(Chemotheraputic Agents)

(Penicillins)

1.1 (Penicillins)

1

Penicillin G 01101 IPC3 Penicillin G Sodium Penicillin G Sodium inj 3,000,000 U Vial

1. Penicicllicum mold 2.

(streptococcus)(pneumococcus)(meningococcus)(gonococcus)(spirochetal)

1.

10,000,000

(hyperreflexia) 2. 68 1 200,000500,000 10 300,000 8 ( 3 )

3. 25,00090,000 /kg 36 300,0001,200,000 / (10,000,0000 )

Jarisch-Herxheimer 1. 2.

a b 0.1% 0.5mlc Hydrocortisone 50100mgd Aminophylline 0.250.5ge

B

1.Tetracycline Penicillin Penicillins Chlortetracycline

2.Penicillin MethotrexateMTX MTX

3. Ceftazidime Penicillin Penicillinase CNS

15 ~ 25

2

01102 Retarpen IRETA Penicillin G Benzathine Retarpen inj 2,400,000 IU Vial Biochemie Gesellscha

1. 2.

1. 240 ; 240 3

2. 120 60 4

3. 1200000 300000900000 4. 4 1 1200000 --()

1.

2. 3. 4. 5. 4

6. B

1. 2. Cephalosporines 3. 1.( IndomethacinPhenylbutazone

Salicylas)

2. Penicillin

15 ~ 25

1.2 (Penicillinase-Resistant)

3

01201 Prostaphlin IPRO5 Oxacillin sodium Prostaphlin inj 500mg Vial

1. 6 250500mg 6 5001000mg

2. 50100mg 40kg

3. 25mg 4.

1. 2.

1.Tetracycline Penicillin 2.Penicillin MTX

15 ~ 25

01202 Cloxacillin OCLOX Cloxacillin sodium Cloxacillin 250mg Cap /

1. 2. 3.

G 1.

2. 1. 46 1 500mg, 7 2. 40 : 50100mg/kg,

B

penicillin 1.probeneciddisulfiram

2. 1. 6 40%

2. 250mg 1 3-7mg

15 ~ 25

1.3 (Aminopenicillin)

4

01301 Ampicillin OAMP5 Ampicillin Ampicillin 500mg Cap -

01302 Ampolin IAMPI Ampicillin Ampolin inj 500mg 500 Vial

penicillin glycopeptide transpeptidase peptidylglycan

1.

a.>40kg 2050mg/kgq68h b.>20kg250mg q6h

6

01304 Supercillin Suspension OAMOS Amoxicillin Supercillin Suspension 1.5mg/60ml Suspension

8 250mg 500mg 3gm Probenecid

1. 2.3.

Supercillin (amoxicillin) 1-2

Supercillin powder for Oral Suspention 60cc

1.4 (Broad-Spectrum Penicillin) 01401 Lilacillin

ILILA Sulbenicillin sodium Lilacillin inj.1gm Vial

1. 24g 4080mgkg 24 2. 13g 180mgkg

1. 2.

3. 1. 2. 3.

15 ~ 25

1.5 Penicillin

7

01501 Soonmelt F.C OSOON Amoxicillin 250mg /Clavulanic acid125mg Soonmelt F.C Tab 375mg Tab YSP 4

01502 Augmentin syrup OAUGS5 Amoxicillin 80mg/ml & Pot. Clavulanate

11.4mg/ml Augmentin syrup 457mg/5ml35ml/bot Bot Smithkline Beecham

01503 Soonmelt IAUGM1 Amoxicillin 500mg/Clavulanic Acid 100mg. Soonmelt For Intravenous injection Vial

Amoxicillin Clavulanic acid - Amoxicillin

1. 3 1 375mg 8 25-50mg/kg 1-2ml/kg 3

2. IV 20 100ML 30 1 3 1 1.2mg 8 1 6 1 1 4 30mg1 3 6 8 1

3.

AST / ALT 1. amoxicillin/clavulanic acid

2. amoxicillin/clavulanic acid

B

1. 2. -lactam Cephalosporin 3. penicillins / 1. amoxicillin/clavulanic acid

2. 3. probenecid probenecid amoxicillin amoxicillin/clavulanic acid 70%amoxicillin/clavulanic acid

1. 25 2.

8

01504 Subacillin ISUBA Ampicillin sod.1gm / Sulbactam sod. 500mg Subacillin inj 1.5g Vial

Sulbactam sodium Ampicillin

mucopeptide

( Bacteroides Fusobacterium Clostridium difficile)Branhamella catarrhalis 1. 15g 12g 6 8 Sulbactam 4 g 12 1,500mg 115mg5 1.5 -3g 6 8 1.5g 1.0g probenecid

2. 150mg/kg/ 6 8 75 mg /kg/ 12

Sulbactam

Allopurinol allopurinol Ampicillin Ampicillin

CSF -lactam Ampicillin Sulbactam

1. 2. 3. 0.5 lidocaine hydrochloride anhydrous

(15-30)

9

01505 Tapimycin ITAPI Piperacillin 2g / Tazobactam 250mg. Tapimycin inj 2.25gm. Vial

Piperacillin Piperacillin Piperacillin/ Tazobactam -lactamase

30 12g/1.5g 16g/2.0g 4.5g

1. -lactam Piperacillin

2.

() 3.Tapimycin Piperacillin Tazobactam Piperacillin 2.35 (54mg)

4.

5.Piperacillin

B -Lactamase

1. Tobramycin (AUC) 2. Probenecid Tazobactam 3.Piperacillin Vecuronium Vecuronium Piperacillin/Tazobactam Vecuronium

Penicillins

( diazepam barbiturates) Piperacillin 5ml

(15-30) 24 (2~8) 48

10

(Cephalosporins)

2.1 (Cephalosporins) 02101 U-Save

OUSAV Cephradine U-Save cap 250mg Cap -TW /, UL 016

11

02102 S-60 IS60 Cephradine S-60 inj.1gm. Vial -LACTAMASE

1.

a 6 250mg 12 500mg b 6 250mg 12 1mg c 6 500mg 12 1mg d 6 1gm

2. 2550mg/kg/ 6 3.75100mg/kg/ 6 12 4gm

4. 500mg 1gm AMCEF 2~4 gm 4 50~100 mg/kg/day

5.AMCEF 50100mg/kg/ 4gm

1. 2.

3. SGOT SGPT 4. BUN 5. 6.

1. 2. 3. B

1. Cephalosporin 2. Furosemide Ethacrynic 3.Probenecid Cephalosporin

1. 4.0ml 1.0gm 2. 10ml 1.0gm

3. 10ml 1.0gm 5%M/6

(15-30)

12

02103 Winzolin IWINZ Cefazolin sod Winzolin inj 1gm Vial

cefazolin (PBP)

1gm20~40mg/kg1.5~3gm 50mg/kg 5g 100mg/kg

1. 2.

3.

4.

5. BUNCreatinine 6.

7.

8. K Prothrombin B CANDIDA

9. 1. Lidocaine

Anilide

2. Pencillin Cephem Cephalosporine Cephamycin

Vitamin K 3.

4. 5. 6.

Cephalosporin

13

Probenecid Cephazolin 1. 2. 2ml Lidocaine Hcl inj0.5%

48

02104 Cefadroxil OCEF1 Cefadroxil monohydrate Cefadroxil 500mg Cap , ST. 008

1. 12g 34g a 1gm 2gm2gm

b 1gm c

1gm 10 2. kg 50mg kg

75~100mg

1.

2. 3. Creatinine 4. 5.

Cphalosporin

Cephalosporin Aminoglycoside

(15-30)

14

02105 Keflex OCEP5 Cephalexin Keflex 500mg Cap /, S/416

02106 Ulex Susp OULEX Cephalexin Ulex For Oral Susp 25mg/ml.(60ml./Bot) Bot

methicillin

1. 2550mg/kg 2. 14gm 6 250mg 6 500mg1gm

3. 60ml

vitK vitB 1. Penicillin

2. 3.

