1 GC-MSD Introducing the new 7890B/5977A January 8, 2013 Agilent Confidential Badr Astiphan GCMS...

Agilent Confidential1

GC-MSDIntroducing the new 7890B/5977A

January 8, 2013

Badr AstiphanGCMS Product Sales Specialist1-866-524-7936302-290-5631 [email protected]

Agilent Confidential2 January 8, 2013

We are First in GCContinuously innovating

5970 MSDFused SilicaCapillary Column

Microprocessor Control

5840 GC

5880 GC

5890 GC

HyperbolicGold Quad

Inert MS Ion Source

6890 GC

7200 GC QTOF7000 GC

Triple Quad

Capillary FlowTechnology

AutoInjection

Electronic PneumaticControl

Retention TimeLocking

2nd Gen LinearElectron Capture

Detector

Low Thermal MassTechnology

Units Installed>250,000 GC>60,000 MS

Multi-ModeInlet

1970’s1980’s

1990’s

2000’s

2010’s


7890A/5975C GC/MSD:The Most Popular GC/MS in the World

Over 20,000 5975 systems since 2005

The industry standard GCMS

Agilent 5977 MSD

January 8, 2013Agilent Confidential

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Proven TechnologiesImproving the Industry Standards for GC/SQ

Gold Quartz Quad Triple Axis Detector

High Temperature Inert Source

Unique Entrance Lens Design

All of 5975’s features also built in 5977, such as “Gold Quad”, SIM/Scan, Gain tuning, Triple-Axis Detector, Trace Ion Detection, Auto CI, etc..

January 8, 2013


230°C

275°C

300°C

325°C

350°C

January 8, 2013

High Temperature Ion Source

Solid inert material – not a coating– Not damaged by multiple cleanings

Programmable to 350ºC Improved response for many compounds

– More robust operation for “dirty” samples – Better response for “sticky” compounds– Sharper peaks for high boilers (late eluters)

… more performance for a wide range of

applications

Polyaromatic Hydrocarbon (PAH)


Unique Entrance Lens Eliminates Pre-filter

New, improved lens


Fringe fields

Unique Entrance Lens Eliminates Pre-filter


Quartz – Gold – Hyperbolic and Beautiful!

Why quartz?

– Low coefficient of linear expansion

(expansivity; α)

• dL = α L0 dt [t = ºC; dL = change in length

(m); L0 = length at 0 ºC]

Why gold?

– Inert material with excellent electrical

properties for high voltage

Why hyperbolic?

– Ideal electrical field is generated by

hyperbolic surfaces (NOT ROUND)

Much more than just a beautiful piece of glass

Round Quad


Triple-Axis Detector

ion beam

X

Y

OffsetZ

With a combination of three axes and appropriate shielding, noise from secondary particles can be reduced to a minimum


Triple Channel EM

Triple channels improve signal amplification

– Lower initial EM voltage required

Triple channels increase life– Lower cost of operation

Exit of the triple channels

Collector removed to show exit passages

Collector


Expanded Capabilities: 7890B/5977AImproving the Industry Standards for GC/SQ

Higher Ion Count• Extractor EI source• Increased ion count• S/N > 1500:1• IDL < 10 fg (industry first)• Improved thermal profile

Save Time & Energy •Sequence Scheduler• “Standby” post run• “Ready to run” from standby• “Bake Mode” as needed• Factory backflush option• Fast Vent capability• DS42i rough pump“standby” power reduction

Safety/Protection• Vacuum failure Shut off gas (He or H2)

Better Vacuum by Agilent Pump• New Agilent V304 Turbo

• TwisTorr• Molecular Drag technology

• Improved pumping light gases• H2 (220 L/s); He (255 L/s)

• Agilent Floating Suspension• Longer life• Quiet operation

Faster Scanning• 20,000 u/s• But never equal to the 7200 Q-

TOF speed or ‘scan’ sensitivity

7890B GC “Direct Communications Features• EMF, calculator, etc.

January 8, 2013

New Extractor Ion Source for 5977

Agilent Confidential

Why the Extractor EI Source?

Increase in ion count True increase in sensitivity

Better trace level precision Lower IDL and MDL

Proven sensitivity increase demonstrated with over 1500 7000 Series GC/TQ!

