김아람의 면역학 강의노트 V
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Transcript of 김아람의 면역학 강의노트 V
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SelfSelf--DiscriminationDiscrimination, , a Life and Death Issuea Life and Death Issue
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IMMUNOLOGYIMMUNOLOGY
www.aramblog.com
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IMMUNOLOGY : PREFACE
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IMMUNOLOGY : LAY OUT
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Innate immunity and decoding the patterns of self and nonself
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I. Introduction
II. Innate Immunity
1) What is the innate immunity?
2) Why is innate immunity so important?
3) Who are the members of innate immunity?
III. Decoding the patterns of self and nonself by the innate immunity
1) Immune logic: How do they recognize the pathogens?
2) Recognition of microbial nonself
3) Recognition of self
4) Recognition of altered self
IV. Self discrimination of adaptive immunity
V. References
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I. INTRODUCTION
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IMMUNOLOGY : INTRODUCTION
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IMMUNOLOGY : INNATE IMMUNITY
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II. Innate Immune System
1. What is the innate immunity?
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IMMUNOLOGY : INNATE IMMUNITY
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2. Why is the innate immunity so important?
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IMMUNOLOGY : INNATE IMMUNITY
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IMMUNOLOGY : BARRIER
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IMMUNOLOGY : PHAGOCYTES
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IMMUNOLOGY : NK CELL
9
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IMMUNOLOGY : LEUKOCYTE RECRUITMENT
10
BOX . 1 Leukocytes recruitmentBOX . 1 Leukocytes recruitmentDNHBMDKDBKNMFDGM
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BOX . 2 Attack of NK cellBOX . 2 Attack of NK cell
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IMMUNOLOGY : DENDRITIC CELL
11
BOX . 3 BOX . 3 DendriticDendritic cellcell
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IMMUNOLOGY : DENDRITIC CELL
12
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IMMUNOLOGY : DEFENCE PROTEINS
13
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,MDKG@MODI@M@
( .>B B@LLB@I@M@ R I 9 M \M L 5 5,25L V
#/DODHIFDGMHEGE@FF@MHG 9 R \M M R> \ \M V HILHGG" W R> *V IKHMD@LDBHFID B BHFID 2,.FDFAK@GD @MM@BBHFID V? - V +L*B > .$C -BD 9BD ] < . .># ` -BD ? M
2@GGHLDAGCGDBMG2-
HILHGG W 2- 2@BKHI@D F@GGHLDKDBDIMHK ` F@GGHLD ENBHLD ` \M .VI . 2- \MB M$ M `
.KD@BMODIKHMDG
IGDNFHBHBB@ A@BMDK@ B@ILND R> V !V IHLIHKBHGD .IHLIHICL R>HILHGG +
%.MHGDL
W . \ ` -\ DNHBMDLKDBKNMFDGM\DNHBMDL@BMO@MHG\ LLMDFB@MDK@MHG . ` F@BKHI@DGDNMKHIL3BDDGCHMD@BDL W ` W . .+
"4ILHGG5@HBMHLL 2@BKHI@DHILHGG ` 8 ` * >
#-BD 9 M DIDK9BD \V 99BDGCDIDGCDGM-BD@BMO@MHG
IHL@BB@KCDLBHICGNBDB@BC
9 ` $ 5 DIMHID IHO@DGB V V V \ \ .$C
$W M V 5,25I@MHDG @LLHB@MDCFHDBN@KI@MMDKG
.H@N@MHGE@BMHK
W ] R> \M > 9 $ ? \M M %M ?
12,.
12-
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IMMUNOLOGY : CYTOKINES
14
. .+ R .
Bone marrow production of neutrophils, etc
IL-6
Limit inflammationIL-10, TGF-b
Macrophage activationIFN-r
Proliferation and activity of NK cells
IL-12, IL-15
Mediate local inflammationTNF, IL-1, chemokine
Control of viral infectionIFN-a, IFN-b
XY]/7/`\Z_/`/F__X/Z^^_Z
W . 931 " V` \8931 " V 2@BKHI@D 2@BKHI@D W W
W W L W >W W ` IL W W . W < V L
R \8 W W 7 VIL W W L H . V
9"BD DIDK9BD \ 9#BD 8 ./%DIDK9BD 3@ïOD./%9BD R W L ` . . 9"BD > 9#BD
9"BD "# B V I@HBMDL ] .9 L
9#BD % M V -BD L ? M 0HLGHI L IL 2@BKHI@D I@HBMD
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IMMUNOLOGY : S ELF DISCRIMINATION
15
">7DNF@MHC@KMKML
` > W ` + W >
> M R` * WV > * 2. /7% . ` R +
# " ]R9ID"C@ADMDL
" ]R GLNGCDIDGCDGMC@ADMDL . \ MI@GBKD@MB BD W V\ ]R M
W R . Y . 4 W + \` . . . V . * >" ]R# V > . ` *? W V > \ + B + \ BB . 4 ` B > 5 ` L LL \ * V. *\ . 4 W M < B W > /$ B W . > W 7+ LDE GHGLDE 9 7 M V ; ` V W *` + B
1.Immune logic: How do they recognize the pathogens?