B Cephalosporin

1.. 2. 14

2.2 (Cephalosporins)

15

02201 Cefaclor OCEFA Cefaclor Cefaclor 250mg Cap /, G3213

Pseudomonas Methicillin

... 1. 250mg 10 250mg

3gm 1gm Probenecid 4gm

2. kg 20mg 8 kg 20mg

1gm

1. 2.3.

5 (15-30)

16

02202 Cefuroxime ICEFU Cefuroxime sod Cefuroxime 750mg Vial

GG -LACTAMASE

1. 8 750mg 8 1.5gm 36gm

2. 30100gm/kg 34 3. 1.5gm 750mg

1. penicillin 2.3.

Benedict's Fehling'sClinitest 4. 5. 6. 7.

Cphalosporin Cephalosporin Aminoglycoside

1.Cefuroxime 250mg 1ml 750mg 3ml

2.Cefuroxime 250mg 2ml 750mg 6ml

.

2.3 (Cephalosporins)

17

02301 Flumarin IFLUM Flomoxef Sod Flumarin inj 500mg

Vial

Oxacephem G(+) G(-) 1.() Methicillin (MRSA) Cephem

2. Cephem

( )peptostreptococcus Branhamella catarrhalisKlebsiella Proteus Influenzae Bacteroides 1 1~2gm 2 1 60~80mg/kg 3~4 1 150mg/kg 3~4

02302 Loforan

ILOFO Cefotaxime Loforan inj 1gm Vial

1. 1gm 2gm 68 12gm 3090 1g

2. 50100mg/kg 612 150200mg/kg

3. 1gm 23 612

4. 50mg/kg 5.

6. 3

1. 35 2. 3. 30

1. Aminoglycoside 2. Coombs Enzymatic Method

Cphalosporin Cephalosporin Aminoglycoside

18

02303 Unizid IUNIZ Ceftazidime Unizid inj 2gm Vial

-LACTAMASE

1. 16g 2 3 2.02 2560mg/kg 3.2 30100mg/kg 2 3 1.

2.Benedict's Fehling's Clinitest 3.Creatinine 4. COOMBS

cephalosporin

02304 Sintrix ISINT Ceftriaxone sod Sintrix 1g inj Vial

19

02305 Tricef ITRIC Ceftriaxone sod Tricef inj 1gm Vial

1. 12g 50mg/kg 50mg/kg 30 4g

2. 2050mg/kg 3. 2080mg/kg SGPTSGOTBUN

1.

2.Ceftriaxone cephalosporin Albumin Bilirubin Hyperbilirubinemia

3. 4. Epinephrine Glucocorticoid

Penicillin & Cephalosporin Aminoglycoside

1. 2g 2.

2.4 02401 Mepem

IMEPE Meropenem Mepem inj.250mg. Vial Dainippon-Japan

1.

non-glucose-fermenting G(-)-Pseudomonaseruginosa

lactamase -1(DHP-1) DHP-1

2.(PBPs) peptideglycan

Meropenem Mepem ( Staphylococcus spp,Streptoccus spp, Enterococcus spp, Klebsiella spp, Enterobacterspp, Serratia spp, Proteus spp, Pseudomonas spp, Haemophilusinfluenzea and Bacteroides spp)

1. 14

2. 1 0.5~1g Meropenem() 2~3 30 2g()

1.

2. 3. 4.PIE syndrome X

5. 1.

2. 3. 7 GOTGPT

4. 5.

carbapenempenicillin cephem Sodium Valproate( Valproic Acid )

0.25g() 0.5g() 100ml

2.5 Cephalosporins

20

02501 Tienam ITIEN500 Imipemen/Cilastatin Tienam inj 500mg. Bot

G+G- 1. Imipenem 2.

8 250mg 8 500mg 8 5001000mg

1.

2.

21

(Tetracyclines)

3.1 (Tetracyclines) 03101 Tetracycline

OTETR Tetracycline Hcl Tetracycline 250mg Cap /, 184

Oxytetracycline Chlortetracycline

1gm 2050mgkg

1. 13 2. 3. 4. 5. 6.

7.8.D

15 ~ 25

22

03102 Doxymycin ODOXY Doxycycline Doxymycin 100mg Cap /, DEC

2 1 2

12

2

l. 2.

D Doxycycline/Tetracycline products

1.Barbituratescarbamazepinephenytoin doxycycline

2. Doxycycline 3. ~90%18~22hr0.9~1.8 L/kg82~93%

(15-30)

23

03103 Tygacil ITYGA Tigecycline Tygacil 50mg/vial Lyophilized Powder Vial

Tigecycline glycylcycline tRNA 30S tigecycline 30S A site tRNA

Tigecycline

100mg 50mg 12 5~14 18 D

Tigecycline warfarin

15 ~ 25

( Macrolides)

4.1 ( Macrolides) 04101 Ilosone

OILO Erythromycin Estolate Erymycin (Ilosone) 250mg Cap /

t-RNA

1. 14gm 250-500mg 6-8 2. 30-50 mg/kg/ 6 3. 4g -

1. 2.

B

1.Erythromycin bromocriptine

2.Erythromycin cyclosporine cyclosporine

3.Theophylline erythromycin 15 ~ 25

24

04103 Erythromycin EERYO Erythromycin Erythromycin TUBE

G+

(N.gonococcus)(C.trachomatis)

1

1.

2. 1. 15 ~ 25 2.4

25

04104 Klaricid OKLAR1 Clarithromycin Klaricid Film-coated Tablets 500mg Tab Abbott

Omeprazole

1. 250mg~500mg250mg7~10

2.500mg Omeprazole 40mg 14

PimozideAstemizoleCisapride Terfenadine C macrolide

Theophylline Carbamazepine Clarithromycin

15 ~ 25

04105 Zithromax OZITH Azithromycin Zithromax 250mg Tab , ZIM 250

04106 Zithromax Susp OZITS Azithromycin 200mg/5ml Zithromax Powder for oral Susp Bot

()

1. (Chlamydia trachomatis)

26

1 500mg 24 250mg 4 15 3 500mg 5 500mg 25 250mg

2. 30mg/kg 10mg/kg 3 10mg/kg 25 5mg/kg

1.(/)

2. 3.

1. 1 2 2. 3. warfarin 4. 2 5. 6. 7.

B azithromycinerythromycinmacrolide 1. 50%

2. erythromycintroleandomycin dirithromycintheophylline theophyllines

50% 1 2

30

(Aminoglycosides)

5.1 (Aminoglycosides)

27

05101 Gentamycin Vial IGM1 Gentamycin Sulfate Gentamycin inj. 80mg/2ml Vial

05102 Gentamycin Amp IGM2 Gentamycin Sulfate Gentamycin inj. 80mg/2ml Amp

Aminoglycoside

1.

2. Pseudomonase CNS 1. 3mg/kg 3 (q8h) 5mg/kg 3mg/kg 710a.22.5mg/kg q8hb.()2.5mg/kg q8Hc.()2.5mg/kg q12h

2.() ampicillin12g gentamicin 1.5mg/kg( 80mg)8 2 6 penicillin V 1g q6h

3.() 0.51 ampicillin 2g gentamicin 1.5mg/kg( 80mg)8 2 3,0000units/kg aqueous penicillin G50mg/kg ampicillin 2mg/kg gentamicin

4.a.()= x82mg/dl 16 b.=/ 60kg 60mg q8h 2mg/dl 30mg q8h

5. 0.52 23 6. 48mg qd(>3)12mg

--

- 1. 3~5

2. 2mcg/ml~12mcg/ml

3. I/O Gentamicin I/O

4. Gentamycin Fanconilike

5.

