G Gabstracts.eurospe.org/hrp/0092/eposters/hrp0092p1-72_e...(Siemens, IMMULITE 2000/Xpi);CV %
Transcript of G Gabstracts.eurospe.org/hrp/0092/eposters/hrp0092p1-72_e...(Siemens, IMMULITE 2000/Xpi);CV %
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58ES
PE
Poster presented at:
Diagnostic value of random serum growth hormone, IGF-I and IGFBP-3
concentrations for the diagnosis of growth hormone deficiency in
patients below one year of life.
P1- 72
Design: Diagnostic validation study at a tertiary hospital.• Random serum samples.
• GH (IRS 98/574), IGF-I (WHO 02/254) and IGFBP-3
(Siemens, IMMULITE 2000/Xpi); CV% < 5%
• IGF-I was log-transformed
• Statistics: Multiple regression analysis, Kruskal-Wallis,
Fisher t Test; Receiver operating curve (ROC):
GHD (true positive) versus TH (true negative)
• Primary main outcomes: GH SDS, IGF-I SDS, IGFBP-3
SDS.
• Measures by ROC: Diagnostic accuracy (DA), Area
under the curve (AUC), Sensitivity (S), Specificity (Sp),
Positive and Negative Predictive Value (PPV and NPV).
1- To establish reference intervals for serum concentration of GH,
IGF-I and IGFBP-3 for the whole first year of age.
2- To investigate GH, IGF-I and IGFBP-3 usefulness for GHD
diagnosis in neonates and early infancy.
PatientsInclusion criteria: Infants 1m
** **
*
* p< 0.01 vs. 31-60 d
p< 0.01 vs. girls
+++
+ p< 0.001 vs. 2-6 m
++ p< 0.001 vs. 31-60 d
Neonates Neonates
Age
ug
/L
1º w
2º w
3º w
4º w
1st m
2-6
m
7-12
m1º
w2º
w3º
w4º
w
1st m
2-6
m
7-12
m
0
15
30
45
60
75
90
*****
+++++
*** p< 0.0001 vs. 2º-4º w
** p< 0.001 vs. > 1m
++ p< 0.01 vs. 2-6 m
+++ p< 0.0001 vs. 2º w to 2 m and vs. 7-12 m
p< 0.01 vs. 3º w girls
p< 0.01 vs. 2-6 m girls
Neonates Neonates
Age
ug
/L
1º w
2º w
3º w
4º w
31-6
0 d
2-6
m
7-12
m1º
w2º
w3º
w4º
w
1st m
2-6
m
7-12
m
0
1
2
3
4
***
***** p< 0.0001 vs. > 2º w
** p< 0.01 vs. > 2m
+++
++ p< 0.01 vs. 3º w
+++ p< 0.0001 vs. > 2º w
p< 0.01 vs. 4º w or 2-6 m ingirls
p< 0.01 vs. 3º w in girls
Neonates Neonates
Age
ug
/L
-2
0
2
4
Cut-off: -1.0 SDS
*** p< 0.0001 GHD vs TH and HI
***
SD
S
P1-072María Gabriela Ballerini DOI: 10.3252/pso.eu.58ESPE.2019
GH and IGFs
Número de diapositiva 1