0 2017 Investor · Global Market Growth Estimate ... Medical Devices, Orthopedics and Regenerative...
Transcript of 0 2017 Investor · Global Market Growth Estimate ... Medical Devices, Orthopedics and Regenerative...
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InvestorPresentation
MARCH
2017
Accelerating Biomedical Technologiesfrom Incubation to Monetization
QBIO
Forward Looking StatementsThis presentation contains "forward-looking statements" as that term is defined in Section 27A of the United States Securities Act of1933, as amended and Section 21E of the Securities Exchange Act of 1934, as amended. Statements in this presentation which arenot purely historical are forward-looking statements and include any statements regarding beliefs, plans, expectations or intentionsregarding the future. These forward-looking statements generally can be identified by phrases such as Q BioMed, Inc. (“QBIO”) or itsmanagement "believes," "expects," "anticipates," "foresees," "forecasts," "estimates" or other words or phrases of similar importance.Such forward-looking statements include, among other things, the development, costs and results of new business opportunities.Actual results could differ from those project these forward-looking statements are made as of the date of this presentation, and weassume no obligation to update any forward-looking statements due to numerous factors. forward-looking statements, or to update thereasons why actual results could differ from those projected in the forward-looking statements. Although we believe that any beliefs,plans, expectations and intentions contained in this presentation are reasonable, there can be no assurance that any such beliefs,plans, expectations or intentions will prove to be accurate. Investors should review all of the information set forth herein, and shouldalso understand the risk factors and the inherent uncertainties associated with new business opportunities and development stage.Any use of this information for any purpose other than in connection with the consideration of an investment in Q BioMed, Inccompanies. (“QBIO”) may subject the user to criminal and civil liability.
This presentation does not constitute an offer to sell any securities or the solicitation of an offer to sell any securities by Q BioMed Inc.
Biotech Growth &The Problem It Created QBioMed Solves It by Accessing Undiscovered
Biomedical Technologies for Investment
Pharma sales continue on a five-year growth track
and is expected long term.
An aging population provides consistent demand
and high growth rates.
Demand for affordable drugs remains inelastic.
International market growth creates a positive
Global Market Growth Estimate
The Biotech & The Life Science Sectors
0
200
400
600
800
1000
1200
2010 2011 2012 2013 2014 2015
Sales $M 60+ Population
Pharma Sales Linked to 60+ Population
However, the reality for many is approximately 8 out of 10 biomedical ideas
are under-recognized and under-capitalized.
Only very few have access to capital leaving
viable ideas unfunded and neglected.
Sources: UNDESA Population and Pharmafile
0
50
100
150
200
250
300
350
400450
500
2015 2016 2017 2018 2019
USD $B
Global Biotech Market Estimate
Sources: UNDESA Population and Pharmafile
p. 4
of biomedical start ups lack capital and resources to transition from incubation to development and beyond.
Reasons
Too small Unrealistic goals Unproven IP/ formulation
Missed milestones Not ready to go public Previous financing
Cannot attract / retain talent Not attracting partnerships
80
The Result Billions of dollars in market value remain locked in academia, early-
stage IP, unfocused management, challenging capital structures and failed IPOs. Investors cannot access them. They live in limbo or stuck in ‘dead money’
investments.
The Problem%
QBioMed Solves the Problem by
availing capital to develop biomedical technologies while
also providing investors access to participate in
our assets' growth and value.
p. 5
Our vision is to create a pipeline of innovative biomedical assets in various
stages of development in multiple therapeutic areas. Our strategy will minimize risk, share success and accelerate our assets' technologies to monetization.
