

Julian and Barbara CaneDavid and Victoria ChangStanley and Jean ChangFrederick A. ChristiansenMr. and Mrs. Jerry C. ColeMrs. Olive CookHartley and Mary Lou

CravensAndrea CunninghamMr. and Mrs. Richard R.

DavisMark H. EliasMr. and Mrs. Roger GaultJohn and Marcia GoldmanMimi and Peter HaasPauline L. HaddadMaurine and Philip HalperinRobert E. Hopkins, MDCreig S. Hoyt, MDJanet and David HwangRobert and Linda KlettAlbert F. Knorp, Jr.Kajito Kusumoto FamilyShiu Y. Kwok, MD, PhDNancy LeavensThomas and Linda LeonDaniel and Irene LevineLocal Independent CharitiesBrian R. Matas, MDDr.Andrew Mecca and Dr.

Kate MeccaKatherine MellonPeerless LightingMichael and Leslie PerlmanJames Pickrel and Carolyn

WoolleyGregory J. RykenMr. and Mrs. Dean W.

SkanderupTed and Doris SmithDonald R. and Patricia P.

StephensJohn and Peggy StockGeorge and Sheila TichyKatherine and Mark ValentineAlexander S.Walker

Patrons - ($250 + )Lisa M.AliAndrew BerlinerKatherine M. BonniciBlaine S. Boyden, MDBarton Byers, MDRaymond and Marian

ChristensenSally Collins and Chris WarthBen Colloff, MDPatricia S. DinnerBetsy and Roy EisenhardtMichael F. and Netta F. FedorBettye Poetz Ferguson

Foundation

M.Wallace Friedman, MDMrs. Ida K. FujiiPete Greco, Jr., and Nancy K.

GrecoRobert and Susan GreenCynthia Sperry HarrisChristine Miller HighDean and Debra HirabayashiKaren K. HoCharles and Alice HoffnerLeonard E. KingsleyJohn G. and June R.

LilienthalFrank E. LindskoogSharon and Paul MelodiaMr. and Mrs.Thomas MortonF.Ward and Mary P. PaineCeleste and Roger PhillipsLouise H. RenneCharles J. RobelBernice RosenthalDaniel M. Schwartz, MDEdwin A. Seipp, Jr.Dr. and Mrs. Robert N.

ShafferMarshall and Mary SmallJudith Good StearnsVera Berg and Mark

Strassberg, MDUnited Way of the Bay AreaP. Mason Wood

Friends - ($100 + )Anonymous (3)Lorita D.AaronsCecilia and Richard AbbottJames A.AleverasAbdul R.Al-Shamma, MDCharles J.Astrue, Jr.B. H. BallardEdward C. BarmakianBarton Family TrustAnn and David BaudlerElaine G. BauerAlbert and Mary BerrymanMark BienenfeldMr. and Mrs. Perry B.

BiestmanMichael C. Brodsky, MDPatricia BrownSandra S. BrownNewman and Joanne BuckleyBarbara and Ric CharltonCatherine E. ChiltonThomas F. and Irmin ClarkFrancisco Contreras, MDJudge and Mrs. John S.

CooperDavid and Joyce CopenhagenJ. Hallam Dawson and Mary

McVeyDr. and Mrs. John T. Dawson

Shirley ReichSaints and Sinners FundDavid P. SinaiSkaer Family FoundationJacqueline and Robert YoungEric and Pamela Zankman

Dream Makers - ($2,500 + )Mr. and Mrs. Jeff BleichMr. and Mrs. Norman E.

CimaMark FeldbergWilliam H. and Frances D.

GreenLarry and Carie HaimovitchKomes FoundationWalter J. and Patsy R. PartonPayne Family FoundationToni and Arthur RockKathleen L. RydarAlbert R. SchreckHank C.Wuh, MD, MPH

Innovators - ($1,000 + )Anonymous (4)Allergan Pharmaceuticals*Gordon and Pam AndrewsDorothy and Richard

AnnesserPeter and Joan AvenaliBryant and Inga BennettPeggy E. Blakeslee EstatePaula and Joel BlankMr. and Mrs. Robert N.

BlochMr. and Mrs. Johnson S.

BogartDr. and Mrs. Edwin E.

BoldreyJoyce and John BorgwardtDrew and Ellen BradleyMae M. Brizz EstateJosephine H. BrownbackJack Busch and Patty Hagen-

BuschEdward B. CollinsMr. and Mrs. Daniel G. CookDr. and Mrs. J. Brooks

CrawfordDr. and Mrs. Emmett

CunninghamPeter D’Alena, MDRosalind Gray Davis and

Robert M. DavisJohn de Benedetti and Nina

SrejovicSusan and John DiekmanJanet and Bill DinsmoreAnnette DobbsMr. and Mrs. John R.

DougeryDr. and Mrs. James E.

DowlingLeonard J. Shustek and

Donna DubinskyDr. and Mrs. James F. EggertElaine A. Eklund

Emily H. FineDr.Allan and Teri FlachBernard and Leah FreiwaldPaul and Béatrice GomoryLorrie and Richard GreeneGrimm Family FundDr. and Mrs. Plato J. GrivasThe Hartless FoundationCharlene HarveyThe Herbst FoundationJonathan and Lidia HortonMrs. Jacqueline C. HuddlesonLouis HuntingtonMargaret M. JacobsenJoan and Paul KaufmannElizabeth H. KemsleySteven and Michele Kirsch

FoundationRobert L. KnoxHeinrich KonigArthur Lampson EstateEric and Pili LienShan C. Lin, MDLee L. Manansala*Angiolina MartiniMr. and Mrs. J. Patterson

McBaineStephen D. McLeod, MDIvan, Maris, and Harry

MeyersonPeter and Lela MoulthropLary Lynn and Anthony

MullerRosanne and Michael OglesRichard and Susan OlnessLarry A. PattersonKathy and Kent PenwellBarry and Jan PetersenFred and Judy RiedelJack W. and Barbara H.

RosstonMr. and Mrs. John C. SavageGeorge A. SchiesslIsabel P. SchuchardtStuart R. Seiff, MD, FACSTheodore and Suzanne SetonRajbir and Rita SinghWillis and Marion SlusserDr. and Mrs. Robert L.

StamperWendy and David TeplowDenise and Terry ThomasMr. and Mrs. Dexter C.TightLori and Christopher ToomeyThe Tumori FoundationMichel and Masako VacheronTerry and Madeline WelshCarl K.WetzigJack and Marilyn WhitcherDrs. Myra and Burton Wise

Supporters - ($500 + )Thomas and Paula AlkonMr. and Mrs. George A.

BlackstoneMichael and Leslie BraunBunker & Company, LLP

Donors

Thank You for EndowmentsEndowed Chairs &ProfessorshipsProfessorships and Chairsprovide sustained supportfor research and clinicalfaculty.Jean Kelly Stock

Distinguished Professorship

Theresa M. and Wayne M.Caygill, MD Chair inOphthalmology*

William F. Hoyt Chair inOphthalmology

Samuel J. Kimura, MD Chairin Ophthalmology

Steven G. Kramer, MD, PhDChair in Ophthalmology

Steven P. Shearing Chair inOphthalmology

Michal D.Vilensky Chair inOphthalmology

Thomas W. Boyden Chair inOphthalmology

Endowed Research FundsResearch Funds supportinnovative research.Dawn Society EndowmentHeleanor Campbell Foerster

Ophthalmic PathologyEndowment*

Samuel J. Kimura, MDEndowment Fund

2004-A N N U A L

DISTINGUISHED CONTRIBUTORS

9V I S I O N S Fall 2005

2004-2005Deogracias de la RosaDiablo Valley Eye CenterMr. George Ditz, Jr.Bill and Virginia DoerksenMr. and Mrs. Stephen R.

