1: Hematological system development and Function. 2: Cellular movement. 3: Immune cell trafficking....

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M C+/+_PEA_R vsUR M C+/+_Veh_R vsUR M C W s/W s_Veh_R vsUR M C W s/W s_PEA_R vsUR 1 3 4 2 1 3 5 6 7 9 8 1 2 4 5 8 9 7 6 3 2 4 5 6 7 6 8 9 1 5 3 4 2 9 7 8 1: Hematological system development and Function. 2: Cellular movement. 3: Immune cell trafficking. 4: Cell-to-cell signaling and interaction. 5: Inflammatory response. 6: Small molecular chemistry. 7: Lipid metabolism. 8: Molecular transport. 9: Tissue development Suppl. Figure 1

Transcript of 1: Hematological system development and Function. 2: Cellular movement. 3: Immune cell trafficking....

MC+/+_PEA_R vs UR

MC+/+_Veh_R vs UR MC Ws/Ws_Veh_R vs UR

MC Ws/Ws_PEA_R vs UR

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1: Hematological system development and Function. 2: Cellular movement. 3: Immune cell trafficking. 4: Cell-to-cell signaling and interaction. 5: Inflammatory response. 6: Small molecular chemistry. 7: Lipid metabolism. 8: Molecular transport. 9: Tissue development

Suppl. Figure 1

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Intrinsic Prothrombin Activation Pathway

Coagulation System

HIF1α Signaling

Type II Diabetes Mellitus Signaling

p70S6K Signaling

Extrinsic Prothrombin Activation Pathway

p38 MAPK Signaling

Intrinsic Prothrombin Activation Pathway

Coagulation System

HIF1α Signaling

Type II Diabetes Mellitus Signaling

p70S6K Signaling

Extrinsic Prothrombin Activation Pathway

p38 MAPK Signaling

Intrinsic Prothrombin Activation Pathway

Coagulation System

Extrinsic Prothrombin Activation Pathway

p38 MAPK Signaling

Type II Diabetes Mellitus Signaling

HIF1α Signaling

HMGB1 Signaling

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Suppl. Figure 2

Clathrin-mediated Endocytosis Signaling

Production of Nitric Oxide and Reactive Oxygen

Species in Macrophages

TREM1 Signaling

Crosstalk between Dendritic Cells and Natural Killer Cells

IL-12 Signaling and Production in Macrophages

Role of cytokines in Mediating Communication

between Immune Cells

Caveolar-mediated Endocytosis Signaling

Communication between Innate and Adaptive

Immune Cells

MSP-RON Signaling Pathway

IL-10 signaling

P38 MAPK Signaling

Role of Pattern Recognition Receptors in Recognition of

Bacteria and Virus

IL-6 signaling

Role of Pattern Recognition Receptors in Recognition of

Bacteria and Virus

TREM1 Signaling

MSP-RON Signaling Pathway

Crosstalk between Dendritic Cells and Natural Killer Cells

Communication between Innate and Adaptive

Immune Cells

IL-12 Signaling and Production in Macrophages

Role of cytokines in Mediating Communication

between Immune Cells

T Helper Cell Differentiation

MIF-mediated Glucocorticoid Regulation

Production of Nitric Oxide and Reactive Oxygen

Species in Macrophages

MIF Regulation of Innate Immunity

IL-10 signaling

IL-6 signaling

Role of Pattern Recognition Receptors in Recognition of

Bacteria and Virus

TREM1 Signaling

MSP-RON Signaling Pathway

Crosstalk between Dendritic Cells and Nature Killer Cells

Communication between Innate and Adaptive

Immune Cells

Dendritic Cell Maturation

IL-12 Signaling and Production in Macrophages

Role of cytokines in Mediating Communication

between Immune Cells

T Helper Cell Differentiation

IL-10 signaling

IL-6 signaling

Airway Inflammation in Asthma

Toll-like Signaling

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A B CSuppl. Figure 3

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Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL

17-FTREM1 Signaling

Regulation of Cytokine Production in Intestinal Epithelial

Cell by IL-17A and IL 17-F

Acute Phase Response Signaling

Dendritic Cell Maturation

IL-12 Signaling and Production in Macrophages

Role of cytokines in Mediating Communication between

Immune Cells

T Helper Cell Differentiation

Airway Pathology in Chronic Obstructive Pulmonary

Disease

IL-10 signaling

IL-6 signaling

Role of IL-17F in Allergic Inflammatory Airway Disease

Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL

17-FTREM1 Signaling

Regulation of Cytokine Production in Intestinal Epithelial

Cell by IL-17A and IL 17-F

Acute Phase Response Signaling

IL-12 Signaling and Production in Macrophages

IL—17A in Arthritis

Role of cytokines in Mediating Communication between

Immune Cells

T Helper Cell Differentiation

Airway Pathology in Chronic Obstructive Pulmonary

Disease

IL-10 signaling

IL-6 signaling

Role of IL-17F in Allergic Inflammatory Airway Disease

Acute Phase Response Signaling

Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL

17-FTREM1 Signaling

Regulation of Cytokine Production in Intestinal Epithelial

Cell by IL-17A and IL 17-F

IL-12 Signaling and Production in Macrophages

Chemokine Signaling

Role of cytokines in Mediating Communication between

Immune Cells

IL-10 signaling

P38 MAPK Signaling

IL-17A Signaling in Gastric Cells

IL-6 signaling

Role of IL-17F in Allergic Inflammatory Airway Disease

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Suppl. Figure 4