D

Gentamycin Aminoglycoside Aminoglycoside

1.Aminoglycoside acetylcholine acetylcholine

2.Loop Diurtic Aminoglycoside

15 ~ 25

28

05103 Gentamycin eye drop EGEND Gentamycin Sulfate Gentamicin eye drop 5ml Bot

Gentamicin Amino-glycoside Antibiotics

:12 1 34

D Gentamicin 15 ~ 25

4

29

05104 Neomycin ONEOM Neomycin Sulfate Neomycin 250mg Cap , GCPC 1403

1. 8 2. 16 13 -

D

aminoglycosides (15-30)

05105 Neomycin Oint

ENEOM Neomycin Neomycin Oint Tube

05106 Bacitracin Neomycin EBACI Neomycin sulfate/Bacitracin zinc Bacitracin Neomycin 30g Tube 2~4

30

05107 Sisogen ISISO Sisomicin Sulfate Sisogen inj 100mg/2ml Vial

1. 100mg 150mg

2. 5%

Sisomicin Aminogly cosides

1. Dextran sodium Alginate 2.

05108 Tobramycin ITOBR Tobramycin Sulfate Tobramycin inj 40mg/ml 2ml Vial

DNA DNA

1. 3mgkg 2. 5mgkg 34 3. 67.5mgkg 34 4. 4mgkg

5. 1mgkg

SGOT 710 10

31

05109 Unikin IUNIK Amikacin Unikin inj 250mg. Vial

kanamycin

1. 8 5 12

7.5 () 20 7 10

2. 12 250 3. 1.5 10 4. 10mg/kg 12 7.5mg/kg 5. 4 6 5 7.5 (1 1.5 )

1. 2. 3. 10 D

Amikacin Aminoglycosides

(15-30)25 3 2-8 7 25 1 2-8 3

(Polypeptides)

6.1 (Polypeptides)

32

06101 Targocid ITARG Teicoplanin Targocid inj 200mg Vial Gruppo Lepettt S.P.A. -ITALY

Methicillin

1. 400mg IM IV 200mg 12 IV 400mgIV IM400mg

2.

1. 2. Vancomycin Vancomycin teicoplanin

3.teicoplanin

4. /Aminoglycosides, Colistin, Amphotericin B, Cyclosporin, Cisplatin, Furosemide Ethacrynic acid

5. Targocid teicoplanin

Teicoplanin CSF ( 0.3 3 ) 70100 0.6l/KG 9095%teicoplanin

97% teicoplanin

4 12 12

( Quinolones)

7.1

33

07101 Urintestin ONEGA Nalidixic acid(Negacide) Urintestin 500mg tab , 750

pH DNA RNA proteus , E.coli, Enterobacter Klebsiella

1. 1 4 2 1g 2 2.1 2g 1 3. 1 55mg 4 2 1 33mg/kg

()()

()

1. Oxolinic Acid 2. BishydroxycoumarinWarfarin 3. Ketogenic Steroids 17-Keto 4. 12 5. ClinistixTest-Tape

6.

7.

Nalidixic acid warfarin warfarin warfarin

15 ~ 25

7.2

34

07201 Cixa ICIXA Ciprofloxacin 100mg Cixa 100mg/50ml.inj Bot

07202 Cinolone ICINO Ciprofloxacin 200mg Cinolone 200mg/100ml inj Bot Quinolone DNA gyrase

2 100200mg 3060 100mg

()

1. warfarin quinolones ( prothrombin timesINR ) warfarin

2.

Quinolone

1.Ciprofloxacin methadone quinolones methadone (CYP1A2 and 3A4)

2. warfarin warfarin PT INR

1~2 20%3.5~4.5 30~50%

15 ~ 25

3

35

07203 Sinflo FC OSINF Ofloxacin Sinflo FC Tab 200mg Tab

07204 Tarivid

ETARI Ofloxacin Tarivid OTIC Bot Daiichi-Japan

Quinolone pyridone carboxylic acid

1.

2.

1. 300600mg 23

2. 2 6 10 10 10 1~12 5 0.25 mL0.75 mg ofloxacin 10 0.5 mL1.5 mg ofloxacin

S-GOTS-GPTALPr-GTPTotal Bilirubin BUNCreatinine

1. 2. 3. 4.HemoglobinHematocrit

5.

6.

1.

(Cmax )(AUC) 100600mg (T) 35

2.

0.3 % 602 mg/gotorrhea389-2850 mg/g 0.3 %100.5 mL1.5 mg ofloxacin4.1 5.4 ng/mL10 ng/mL

28

7.3

36

07301 Cravit OCRA5 Levofloxacin Cravit 500mg FC Tab Tab

DNA Gyrase Ofloxacin 2 MIC MBC MIC

1. Clcr>50ml/min 500 1 ()250 1 500 1

2.(Clcr>50ml/min)Creatinine clearance 24 250 250mg 24 500 500 12 500 500

1.()(Lyell )(Stevens-Jonson )()(

)

2.; BUNCreatinine ; GOTGPTALPr-GTP

1. 2. 3. levofloxacin 4.

:D- Ofloxacin

1.Quinolone class Ia class III QTc torsades de pointes cisapridephenothiazine

2.quinolones warfarin PT INR

15 ~ 25

(Sulfonamides )

8.1 (Sulfonamides )

37

08101 Kingmin ESINO Sulfamethoxazole Kingmin Eye Drops 4% 10ml Bot

sulfsoxazole 2

1 3

1. 2. 5~10

38

08102 Bacide OBAKT Sulfamethoxazole 400mg/Trimethoprim 80mg Bacide (Baktar) Tab , 705

LYELL GOTGPT BUN PIE

1.

2.

3. Bilirubin

1. methotrexate methotrexate

2.warfarin wafarin

15 ~ 25

08103 Spasmo-Euvernil OSPAE Sulfacarbamide 500mg / Phenazopyridine 50mg Spasmo-Euvernil - Tab

10

1. 2. 3.

39

08104 Sulfasil Cream ESULF1 Siver Sulfadiazine Sulfasil Cream 1% 25gm Tube

08105 Sulfasil Cream ESULF Siver Sulfadiazine Sulfasil Cream 1% (1bot=200gm) Bot

Enzyme Blocker DNARNA Siver Sulfadiazine

Deformation

2 3 12 1/16

Sulfadiazine

1. 2.

3. glucose 6-phosphate

1.Silver Sulfadiazine 2. Silver Sulfadiazine

Siver Sulfadiazine Amorphous colloids 100%

15 ~ 25

(Miscellaneous Antibiotics )

9.1

40

09101 Clindamycin OCLIN Clindamycin Clindamycin cap150mg Cap /, SK G-1162

09102 Clindamycin inj ICLIN Clindamycin Phosphate inj 300mg/2ml. Clindamycin inj 300mg/2ml Amp

50s

1. 2400

2700mg 24 12001800mg600mg

2. 2024mg/kg 3. 1520mg/kg

-( IV ) 1. 2. 1060 3. 4.

B Clindamycin Lincomycin

nondepolarizing muscle relaxants

41

09103 Vanco IVANO Vancomycin Vanco inj 500mg Vial

[] ( )Penicillin,Cephalosporins clostridium 1. 6 500mg 12 1g1 44mg/kg

2. 10m 100~200ml 6 1 30

- 1. 2.

C

1. aminoglycosidescephaloridinepolymyxin Bcolistinfurosemide

ethacrynic acid

2. tertacyclineserythromycins Vancomycin

15 ~ 25

09104 Fucidin OFUCI Fusidate Fucidin 250mg Tab Laboratoires LEO S.A. , 121

Fusidic acid Fusidic acid fusidic acid

1 3 1 500mg50mg/kg 3

1. ,Lincomycin rifampicin ,

2. D

1. Coumarin derivatives 2. HMG-CoA stain rhabdomyolysis

3. HIV Ritonavir Saquinavir

4. Cyclosporin Cyclosporin Fucidin Fucidin Suspension

Fucidin 0.03-0.16 mcg/mlFusidic acid ()

(15-25 )

(Antituberculosis Agents)

10.1

42

10101 Ebutol OEMB Ethambutol E M B , Ebutol 400mg Tab

1. 2.

3.

43

10102 Duracrin OINAH Isoniazid Duracrin 100mg Tab , GCPC

INH B6 1.