Asset Search and Due Di l igence Ongoing Since Incept ion
Management Team
GRAH 1Denis Corin William Rosenstadt David Laskow-Pooley Ari Jatwes
Chief Executive Officer
Chairman of the Board
General Counsel
Director
VP Product Development
Director
Analyst
Director
Advisory Board
Dr. Geert Cauwenberg
Dermatology, Wound, Infectious
Diseases, Women’s Health
Dr. Helga Grupe
Oncology
Dr. Jose de Chastonay
Contract Services
Dr. Scott P Bruder
Medical Devices, Orthopedics
and Regenerative Medicine
Andy Watson
Diagnostics, Companions,
Genomics, Life Science Tools
John Erb
Medical Device
Cardio Vascular
Mary Jan Rafii
Ophthalmology
Dr. Susan Quaggin
CSO, Manin Resarch
George Nikopoulos
CEO, Mannin Research
Rosanne Satz
CEO, BioNucleonics,
Dr. Stanley Satz
Chairman, BioNucleonics
Jean-Jaques
Mondoloni
Advisor Wombat Capital
Our Milestones
August Established
Management Team
June
Initiated new
business model
October MAN-01 Exclusive
License Option
February SR89 Exclusive
License Option LOI
April MAN-01
Molecule Opt.
September Closes SR89
License Option
November
$4 M
Financing
September Engages Wombat
Capital as Scientific
Advisor
Planned
1Q 2017
initial Sr89
production
2015 2016 2017
p. 7
We unlock capital through US public markets to fund the development of our assets.
We make liquid investments in high-value assets that can produce exponential returns.
We diversifiy risk over several therapies in various stages of development and deploy performance-
based capital only.
We accelerate our assets' development with our management and advisory teams'
expertise, experience, and industry relationships.
How We Accelerate Biomedical Technology Development
Our ownership of an asset and our ROI steadily increase as assets hit milestones
and cross value-creating events during development lifecycles.
Our Business Model
INVESTCapital attached to goals
ACCELERATEIncrease investment and ownership
MONETIZEOperate, partner, license, IPO or sell
Preliminary scientific and commercial criteria review. Determining management's expectations and flexibility moves the asset to the next step.
Due diligence is combined with a validation of management's development and capital requirements.
Performance-based capital is deployed to meet specific and mutually-agreed goals in each stage.
Additional resources are infused to move the asset through development stages and to a value-creating inflection point.
Assets can be sold, licensed, joint-ventured or operated as cash flow positive product lines. QBIO's goal is to maximize value for its shareholders.
IDENTIFYCriteria match and fit
ANALYZEAsset and development plan
The Importance of an Asset's Development Plan
Development plans provide QBio a tool to assess management's
work to date and an insight into an asset's biomedical
technology and value.
The plan should have clearly defined milestones and quantify
capital needed to accelerate development.
QBIO's Team and Advisors can pinpoint their resources
to help transition a plan through development
to monetization.
Managing to milestones mitigates investment risk. QBio's capital
is released only when milestones are met.
A Requirement to Access QBio Capital
Drug Candidate Preclinical Phase 1 Phases 1b/2a Phase 3 Approval
A Growing Pipeline Mitigates Risk and Drives Shareholder Value
In YEARS 1&2 we are focused on licensing and acquiring assets, some with near term (6-12 months) REVENUE or value-creating opportunities.
In YEARS 2&3 we will look to grow the pipeline and monetize investments through partnerships, JV, IPO and sales revenue growth.
ASSET 1SR-89 Radiopharmaceutical
ASSET 2MAN – 01 Topical Eye Drops
TARGET ASSET 4
TARGET ASSET 5 Protocol Design for Ph4
ASSET 3UTTROCIDE-B Chemotherapy
TARGET ASSET 6 IND Preparation for Ph2/3
p. 11
Drug Candidate 505(b)2 Preclinical Phase 1 Phases 2/3 Phase 4 Approval
Our Current Portfolio of High-Value Assets
Strontium Chloride Sr89Injection, USP
FDA-Approved, Commercialization Planning and
Accelerating Development of Additional
Large-Market Therapies
UTTROCIDE-B
Pharmaceutical: Generic SR-89
Radiopharmaceutical
Condition: Bone Cancer Therapy
and Pain Management
Addressable
Market:
~110,000 yearly
diagnoses from
breast and prostate
cancers
Technology BioNucleonics
Stage: - Approved
Commercializing
Asset 1
Strontium Chloride Sr89Injection, USP
BONE METASTESES from Prostate and Breast Cancer
▪ Pain is the most common sign of bone cancer, and may
become more noticeable as the tumor grows.