\ . W . + R \
-\W 4
"/DMDBMHG@I@MMDKGBLL@KDCMI@MHDGL
\W M *
#/DMDBMHG@2@KDKBE@LLDE
\W \ M
$7DBHGDGHGLDE MKHNLDEF@D
\W B + DIDK9BD
%1KLMIKD@BMO@MHG-NMGDDCLIDKFLLHGEHKIKHEDLLHG@@MM@B
\+ V . 7 . W
7DBHGMHGHEFBKHA@GHGLDE7DBHGMHGHELDEF@KDK7DBHGMHGHEGCNBDCHK@MDKDCLDE
III. Decoding the patterns of Innate immunity
$W LDECLBKFG@MHG
72DCMHO.,@GD@ K/DBHCGMDI@MMDKGLHELDE@GCGHGLDE AMDGG@MDFFNGDLLMDF8BDGBD#'#!!##$!!
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IMMUNOLOGY : SELF DISCRIMINATION
16
2. Recognition of microbial nonself(nonself marker + activating receptor)
W M - \ \M M LL R V . 4 . V \M B 5,25L5@MHDG@LLHB@MDCFHDBN@KI@MMDKGL V 5,25L > . 4 \M \` W W . \M + LNIIKDLLHK9BD$ V*
. 5,25L \ 58IHIHL@BB@KCD \ IDIMCHB@GV 5,25L . 5577L5@MMDKG KDBHGMHGKDBDIMHK 5,25L \M B M* ` M \V V 5,25L M V
577L 577L 5,25L M W * 577L ` \M` MV MW
577L . 97L9H DKDBDIMHK 97L 577L V
97L W FFNGM’LDD .4 B 5,25L M 2@BKHI@D W V97L 577L \M ‘` ’ . . 97L 97#97%97&97 5,25L M \ V 9 97L *V BHFAG@MHG R > 5,25L M > 577 97 5,25L M ] 97L B
97L W
\M V9 L*,BMO@MHGHELG@GI@M@LM@MGCNBD@GMFBKHA@DEEDBMHK KDLIHGLD
W L 7HDGMDGM@MHGHE@C@IMODFFNGDKDLIHGLDL
97L 5,25L M Q V VV ,5" 31- MK@GLBKIMHGE@BMHK L W L* 2@BKHI@D /DGCKMB BD \V V \ >
97 MMI LBDGBDGDLHK #!!"!! AHA@LI
"5,25
CL73,582@GGHLD:[email protected] GNBDHMCD
#577
CL73,@BMO@MDCG@LD972@GGHLDKDBDIMHK
$8NIIKDLLHK9BDDIDK9BD` .MHMB 9BD ` ? . V 9BD` B W \ LNIIKDLLHK9BD W
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IMMUNOLOGY : SELF DISCRIMINATION
17
97L /DGCKMB BD 9 V .HLMFN@MHK /DGCKMB BD 2. !VL \M \ 2. ! > MDIDK9BD CDGCKMB BD BHLMFN@MHK \ \M . L ` %M L,5. L +L DIDK9BD M + <BHLMFN@MHK \M 5,25L .577L B
3D@MODLDDBMHG-4& ` FBKHA@GCNBMHGHEBHLMFN@MHK FHDBNDL W B B *` +
3. Recognition of self (self marker + inhibitory receptor)
M 4 * M \ B * V 3BD 7 3BD B >\V 3BD . 4
. 4 * V .@LL2. B \M B > V `V > V \ .` 2. V < \V 2. 2. < V L 2. B + M
7 3BD 2." GAMHKKDBDIMHK M GAMHKKDBDIMHK 3BD + R1B KDBDIMHK + IL GAMHKKDBDIMHK +
GAMHKKDBDIMHK 92FFNGHKDBDIMHK MKHLGDGAMHKFHME 2." M . IHLIHK@MHGL* 92 85"` 85# MKHLGDIHLI@M@LD * 3BD L L \
L + 3BDB >V . W R .+ \
F_/^5/KH/]]/XZXZ`_/Z/c]X/Y/X/YX]X_/Y_/Z_X]/X/Xc/_cX/c`^/XZXZ_/ca`c/X_/Z_ZYZ`c/ca`c7
F_/^5/KH/]]/XZXZ`_/Z/c]X/Y/X/YX]X_/Y_/Z_X]/X/Xc/_cX/c`^/XZXZ_/ca`c/X_/Z_ZYZ`c/ca`c7
B \M IL 5 9BD +L M 7
> W <
V .9 + 2. L*\V V 3BD
V V V V \V V LL V B \V V V V > B\ V V . 4 V MKHLGDKDLCND + 5MKHLGDKDLCND ! \ \ \V GAMHKKDBDIMHK IHLI@M@LD * V L 3BD + ?