DohrmannEleanor W. DommerichSandra and Conrad DonnerRosalind and Sanford DorbinJacque and Keith DuncanRobert and Louise ElliottRobert and Lillian FisherMichael E. FoleyThorne and Dennis FosterChristie L. FraserKaren K. FuMr. and Mrs. Richard GossJeanne S. GressensW.W. GudmundsonRobert C. HarrisMrs. John N. HauserMr. and Mrs. Patrick HealyRichard F. Hoedt, Jr., DDSA. Joan HolstiusJill J. HorowitzDr. and Mrs. George K.

HortonDr. and Mrs.Thomas C.

Hoyle, IIIDr. and Mrs.Yuh Lin HwangWilliam E. Jensen and

Corinne J. JensenDouglas W. JohnsonLev and Berta KatsnelsonJo KennedyMax and Betty Kniesche, Jr.Richard and Susan KramerTerry and Bill KrivanJanet B. LandauerMarianne J. LarimoreBarbara and Bob LeeBarbara LivingstonDorinne S. and Howard J.

LowGeorge LozovikJames J. LudwigPatricia and Joseph ManciniDouglas M. ManselGretchen Kah MarxDonald and Judy McCubbinPaul and Joan McKnightT. Neal and Deana

McNamaraGeorge W. McNelly and B.

Louise McNellyBonnet J. MeihoeferClarence and Joan MiguelVirginia and David MillerJanet MiyataBarbara J. MoniePatrick M. MooneyHerbert P. Moore, Jr.

Kay J. MooreWalter J. MorrisRichard NormanMarcia V. NorrisJoseph J. O’BrienEdith O’ConnorMr. and Mrs. Richard C.

OtterAlan R. ParsonsMrs. Florence C. PauliMr. and Mrs. Eric PedleyRenaldo and Ellen PepiRose PeraMr. and Mrs. John PientaClyde E. and Suzanne G.

PitchfordMichael PolaMr. and Mrs. Paul C. PringleDavid and Pamela ReeseTom ReillyDr. and Mrs.Richard

ReynoldsPatricia M. RheinMr. and Mrs. Lee RiordanBenson B. RoeDebra B. RoseNorman and Nan RosenblattRoss Academy Montessori

SchoolJoel and Sylvia SaldingerAlbert L. SchultzEdwin J. and Elisa E.

SchwartzNorman F. Schwilk, Jr., MDBeth and Kurt SeibertJane and Edward C. ShotwellMary Ann Milias St. PeterJohn A. Stanley, MDDr. and Mrs. Stuart B.

StephensSusan Farley StifflerGerhard StollDaniel E. StoneEdgar N. StonePearl TalbotR. E.ThakarJack and Jane ThrelkeldSusan G.TillingGeorge and Gloria TomasiniJ. P. Van OverveenStephen and Sharon VanceWilliam and Camele WanatR. Douglas Wayman, MDRichard and Joyce WeismannTimothy and Jennifer WelshMr. and Mrs. Ian S.WishartCarl and Virginia WongSusan Wong, MDKathleen Ouchi Yamaguchi,

MDLucy and Peter Yang

Mr. and Mrs. Jacob RosenfeldWilliam and Wilma RyanRuth M. SakaiElaine SalzWilliam SandlundJohn N. SchroederAriah Schwartz, MDRoseann and Edwin ScottLarry and Dona ShaidnagleGrigoriy ShpayerMichelle Lee SkeenHelen SlateNorman and Masa SoskinC. Coe SwobeMrs. Kuwako TakahashiJerry and Merilyn ThallKathleen ThielMr. and Mrs. Edwin H.

TierneyDiana ToomajianColleen E.TrawickGilbert VasserotAlison Beyer VicasGeorge, Joan, and Alex

WeickhardtJack C.WelischChris WhiteMarjorie J.WilcoxJack and Connie WolfmanMarilyn WolperElsie WrightStanley S.WulfJohn C.WurrYing Chuen and Sheung Yee

Yip

Gifts In KindThomas J. BirdThomas R. Mazzocco, MDRichard and Candace OlsenDavid and Marilyn PrattStephen S. Smith and Paula

K. Smith

Visionaries for the FutureThose who have chosen toinclude That Man May See,Inc. in their estate plansMs. Lillian AlbertsenMrs. Helen E.AmmenMs. Elaine G. BauerMrs. Clyde CarringtonMrs. Sarah Carroll-HirschTheresa M. CaygillMr. Ralph CechettiniMr. and Mrs. Ralph A. CoddeJoan E. Diblin, PhDJanet and Bill DinsmoreMrs. Barbara P. DoyleDavid and Adeline EdwardsMs. Denise B. EvansMrs. Janet GolnerJohn E. Hall IIIMr.Arthur O. HarperMrs. Mildred B. HartMr. and Mrs.William G.

Hoffman

Ms. Marjorie JacksonClare & Gordon Johnson

Charitable TrustMrs. Clarence K. JonesMrs. Elizabeth KennedyMrs.Walter KesslerMrs. Samuel J. KimuraMr. and Mrs. Sigmond A.

Kriegsman, Jr.David and Mary Jane LaityMr. and Mrs. Harold LillardJames P. LivingstonMr. and Mrs. McKay MarlerMs.Angiolina A. MartiniBoris D. Nahlovsky, PhDMrs. Marjorie A. NolteJames J. O’Donnell, MDMr. Elton L. PufferJ. Frederick Riedel, MDMiss Emily B. RievaulxKathleen L. RydarMr. Jon B. ShastidMr. David P. SinaiMrs. Branna SisenwienMrs.Arthur T. SkaerMrs. Marshall Steel, Jr.Mr. John P. StockMr. Daniel E. StoneMs. Carol StraussMr. Dexter C.TightMrs. George A.WatsonMr. and Mrs. Richard M.

WeismannMr. Ronald P.Winiker

BEQUESTSRealized bequestsbenefiting the UCSFDepartment ofOphthalmologyEstate of Dagmar L.

Bengtson-OlsonEstate of Peggy E. BlakesleeEstate of Helen H. BoothmanEstate of Mae M. BrizzEstate of Eleanore CompagnoEstate of Burnham and Nina

EnersenEstate of James Feehan*Estate of Arthur L. LampsonEstate of Joanne M.

PochobradskyEstate of Thomas K. and

Martha A. ProcterEstate of Robert Sanborn*Estate of Rose Beatrice

Williams*

We have made every effort toprovide a complete andaccurate listing of donors andgifts. Please accept our sincereapologies if any mistake oromission has been made.

* Gifts received via the UCSFFoundation or Board of Regents

Contributors Scott T.Anderson, MDDorothy S. Battcher and

Donna J. BattcherHilary Beggs, PhD, and

Thomas BarbashNiklas BellBernice BiedermanShirley A. BlewerPhyllis B. CarmichaelAlex and Justin ChiangAnne ChiuNay and Marie ChuChung/Wells Family (Adam

and Alex)Joan G. CogenEdward L. Culin, IIIWalter and Ruth DamanWillee DanielChosen Ones Sunday School

ClassVirginia De FrancisMary H. DillJohn and Virginia DoyleMarta B. DuntonJeremy N. EgenbergerFrieda H. EngelSeth and Alison Ferguson and

FamilyRachael FerroniDr. and Mrs. Robert C.

Frates, Jr.Elsie FrazierBeatrice FreundJoyce and Jay FriedrichsNancy FromRaymond and Deborah

Gadbois and FamilyEdward A. GallagherFrancisco Garcia, MD*James GeeSuzanne L. GeorgeRobert, Bonnie, and Tyler

GerlachMr. and Mrs. Harold J.

GieblerHoward and Lenore

GoodmanJim, Pam, and Kyle HaighWilliam Halprin and Mary

FoxWanda R. HambyTanya D. HarperM.J. HarveyFrank W. HellmanSusan HerpelStanley and Maria HertzPeggy HeuerDiana HicksMarcia T. HillMr. and Mrs. Roy E. Hills, IIIMr. and Mrs. George H.