▪ Bone pain can cause a dull or deep ache in a bone
or bone region (e.g., back, pelvis, legs, ribs, arms).
▪ Treatment options include:Pain Medications - OpioidsOrthopedic ProceduresRadiation TherapyRadiopharmaceuticals
▪ Sr89 is NON-NARCOTIC and can mitigate opioid
use and abuse
Pain Management
▪ 450,000* new breast and prostate cases are
recorded each year
▪ 1 in 3 people will develop bone metastases from the
spread of breast and prostate cancer
*Source: American Cancer Society, 2016p. 14
Market Potential for Bone Cancer Pain Palliation is
Estimated at $60-$80 Million
How it worksDrug targets bone-cancer afflicted areas providing direct radiation to destroy active cancer cells and relieve symptoms.
Effective In 70% of patients, usually within two weeks and can last six months.
▪ Indicated to relieve bone pain from skeletal metastases from breast and prostate cancers
▪ Can be used with opioid based drugs and cancer
therapeutics
▪ Studies demonstrated a prolonged progression-free result and overall survival with acceptable
toxicity
p. 15
Strontium Chloride Sr89Injection, USP
Non OpioidPain Medication
Pharmaceutical: MAN-01 Topical
Drops
Condition: Glaucoma
Addressable
Market:
60 million patients
worldwide
Technology
Stage: Exiting Preclinical
MAN-01
Asset 2
60 million patients worldwide
8 million with bilateral blindness
Typically no early warning signs
Therapy only slows progression
GLAUCOMAA Devastating Condition with No Cure
Vision with Glaucoma
Current Standards of Care
Medical (Pharmaceuticals)No new glaucoma pharmaceutical in 20 years (1996)
Laser Surgery (Out-patient)Requires two procedures and use of pharmaceuticals
Traditional Surgery (In-patient)Requires two procedures and use of pharmaceuticals
Painful, costly, and invasive Normal vision
p. 17
60.5
79.6
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2010 2020
Drug (Company) Target/MOA Stage
BOL-303259 (Bausch +
Lomb) NO-donating latanoprost Phase 3
K115 (Kowa) ROCK Inhibitor Phase 3
DE-117 (Santen) EP2 agonist Phase 2a
ONO-9054 (Ono) FP/EP3 agonist Phase 1
AMA0076 (Amakem) ROCK Inhibitor Phase 2a
LX7101 (Lexicon) LIMK2 inhibitor Phase 1/2
SYL040012 (Sylentis) RNAi beta blocker Phase 2
AR-13324 (Aerie) ROCK/NET Inhibitor Phase 3
▪ First in class drug for Intraocular Eye PressureNo new drugs in "IOP" for 20 years
▪ Only drug targeting the critical ‘Schlemms’ Canal
The Schlemms Canal is responsible for 70%-90% of fluid
drainage in the eye
▪ Testing results shows normalizing IOP
▪ Primary indication for Adult Open Angle Glaucoma
Additional indications may include:
- Age Related Macular Degeneration (AMD)
- Cystic Kidney Disease
▪ Mannin Research accepted into Johnson & Johnson Innovation, JLABS @ Toronto
Partnership to develop a novel eye-drop to treat Primary Open-
Angle Glaucoma utilizing the Tie2 Mechanism of Action
Treatment Comparative AnalysisNone of the follow address the Schlemms Canal
Source: W.H.O. 2010
Glaucoma Cases Expected to Increase 30% by 2020(millions of cases)
▲3
0%
In
cre
as
e in
Cas
es
Glaucoma Drug
Public Market Comp Aerie Pharmaceuticals - AERI $1.5 b MCAP
MAN-01
p. 18
Pharmaceutical: Uttrocide-B
Condition: Liver Cancer
Addressable
Market:
700,0000 diagnoses
per year
Technology: Chemotherapy
Stage: Exiting Preclinical
UTTROCIDE-B
Asset 3
Estimated 39,230 adults in the
United States will be diagnosed every year
Short 1-year survival rate