MB > ! .
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IMMUNOLOGY : SELF DISCRIMINATION
18
2HDBN@K5@LLHKCL
+ GHGLDEB M+ M W NFHK@ FFNGM W * W L VVR> R> R>` + 5
"L L V R> V R> R> * ,BMOMHEBHFIDFDGMGOHODLMDLDJNDGM@IKHMDHLLHEIKHMDGLMHDGDK@MDDGFDLMIKHMDHMB @BMOM
# \M V \M \. \V \ V 9DIKHCNBMLHEBHFIDFDGM@BMO@MHGADBHFDBHO@DGM@MM@BDCMHFBKHA@BDLNKE@BDLHKMH@GMAHCDLAHNGCMHFBKHADL@GCMHHMDK@GMDGL-NM@DBHFIHGDGMHEMDBHFIDFDGM@LDKNFIKHMDGB@DC.$B@GBHO@DGM@GCGCLBKFG@MD@MM@BMLDEMHMDLNKE@BDLHE@NMHHHNL@GCFBKHA@BDL
$ + >+ VB . \M . R> .HFIDFDGM@BMO@MHGLGAMDCAKDN@MHKIKHMDGLM@M@KDIKDLDGMHGGHKF@HLMBDL@GC@ALDGMEKHFFBKHADL9LLADB@NLD@LDEBDLNAJNMHNLDIKDLLLDODK@DGDIKHCNBMLGBNCG./%'@GC./&&BGAMEHKF@MHGHEMD@BMOD.$BHGODKM@LD
5 Y + LDEF@KDK+ .$ .$A V ./%'` ./&& < VB .$BHGODKM@LD 2,.FDFAK@GD @MM@BBHFID \ V +L
CD47 : erythrocytes NZZ2&2. 2"Z2&F_-2Macrophage 22.
Sialic acids : FZ2&[" sialic acid Z. F Macrophage, dendritic cell, neutrophilZ.
CD46, CD55 : C3 JJNZ6Z. "ZC3 " C3 convertaseZQNZ.
MHC-1: 1#FZ2& KH/]]/ 1 7/ Y; 7
"W \ 5 \]
NFHK@ FFNGMBDFDC@MDCFFNGM
NFHK@ FFNGM V V . . ] \V V + < \V V BDFDC@MDCFFNGM
Absence of CD46,CD55
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IMMUNOLOGY : MHC MOLECULES
19
BOX . 4 what is a MHC ?BOX . 4 what is a MHC ?
9DKHDHE2.IKHMDGLGAGCGEHKDG@GMDGL@GCIKDLDGMGMDFMH9BDLIKHOCDL@GDI@G@[email protected]@GCMDKDAKDDBMEHKDGHK@GK@[email protected]@GDGCHDGHNLIDIMCDGMDKIDIMCDAGCGKHHODBKD@MDBHFIDDLM@[email protected] MEHKDGIDIMCDL8HFDBMHMHB 9BDBHGDLM@MKD@BMMH@OK@@GMDGG@LLHB@MHGM@[email protected]@FID@ODADDGLHGMHKD@BMMH@[email protected]@ALDGBDHEMDOK@@GMDG
