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Pharmaceutics I (Pharm351)05 Solubility & distribution phenomena

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Introd

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Defi

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Solubility exp

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Solubility expressions (C

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Solent!solute intera1. Polar so

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Solent!solute intera1. Polar solvents (C

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Solent!solute intera1. Polar solvents (C

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Solent!solute intera2. Nonpolar so

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Solent!solute intera!. Semipolar so

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Solubility of "ases in li#uids

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Solubility of "ases in l"ntrod

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Solubility of "ases in l$a#tors that a%%e#t the solubility o% ases in

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Solubility of "ases i$a#tors that a%%e#t the solubility o% ases in li'uids

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Solubility of "ases i$a#tors that a%%e#t the solubility o% ases in li'uids

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Solubility of "ases i$a#tors that a%%e#t the solubility o% ases in li'uids

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Solubility of "ases in lSolubility #al#u

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$xam

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$xample 1 (C

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Solubility of li#uids in li#uids

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Introd

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Ideal s% real so

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$xam

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$ffect of internal pressure on misc

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Complete s% partial miscibility

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Phase e#uilibria ' the phase (ibb

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$xamples on phas

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Pha1% Sin"le component system (

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Phase1% Sin"le component system (C

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Phase1% Sin"le component s

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+,o components system

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Condensed sy

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-ater!phenol partially miscible condensed

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-ater!phenol partially miscible condensed system

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$xample 3* -ater!phenol s

Example 4: Water Ph

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Example 4: Water-Phsy

Factors that afect miscibili

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two component liquid-lisyst

.actors that affect miscib

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.actors that affect miscib1. emp

 miscible as a unction o temper

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p They do not show neither upper nor

critical temperature

.actors that affect miscib

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.actors that affect miscib2. Presen#e o% %orein subs

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+hree components system (C3

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Phase rule in three component s

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/ules in dealin" ,ith trian"ular sy

/ules in dealin" ,ith trian"ular sy

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/ules in dealin" ,ith trian"ular sy(C

+ernary Systems ,ith 0ne Pair of Partially

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+ernary Systems ,ith 0ne Pair of Partially

+ernary Systems ,ith 0ne Pair of Partially

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y y y2i#uids (

%%e#t o% tem

+ernary Systems ,ith +,o Pairs of Partially

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+ernary Systems ,ith +,o Pairs of Partially

+ernary Systems ,ith +hree Pairs of Partially

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+ernary Systems ,ith +hree Pairs of Partially