2.a b

Corticosteroits 1.- 5mg/kg(1 300mg)-1 10~20mg/kg(1 300mg)

2.-1 300mg)-1 10mg/kg ()()

1. B6(1 10100mg) Isoniazid

2. 6 2 3. 4. 5. 6.

1. carbamazepine

Carbamazepine isoniazid 2. hydantoins

12 16 50% acetylate hydrolyzed 2~3 90% 6

44

10103 Pyrazinamide OPZA Pyrazinamide P.Z.A. Tab 500mg(Pyrazinamide )"Y.S. Tab , GCPC-1614

34 1.52gm INAH0.30.4gm 13

1. 2. 3. 4.

1. Probenecid Sulfinpyrazone 2. cyclosporine cyclosporine 2 910 (70%)

(15-25)

45

10104 Rifampin 300mg ORIF3 Rifampicin Rifampin 300mg Cap /

10105 Rifampin 450mg ORIF450 Rifampicin Rifampin 450mg Cap /, 476

Rifamyicin

450600mg 450mg

S-GOTS-GPT

1

2. 3. 4. 5. 6.

1.Rifampin cyclosporine 2.Rifamycins warfarin 3.Rifamycins theophylline theophylline

4. Ethambutol 5. bumarin Digitalis

Isoniazid Streptomycin 150mg 2 8 24 3 8090%()

10.2

46

10201 Rifinah 150mg ORIFI1 RIF 150mg+INAH 100mg Rifinah 150mg 150 Tab Gruppo Lepettt S.P.A

10202 Rifinah 300mg ORIFI RIF 300mg+INAH 150mg Rifinah 300mg 300 Tab Gruppo Lepettt S.P.A

1.RIF DNA-dependentRNA polymerase

2.INH INH B6

RIF 600mgINAH 300mg

1. 2. S-GOTS-GPT 2~4

3. Vitamin B6 D

1.Rifampin Corticosteroids

2.PAS rifampin 3.PAS isoniazid PAS INH acetylation 4.INAH

5.Rifampin isoniazid

(15-25)

47

10203 Rifater ORIFA Rifampin 120mg+INAH 80mg +PZA 250mg Rifater Tab Gruppo Lepettt S.P.A

1.RIF DNA-dependentRNA polymerase

2.INH INH B6

3.PZA PH

1.-1 600mg 5 1 1020mg/kg

2.Meningococcal -1 600mg 4 5 1 10~20mg/kg 3

1.

2. S-GOTS-GPT 2~4

3. Vitamin B6 D

rifamycinisoniazidpyrazinamide 1.Rifampin

Corticosteroids

2.PAS rifampin

3.PAS isoniazid PAS INAH acetylation 4.INAH

5.Rifampin isoniazid 6.Pyrazinamide probenecid sulfinpyrazone

(15-25)

(Anthelmintics)

11.1

48

11101 Conquer OVER Mebendazole Conquer 100mg. Tab , YY SSS

ATP

1. 1 100mg 1 3 2~3 3 2

2.100mg

1. 2. 3. 4.

5.

6. 7.

Phenytoin Carbamazepine mebendazole

mebendazole valproic acid(depakine)mebendazole 5~10%~80%2.8~9.0hr1.0~1.2 L/kg95%

(15-30)

(Antitrichomonal Agents and Anticandidal Agents)

12.1

49

12101 Frotin OFROT Metronidazole Frotin 250mg tab

12102 Medazole IMETR Metronidazole Medazole inj 500mg. bot

12103 Sutrol gel-vaginal ESUTR Metronidazole 7.5mg/g vaginal gel Sutrol gel-vaginal 25g Tube

DNA

Metronidazole

50

1. 250mg 2 10 15mgkg 7

2. l5mg 7.5mg 1g 6 7 4g30~60

3. 3 9

1.

2.

1. 2.3. 4.() 5. 46

B 6

1. Metronidazole Nitroimidazole 2. 3.

1. Acetaldehyde Disulfiram

2. warfarin

60-80% 100%6~9hr0.6~1.1 L/kg0~20% 6-12 8

25

51

12104 Clomazole ECLOM Clotrimazole 500mg Clomazole Vaginal Tab EA , P-1005

1.

2. 46

15

clotrimazole tacrolimus tacrolimus (CYP3A4)tacrolimus clotrimazole AUC 2

25

12.2 12201 Talsutin

ETALS Tetracycline/ Amphotericin B Talsutin Vaginal EA SQUIBB

12 2 2

1.

2.

3.

4. 5.

25

(Scabicides)

13.1

52

13101 Jaline EBB Benzyl Benzoate Jaline 150ml Bot

1. 10 25% 24

2. 3. 10ml 10ml

1. 2. 3.

25

13102 Scabi ESCAB G-benzene hexachloride Scabi Cream 10gm Tub e

Lindane(Gamma-BHC)

1.812 . 30g 1 2

2. 35 1. 2.12

3. 1. 2. 3. 4. 24 C

-BHC 15 ~ 25

53

13103 Scalphen ESCAL Mesulphen Scalphen Ointment Tube

1~2

1.

2.

54

13104 Ulex EULEX Cortamiton Ulex Cream 10g Tube

Hydrocortisone

() C

1. 2. 3.

13105 Biofur EBIOF Sulfur Precipitated Biofur Acne Lotion 50mg/g 30 ml Bot

D

(Antifungal Agents)

14.1

55

14101 Mycostatin ONYST Nystatin Mycostatin 50 U Tab 580

14102 Mycostatin Syrup OMYCS Nystatin Mycostatin Syrup 10 U/ml Bot

14103 Nystatin EMYCO Mycostatin Vaginal 10 U Nystatin EA 7117

Nystatin Polyene

1. 2. 3.

1. 1~2

48 2. 1ml100000 48

3. 1-2 2

36 1. 2. 1.1 150 1 2.

A

56

14104 Diflucan ODIFL Fluconazole Diflucan 150mg. cap , FLU-150

14105 Diflucan inj IDIFL Fluconazole Diflucan inj 100mg/50ml Vial

triazole sterol

CSF

1.200400mg

a. 400mg 200400mg 68

b. 100mg AIDS c. 400mg 200mg 400mgd. 50mg 714

e. 50mg 14 f. 50mg 1430 100mg 150mg

g. 50mg 2.

12mg/kg 36m/kg

3.

1. 200mg/100ml 15mmol

2.

1. triazole 2. 1. HMG-CoA reductase lovastatinatorvastatinsimvastatin

2.warfarin azole warfarin

Fluconazole IV () IV 90 0.5~1.5 30 4~5 90% 11~12

80% 80%

50%

57

14106 Icomein OICOM Itraconazole Icomein 100mg Cap , ICOMEIN / EVEREST triazole

1. 200mg

200mg

2. 200mg 3. 100mg 15 4. 100mg 15 15

5. 100mg 15 6. 200mg 21

1. 2. 3.

C - 15 ~ 25

58

14107 Grisen OGRIS Griseofulvin Grisen 500mg. Tab , 728

1.

2.

1. 500mg

2. kg 10mg

12 3.

1. 4-6

2. phenobarbital phenobarbital 3.4. 5.

Penicillin phenobarbital primidone griseofulvin griseofulvin griseofulvin

59

14108 Lamisil OLAMI Terbinafine Lamisil tab 250mg Tab Novartis , S/T

Allylamine

Squalene Squalene epoxidase

24 6 4 125mg 250mg 26 24

()()

1. 2

2.

3.( 50/ 3000 /)

4. terbinafine

terbinafine 1.terbinafine tricyclic antidepressants nortriptyline

nortriptyline 2. rifampicin

P450 cimetidine 250 2 0.97g/ml 3 3 6 3

15 ~ 25

60

14109 Jia Mei EJIAM Naftifine Jia Mei Cream 10g Tube ergosterol

Naftifine

(Antivirals agents)

15.1 15101 Zovirax

EZOV2 Acyclovir Zovirax cream 2gm Tube

61

15102 Zovirax oph EZOV3 Acyclovir Zovirax ophthalmic oint oph 3% 4.5gm Tube

thymidine kinase acyclovir monophosphate diphosphate triphosphatetriphosphate DNA polymerase DNA DNA polymerase

1.