More than 700,000 people
worldwide are diagnosed each year
LIVER CANCER10th Most Common Cancer
Current Standards of Care
Surgical Hepatectomy or Liver Transplantation
Thermal AblationRadiofrequency ablation (RFA) and microwave therapy
Percutaneous ethanol injectionAlcohol is injected directly into the liver tumor
RadiationHigh-energy x-rays or other particles destroy cancer cells
Drug Treatment tryosine kinase inhibitor antineoplastic agent, Nexavar™
p. 20
500
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Uttrocide-B Sorafenib
Sorafenib Tosylate (Nexavar™) is the only FDA approved drug for the treatment of liver cancer
P Uttroside-B appears to affect phosphorylated JNK (pro survival signaling) and capcase activity (apoptosis in liver cancer)
A natural compound
Fractionated Saponin derived from S. nigrum
Small molecule
Steriod Glycoside
Uttroside B increases the cytotoxicity of a variety of liver cancer cell types
Up to 10x more potent than Sorafenib in
pre clinical studies
Cytotoxicity specific to cancerous liver cells
Provisional patent filed
Chemotherapy
OMRF’S SolutionA compound that increases cytotoxicity in liver cancer cells by increased
apoptosis and decreased pro survival signaling
UTTROCIDE-BIN VITROIC-50 of Sorafenib is 5.8 uM in Hep G2 while Uttrocide-B is 500
IN VIVOHepG2 Injected Into Mice Then Treated with 10mg of Uttrocide-B for One Month
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Week 1 Week 2 Week 3 Week 4
Control Uttrocide B p. 21
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$0.00
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$2.00
$3.00
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$5.00
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12/5/2016 1/4/2017 2/3/2017
News Flow
Q Biomed Joins with Oklahoma Medical
Research Foundation and Rajiv Gandhi
Centre for Biotechnology to Develop Liver
Cancer Chemotherapeutic
Q BioMed Inc. Announces Mannin Research
Accepted Into Johnson & Johnson Innovation,
JLABS @ Toronto
Q BioMed Inc. Announces Entry Into
Definitive Funding Agreement for up to
$4,000,000
Q BioMed Inc. Technology Partner Mannin
Research Inc. to Participate in a Webcast on
Innovating for Ophthalmic Diseases
Q BioMed Drug Development Partner to
Attend EANM 2016 in Barcelona, Spain
October 15-19 2016
Q BioMed Partner Mannin Research
Executives Attending
OIS@AAO 2016 & AAO
QBIO
3-Month Trading HistoryAs of March 1, 2017
Shares Outstanding
Warrants Data as of 11.30.16
9,200,000
1 MMarket Cap ~$40 M
Inside Ownership 35% Avg. Volume 125,421
Float 5,775,000 Yearend November 30
PR
ICE
VO
LU
ME
Recent Conferences
January 2017
Biotech Showcase, San Francisco
$3.95
p. 22
Low Float ● Tightly Held ● OwnershipAttractive entry level valuation
Current assets and acquisitions value
Revenue in 1H17
Launch and commercialize FDA-Approved SR89 Revenue generation expected in 1H17
Accelerate MAN-01 Asset DevelopmentMolecule optimization
Up list to National exchange in 1H 2017
Complete pre-clinical and Prepare IND for Uttrocide-B in Liver Cancer
Add one or two additional asset licenses in 2017
What to Expect From Us
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QBIO
p. 23
5
Corporate501 Madison AvenueNew York, NY 10222
USA
+1 (888) 357-2435
Executive & Investors
Denis Corin, CEO
Accelerating Biomedical Technologies
from Incubation to Monetization
QBIO