January 8, 2013

Comparison of Inert and Extractor Ion Source


Repeller(Push)

Drawout Plate

Ion Focus Lens

Entrance Lens

Ionization area

Ions

Inert Ion Source

Extractor Lens(Pull)

Extractor Source

More ions to Mass Filter

Mass Filter

January 8, 2013


Extractor Source “Etune” Sensitivity Increase

January 6, 2013

Blue – Extractor 40ppb solution (SVOC)Red – Standard 40ppb solution (SVOC)

More improvements on 5977’s Extractor Ion Source: Improved Thermal Profile

Why is this important?Better performance of high boilers i.e. PAH even at lower concentration!

+ TIC SIM pah_etune_300_long_R9.D Smooth

Counts (%) vs. Acquisition Time (min)

10 Injections80 min analysis

Good repeatability of PAH even at the trace level (5ppb)!!

Improvement for better Mass Spectrometer of Gas Chromatograph

January 15, 2013

Comparing repeatability of 80min Method

Phthalates analysis with 5977 GC/MSD

Oct 2012

1x10

0

0.5

1

1.5

2

2.5

3

3.5

4

4.5

5

5.5

6

6.5

7

7.5

8

8.5

9

+ TIC SIM PAHs-12.D

Counts (%) vs. Acquisition Time (min)37 37.1 37.2 37.3 37.4 37.5 37.6 37.7 37.8 37.9 38 38.1 38.2 38.3 38.4 38.5 38.6 38.7 38.8 38.9

5977 result

5975 resultTwo years ago

1x10

-0.1

-0.05

0

0.05

0.1

0.15

0.2

0.25

0.3

0.35

0.4

0.45

0.5

0.55

0.6

0.65

0.7

0.75

0.8

0.85

0.9

0.95

1

1.05

1.1

1.15

1.2


Counts (%) vs. Acquisition Time (min)35.2 35.4 35.6 35.8 36 36.2 36.4 36.6 36.8 37 37.2 37.4 37.6 37.8 38 38.2 38.4 38.6 38.8 39 39.2 39.4 39.6 39.8 40


Counts (%) vs. Acquisition Time (min)

+ TIC SIM PAHs-12.D

Counts vs. Acquisition Time (min)

5977 result

200ppb PAH 5ppb PAH

Key features of “Direct Communication” between 7890B and 5977A


Sleep/Wake mode• Sleep mode saves power (320W 190W) Lower lab operating cost

Safety Control• If 5977A MSD pump fail, 7890B will shut off the gas supply

Cool Down MSD Faster (FastVent)• When MSD Vent Cycle started, GC will cool down MSD analyzer at the

optimum gas flow to MSD.

Helium carrier gas : gas waste is eliminated Hydrogen carrier gas: risk of explosion is reduced

40% faster when cooling down from 280C to 100C (< 25 min)

January 8, 2013

Saving Energy and Time

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Normal Op Standby0

50

100

150

200

250

300

350

400

Power Consumption - 5977

0 4 6 7 15 20 23 30 35 400

50

100

150

200

250

VentFastVent

Power saved

Time saved

Pow

er(

VA

)

So

urc

e T

em

p

Time(min)

Time saved using Fast Vent

Better HW Features: Agilent Turbo Pump (V304)


Agilent Quality Standard

TwisTorr 304 FS

Innovation for: •Higher pumping performance

• especially for He and H2

•High reliability• lower cost of operation

January 8, 2013

Press release : http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html

http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html

http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html

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TwisTorr 304 FS: Vacuum Design

8 EDM turbo stages (rotor) designed to optimize pumping speed for light gases

8 Turbo stators made by pressed SST sheet technology

3 TwisTorr drag stages (spiral channels) designed for high compression ratio performances

Agilent’s new patent-pending Floating Suspension for robust, low noise operation

Better HW Features: Agilent Rough Pumps


New DS42i New IDP-3c

High performanceEnergy saving design“Inverter” not compatible with diff pump

High performanceOil-free scroll pumpNH3 CI compatible

with Agilent Quality Standards

January 8, 2013


Agilent Inert Flow Path … From Injection to Detection

Ultimetal – TCD, FPD, NPD/FID Jets

Ultimetal Capillary Flow TechnologyDevices, Ultimate Union

Ultimetal Inlet Weldment, Shell and Transfer Lines

Ultra Inert GC Column

Ultra Inert Gold Seal

Ultra Inert Inlet Liner

New

…now from a single supplier

Programmable Helium Conservation Module

Works with Gas Saver function of 7890 based GC

Standby Method can be programmed after the sequence ends

Analytical methods are unchanged since Helium is still the carrier during the run

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5977A GC/MSD IDL Specification

IDL is a statistically derived value from the precision (%RSD) of 8 consecutive, splitless injections of 100fg OFN at 99 % confidence level. The more precise instruments (lower %RSD) will generate lower IDLs.