2. 1. 5 2. 1 5 4 3

-(stinging)Zovirax IV -

1. finger cot 2. 3.

4. B

acyclovir propylene glycol 1. Probenecid 2. Zidovudine

3.acyclovir theophyllines

30

15103 Valtrex OVALT Valaciclovir Hcl Valtrex tab 500mg Tab

, VALTREX 500 Valaciclovir aciclovir valine Aciclovir DNA DNA DNA

1. 1000mg

2.

valaciclovir(1 8g)

valacicloviraciclovir

1.Cimetidine probenecid aciclovir aciclovir AUC

2. aciclovir 15 ~ 25

15.2

62

15201 Amantadine DC amanda OAMAN Amantadine Amantadine 100mg Cap

15202 Amanda OAMAN1 Amantadine Amanda 100mg Tab , WD

1.(corpus striatum) Dopamine dopamine Dopamine

2.

A 1.100mg 12 400mg 100mg 2 300mg

2.(influenza)100mg 2 19 24mg// 150mg/

()1.

2. 7

C

amantadine anticholinergic

63

15202 Tamiflu OTAMI Oseltamivir Tamiflu 75mg Cap

/ , ROCHE,75mg

1. 2.(neuraminidase)

3.

(A B ) 1. 2 1 75mgCrC1 1030mL/ min 1 5

2.a.2 1 ()7 1 6 CrCl 1030mL/min 1 75mgb. 48

FDA

C

oseltamivir phosphate probenecid oseltamivir carboxylate oseltamivir

24 40 2 1.3 24 23 60%

15.3 B I

64

15301 Zeffix OZEFF Lamivudine 100mg Zeffix 100mg tab , GX CG5

B triphosphate(TP) lamivudine-TP B (polymerase)DNA DNA Lamivudine-TP (deoxynucleotide)

B B 1. B B 2.3.4.

1. Lamivudine 2. HIV zidovudine

a. 12 50 150 mg

50ml/min 3. HIV 37CTM(lamivudine)

CombivrTM(lamivudine/zidovudine) HIV 150 2

C

trimethoprim-sulfamethoxazole (TMP-SMX) lamivudine

triphosphate 1719 18g/ml

15.4 C

65

15401 Rebetol OREBE Ribavirin Rebetol 200mg. Cap

1.Ribavirin RSV RNA DNA Mrna Guanosine methylation

2.Ribavirin HCV- HCV

Peginterferon -Interferon 1. -Interferon C 2. C

1000-1200mg

1.Rebetol 18 2.

3.Ribavirin interferon alfa-2b 4. 5. 6 6. X

1. Ribavrin Rebetol interferon alfa-2bIntron A -

2. 3.

ribavirin warfarin warfarin Ribavirin C 6 12 6 (HCV-RNA) C interferon alfa-2bRibavirin interferon alfa-2b interferon alfa-2b 10 HCV-RNA ALT

(Antineoplastic Agents)

16.1 (Alkylating Agents)

66

16101 Endoxan OENDO Cyclophosphamide * Endoxan 50mg Tab Baxter-Germany

16102 Endoxan inj IENDO Cyclophosphamide * Endoxan inj 200mg vial Baxter-Germany

oxazaphosphamide 4-hydroxycyclophosphamidealdophosphamide DNA DNA G2

1. 50200mg25mg/kg 50150mg/

2 2.4050mg/kg 25 1015mg/kg 710 1 35mg/kg 2 1.53mg/kg28mg/kg 60250mg/ 6 6 1015mg/kg 710 1 30mg/kg 34 1

3.

1. 2.

3. 4. X Cytatoxic agent Endoxan Endoxan

- D

1. cylcophosphamide 2.(active infection)( cytotoxic agent )

1. 2. phenobarbital

16.2 (Anti-metabolites)

67

16201 Fluorouracil IFLUO Fluorouracil * Fluorouracil inj 500mg/10ml vial Pharmachemie B.V

Fluorouracil Fluorouracil 5-fluoro-2'-deoxyuridine-5'-phosphate thymidylate synthetase deoxyuridylic thymidylic DNA

68

fluorouracil RNA RNA uracil phosphatase RNA DNA RNA fluorouracil

1. 2.Bowen

1. 0.250.5g l 5~10g 1~2 2

2. 0.5~1g l0~20mg/kg 5% 500~1000ml l 815g

( 2-3 3-4 )

1. 2. 3.

4. 23 5. 12

D

Fluorouracil

1. fluorouracil 2. 3. 4.

Fluorouracil/Leucovorin fluorouracil Fluorouracil//

1.5-FU

2. 0.2-0.5L/Kg10% 5-FU IV 5-FU 5-FU

3.5-FU -fluoro--alanine

4. 15%( 90%)60-90% 5-FU 5-FU 5-20

5.(15%)5-FU

5-FU

69

16202 Methotrexate OMET2 Methotrexate * MTX(Methotrexate)2.5mg tab Heumann(Wyeth)-Germany , 2.5

16203 Abitrexate

IABIT Methotrexate * Abitrexate inj 50mg/2ml vial Pharmachemie B.V.

methotrexate DNA RNAmethotrexate s

1. 30mg/m2 5 2

2.1 1 1025mg 1 50mg 3. methotrexate100mg/10g/, 6~24 1~3 1 70mg/m2 calcium folinate

4. 5 --

1. Cytarabine methotreate (anaphylactoid reactions)

2.

3. 4. 1-2

5. Methotrexate 6. X

Calcium leucovorin methotrexate methotrexate 12 IV 75mg calcium leucovoorin 6 IM 12mg 4 methotrexate 6 IM 12 4 Calcium leucovorin methotrexate 1

16.3

70

16301 Pharmorubicin IPHAR Epirubicine Pharmorubicin inj 50mg/1vial vial Pharmacia Italia S.P

DNA

1.Pharmorubicin 60~90mg/ 2. I.V. 3~5 21

3.60~75mg/

4. 23

5.a.bilirubin1.4~3mg/100ml BS Prevention9~15% 50%b.bilirubin>3mg/100ml BS Prevention>15% 75%

6.

1. 2. 3. Pharmorubicin

X

4. Cytotoxic Pharmorubicin

5. 1~2 6. 7 550mg/m2 8.mediastinal/pericardial

area 400450mg/m2 9.

D

1. 2. Anthracycline

Doxorubicin

16.4

71

16401 Leuplin Depot ILEUP Leuprorelin Acetate Leuplin Depot inj 3.75mg vial

Leuplin Depot (LH-RH) LH-RH Leuprorelin acetate) 4 4 Leuprorelin- estradiol testosterone

1. 4 3.75mg 1-5 6

2. 4 1.88-3.75mg 1-5

3. 4 3.75mg 4. 4 leuprorelin acetate

30mcg/kg 90mcg/kg

pleuralrub 1.

2.LH-RH

3./

X

1. LH-RH 2. 3.

72

16402 Tamoxifen OTAMO Tamoxifen Tamoxifen 10mg. Tab Pharmachemie B.V

10mg 2 20mg 2

1.

2.

1. 2.

3. 4. D

16.5

73

16501 BCG IBCG B.C.G. Vaccine Freeze-Dried BCG Immunothregpeutic Immucyst BCG Bot

cytokines TA T1

1.BCG 15 60 5% 15

2. BCG BCG 6 6 1 1 3

3 1 6 1 6 4.(CIS) 7 14 3 6

1 (bladder irritability) (granulomatous prostatitis)

2. 2~4 24~72

3. 13 (fever)

4. 1. 2.""

3.4.

5.

6. isoniazid 300mg

BCG BCG Isoniazid

7. BCG 2 isoniazid 300 mg Rifampicin 600mg/ ethambutol 120mg/ cycloserine 250500mg

C

1. BCG

2.// BCG

3. 4. BCG

1. 2 ~ 8 () 2 2hrs

74

16502 Pegasys IPEGA Peginterferon-Alfa-2a Pegasys Prefilled 180mcg/0.5ml/syringe Syrg

-2a

1. B HBeAg HBeAg /anti-HBe

2. ribavirin C

1. B HBeAg HBeAg B 180mcg 48

2. C ribavirin 180mcg 48

ribavirin

ribavirin 1.2. 50,000/mm3

25,000/mm3

3. (CBC) 4. 5.6. 7. 8.