[email protected]@G@LHDI@GMDDMDGLODIHFHKILFHEMDLDFHDBNDLGMDDOHNMHG@K@KADMDDGI@MHDGBFBKHHK@GLFL@GCMDODKMDAK@MDFFNGDLLMDFFBKHHK@GLFLMDGCMHB@GDMDK@GMDGLMH@OHC@[email protected]@ADMHLDDIMKHN@IHIN@MHG@L@GDICDFBGLNBBKBNFLM@GBDLMDEDGCOCN@LM@[email protected]@MB@G@LLHB@MDM@G@GMDGHEMD@MDKDCFBKHHK@GLF@OD@@KDLDDBMOD@CO@GM@DG@CCMHGGCOCN@LMMHCEEDKDGM@[email protected]@OD@ADMMDKB@GBDHEKDLLMGGEDBMHGM@GMHLDMCDGMB@@DDL@[email protected]@LMD@OD@KD@MDKB@I@BMMHIKDLDGM@GMDGLEKHF@CDK@GDHEI@MHDGL9NLLDDBMHGMDGCMHIKHFHMD@GCF@GM@G@@KDCODKLMHE2.FHDBNDLGMDIHIN@MHG9LIHMDLLM@MGEDBMHNLCLD@[email protected]@LKDBDODCLMKHGLNIIHKMEKHFMDEGCGM@MGCOCN@LGDLM,EKB@M@LIDBEB2.@DD@OD@KDCNBDCLNLBDIMAMMH@LDODKDEHKFHEF@@K@DMD@DDLK@KDDLDDKDMLEHNGCG#&HEMDDLM,EKB@GIHIN@MHGDKDMLEHKFHEF@@K@LBHFFHG
[email protected]@GLKD@MDKKDLLM@GBDMHGEDBMHGCHDD@[email protected]@GC@ODDGHMDOHODCLMK@MDDLEHKGBKD@LGMDKCODKLM A@MDKG@MOD73,LIBGEHKD@FIDHKAMDDGDMBKDBHFAG@MHGFDB@GLFLNLDCMHCODKLE@GMAHCDL*5KDLNF@AMLLADB@NLDD@[email protected]@CCDCMHMDKDIDKMHKDMD9BDLM@MKDBHGDLDEIDIMCDLG@[email protected]@MDCMHF@GM@GLDEMHDK@GBD9DDFG@MHGHEMDLD9BDLHNCBHNGMDK@BMMD@CO@GM@[email protected]@KDIKDLDGM@A@@GBDADMDDGMD@CO@GM@DLHEIKDLDGMG@CDCODKLMHEEHKDGIDIMCDLMH9BDL@@GLMMDCL@CO@GM@DLHEKDLMKBMGMD9BDKDIDKMHKD
$ [email protected]$KCDC<
\8 2. $ 4 IDIMCDACGBDEM 2." 9 Q"" \ +L 2.# 9 "!Q$! \ +L L ? L
2." 9 B@G ` FBKHHANG FBKHHANG * B@G 9 `? $ . I`? ' . \ 2."FHDBND '
2.# 9 B@G ` B@G * `?$I`? V ' \V 2."` B@G* V 2.# ''($'
\V 2.# 9 "!Q#! 2. \ B@G 4I@KM@@EEGM
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IMMUNOLOGY : SELF DISCRIMINATION
20
8@B @BC
V L \ V . 8@B @BC !I V . \ V . ] 8@B @BC "8@@MDC BHIKHMDGL @GCBHIC . 8DBL GAMHKKDBDIMHK ` 8DBL 92 V 8DBL B 2@BKHI@DCDGCKMB BD3DNMKHI V \M V
./## . 8DB -BD V B 7 -BD . R
B > 8@B @BC @MDKG@MODI@M@ 8DKNFIKHMDG E@BMHK ` L@B @BC V .$BHGODKM@LD
\8V 8@B @BC ?
./%7@LLHB@MDCIKHMDG
./% VDDKMKHBMDL L. 2@BKHI@D 875@ V5@HBMHLL ?8DGDLBDGMDKMKHBMDL ./% 2@BKHI@D M
\V LDEF@KDK M *` .
"? R> L@B @BC !