HortonMolly HynesDr. and Mrs. John D. KasterHazel KawajaAli Khamenehpour

Daniel W. KingWilliam H. KingPatrick J. KirraneLillian and Eugene KodaniSidney S. KonigsbergWanara KumalaDonna Lee LampertMargit LandesmanEdwin and Arlene LarsonMike and Teri LaskyDavid and Judith LayneVirginia LeachAndrea Mooney Leavitt and

FamilyJoel Lee and Deborah ChingBrandon LeungA. Levy & J. Zentner

Company*Dillon LewKermit Lipez and Nancy

ZieglerRay and Mary LopezJoseph MaKaren L. MacKenzieMr. and Mrs. Edward MackinMarjorie MahoneyMargaret E. MalloryJoan G. MarshRobert Marshak and Judy

KellyMr. and Mrs. Frank MatheusTodd and Stacey MelcherRoy and Loraine MichaelJan M. MillerMelvin and Mildred MogulofClara MonroeDr. Choo Kim NgMay Wah NgPo-San NgMary M. O’Neill and FamilyRen Orans and Meta Uota

Orans and FamilyNick, Liz,Will, and Teddy

PalmerNick PhelpsLeonor E. PerdomoDr. and Mrs. Edward C.

PersikeCarol J. PfeiferNoelle Naito Pillsbury and

FamilyJohn H. PinskiEugene PlockiGrace PrienPaul and Christine PrusinerDaniel and Doris QuanMr. and Mrs. Basil A. QuiliciLeola W. RagghiantiSenator William J. Raggio and

FamilyJoyce S. RaicheDonald and Pat RavitchBernard and Florence

RechtschaffenH.T. and Marguerite RichterJoanne RobertsJohn W. Rose and Linda

Hammersmith Rose

Jane and Marshall Steel, Jr.Endowment Fund forVision Research

Dexter C.Tight MacularDegeneration EndowedResearch Fund

Endowed Education FundsEducations Funds providepermanent funding foracademic lectures.Amy S. McNamara Endowed

Fund*

George and Rosalie HearstFellowship inOphthalmology*

Francis I. Proctor LectureFund*

Transamerica VisitingProfessorship in VisionScience

General Endowed FundsThese endowments areapplied wherever the needis greatest.Frances W. and Levon K.

Garron Endowment

Michael J. Hogan, MDEndowment

Charles Taylor ReeveEndowed Fund*

Agnes M.Welsh Eye Fund*

-2005 R E P O R T

Endowed funds raised by ThatMan May See are managedby the UCSF Foundation.

* UC Regents’ Endowments.Others are held by the UCSFFoundation.

10 V I S I O N S Fall 2005

2004-2005A N N U A L R E P O R T

Received and Influenced by Gifts Committed by 6/30/05 to beTMMS FY Ending 6/30/05* Received in FY 06 Total

Board Gifts $476,539 $63,000 $539,539

Individual Gifts $818,710 $10,000 $828,710

Bequests $6,927,945 $1,570,000 $8,497,945

Corporations, Foundations, Other $527,987 $550,000 $1,077,987

Total $8,751,181 $2,193,000 $10,944,181

*Some gifts are processed through the UCSF Foundation and Board of Regents, primarily as bequests.

TMMS – Sources of Private Support

Seed Funding for ResearchThat Man May See Awards to the Department of Ophthalmology: $1,033,058

July 1, 2004 to June 30, 2005

Select Patient Care and Education AwardsDouglas Fredrick, MDJonathan Horton, MD, PhDJoan O’Brien, MD

Select Research AwardsJorge Alvarado, MD

Hilary Beggs, PhD

Kimberly Cockerham, MDDavid Copenhagen, PhDDavid Hwang, MDDavid Krizaj, PhDMatthew LaVail, PhDThomas Lietman, MDShan Lin, MDJoan O’Brien, MDJulie Schnapf, PhDDaniel Schwartz, MDRobert Stamper, MDErik Ullian, PhD

Residency Education FundNeuroscience Program Seminar SeriesReorganize and Expand Adult Ocular Oncology Unit

Role of Gene Expression in the Modulation of Barrier-Permeability inTrabecular Meshwork and Schlemm’s Canal Endothelial CellsUnderstanding the Genes, Cellular Mechanisms & Signaling NetworksInvolved in Organization of Ocular Basement MembranesOrbicularis Reanimation for Cranial Nerve Seven PalsiesAssessing Bipolar Cell Synaptic Function Equipment and Instrument PurchaseCellar Basis of Retinal Function and DysfunctionElectroretinography for Studies on Retinal Degenerative DiseasesDo Children Form a Core Group for the Transmission of Trachoma?Ultrasound Biomicroscopy Research SupportDevelopment of an International Retinoblastoma Mutation DatabaseMechanisms of Photoreceptor Interactions in Retinal SlicesAge-related Macular Degeneration Research SupportThe Accumap - Multi-Year AssessmentGlaucoma and Axon Guidance Molecules: Effects of Retinal Ganglion Cell Axonal Transport and Survival

Clinical Revenue $7,146,273

National Institutes of Health $3,170,784

Private Sources of Funds $2,544,024

Endowment Income $1,207,596

State Funds $996,231

Total $15,064,908

UCSF Department of Ophthalmology Source of Funds

■ Clinical Revenue ■ National Institutes of Health ■ Private Sources of Funds

■ Endowment Income ■ State Funds

Faculty/Clinical Fellows $4,911,845

Research & Administrative Staff, Supplies & Equipment $6,231,223

Practice (clinic) Expenses $3,204,387

Institutional Taxes and Fees $717,453

Total $15,064,908

UCSF Department of Ophthalmology Use of Funds

■ Faculty/Clinical Fellows ■ Research & Administrative Staff, Supplies & Equipment

■ Practice (clinic) Expenses ■ Institutional Taxes and Fees

‘‘ Doheny focused on new waysto deliver drugs to thesubretinal area affected bychoroidal neovascularization(overgrowth of blood vessels) in‘wet’AMD.

Culture of Innovation

“I chose to come to UCSFnow, because UCSF has aunique culture of innovation,”Dr. Stewart says.“It is a top-notch university, withoutstanding people – fromstudents and staff to faculty.

“Retina strikes me as a ‘newfrontier,’ in research and insurgery. I am awed by theprecision of microsurgery,where surgical techniques arestill developing,” he says.“Here,I have the opportunity to makea difference for a lot of people.As the population is aging,growing numbers of patientsare affected by the major retinaldiseases – including maculardegeneration and diabeticretinopathy – and I am excitedby the challenge.

“My mentors, who arenationally recognizedauthorities on retinal surgeryand treatment, have taught meto look for new ways toapproach clinical challenges,” hesays.“At UCSF, Dr. Daniel

Schwartz has incorporatedlessons learned in cardiologyresearch, as well asbioengineering, in innovativeophthalmology projects. Dr.Eugene de Juan, Jr., at Doheny,also directs the MicrosurgicalAdvanced Design Laboratory(MADLAB), wherebioengineers collaborate withvision researchers to developnew surgical instruments andtechniques.”

Dr. Stewart is studyingsubretinal drug delivery andslow release of drugs in the eye,in order to maximize thebenefit of treatment andminimize the side-effects. He isalso looking at new models andtreatments for macular edema(swelling and leakage), which isa significant problem forpatients with diabeticretinopathy.

“I look forward to contributingto efforts to put UCSF on themap nationally, for innovativeachievements in retinal researchand treatment,” he says.

Harvard to Brazil to UCSF

Raised in Ft. Lauderdale, Dr.Stewart attended HarvardCollege and Harvard MedicalSchool, and interned atHarvard’s Brigham and

Women’s Hospital in Boston.He came to UCSF as a residentfrom 2000-2003.