9.10.

11. 12.

1. PEGpolyethyleneglycol

2. 3. 3

Pegasys P450 1A2 theophylline AUC1. 72-96 180 3-6 2480%84%-2a

2.Vss 6-14 Pegasys

3. Pegasys 100/ -2a 100 10% peginterferon -2a

4. 60 80 50-130

2-8

16.6

75

16601 Campto ICAMP Irinotecan * Campto conc soln I.V infusion 100mg/5ml

vial

76

1. (Camptothecin) DNA topoisomerase I carboxylesterase SN-38SN-38 Irinotecan DNA topoisomerase I DNA DNA S

2. acetylcholinesterase 1.

2. 5-FU Folinic Acid 3. 5-FU

300350 mg/ 30 90

1.

2. 3. 86%

1.

2. 3.

4. WHO (performance status)>2

5.()

6. 30 90

7.(complete blood cell counts)

( 381,000 /)

D

1. irinotecan hydrochloride trihydrate

2.(bilirubin)>1.5 3./ 4. WHO (performance status)>2

1.Dexamethasone 2.Live vaccine 3

16.7

77

16701 Plaquenil OPLAQ Hydroxychloroquin Plaquenil 200mg Tab Sanofi , 200 HCQ

DNA RNA

1.

2.

400-600mg 200-400mg

1. 6-(glucose-6-phosphated ehydrogenase)

2. 4-aminoquinolines quinine

3.

4. C

15 ~ 25

16702 Eloxatin IELOX Oxaliplatin * Eloxatin inj 50mg Vial Sanofi Aventis

78

1. platinum oxalate 1,2-diaminocyclohexane (DACH) platium

2. oxaliplatin (DNA)(intra and interstrand crosslinks) DNA

3.Oxaliplatin cisplatin

fluoropyrimidines 5-fluorouracil Folinic acid

130mg/m2 3

250~500ml5% 2~6

1. 3

2. 3.

4.

5. 2 6

6. 7 25% 25%

7.(

oxaliplatin 5-fluorouracil

79

16703 Filgrastim IFILG Granulocyte Colony Stimulating Factor Filgrastim inj 300mcg/0.7ml M300 Amp Kirin-Japan

1. 2. 3. 4. 1 5 300ug/m2 5000/mm2

2.50ug/m2 1 100ug/m2 1

3. 1000mm2 200ug/m2 1

S-GOT,SGPT

AlpLDH Creatinine

1. 2.

3.

4.

5.

6.

7. C

1. 2.

2-8

16.8

80

16801 Ufur OUFUR Tegafur 100mg.& Uracil 224mg * Ufur cap , UFUR

tegafur 14 uracil tegafur 5-FU

cisplatin

tegafur 500-800 mg/day 300-350 mg/m2/day 2~3

1.

2.()

() 3. 4. 5. 6. X

1. 2. sorivudine

1.uracil soriyudine

2. phenytoin phenytoin phenytoin

3.()

Tegafur 7.861.19 5-FU 13.14.2 Uracil 1.500.76 35.319.2

81

(Drugs Acting On the Central Nerve System)

-

( Nonbarbiturate Sedative- Hypnotics)

17.1 Benzodiazepepine(BDZ)- 17101 Dormicum

IDORM Midazolam Dormicum inj.5mg/ml. amp

17101 Midazolam IMIDA Midazolam Midazo inj.15mg/3ml

amp

7.5~15mg 4

82

1.

2. 6 12 3. 4.

Benzodiazepine 1.

2. 15 ~ 25

17103 Eszo

OESZO Estazolam Eszo 2mg Tab , ST

1 1~4mg 1.

2.

3. 1.

2.

3.

1.MAO Inhibitor Phenothiazine

2.

83

15 ~ 25

17104 Modipanol

OMODI Flunitrazepam ()Modipanol 2mg. Tab , F 2

0.5~1mg 2mg

4mg 6~8

flunitrazepam

flunitrazepam

flunitrazepam () Benzodiazepines

1.

2.(/)

3. 4.( cytochrome P450)

benzodiazepines benzodiazepines 5.

15 ~ 25

17.2 - 17201 Insopin

OINSO Zopiclone Insopin 7.5mg. Tab Doupharma-Malysia , 8/61 DUO Non-benzodiazepine benzodiazepine

(benzodiazepine receptor complex) gamma-aminobutyric acid (GABA) 1 GABA GABAA- chloride ionophore protein complex Cl- Cl-(threshold)

1

1 1.

2. 3.

4. 5. 6. 7.

Zopiclone 15 1.Curare-Like Compounds

84

2. Neuroleptics

3. Benzodiazepines 15 ~ 25

17202 Zolnox FC

OZOLN Zolpidem Zolnox FC Tab 10mg Tab , ZOLNOX benzodiazepine

GABA GABA GABA

10-20mg 5-10mg 1.

2. 3.

2 6

15 1.Zopiclone

2. 3. 4. 5.

phenothiazines 15 ~ 25

85

(Antipsychotic Drugs)

18.1 Benzodiazepepine(BDZ)- 18101 Hopan

OHOPA Haloperidol Hopan Tab 0.5mg tab , KOJAR

18102 Binin-U IBINI Haloperidol Binin-U inj 5mg/1ml.

amp

2

1 23 1 1

1 23 0.55mg 5mg

1. 2. 3.

4.

Lithium

15 ~ 25

18103 Fluanxol OFLUA

86

87

Flupentixol Fluanxol 3mg. tab Lundbeck-Denmark

18104 Fluanxol Depot IFLUA Flupentixol Fluanxol Depot inj 20mg Amp H.Lundbeck-Denmark 1. 3mg

2.

1. 315mg 20

60mg 1530mg50200mg 24

2. 2 0.5mg 23 1mg 11.5mg

3. 12mg 4mg

1. 2.

1. 2.

3.

1.Flupentixol decanoate

2.guanethidine

3.

88

4. 5.Flupentixol decanoate levodopa

metoclopramide piperazine 15 ~ 25

18105 Betamac

OBETM Sulpiride Betamac 200mg tab Sawa-Japan

18106 Sulmatyl

OSULM Sulpiride Sulmatyl 50mg tab

, PL 1.

2. 3. 4.

1 150mg 3 (Gonadotropin

Prolactin )

()

1.(Atropine, Methylscopolamine )

2. Digitalis Digitalis

15 ~ 25

18107 Morefine(Wintermin) OWINT Chlorpromazine Morefine(Wintermin)100mg tab ,, 609 50450mg

1.

2.

15 ~ 25

18.2 (serotonin dopamine antagonists) 18201 Abilify

89

90

OABIL Aripiprazole Abilify Tab 10mg tab -JAPAN , A-008 / 10

1. D2 D3 5-HT1A 5-HT2A

2. D4 5-HT2C 5-HT7 1 H1

3. D2 5-HT1A 1. KetoconazoleQuinidineFluoxetine Paroxetine

50% 2. 15 -30 C

1.15-20mmHg

2.MMS MMS

3. 4.

ARIPIPRAZOLE KetoconazoleQuinidineFluoxetinParoxetineARIPIPRAZOLE

15 ~ 25

18202 Lodopin

OLODO Zotepine Lodopin 50mg. tab Astellas-Japan , 651

91

1. dopamine 2. serotonine 3.

4. 1.

2.()() -

3. a. b. c. d. e. f.() g. ()

4.