V R> >
07` H R> ` M R> \ 07 \ R> ` V L
BHL@MHG ` ]B@KAHCK@MD + R> > ` V >? $@@BMHLD $ L@B @BC !V
07 ODLBD H ? R> M@@BMHLD L@B @BC ` ! V? * \V V ? R> L@B @BC . W V
3GDCHHL@BB@KCDL@KDIKHBDLLDCMGMDH@II@K@MNLG@GHKCDKDCLDJNDGBDHEKD@BMHGL9DEKLMFHCEB@MHGHEIKHMDGLCDLMGDCEHKLDBKDMHGHKEHKMDI@LF@FDFAK@GDLMDKDFHO@HEMKDD@CCMHG@F@GGHLDKDLCNDL9LLEHHDCAMDLDJNDGM@@CCMHGHE@G3@BDMNBHL@FGDMDKDFHO@HEMHFHKDF@GGHLDL@GCMD@CCMHGHE@ENBHLD @GCMHFHKD3@BDMNBHL@FGDL1G@MKDD@@BMHLD @GCMKDDL@B @BCKDLCNDL@KD@CCDC
8DGDLBDGBD,CO@GBG@DMDBHFIDHE@DGM@MDODGMN@D@CMHCD@M
8MHDGCDGMM LDEF@KDK \ V . 4 W M 9
F_/^5/JXc`aX/X_/Kc`aZ] aX`/^Zc`YZX]/_`_]Z/]X\/YZ`_Z/aXX/`c/ZX]Z XZ2/X_/XY_`c^X]/]/Z/]`/ZX]Z XZ/acZ`_/YX/`/Z_Z`_5/cX_`c^XZ`_5/`c/__2
F_/^5/JXc`aX/X_/Kc`aZ] aX`/^Zc`YZX]/_`_]Z/]X\/YZ`_Z/aXX/`c/ZX]Z XZ2/X_/XY_`c^X]/]/Z/]`/ZX]Z XZ/acZ`_/YX/`/Z_Z`_5/cX_`c^XZ`_5/`c/__2
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IMMUNOLOGY : SELF DISCRIMINATION
21
4. Recognition of induced or altered self
V ` V V ` > V M > V V %M R`> > V M
> L -@BD@NMHGHFHNLFDB@GLF
\ V V I -DMK@BDN@K LG@CDKODCEKHFHMDKBDL
- \ 9 V ` V 57 73@LD I@M@ /3,C@F@D V 9 I&$CDIDGCDGMI@M@ > V > V +
\ 9V ` V > V\. V4 V 73BD 5 9 V
R> 2."` . 3BD` ./9BD\. FDHCBD 3#/@BMO@MGKDBDIMHK ]
3#/ 92 ,5! 8MKHLGDG@LDL @BMO@MHGI@M@ L @C@IMHK + 9 85" 85#MKHLGDIHLI@M@LDL R 3BD > V @BMO@MGKDBDIMHK GAMHKKDBDIMHK VV M ENCDBLHGF@G > + M
T 5/OD6:569
5/JFD5/IEM
/aZYZ]Z/`//Xc/]]/`/\Z]]Z_/Y/KH/]]/a_/`_//YX]X_/`//]ZX_ `c/XZXZ_/X_/Z_ZYZ`c/ca`c7/Z//ZZ`_/^X\Z_/^X_Z^/Xc/^`c/cZX_//`/cc`c/X_/Zc5/X]]/`c/_`_/ac`7
/aZYZ]Z/`//Xc/]]/`/\Z]]Z_/Y/KH/]]/a_/`_//YX]X_/`//]ZX_ `c/XZXZ_/X_/Z_ZYZ`c/ca`c7/Z//ZZ`_/^X\Z_/^X_Z^/Xc/^`c/cZX_//`/cc`c/X_/Zc5/X]]/`c/_`_/ac`7
,BMHGHEI&$
CMIDI&$LKDJNKDCEHKAHMBDBBD@KKDLM@GC@IHIMHLLGCNBDCA/3,C@F@D
\885 *
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IMMUNOLOGY : INNATE IMMUNITY
22
13HKF@D@MBDLBHGLMMNMODDIKDLLF@KDKLHELDEBDG@DGAMHKKDBDIMHKLHGMDDEEDBMHKBDLHEMDFFNGDLLMDF
GEDBMDCMK@GLEHKFDCHKC@F@DCBDLCHGKDN@MDMDDIKDLLHGHEMDLDF@KDKL@GCGCNBDMDDIKDLLHGHE@GCL EHK@BMO@MGKDBDIMHKLHG3@GCHMDKDEEDBMHK BDL
,IHIMHMBHKLDGDLBDGMBDLCLI@F@KDKLM@MM@MDFEHKI@HBMHLL AF@BKHI@DLDKD@LGDBKHMBBDLDIKDLLLG@LM@MGCNBDMLLNDKDI@KKDLIHGLDL,IIKHIK@MDDIKDLLHGHEMDLDF@KDKLDG@ADLBDLHEMDGG@MDFFNGDLLMDFMHCLBKFG@MDADMDDGGHKF@D@MBDL@GCGHGLDE @AGHKF@BDL@GCMHGHKDI@HBMHLDHKMDF@LGDDCDC
8DECLBKFG@MHG;8/@GDKMDHK
W VV \ * 8DEGHGLDECLBKFG@MHG WL `\ B * \M$ M 1 * + 2DAHNKGD H 2@BE@K@GD-NKGDM9"$"&$"` LM V M 5W "'! 5DMDK-2DC@@K9` * I \ W LFFNGHHB@8NKODK@GBD@LMD@C5KDLL8CGD"! L