Dr. Stewart is fluent inPortuguese and Spanish, and he spent time as a public healthresearcher and volunteer inBrazil during medical school.A research project onleishmaniasis (a parasitic disease)took him to Fortaleza, innortheastern Brazil, and he didinfectious disease training inTeresina, Brazil. Beforecompleting his medical

Discovering Fresh Ways to SolveRetinal Problems

Iam looking for fresh ways toapproach the clinical

challenges that our patientsface, and to draw from thebroad pool of knowledge inophthalmology and medicine,”says Jay M. Stewart, MD, whojoined the Department asAssistant Professor ofOphthalmology this summer.Aformer UCSF resident, hereceived the Cordes Society’sHogan-Garcia Research Awardfor his 2003 study of the role ofcholesterol in the retina,examining proteins that mightsomeday be targets for therapyin age-related maculardegeneration (AMD). Dr.Stewart recently completed aprestigious retinal fellowship atDoheny Retina Institute at theUniversity of SouthernCalifornia.

“I’m excited about comingback to UCSF with new waysto approach retinal disease, andbuilding on the strongfoundation of ophthalmologythat I learned as a residenthere,” he says.At Doheny, Dr.Stewart worked with a largeretina faculty, whose membershad trained at many differentinstitutions and each of whomtaught the fellows very differentapproaches to common retinalproblems. His research at

training, he also worked as atranslator for orthopedicsurgeons with the volunteermedical group Esperanca, inthe Amazon.

Jay Stewart and his fiancée,Emmanuelle Ejercito, who isa corporate attorney, movedto the Bay Area from LosAngeles, this summer.Theyenjoy running together andwill be competing in theNew York Marathon inNovember.They will bemarried in February 2006. •

F A C U L T YProfile

11V I S I O N S Fall 2005

‘‘Renowned basic scientists andclinicians from universities

throughout the U.S., Britain andAustralia will join UCSF faculty inNovember for a unique scientificconference, focused on preventing visualloss from AMD (Age-Related MacularDegeneration).AMD is the mostcommon cause of vision loss for adultsover 60 in the U.S. Showcasing expertsin their fields, the program bringstogether 32 speakers, who areophthalmologists, biologists,pharmacologists, and venture capitalists,to consider current and futuretreatments for ‘dry’ (atropic) AMD, aswell as ‘wet’ (neovascular) AMD.

“This should be a strong impetus fordeveloping effective interventions forpatients with AMD, long before theyhave suffered visual loss,” says ProgramChair, Daniel M. Schwartz, MD,Associate Professor of Ophthalmology,and Director of the UCSF RetinaService. Dr. Schwartz actively

collaborates with scientists in other fields to solve ophthalmic problems, andis investigating new drug treatments for AMD.

Stuart L. Fine, MD, Chairman of the Department of Ophthalmology,University of Pennsylvania, and Directorof the Scheie Eye Institute, has mademajor contributions to prevent blindnessfrom AMD. He will talk on Clinical Trialsfor a Novel AMD Therapeutic.

John Marshall, PhD, the FrostProfessor of Ophthalmology at StThomas Hospital, London, hasconcentrated research on therelationship between light and ageing.He will discuss the etiology of AMD.

Shirley Sarks, AM, MD, FRCS,FRANZCO, Honorary ResearchAssociate, Prince of Wales MedicalResearch Institute, Sydney,Australia,has made major contributions tounderstanding AMD. She will speak on Anatomy of Early AMD.

This groundbreaking program is co-chaired by Marco A. Zarbin, MD, PhD,Professor and Chairman, Ophthalmologyand Visual Science, UMD New JerseyMedical School; and Lawrence S. Morse,MD, PhD, Professor of Ophthalmology at UC Davis.

To register, please call (415) 476-5808,or register on line athttps://www.cme.ucsf.edu/cme and selectthe course title: Tackling Early AMD.For more information please see:http://ucsfeye.net/decembercourse.shtml •

Tackling Macular DegenerationDevising New Strategies To Prevent Visual Loss

Unique UCSF ConferenceThanks to the generous

donors supporting this

important AMD conference:

Allergan, Novartis

Ophthalmics, Genentech,

Eyetech, Alcon and Pfizer.

Dr. Jay M. Stewart

12 V I S I O N S Fall 2005

What happens when a visual artist’s eyesight begins to fade? Some say Claude Monet’s

cataracts may have contributed to softness of line,one of the hallmarks of Impressionism. Edgar Degasturned to sculpture when myopic degeneration made it a challenge to paint. Henri Matisse suffered fromdeteriorating eyesight, and brush painting gave way tothe medium of cutouts, or “drawing with scissors,” as he called it.

For internationally renowned Bay Area artists,Theophilus Brown and Paul Wonner, clarity of vision is a way of life.“One of the best things is to find out who we are,” says Wonner, describing the role of the artist in the world as one who pointsout meaning and significance.

Both men encountered cataracts at nearly the sametime, and both opted for cataract surgery with cornealspecialist, Professor David Hwang, MD.“It is a rareprivilege to have helped restore eyesight to each ofthese master artists, so that they may continue to sharetheir unique and creative vision of the world throughtheir compelling artwork,” says Dr. Hwang.

“Of all my five senses, vision is the one I value most,”comments Brown.

“Losing sight was pretty scary,” remembers Wonner,“and I had to ask: ‘Can I continue to work?’”

Significant Bay Area Figurative Artists

Brown and Wonner met at Berkeley in 1952 andformed a lasting life partnership. Both began painting atyoung ages and emerged from art schools to takeprominent places among the elites of the Bay AreaFigurative movement. Brown’s first exhibition at age 11was a show juried by American realist painter, GrantWood. Brown had drawn a portrait of his father, aninventor of agricultural implements, who entered the

Patients’ Point of ViewTheophilus Brown& Paul WonnerClarity of Vision is a Way of Life

portrait in an adult art competition.“The young painterwho came up to receive his award surprised Woodtremendously,” recalls Brown.

Wonner, the first artist in his family, says his father alsowas supportive of his intention to pursue art as a career,and it was important to his decision.“We all felt likeoutsiders,” says Wonner.“People thought we werestrange and kookie to be going to art school. None ofus expected to make a living by being artists.Wesupported each other.”

Brown and Wonner have created a world through theirart that includes ideas, enduring friendships, andnumerous exhibitions.They are collected by privatepatrons and are represented in major museumcollections including the Oakland Museum ofCalifornia, San Francisco Museum of Modern Art, theSmithsonian Museum of American Art, the SolomonR. Guggenheim Museum and Metropolitan Museum ofArt in New York.They still paint daily in their south ofMarket studios.This summer, Brown and Wonner werefeatured in a two-person show of their recent work atthe Sanchez Art Center in Pacifica.

In Appreciation of David Hwang, MD

“Dr. Hwang is a kind of genius,” says Brown.“He hassuch a wonderful way of coming into the office –beaming.” Brown describes Dr. Hwang’s great sense ofhumor as important to the process.“The procedurewent magnificently in the first eye, and the secondcame around with a little more time, so I recommendedcataract surgery to Paul,” he says.

“Most people are not very visual, but for an artist, it’scritical,” says Wonner.“My vision is so good now, Idon’t even need glasses to drive,” he reports.

Following surgery, Brown revisited some of his earlierpaintings and made changes based on his new eyesight.“He does that all the time anyway,” chides Wonner. •

Top to bottom: SelfPortrait by Theophilus

Brown; photo ofTheophilus Brown andPaul Wonner; Untitled

Still Life by Paul Wonner.

TMMS Appreciates Recent Gifts

Benefactors - ($500,000 + )Edward Alexander EstateShirley Reich Estate

Visionaries - ($100,000 + )Theresa M. CaygillChartrand Eye Research

FoundationFrannie FleishhackerOptiMedical

Entrepreneurs - ($50,000 + )Doris S. and Theodore B. LeeJohn and Lisa PritzkerR. Jean and James D.Taylor

Foundation

Investors - ($25,000 + )Alcon USAMort and Frannie FleishhackerThe Hellman FamilyStephen S. Smith and Paula K.