1.() 2. Barbiturates ()

3. Epinephrine Phenothiazine

4. Terfennadine Astemizole ( QT )

D

1.()

2. Barbiturates ()

3. Epinephrine Phenothiazine

92

4. Terfenadine Astemizole ( QT )

1. Epinephrine( Epinephrine )

2.(1)(Barbiturate ) Atropine ()(2)Ethanol()(3)Metoclopramide Domperidone

3.() Zotepine first-pass metabolism

7%~13% 97% 13.7-15.9

15 ~ 25

18203 Risperdal solution ORISL Risperidone Risperdal 1mg/ml(30ml/bot) bot Janssen-Belgium

18204 Apa-Risdol F.C OAPAR Risperidone Apa-Risdol F.C. Tab. 1mg tab

RIS/1/WWIN 18205 Risperdal

ORISP Risperidone Risperdal 2mg. tab Janssen-Korea

, RIS/2

18206 Perisdone

93

OPERD Risperidone Perisdone 2mg tab

Catalepsy 1.

2. 3.

1. 1 2 1mg 2 2 2mg 3 2 3mg 3 2 3mg

2. 2 0.5mg2 0.5mg 2 12mg

3.15 4. 2 0.5mg 2 12 mg

1. 2. 3. 4.Siadh

1. 2.

3. 4. 5. 6.

RISPERDAL 1.

94

2. Levodopa 3.Carbamazepine C Carbamazepine

4.Phenothiazines - risperidone

1. 12

2. 9-hydroxy-risperidone

risperidone N- 30 9-hydroxy-risperidone 24 risperidone 9-hydroxy-risperidone 45

15 ~ 25

18207 Utapine OUTAP Quetiapine Utapine F.C Tab 200mg tab

, UN453, 200MG serotonin(5HT2)

dopamin D1 D2 2 50mg100mg200mg

300mg 300~450mg Seroquel ( carbamazepine)

quetiapine Seroquel

15 ~ 25

95

18208 Clopine

OCLOP Clozapine Clopine 100mg tab

Z/E SWISS 18209 Mezapin

OMEZA Clozapine Mezapin 100mg tab , PANBIOTIC

1. 2. Serotonin 3.

1 25mg 1~2 200~450mg 600mg 150~300mg 1~2

1. 2. 3. 4.

1. 2. 3. 4.

1.

2. 3. 15 ~ 25

18210 Zyprexa OZYP10 Olanzapine Zyprexa 10mg tab Eli Lilly-England , LILLY4117

10

10

1.ALTAGT

2.

15 ~ 25

(Antianxiety drugs)

19.1 Benzodiazepanines 19101 Anzepam (Ativan)

OATIV Lorazepam Anzepam (Ativan) 0.5mg. tab

96

97

, SK/206 19102 Neuropam

INEUR Lorazepam Neuropam inj 2mg/ml amp Limbicsy Stem

Efficacy

1. 2.

3. 4. 5.

1.5mg~3mg 3mg~10mg

1. 2~3

2. 3. 4. 2~4mg 5. 6.6~12 7.6 8. Neuroleptices

1. Minor TranquilizersChlordiazepoxide, Diazepam,

and Meprobamate 2. Benzodiazepine

3.

98

1. BENZODIAZEPINES

2. 3. 4.

15 ~ 25 2~ 8

19103 Vanconin (Valium) OVAL2 Diazepam Vanconin (Valium) 2mg. tab

, 181 19104 Dupin

IVALI1 Diazepam * Dupin inj 10mg/2ml "C.C.P." amp

1. GABA GABA

2.Amnesia

3.

4.

1. 2.IV 3.IV 4. 5.

99

1.1 /2mg 3 2.1 /2mg 3 3. 530mg 4.1 /1020mg 5. 1030mg 6.1 1030mg 3

8. 1020mg 20mg 9.1 /10mg 1 2 10. 20mg 10mg 1 4

TagametCimetidine Benzodiazepine

15 ~ 25

19105 Alepam

OALEP Oxazepam Alepam15mg tab Alphapharm-Australia , OM15/G

Benzodiazepine 1. 3~4 10~30mg

2. 3~4 10mg

1.

2.

3. 4. 5. 2

100

6. OTC 7.6 8.

Benzodiazepines 2

1. PhenothiazinesBarbiturates MAO

2. 15 ~ 25

19106 Erispan

OERIS Fludiazepam * Erispan 0.25mg tab , 017

1 0.75mg 3 1.

2.3. 4.

1. 2. 3.

1.3

2. 1.

2.Phenothiazine Barbiturie Acid Monoamin

101

15 ~ 25

19107 Amprazo OALPR Alprazolam Amprazo 0.5mg. tab , CCP C60

Benzodiazepine

Benzodiazepine

18

Benzodiazepine CNS CNS

15 ~ 25

19108 Lexotan OLEX1 Bromazepam Lexotan 1.5mg tab

102

, ROCHE/1.5 1.

2.

1.5~3 mg 3

6~12 mg 2~3 ()

1.

2. 1. psychoactive substance

Lexotan 2. Lexotan -narcotic analgesics antipsychotics/antiepileptic drugssedative antihistamines

3.euphoria 4.

Benzodiazepines Cimetidine Bromazepam

15 ~ 25

19109 Relac ORELA Buspirone Relac 5mg tab

103

, 432 1. BZD

2. D2-doopamine

15mg

2~3 5mg/ 60mg 1.

2.

Fluoxetine Buspirone 15 ~ 25

19110 Serenal

OSERE1 Oxazolam Serenal 10mg. tab , SANKYO 107

kg 12mg

3 1020mg 1.

2. MAOI

rat 14C-Oxazolam 30

30-60 peak 15 ~ 25

19111 Calmday SC

OCALM Nordazepam Calmday SC Tab 5mg tab S.A WILL PHARM-BELGIUM 10mg/day,; 1.

2. 3.

4. 5. 6. 7.

, 1. 2. 15 ~ 25

19.2 19201 MELIXOL S.C.

OMELI Flupentixol 0.5mg/Melitracen 10mg Melixol S.C. TAB tab 2 1 2

1 1

104

6 1.

2. guanethidine 3.MAO 4.

15 ~ 25

(Antidepressants)

20.1 20101 Sinequan

OSINE Doxepin Hcl Sinequan 10mg cap PFIZER AUSTRALIA /

20102 Ichderm Cream EICHD Doxepin Hcl Ichderm Cream 15gm. tub 15gm

H1 H2

105

106

3 25-50mg( 300mg)12 4 34 15 75% 7

1. doxepin

2. 3. MAOIs

1.MAOIs doxepin MAOIs MAOIs

2.Cimetidinecimetidine TCAs anticholinergic effect cimetidine TCAs cimetidine TCAs

3. 4. CYP450 IID6 (poor metabolizers) TCAs CYP450 IID TCAs TCAs ( SSRIs)phenothiazinescarbamazepinequinidine() Type1C ( propafenoneflecainideencainide )

15 ~ 25

20103 Tofranil OTOFR1 Imipramine Tofranil 10mg. tab CIBA GEIGY (JAPAN)

, CG. 209 20104 Imimine (Tofranil)

OTOFR Imipramine Imimine (Tofranil) 25mg. tab

1 2575mg 1 200mg 300mg 1 2550mg12 1 2

1.

2.

1. Dibenzazepine

2. 3. 4.