The Agilent 7890B/5977A with an ALS or CTC autosampler has the following specifications:

January 15, 2013

Ion Source type High Vacuum pump type

IDL of OFN by 8 replicates of ALS*

Extractor Source Turbo Pump 10fg

Inert SourceTurbo Pump 24fg

Diffusion Pump 30fg

*Systems without an Autosampler will have only S/N specification.

These are installation specification, performed on customer site, immediately after installation and carry a lot more value than a reference specs.

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Why IDL specification is useful for the 5977 in SIM?

Influence of Noise in S/N specs

• In SIM (or MS/MS) when the Noise is too low, such as during acquisition of an OFN standard, S/N results may not give the best characterization

• If the noise level is insignificant - varies a lot and too low- the derived value from it (S/N) also becomes insignificant

Value of IDL

• IDL is derived from reproducibility/precision results, the same metrics most users utilize every day in their work. The IDL statistical process is the same used for Method Detection Limit calculations, and the %RSD values are tools to monitor analytical performance

• IDL characterizes the whole system – AS, GC, MS- giving confidence in overall reliability. It is the results of 8 consecutive injections, unlike S/N in a single shut, which can be influenced by many parameters/conditions

January 15, 2013

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The Influence of the low Noise on S/N valuesSame Data File, RMS, 5 Second Noise Region

Noise region: 5.66min - 5.74 minS/N: 3335

Noise region: 5.65min - 5.73 min S/N: 10785

A 0.01 min. shift in the noise region resulted a 6000 higher S/N value. When the noise is insignificant (low), the derived S/N value is also insignificant!

Noise region: 5.65min-5.73 min

Noise region:5.66min-5.74 min

S/N S/N

January 15, 2013


Market Leading PerformancePremium Value: The Best Just Got Better

Detector Performance

MSD Scan 1500:1 S/N; SIM 10 fg IDL – Best in Class with IDL tested at installation when ALS or Combi available (with Extractor Source)

FID <1.4 pg C/sec

ECD <4.4 fg/sec

FPD <2.5 pg S/sec; <45 fg P/sec

SCD <0.5 pg S/sec

NPD Best for P, 0.08 pg/sec N beat only by Thermo 0.05 pg/sec– but only using OUR Blos bead!

TCD 400 pg/mL

No one can now offer a better specification package than Agilent


Market’s Best S/N (SNR) > 1500:1

Market’s Best Scan Rate = 20,000 u/s

Market’s ONLY IDL < 10 fg

Better science from AgilentStatistical confirmation of entire system’s performance

January 8, 2013


Mass Hunter GC/MSD Software MassHunter Qual

MassHunter QuantMH

CS

MassHunter GC/MS Acquisition

And Use EitherMassHunter Data Analysis

ORMSD ChemStation Data AnalysisMSD ChemStation DA

G1701FA


MSD ChemStation DA

QEdit

Reports

MSD ChemStationStandard interface

Quantitation

Macros

Library Searching


MassHunter WorkStation Qualitative AnalysisData Navigator

Method Explorer

Chromatogram Results

Method Editor

Spectrum Results


Mass Hunter Quantitative Analysis

Compound Information

Results Information

Batch Information(i.e., Calibration Curve)

Results Informationfor the batch can be displayed. Visual guides highlight specific data that fall outside specific, predefined conditions.

Batch Information provides easy visualization and customization of relevant desired data.

The Quant Batch screen looks like this.

Compound Information displays graphical representation of the peak, qualifier information, spectral information, and the ISTD. Visual guides help identify associated data problems.


Unknowns Analysis


MassHunter Excel Reporting

•Excel Based (Excel 2010 supported)

•MassHunter application exports data in XML and graphics files

•Templates define report formatting

•Over 100 shipping report templates

•Reports can be altered for desired information & appearance

•Customization using Excel features (function, formatting, code)

•Computer Based Training for report customization by users

•Some customization available through Agilent


Application Notes

Flexibility: Performance and Budget

Lowest PricePerformance MeetsMethod Requirement

5977E Turbo MS5977E Diff MS

7820A Stainless source

HighestGC Performance& MS Performance

5977A EI5977A EI/CI

7890B GC Extractor source DS42i

Balance of Price, GC performance,& MS performance

5977A Turbo MS5977A Diff MS

7890B GC Inert source


Maintenance and Support Issues

January 8, 2013Agilent Confidential

39

Q&A Discussion

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