Smith Family Foundation

Director’s Council - ($10,000 + )

Daniel and Jeanne BenatarKimberly P. Cockerham, MDOssama R. Hassanein, PhD

The Joan Leidy FoundationMr. and Mrs. James P. LivingstonLumenisMellonJeanne and Sanford Robertson FundThe Schreck FamilyWalter H. ShorensteinLarry SpittersGloria Stefani Estate

Luminaries - ($5,000 + )Larry and Carie HaimovitchDavid and Marilyn Pratt

Innovators - ($1,000 + )AnonymousEleanore Compagno EstateMr. and Mrs. Daniel G. CookAnnette DobbsJohn and Marilynn FultonArthur and Shirley HarperChristine HarrisJonathan and Lidia Horton in

memory of Irmgard WoodLewis and Joan PlattStuart R. Seiff, MD, FACSRobert and Naomi StamperMichel and Masako VacheronJack and Marilyn Whitcher

Supporters - ($500 + )Marcus and Elaine BitterGene L. Campbell and Lee

Devereaux CampbellEmma Dong, MDDan and Meta LightfootMrs.Ann C. SteppanJohn and Peggy StockMrs. Laverne M.WalshMichael L.Wang, MD, FACSMr. and Mrs. Hulton B.Wood

Patrons - ($250 + )Cecilia and Richard AbbottVon Joseph BarsottiBen Colloff, MDPauline L. HaddadCynthia Sperry HarrisMr. and Mrs. Owen Oakley, Jr.Lata Krishnan Shah and Ajay Shah

Friends - ($100 + )Joan and John BarkanDaphne BranstenJanet Tashima DeboskeyAnn and Don Gralnek

Dr. and Mrs. George K. HortonJames J. LudwigV. David ManahanBonnet J. MeihoeferDr. and Mrs. Stacy R. Mettier, Jr.New United Motor Manufacturing,

Inc. (NUMMI)Joseph J. O’BrienRenaldo and Ellen PepiVibeke H. Petersen-JensenJulia J. PonRichard L. SegalRichard SlavinJudith Good StearnsRuth S.White

Contributors AnonymousLorita D.AaronsElaine G. BauerJohn R. BlackmanThe Chavez FamilyJoan G. CogenDavid B. Cooper, Kate Mitchell and

Daniel CooperSharon A. Daniel

Marta B. DuntonJeremy N. EgenbergerMichael F. and Netta F. FedorIda GearyCraig L. GerlachPete Greco, Jr., and Nancy K.

GrecoW.W. GudmundsonWanda R. HambyMr. and Mrs. Roy E. Hills, IIIRosemarie HirschlerRobert and Anne JohnsonRobert and Marilyn KlingerWanara KumalaMargaret E. MalloryEleanor C. MooreJan W. Olsen and Teresa L.

Kangas-OlsenFred and Judy RiedelElaine RosenfeldHelen Almazan RudnickMargaret RussellMarjorie C. StockettMr. and Mrs. Edwin H.TierneyWilliam and Camele WanatMrs. Harry Yaglijian

Thank you for your gifts toward fiscal year 2005-2006, receivedbetween July 1 and October 3, 2005.

Drs. Joan O’Brien,David Krizaj andHilary Beggs.

Clinic Administrator, Greg Tung

13V I S I O N S Fall 2005

In support of well-established scientists and promisingyoung faculty, as well as Department-wide

ophthalmic study, Research to Prevent Blindness (RPB)has awarded major research grants to the UCSFDepartment of Ophthalmology this year. RPB is theworld’s leading voluntary organization supporting eyeresearch, and provides generous unrestricted funding for vision research.

Neurobiology researcher, Hilary Beggs, PhD,AssistantProfessor of Ophthalmology and Physiology, received an RPB Career Development Award, to supportpromising juniorophthalmologyfaculty in basicresearch. She is the sixth UCSFOphthalmologyscientist to receivethis prestigiousaward, includingJacque Duncan,MD, and TomLietman, MD.(See profile of Dr. Beggs on page 6.)

Research to Prevent Blindness AwardsGenerous Support for Research

‘‘Imake sure that the Clinic of theOphthalmology Department works

well and stays financially healthy,” saysGreg Tung,Administrative Directorand Practice Manager for theOphthalmology Clinics.“It’s myresponsibility to be sure that thingsflow efficiently in the clinics forpatients, staff and physicians.” His jobencompasses everything in the clinics– from supervising front desk staff,technical staff and surgical scheduling,to monitoring billing and revenue.

“All financial indicators are lookinggood,” Greg says, as he complimentsthe staff on their efficiency, followinga reorganization he recommended last year. Now the clinic has threesupervisors, including a new technicalsupervisor who is experienced inrunning the highly specializedequipment required forophthalmology.An administrativesupervisor facilitates front deskworkers and support for thephysicians; and a revenue analystmonitors the high-cost scheduling of surgeries, as well as insuranceauthorizations and billing.

International Living

Trained as a management consultantand evolutionary biologist, Gregworked as a financial analyst with theDepartment of Ophthalmology, beforetaking a leave of absence to travel to

Vietnam in 2003. In 2004,he returned toUCSF as ClinicAdministrator.He was previously a biologist andHoward HughesBiology Fellow at UC Berkeley,where heconducted researchon mammalpopulations in Kenya.

Greg and his wife,Kim-Lan Bui, spenta year in Vietnam.There, Greg workedfor the Bach MaNational Park nearDa Nang as a scientific resourcevolunteer. He also assisted withcommunity development efforts,including building and staffing a newschool for rural children. His wifetaught English at Hue University.

“We found living in Asia veryagreeable,” Greg says.“My family cameto the U.S. from Taiwan as graduatestudents, and I spent several years andmany summers there. I speak Mandarinand Vietnamese, and my wife, who wasraised in Little Saigon in Los Angeles,speaks Vietnamese.”

Back to School

Furthering his interest in healthcare,Greg is now a distance-learning studentat Johns Hopkins University inBaltimore, studying for a Masters inPublic Health. He joins 90 studentsfrom all over the world, most of whomare physicians in public health.Thegroup visits Baltimore for several weeksa year, completes research papers, andinteracts with classmates in a

sophisticated ‘live talk’ chat room,where professors lecture and every student participates in the conversation.

“My studies are focused on how to positively impact the public’shealth,” Greg explains,“throughunderstanding disease andstrengthening international policiesthat will improve public health.” •

From Vietnam to UCSFClinic Administrator Greg Tung

Meets the Challenge

Staff

Infectious ocular disease specialist, Professor ToddMargolis, MD, PhD, Director of the ProctorFoundation, received the RPB Senior ScientificInvestigator Award in December 2004, which supportswell-established scientists who are recognized leaders in their field and actively engaged in research.

As Chairman of UCSF Ophthalmology, Professor CreigHoyt, MD, has also received a generous unrestrictedRPB research grant to be used by the Departmentwhere the need is greatest, providing opportunities for creative planning beyond the scope of restricted

project grants.To date, RPB has awarded over$4.2 million tothe UCSFDepartment ofOphthalmology. •

P R O F I L E

Ocular oncology investigator, Professor Joan O’Brien,MD, received the RPB Lew Wasserman Merit Awardthat supports mid-career scientists who are recognizedin their field and actively engaged in eye research.Jonathan Horton, MD, PhD, has also received this award.

Retinal scientist, David Krizaj, PhD,Assistant Professor,was named an RPB James Adams Scholar, an awardgranted to encourage promising young ophthalmicresearchers. His work is focused on calcium regulation,neuromodulation, and glutamine metabolism, whichmay affect retinal disease.

14 V I S I O N S Fall 2005

TMMS News

campaigns that result insuccessful fund development —someone who keeps the spiritof the legendary fundraiserHank Rosso alive throughprofessional leadership andcommitment to the field of fundraising.

Kathleen will receive thisprestigious award at theNational Philanthropy Dayluncheon on November 14,at the Oakland ConventionCenter.