\V \ 93VW V W 5@N2@GDK "% 42@GDK 59HDK@GBDC@GDK@GCMDDMDGCDCE@F,GGN@7DODHEFFNGHH "#""!%&"%WL * V < WL C@GDK L ] I $ @GMAHCBHK<
. 8DECLBKFG@MHG` /@GDKMDHK B 8DECLBKFG@MHG D B % <B > /@GDKMDHK + > 8DECLBKFG@MHG \ V .` \V LDE B + \R /@GDKLG@ W + . *
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IMMUNOLOGY : ADAPTIVE IMMUNITY
23
IV. Self discrimination of Adaptive immunity
W M W \ 4 > *
R "!! $ V\ "! * \ $ "!! $ .4 \ .4 $ \ $ B $ 7
$ V .4 \. a $ 4 \.\ 4\V *
B * B ! \ B \ 4* ` * < "!B
W . .+ < D > \ /3, < W LDE \ > B * ` + M M
R W M > 5 9BD 9 -BD 9 R 5> > \*
5HLMODLDDBMHG
3D@MODLDDBMHG
\* $ ` $ 4 BW \* 9 \ M V M 7 V H
M B M \* IHLMODLDDBMHG V \* 3D@MODLDDBMHG M 7 V \ ` . 4 . M 9-BD V ` > \ M ` + M VB M M 3 + *` +
9BDF@MNK@MHGG9FNL
9BD W \ 9BD W 9BDDIDK9BD./%9FIHBMD` BMHMB9 BD
‘9’ ‘-’
> W \ V 9FNL - ‘9’ 9BD R-HGDF@KKH > M V -BD .
*
V MV +
2. LDEIDIMCD+ > 8NKOO@LG@ M * M
\` 8NKOO@LG@ =*
W W B M \B 5 + V R .\V W < D * \V 5 \ VB M V %$ \ \ RL V . 4 + \ + -9BD H . $ VR . LNKOO@LG@ \ V 9 LNKOO@LG@ + VR 2. IDIMCD LNKOO@LG@+ LNKOO@LG@ > V VW L L B V ` 7\* < V W* ] L*
B LNKOO@LG@ D 7 *
W > D \B W + LG@ < ` >
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IMMUNOLOGY : T CELL MATURATION
24
W ;W ./% DIDK9BDDIDK9BD W
,BMO@MHGHE9BD
,BMO@MHGHE-BD
,BMO@MHGHE2@BKHI@D
GE@FF@MHG
DIDK9BD > M -BD ?M > V + LBMHMB 9BD DIDK9BD > + 2@BKHI@D DIDK9BD .D13K ] W
W ;+ DIDK9BD` ;+BMHMB 9BD 7
R \ 8 I \+ 9FIHBMD9K@GG L \* 9BD * $ ` 9BD` `
8HF@MBKDBHFAG@MHG
DIKDLLHGHE9.7DGD
BDIKHEDK@MHG
@GMDGGCNBDCLDDBMHG3D@MOD5HLMOD
@BJNLMHGHEF@MNKDIDGHMIDL@GCENGBMHG@B@I@AMDL
V ` -V F@MNK@MHG`` .\V 9V ` -V 2. IDIMCD +
8HF@MBKDBHFAG@MHG
W > M W !4` \. ` \
^^
9FNL B*
9.7 =*
2.,GMAHC ` $ 9BD 9BDKDBDIMHK .9BD,5. \ > M .9.7 ,5. 2. \ +L * M 2. \ 2. +L >
-BD .FFNGHHANG 9BD 9.7 ` . . ?L 9K@GLFDFAK@GD R> BR -BD LHNADEHKF @GMAHC L
N a . .B \ > .MFNLON@KL` V !V \
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IMMUNOLOGY : SOMATIC RECOMBINATION
25
9.79BDKDBDIMHK R> B@G` B@G B@G` B@G R> *;@K@ADI@KM; .HGLDKODCI@KM. \. \8 B 9.7 M V V ` ./$ . V R> H
M 9.7 9BD ] ,5. L \ > B 9.7 \V M \ 9.7 M .4 ."KDIDKMHKD
V \8 Y 8HF@MBKDBHFAG@MHG $9.7 > L . B@G 9;.LDFDGM? LDFDGM VV . \ ` `? . B@GDGD 9 ;LDFDGM `? . B@GDGD 9 & ` LDFDGM ‘ B ` ’ * \8 LDFDGM VV . ` \V . ` LDFDGM B M ;
;/.9.7 B@G` D@OB@G 9B /LDFDGM 9BD` -BD 9FNL -HGDF@KKH `;/.LDFDGM M ` \ ` V 5 ;/.LDFDGM 5 V R . W /$ M
\V V 9.7 B M *-4&