Faculty News & HonorsRichard L. Abbott, MD

Honors: Thomas W. Boyden Endowed Chair in Ophthalmology.Invited Lectures: “On-Line Risk Management Education for Residents,”AUPO Annual Meeting, Phoenix,Arizona;“Management of Corneal Infections:Acanthamoeba Keratitis,”“How to Decrease Medico-legal Risk in Latin AmericanOphthalmology,” XXV Pan-American Congress of Ophthalmology, Santiago, Chile;“Pay for Performance:A New Challenge for Ophthalmology,” Cordes Society AnnualMeeting;“Review of Pay for Performance in Medicine,”AAO Mid Year Forum,Washington, DC;“Responding to Unanticipated Outcomes,”ASCRS AnnualMeeting,Washington, DC;“Update on New ICO Clinical Guidelines,” ICO AnnualMeeting, Florence, Italy;“Evidence-Based Medicine and the Formation of ClinicalGuidelines,” Chinese Ophthalmological Society, Beijing, China.

Robert Bhisitkul, MD, PhD

Invited Lectures: “Anti-VEGF drugs: Clinical applications,” XXV Pan-AmericanCongress of Ophthalmology, Santiago, Chile;“New Therapies in Age Related Macular Degeneration,” Course Coordinator, XXV Pan-American Congress ofOphthalmology, Santiago, Chile;“Anti VEGF Therapies-from clinical trials to practice,”Asociación de Retina de Occidente, Guadalajara, Mexico;“Update on anti-VEGFtherapies in macular degeneration,” Pacific Coast Oto-Ophthalmologic Society,Vancouver, Canada.

J. Brooks Crawford, PhD

Appointments: President,American Ophthalmological Society.

Allan J. Flach, MD, PharmD

Honors: American Academy of Ophthalmology Senior Achievement Award.Appointments: Outgoing President, Cordes Society.Pacific Coast Oto-Ophthalmological Society, Counselor-At-Large.Invited Lectures: “Anti Inflammatory Medications,”“Glaucoma Medications,” UCIrvine;“Nutrition and Ophthalmology,” UC San Diego.

Ed Howes, PhD

Invited Lectures: “Orbital Lymphoma,” Canadian Ophthalmologic Society.

Creig Hoyt, MD

Invited Lectures: Lifetime Distinction Claud Worth Medalist Talk:“Brain Blindness in Children - Are We on the Right Track?,” Changing Lives: Children’s Eye Group & David Taylor’s Retirement Symposium, Institute of Child Health, London;“WhatDo We Really Know About Amblyopia?” and “Dyslexia: In Your Eyes?,” University of Alabama Annual Clinical and Research Symposium;“Nystagmus Surprises inChildren” and “Optic Atrophy in Kids – Now What?,” Diagnosis and Management in Pediatric Ophthalmology and Neuro-Ophthalmology Spring Conference,WKKellogg Eye Center,Ann Arbor, Michigan;“Neurology of Amblyopia” and “CorticalVisual Impairment,” Symposium of Santa Casa, Brazil.

Shan Lin, MD

Honors: Kimura Resident Teaching Excellence Award, UCSF.Appointments: President, Pacific Coast Oto-Ophthalmological Society; UCSFDiversity Faculty Subcommittee; UCSF Council of Minority Organizations.Invited Lectures: “Cyclophotocoagulation:An Endoscopic Journey,” Pan-American

Academy of Ophthalmology, Santiago, Chile;“The Cause of Glaucoma:Are We ThereYet?” and “An Endoscopic Journey into the Eye,” Pacific Coast Oto-OphthalmologicalSociety,Vancouver;“Effect of Statin Drugs and Aspirin on Glaucoma Progression,”Association of International Glaucoma Societies World Glaucoma Congress,Vienna;“Phaco—Chopping Techniques,” Harvard Medical School Cataract Surgical TrainingConference, Boston;“Medical Treatment Update,” Glaucoma Symposium, Jules SteinEye Institute,Yosemite;“Candidate Cytoskeletal Proteins in the Outflow Obstructionof Primary Open-Angle Glaucoma,”American Glaucoma Summit, Salt Lake City;“The Role of the Cytoskeleton in Glaucoma,” Grand Rounds, UCSF, San Francisco;“Lasers in Glaucoma and Interpreting Autoperimetry,” Stanford University, Palo Alto;Global Association of International Glaucoma Societies Consensus Meeting.

Todd Margolis, MD, PhD

Appointments: Blue Ribbon External Review Committee, Schepens Eye ResearchInstitute, Boston, Massachusetts.Invited Lectures: “Choosing Antivirals for the Treatment of Corneal Diseases,”World Cornea Congress,Washington DC;“Understanding Latent Infection withHerpes Simplex Virus,” Schepens Eye Research Institute Biennial Cornea ResearchConference, Boston.

Stephen McLeod, MD

Appointments: Faculty member, Intensive Cataract Surgical Training Conference,Mass Eye and Ear Infirmary.Invited Lectures: “Accommodating Intraocular Lens Technology: Past, Present andFuture,” Honored Alumni Lecturer for the University of Illinois at Chicago,Department of Ophthalmology and Visual Sciences; Update in Treatment,AlconMeeting, Saratoga, New York;“Capsular Bag Fibrosis Following Cataract Extraction”and “Accommodating Intraocular Lens Technology: an Update,”Annual Meeting ofthe Pan America Association of Ophthalmology, Santiago, Chile;“Anterior SegmentComplications of Cataract Surgery,” First Annual Harvard Resident MicrosurgeryCourse, Cambridge, Massachusetts;“Accommodating IOL Technology:The JourneyBegins,” Peter Kronfeld Memorial Lecture, University of Illinois at ChicagoDepartment of Ophthalmology and Visual Sciences;“The Role of Non-SteroidalsAfter Cataract Surgery,”Albany Eye Society, Saratoga Springs, New York.

Julie Schnapf, PhD

Honors: Stanford and Joan Alexander Lecturer, Department of Ophthalmology andVisual Science, University of Texas, Houston.Invited Lectures: “Electrical Coupling of Photoreceptors,” 2005 FASEB ResearchConference: Biology and Chemistry of Vision,Tucson,Arizona.

Stuart R. Seiff, MD

Honors: The Walter Wright Lecturer, University of Toronto; Invited Participant, PanAmerican Association of Ophthalmology, Santiago, Chile; Special Guest Lecturer,The Argentine Society of Ophthalmology;Visiting Professor, Scheie Eye Institute,University of Pennsylvania.Elected: Secretary of Meetings and Executive Committee,American Society ofOphthalmic Plastic and Reconstructive Surgery.

TMMS President Kathleen RydarNamed Outstanding Fundraising Professional

‘‘TMMS President KathleenRydar is an inspiration

and teacher to fundraisersthroughout the Bay Area,”according to the Association of Fundraising Professionals-Golden Gate Chapter and theNorthern CaliforniaGrantmakers.The associationnamed Kathleen the HankRosso Outstanding FundraisingProfessional, honoring anindividual who creativelyorganizes fundraising

Calling her “a provenfundraiser,” the associationpraises Kathleen Rydar’scommitment to That Man May See, where she was named President in 2003. •

‘‘Generosity of spirit can change the world,”says Kathleen.“I’m grateful for those whosay ‘yes’ to support work that improves lifefor others.You make all the difference.’’

15V I S I O N S Fall 2005

‘‘Thelma de Souza Joins TMMSDirector of Corporate Support & Events

Ilove to ask for funding for agood cause,” says longtime

UCSF administrator Thelma deSouza, who joins That ManMay See as Director ofCorporate Support and Events,inviting corporate donors tosupport groundbreakingophthalmology research andcare.At TMMS,Thelma plansdonor receptions and fundraising events and seekscorporate sponsors. She worksat TMMS every afternoon, andin the mornings, she continuesto work for theOphthalmology Department,managing academic personneland post-graduate educationand organizing major academicconferences.

‘‘Creating a Legacy for That Man May SeeJanet and Bill Dinsmore

We want to leave a legacy that can bring sight to

others for years to come,” saysJanet Dinsmore, Board memberof That Man May See. She andher husband Bill recently made a generous estate-planned gift to support visionresearch, training of futureophthalmologists, andexcellence in patient care at UCSF Ophthalmology.

Janet and Bill know themeaning of breakthroughresearch.They support ThatMan May See annually, asmembers of the Chairman’sForum.With their longer-term

gift as a CharitableRemainder Trust, theDinsmores want to createa more significant fundthat can result in qualityresearch to combat thetype of age-related eyedisease that took Bill’sfather’s sight while hewas alive.

Former ChiefExecutive

Officer of The LearningCompany, Bill

led the Companyfrom 1985 to1995, as it became

“I’ve seen the benefits ofresearch funded by TMMS. Iknow how great the need is,and what it costs to do greatresearch, and donor support isjust crucial,” she says.

Thelma came to UCSF as aUC Berkeley graduate in 1975,and in 1983 she joined the staffof former OphthalmologyChair Steven G. Kramer, MD,PhD, as DepartmentAdministrator, when there

were just 12 faculty members(there are now over 30Ophthalmology faculty).

Community Volunteer

“When I have free time, Iwork at Dr. Shan Lin’s ChineseAmerican Eye Study inChinatown, because it willimprove the lives of patients inChinatown and beyond,” saysThelma.” (See American ChineseEye Study, page 1.)

She has persuaded her sisters –also longtime UCSFadministrative staff—to

volunteer for OphthalmologyDepartment events. Mercedesde Souza is with the UCSFAffirmative Action/DiversityDepartment, and Marie deSouza is with UCSF AcademicPersonnel.

Thelma, who lives in SanFrancisco, has also been anExecutive Volunteer Boardmember and volunteer at theAsian Art Museum in SanFrancisco for 6 years.There, shehelps develop and staff largedevelopment events. •

the premier brand of educational software forchildren and adults. Now heserves as a private investor andadvisor to emerging Californiacompanies.“Major investors arecritical for businesses to thrive,”says Bill.“That Man May Seealso needs future gifts in orderto achieve long-termexcellence.”

“We feel honored to supportsuch an outstanding researchand teaching institution,” saysJanet.“We know the future of ophthalmology is in goodhands when over 350 youngnew medical doctors apply for the four to five residencypositions in the UCSFDepartment of Ophthalmologyeach year.All are in the top 5% of the top medical schoolsin the country.We want toencourage such an attractiveplace to maintain its position of excellence – long into the future.”

A well-thought-out plannedgift can be a wise decision fordonors as well as thebeneficiary.The Dinsmoresestablished a CharitableRemainder Trust funded withappreciated securities, anddesignated That Man May Seeas the remainder beneficiary. •

16V I S I O N S Fall 2005

Her Leadership Made a DifferenceShirley Reich Provides Estate Plan Through TMMS

When Shirley Reich, one of California’s firstfemale stock brokers, came onto the Board of

That Man May See, she jumped in with her totalbeing.“That’s how she did everything,” said LindaKlett, close friend for decades.“Shirley wanted thebest for everyone, and she set high standards. She wasso proud of the UCSF faculty and theiraccomplishments, and thoroughly enjoyed serving onthe TMMS Board.”

Ms. Reich provided generously for That Man MaySee with an estate-planned gift, when she passedaway in April. She was a pioneer investmentprofessional, when men largely dominated the field,working at Merrill Lynch in the early 1950s and

then at Dean Witter (now Morgan Stanley DeanWitter). In 1965, she was President of The FinancialWomen’s Association of San Francisco.

TMMS honored Ms. Reich in 2003 with the firstVolunteer Award for Distinguished Service for hercourage and follow-through in fundraising. Shebrought many gifts to the university and was agenerous philanthropist. Ms. Reich also was active onthe UCSF Hospitals Auxiliary Board and was amember of Temple Emanu-El.

“Though retired, she was no slouch,” says AnnGolson, a TMMS Board Member introduced to theorganization by Ms. Reich.“She was a diligent

crusader, and kept an eye out for others who mighthelp fund research to cure vision loss.”

“Shirley was an excellent role model, with her greatsense of social compassion and honesty,” said RobertStamper, MD, who was her UCSF ophthalmologist.“Her inspiring gift will generate hope and keep usstriving for breakthroughs.That’s what she wouldhave wanted.”

For further information about including That Man May See in your estate plan, call (415) 476-4016 or emailtmms@vision.ucsf.edu •

S I G H T I N G S

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Judy Riedel, left, with Terrie Haden, Candace Olsen, Marilee Tinker, and Sharon Welty.Three TMMS Board couples, Janet and Bill Dinsmore, Rosanne and Mike Ogles, and Judyand Fred Riedel, hosted this special event in the Dinsmore home. The evening honored theWayne and Gladys Valley Foundation, the Thomas J. Long Foundation, and That Man MaySee Board member, Dick Olsen.

Over 200 new and old friends of That Man May See were hosted to a Sunday brunch atthe home of Mike and Mary Ellen Fox of Saratoga. UCSF Ophthalmology faculty and formerresident, Dr. David Chang, made inspiring remarks about advancements in research and thepotential to cure vision loss throughout the Bay Area and worldwide.

At the home of Mike and Mary Ellen Fox, Dr. Creig Hoyt presents Dr. David Chang withThat Man May See’s and the UCSF Department of Ophthalmology’s first DistinguishedAlumni Achievement Award.

Deborah and Stan Arterberry and Mike and Margie Blach flank Mike Fox, host of thelively and delicious event celebrating medical research at UCSF Ophthalmology. “We want tocelebrate the work of these wonderful physicians,” says Mr. Fox. “Their education, training,experience, and dedication to That Man May See are remarkable.”

Dr. Harry Chong with Dr. Emma Dong at the Fox event with Judge Dolores Carr. Dr. Dongwas the first female resident at UCSF Ophthalmology and practiced in Salinas for many years.

Mary Ellen Fox welcomes Carol Chang and Dr. Francis Chang, to the Sunday brunchhonoring the Changs’ son, Dr. David Chang.

Pearl Kimura, far right, hosted a dinner for That Man May See in honor of TheresaCaygill, second from left, and celebrating the Theresa M. and Wayne M. Caygill, MD, Chairin Ophthalmology. Dr. Creig Hoyt, left, conferred the endowed chair to Dr. Stephen McLeod,second from right.

Peter and Lela Moulthrop traveled from the East Bay to Saratoga for brunch at the Foxhome. “We are happy to support macular degeneration research and appreciate updates fromthe UCSF Ophthalmology faculty,” said the Mouthrops, whose support is helping Dr. DanielSchwartz advance new therapies and devices aimed at a cure.

“Are you real – and can you read me a story?” Alexandra Cockerham seems to be askingthe artistic sculpture in the garden at the Fox home. Alexandra is the daughter of Dr. Kim Cockerham and Dr. Glenn Cockerham.

Dr. Shan Lin with Adrienne Graves, Santen CEO, near the UCSF Eye Mobile, that windsthrough San Francisco’s Chinatown each week. The American Chinese Eye Study, funded inpart by Santen, examines residents in the hopes of finding cures for glaucoma among Asianpopulations. (See page 1, Saving Vision in Chinatown.)

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BoardO F D I R E C T O R S

TMMS Welcomes New Board MembersPaige HutsonPaige Hutson has over 10years’ experience creatingand managing marketingprograms for a range ofcompanies includingprofessional services,manufacturing, hospitality,and medical groups. She

holds a BA in economics from UC Davis.

A Marin native, Mrs. Hutson is married to KirbyHutson.Their three-year-old son is a retinoblastomasurvivor and a patient of Joan O’Brien, MD.Aspokesperson now in search of a cure, Mrs. Hutsonis currently launching a children’s program for theMarin chapter of the American Cancer Societycalled “The Kids Cure It Club.” Mrs. Hutson hasalso created a program with Dr. O’Brien,“Focus on A Cure,” to facilitate research, support, andeducation for children with retinoblastoma.