6& 1N #FZ 7a=887Y]Z_\7\7`^8Z^^_`X_Z^XZ`_8Z_:7^]
. ;/KDBHFAG@LD * L* * * 7,"KDBHFAG@MHG@BMO@MGDGD"`7,#KDBHFAG@MHG@BMO@MGDGD# V * 7,"7,#
"9BD-BD . \ "!!!B 7 *
-BD 9 + ` & R> RHHI R ;/; V ; & W W ?;&"/#';' V -V L -V ; " . ` .DGDKDBHFAG@MHG + B &"#''(&"$!!#"!!!B
V . L ` WV ` WV \ $% \ $` \. L ` &!!B + "!!#!! %W L*. L ` + %W .4KDBDIMHKDCMG #!! \B ?+ .` .4 @GMAHCBHK<
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IMMUNOLOGY : NEGATIVE SELECTION
26
BOX . 5 NEGATIVE SELECTIONBOX . 5 NEGATIVE SELECTION
. \ M 9BD .9.7` -BD .FFNGHHANG M;@K@ADI@KM 8HF@MBKDBHFAG@MHG /$ \V V \ . M
. \ R>` M* + ]V \V 9FNL -HGDF@KKH \ 8 7 M + V * L* 3D@MODLDDBMHG
\ ` V <WV + < \ 4B9BD 9 ,5. L * LDE2.# 2. .> \ M` 9BD +V * LDE2.# LDEIDIMCD " ‘’ MLDE2.# GHGLDE IDIMCD ‘’ GHGLDE M 9BD ‘’ M +L B M \. ` M # 5HLMODLDDBMHG
\V 2. +L M 7 ] \ V +L M < * \ V V /3, \* @IHIMHLL $
M 2.. W 2. M 89BD < L 2. M 9W M \V M N$ R M . . ?M W
". 4 * V IKHMDHLHFD . R> +L +L * +L . 2." L
,5. B +L * . 8 2.# L
. 4 V V ` * . L * M
4 >\V DIDK9BD V`,5. 2. * L . L \B > ` < `B >2. * . `B \. RDIDK9BD
#DIDK9BD ,5. 2.#B? .MHMB 9BD2."B ? 9.7 7 \ 9.7 ./%./ R> ./% 2.# .HGLDKODCI@KM M ./ 2." .HGLDKODCI@KMM 9.7 ? DIDK9BD ./%B 2.#BM BMHMB 9BD ./B 2."B M
\ IKDBNKLHK M 9BD DIDK9BD BMHMB 9BD *
\
/]]/^XcXZ`_/ "Z N 7a=887_YZ7_]^7_Z7`8Y``\8Y7ZB``]@Y``\]X]]@Y7Z77`Z`_Xcc^@cZ@Z^^7Z`_7;9:
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IMMUNOLOGY : T CELL MATURATION
27
I `? \ 9.7 B@G . \ * B > *
,DBDBNLHG
W 5W 9BD 9.7B \V R LHF@MBKDBHFAG@MHG $. > . B@GDGD R . V 9 . ? R . @DBDBNLHG
\. B . ` 7 7 I `? . W
. B@GDGD$ ./%./* R B@G \ ./%./ * /HNADIHLMOD \ B@G 9.7
5HLMODLDDBMHG
* 9.7 R 5HLMODLDDBMHG $9FB BHKMD .DIMD@BD > 9BD ./% ./ * DIMD@BD L LDEIDIMCD2."BHFID LDEIDIMCD2.#BHFID* V 2.BHFID DIDK9BD./%9BD > BMHMB 9BD./9BD 2.# CHNADIHLMOD9BD ./%B *./ .\. 2.#B DIDK9BD
8DEIDIMCDLDE2.BHFID V LNKOO@LG@ 7 @IHIMHLL $
3D@MODLDDBMHG
B $ > V >B ‘ V’ 9BD BHKMD FDCN@ 3D@MODLDDBMHG $ V M@EEGMV a VB 9FNL W
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IMMUNOLOGY : B CELL MATURATION
28
-BDF@MNK@MHGG-HGDF@KKH
9BD` > -BD R 9BD R -BD . . FFNGHHANGDGD@KK@GDFDGM $9.7DGD@KK@GDFDGM ` 7,"` 7,# D@OB@G MB@G ;;@K@ADI@KMHED@OB@G
` B -.7-BDKDBDIMHK9.7 ` 5HLMOD 3D@MODLDDBMHG \V 5HLMODLDDBMHG 9 9BD` M > B-.7 9 \ LNKOO@LG@ 3D@MODLDDBMHG 9BD \`. +L ` -BD R \V 9BD` -BD
\ KDBDIMHKDCMG"
-BDF@MNK@MHG
\8 Y -BD F@MNK@MHG` * DB ` 9BD` 3 ` M
"7DBDIMHKDCMG
R +L ` V ,IHIMHLL a B \ V 7,DGD L L -.7 . ` MB@G;KDBHFAG@MHG -.7 ` 9 \ V `> V -.7 7 9 R
W L . ` 5HLMOD 3D@MODLDDBMHG \ > ` R ` B * + 9 < ?V ‘’ ?$ 4
? WV DIDK9BD` .MHMB 9BD\. -BD \V W L DIDK9BD V DIDK9BD . *
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IMMUNOLOGY : OUTLINE OF IMMUNITY
29
` > . W 5 5 5 ] WGG@MDFFNGM 5 B > * > W MW@C@IMODFFNGM 5 B 5 \ $ I W MW $ &' 9` V W WIKF@KFFNGDKDLIHGLD I $ \ WV WLDBHGC@KFFNGDKDLIHGLD W R \V L *`MW V 8 >V V MW ] L ` $> W \M $> 5 #$ MW \V B W 9 MW 5 W +
W
W ?M. ?M+ . ?\. `% I ? ` ? ? LDANF @BM@MD` I$& \M GHKF@EHK@ . *` M. ? \ +LHNADE@BMHKL V + LHFDGMDKEDKHGL\. BHFIDFDGML M+ . ? ` M+I@HBMHLL` VDGCHBMHLL + M+ V RFHGBMDLGDNMKHIL\. MF@BKHI@DL V + V KDBDIMHKFDC@MDCDGCHBMHLL` V+IGHBMHLL `% I ? ` ` M V V >BDFB@FDC@MHKL .KD@BMODIKHMDGBHFIDFDGMLLMDFLLM@FGDLGGLBH@N@MHGLLMDFL
MW
MW 5 \M MMV MW 5@GMDGBLIDBEMM CODKLMW FFNGHHBFDFHK MLDE GHGLDE KDBHGMHG % 5 > V MW *` 8 LV@GMDGIKDLDGMGBDL V 8 R R 8 8 ` 8 V ` + 5 MW
8 -8-BDL 989BDL -8 R R V V ] "!& B M -8 ` V L VFDFHK-BDL >VI@LF@BDL*`VDEEDBMHK -BDL V -8 >V #$ Q V B ] #!!! WNFHK@ FFNGM
V WBDFDC@MDCFFNGM ` 98 98 R -8 V. MFNL 9BDKDBDIMHK 5 + V -8 R ` ` LL ` F@[email protected] B M V 2.FHDBND L@GMDGIKDLDGM@MHG [email protected]` [email protected] LV 2.FHDBND V L 98 M 98 %M L V *` V 98 989DIDK9BDL V 989BMHB9BBDL 98 [email protected] L B M M 98 -8V 98M \ W V V %M` V BMHGDL
V 98 98 BMHGDL [email protected] L M M V 98 %M L V *` V 98 V. V 98 BMHGDL V+ V 98 * V WL V ` VOKNLGEDBMDCBDLVMNFHKBDL M VBDLHEMDEHKDGMLLNDK@EM $V [email protected] V V@MDKDCLDEBDL V V 98 BMHGDL V 98
` 98 W V ` V 98 L V VCDGCKMB BDLMF@BKHI@D-8-BDL LVLV \ V ? [email protected] 98 BHLMFN@MHKLG@L 5 LV M+ V+ V V V "#\ [email protected] V L
$ 7><
BOX . 6 OUTLINE OF IMMUNITYBOX . 6 OUTLINE OF IMMUNITY
W . .4MMI LG@LHK CHBL GG@MD>FFNGMMF
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IMMUNOLOGY : REFERRENCES
30
V. REFERRENCES
TEXT BOOK: Cellular and Molecular Immunology, Abul K. Abbas, 4th edition.
1. S.J. Simpson, P.J. Hines, Self-discrimination, a life and death issue, Science 296 (2002) 297-316
2. R.Medzhitov, C.A. Janeway Jr., Decoding the patterns of self and nonself by the innate immune system, Science 296 (2002) 298-300.
3.P.Matzinger, The Danger Model: a renewed sense of self, Science 296 (2002) 301-304
4.R.E. Langman, M.Cohn, If the immune repertoire evolved to be large, Cellular immunology 216(2002) 15-22
5.Bevan M. In thymic selection, peptide diversity gives and takes away, Immunity 7:175-178, 1997