The Hutsons have three children, and Paige is activein her children’s schools and PTA programs. She is astudent of classical piano and a competitive runner.Mrs. Hutson has traveled extensively in Asia,Africa,Europe, and Central and South America, and isfluent in Spanish.

Albert R. SchreckAlbert Schreck is chairmanof Montgomery CapitalCorporation in SanFrancisco, and a graduate of Williams College.Anavid horseman, Mr. Schreckis Master of Fox Hounds,Emeritus Los Altos Hounds

and County Limerick. He is an active philanthropiston behalf of the arts, environment, education, andcommunity capacity building, and serves as adirector of the Abelard Foundation. He is a long-time Board member of the San Francisco Museumof Modern Art, where he has chaired numerouscommittees, including Development. Hespearheaded the campaign for the Portola ValleySchools Foundation.

His ophthalmologist for many years was StacyMettier, MD, a member of That Man May See’sBoard. Mr. Schreck and his wife, Jo, have three sonsand reside in Portola Valley.

A. Sydney Williams, MDDr.Williams currentlypractices as anophthalmologist in SanMateo and is UCSFAssociate Clinical Professorof Ophthalmology. He waseducated at UC Davis, andreceived his MD at

Howard University College of Medicine.

He has served as the Director of GlaucomaServices at Stanford, and was Medical Director of the Health Care Center of North Rockland,New York. Dr.Williams did his Internship at St.Vincent’s Hospital, New York; his Residency atUCSF; and received a Glaucoma Fellowship toMassachusetts Eye and Ear Infirmary. Dr.Williamswas inducted into the Alpha Kappa Alpha MedicalHonor Society in 1981.

Dr.Williams is a Fellow of the American Academyof Ophthalmology and Assistant Vice President of Education of the California Association ofOphthalmology.Among his many honors andmemberships, Dr.Williams is incoming Presidentof the UCSF Cordes Society.

He and his wife, Rosa, live in San Francisco andhave two children.

17 V I S I O N S Fall 2005

Andrew Yau Funds EndowmentDr. Richard L. Abbott Holds the Thomas W. Boyden Chair

Cornea surgeon andinternational leader in

ophthalmic practice guidelines,Professor Richard L.Abbott,MD, holds the newest endowedchair in the Department.

The eighth chair to beendowed at UCSFOphthalmology was created by the generosity of That ManMay See Board member,Andrew Yau. Support for thechair was given in memory ofThomas Boyden, President ofTMMS for 10 years.When Mr.Yau learned of Mr. Boyden’ssudden death in 2003, heresponded with compassionand this thoughtful gift.

“I called Creig Hoyt and toldhim that Tom had asked me tofund a chair some time earlier,and I wanted to do it in honorof Tom Boyden’s work,” recallsMr.Yau.“Giving in support of those who give their heartand soul for the benefit ofhumanity is the mostworthwhile and effective way to give.” Mr.Yau is CEOof the Practical Group ofCompanies in Thailand.

“Holding this special chair isan honor that touches medeeply,” says Dr.Abbott.“Tom

Boyden was a close colleague,and Mr.Yau is a highlyrespected and longtime friendof That Man May See.”

Dr. Abbott’s International

Work To Benefit Eye Care

“My work currently involvestwo regions of the world –Latin America and China—where I am spending anincreasing amount of time,”says Dr.Abbott. (See Hope forWorld Vision, page 1.)

Dr.Abbott’s research andclinical activities have focusedprimarily in corneal andexternal disease, health policy,risk management, and practiceguideline development. Hisefforts are now focused ondeveloping patient-orientededucational materials, ethicalstandards, and risk managementguidelines for refractiveprocedures.

Recognized Leader

A former member of theBoard of the AmericanAcademy of Ophthalmology(AAO), the American Board of Ophthalmology (ABO),and the Ophthalmic MutualInsurance Company (OMIC),Dr Abbott is currently theSecretary for Quality of Care

and Knowledge BaseDevelopment for the AAO.

Dr.Abbott holds a B.S. inBiochemistry from Tufts, andreceived his medical degree atGeorge Washington University.He was Medical Director of aremote comprehensive medicalclinic in the Indian PublicHealth Service, beforecompleting his Residency at CPMC in San Francisco.He was a Fellow atBascom Palmer Eye Institute at the University ofMiami, and at theMassachusettsEye and EarInfirmary.Dr.Abbottlecturesnationally andinternationally,and haspublishednumerousarticles in his field. •

Dr. Richard Abbott

developing new projects together.Investigators from the Proctor Foundation,for example, are discussing research projectsfocused on the unique presentations oftrachoma and HSV infection in women,with Professor of Obstetrics & Gynecology,Nancy Padian, PhD, an epidemiologist whois GHS Associate Director for Research,

and Executive Director of the Women’sGlobal Health Imperative.

The GHS has established“sandwich” training

programs to develophealth care leaders in

developing countries,but prevent ‘braindrain.’ Students areselected from thehome countryinstitution wherethey will get theirdegree; they come

University of California

San Francisco

Department of Ophthalmology

10 Koret WayRoom K-301San Francisco, CA 94143-0730

Director and ChairmanCreig S. Hoyt, MD

Cataract Care

415.476.3705

Cornea Care

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Glaucoma Care

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Vision Correction Center

415.476.5698Individualized vision correctionsurgery, including LASIK andPRK

UCSF Ophthalmology on the Internetwww.ucsfeye.net

Visions Newsletter produced by:

That Man May See, Inc.

a nonprofit, gift-supported

foundation funding vision

research and care at UCSF.

Editors:

Matthew M. LaVail, PhD

Stephen D. McLeod, MD

Joan M. O’Brien, MD

Copy:

Merry Selk

Kathleen Rydar

Thelma de Souza

Design:

Ikkanda Design Group

Anat Rodan

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Chris T. Anderson

Jack Whitcher, MD, MPH

Robert Foothorap

Sheryl Schindler

Russ Fischella

For a free subscription to

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call 415.476.4016.

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HOW TO REACH US

Comprehensive Eye Center

415.353.2800Routine eye care, acute care, eyedisease referrals

Contact Lenses

415.353.2800

Dr. Haile Debas Dr. Todd Margolis

Global Health InitiativeInternational Working Partnerships

Interdisciplinary Cooperation

to GHS for advanced interdisciplinarytraining, and return home to graduate.The first students from Kenya will arrive at UCSF in 2006.

Developing ResourcesCollaborators at GHS are also developingnew resources for international projects,including a computerized database ofinternational faculty, staff and students.

“As an umbrella organization, UCSFGlobal Health Sciences underscoresUCSF’s commitment to global health, andto developing the human resources thatwill sustain and advance science andhealthcare in resource-constrainedsettings,” says Dr. Debas.

Join the Global Health Sciences database tostay informed of GHS programs:http://globalhealthsciences.ucsf.edu/globalhealth/login.aspx •

An extraordinary interdisciplinaryprogram dedicated to the care of

vulnerable populations at home andthroughout the world, Global HealthSciences (GHS) at UCSF is buildinginterdisciplinary cooperation on campus –and training the global health leadershipof the 21st century.

“International health programs have longbeen part of the rich training and researchportfolio of UCSF faculty,” says HaileDebas, MD, Executive Director of GHSand former Chancellor and Dean of theSchool of Medicine.“Our vision is anetwork of collaborative relationships atUCSF and throughout the world,beginning in Africa and Asia.”

Ophthalmology Research & Training“Prevention of blindness is a major target in global health,” says Todd Margolis, MD,PhD, Director of the Proctor Foundationand a member of the GHS SteeringCommittee. “In developing countries,blindness occurs more frequently and atyounger ages, seriously compromisingaffected individuals’ ability to beeconomically productive.We are looking at ways to aid scientists in their owncountries in solving these problems.”

With Global Health Sciences as a catalyst,faculty from disparate areas at UCSF are

Koret Vision Institute + Beckman Vision CenterA facility of the UCSF Department of Ophthalmology