1. Monoamine

2. Choline Adrenaline

15 ~ 25

20.2 (SSRI) 20201 Fluvoxin F.C

OFLUV Fluvoxamine Maleat Fluvoxin F.C 50mg tab , WST, F/03

107

108

Serotonin Fluvoxin Fluvoxin Fluvoxin Fluvoxin 15

() 100~200mg

300mg 50mg 150mg 2~3 Fluvoxin

Fluvoxin Fluvoxin Fluvoxin

1. Fluvoxin 2.77% Fluvoxin Fluvoxin 3.5g(5mg*70 ) 1.MAOI

2. Fluvoxin

Fluvoxin 3. Fluvoxin

4. Fluvoxin 5. Fluvoxin 6.Fluvoxin Benzodiazepines

Fluvoxin 1. Fluvoxin

(Warfarin,Phenytoin, Theophylline)

2. Fluvoxin Propranolol Warfarin

3. Digoxin Atenolol

77% 15 ~ 25

109

20202 Kinloft OKINL Sertraline Kinloft 50mg tab , 200, S / K

2-4 6-8

50mg 200mg 150mg

50mg MAOI

MAOI MAOI

15 ~ 25

20203 Kitapram F.C. OKITA Citalopram Kitapram F.C. 20mg tab , SK

Citalopram Serotonin Cholinergic muscarine receptors,histamine receptors -adrenoceptors Citalopram 24

Citalopram Citalopram

. 20mg 60mg

110

65 40mg MAO 14 MAO Citalopram 24

80% 12

15 ~ 25

20204 Setine OSETI Paroxetine Setine Tab 20mg tab

, TS22 STD 5-HT Serotonin 20mg 10mg

50mg Paroxetine

MAO Inhibitors MAO Inhibitors

Paroxetine

5-HT Paroxetine Tryptophan Serotonin

111

5-HT Phenytoin Paroxetine Isozyme 1.NortriptylineAmitriptyline Imipramine Desipramine2.Phenothiazine Phenothiazine Thioridazine 3.Type IC Propafenone Flecainide

15 ~ 25

20205 Uxetine OUXET Fluoxetine Uxetine 20mg cap /, CCP. B54

Serotonin

20mg

2 1 20mg 80mg 1.

2. 3.

1. 10%~15%

2.1% 3. 4. 5.

6.

MAOI

MAOI 1.Tryptophan

2. 2

3. 4. Diazepam Diazepam

23 norfluoxetine 79 68

15 ~ 25

20.3 (SNRI) 20301 Valosine SR

OVALO Venlafaxine Hcl Valosine SR Cap 75mg cap , STD , 283

O-desmethyl venlafaxin(ODV)(serotonin)(noneinephrine)dopamin ODV (muscarinic)(histaminergic) -1

(anticholinergic)(sedative) ODV

1. 75mg/day

2. 150mg/day 225mg/day75mg/day

112

225mg/day 350mg/day 375mg/day

3.XR 2 2 225mg

/

1. MAOI MAOI14 MAO 7

2.

3. 4. 5. 2 6. C

C 1.

2. 15 ~ 25

20.4 (SDRI) 20401 Wellbutrin Sustained-Release

OWELL Bupropion hydrochloride Wellbutrin Sustained-Release 150mg tab GSK , GX CH7 1.Bupropion (catecholamine)

2. Bupropion (noradrenergic)/(dopaminergic)

3. Bupropion /

4.Bupropion

113

114

1.

a. 150mg Wellbutrin SR 150mg 300mg/

150mgWellbutrin SR 150 8

b. Wellbutrin SR

2. Wellbutrin SR 150mg 3 150mg 2 8 150mg 300mg 7

1.(): 2.: 3.:

4.: 5.: 6./:/

7.: 8.Bupropion

1. Wellbutrin SR Bupropion

Wellbutrin SR :;;;

3.() Wellbutrin SR

4. Bupropion

Bupropion

5. Bupropion Wellbutrin SR

6. Bupropion (NTS)

1.Wellbutrin SR Bupropion 2.Wellbutrin SR 3.Bupropion 4.Wellbutrin SR (MAOIs) MAOIs 14 Wellbutrin SR

1.Bupropion P450 2B6 hydroxybupropionWellbutrin SR CYP2B6 ( orphenadrine, cyclophosphamide, ifosphamide) Bupropion CYPD6 P450 Bupropion hydroxybupropion CYP2D6

2. Bupropion desipramine Bupropion 7 Wellbutrin SR CYP2D6

3.Wellbutrin SR (SSRIsTCAs)

4. Wellbutrin SR CYP2D6

5.Bupropion ( carbamezpine, phenobarbital,phenytoin)

6. Bupropion levodopa levodopa Wellbutrin SR Wellbutrin SR (NTS)

7.(CNS)Bupropion

Wellbutrin SR 15 ~ 25

20.5 (MAOI)

115

116

20501 Clopine OCLOP Moclobemide Clopine 100mg (Clozapine) tab Z/E SWISS

20502 Euta OEUTA Moclobemide Euta 150mg/F.C tab , ST 150

1. 300mg 2~3

1 150mg 600mg

2. 3. 1/2 1/3

1.

2.

Benzodiazepine 3.

4.Tyramine

1. 2.

1. Ibuprofen

2.Cimetidene Cimetidine

3.

15 ~ 25

20.6 20601 Lidin

OLITH Lithium Carbonate Lidin 300mg tab , 031 U/L

norepinephrine serotonin norepinephrine cyclic AMP

1.

2. 57 1500 2000mg 7 3 5001200mg

3. 5001000mg 4.

1. 2.( 1.5mEq/l ) CNS

CVGI--

117

118

1.

2. Lithium

1 4

1 ( 24 )

15 ~ 25

20602 Mesyrel

OMESY Trazodone Mesyrel 50mg. tab , LO

20603 Trazo OTRAZ Trazodone Trazo 50mg tab , CH 27

CNS 150mg 3~4 50mg/day

400mg 600mg 1 50mg 2 100mg3 150mg

()

1.

2. 3. carbamazepine

trazodone 15 ~ 25

(Anticonvulsants)

21.1 21101 Phenobarbital

OPHEN Phenobarbital * Phenobarbital Tab 32 mg "F.Y." tab Focal

Seizures 1.a. 2~4 16~32mg 2mg/kgb.

50~200mg 3~6mg/kgc. 120~200mg 1~6mg/kg

2. 30~50mg 600mg 3. 100~320mg 600mg

15 ~ 25

21.2 Hydantoine 21201 Phenytoin (Dilantin)

119

ODILA Phenytoin Phenytoin (Dilantin) 100mg.

tab , 215

21202 Aleviatin(Dilantin) IDILA Phenytoin Aleviatin(Dilantin) 250mg/5ml.inj.

amp

Jackson 1 0.3g 3

10 1 0.10.2g 0.1g 1 0.1g1 0.3g 1 0.3g1 1g

120

1.2.

3.

Hydantoin Bishydroxycoumarin DisulfiramIsoniazid

15 ~ 25

21.3 Benzodiazepanines

121

21301 Anzepam (Ativan) OATIV Lorazepam Anzepam (Ativan) 0.5mg. tab , SK/206

21302 Neuropam INEUR Lorazepam Neuropam inj 2mg/ml amp

Limbicsy Stem

Efficacy 1. 2.

3. 4. 5.

1.5mg~3mg 3mg~10mg

1. 2~3

2. 3. 4. 2~4mg

5. 6.6~12 7. 8. Neuroleptices

122

Minor TranquilizersChlordiazepoxide, Diazepam, and Meprobamate Benzodiazepine

1. BENZODIAZEPINES

2. 3. 4.

15 ~ 25

21303 Rivotril ORIVO Clonazepam Rivotril 0.5mg. tab , ROCHE 0.5

0.5~1mg 1.5~3mg 3~6mg4~8mg 3~4 20 mg

1. 2. 3. 4.

15 ~ 25

123

21304 Vanconin

OVAL2 Diazepam Vanconin (Valium) 2mg. tab

, 181 21305 Dupin

IVALI Diazepam Dupin inj 10mg/2ml . , 181 amp

1. GABA GABA

2.Amnesia

3.

4.

5. 1.

2.IV 3.IV 4. 5.

1.1 /2mg 3 2.1 /2mg 3 3. 530mg 4.1 /1020mg 5. 1030mg

6.1 1030mg 3

8. 1020mg 20mg 9.1 /10mg 1 2 10. 20mg 10mg 1 4

Benzodiazepines TagametCimetidine Benzodiazepine

15 ~ 25

21.4 21401 Depakine Lyophilized

IDEPA Valproate Sod Lyophilized Depakine Lyophilized inj 400mg/4ml

vial GLAXO WELLCOME-FRANCE

21402 Depakine ODEPA Valproate Depakine 200mg tab SANOFI WINTHROP-FRANCE

21403 DEPAKINE SOL ODEPS Valproate DEPAKINE SOL 200MG/ML 40ML

bot SANOFI WINTHROP-FRANCE Aminobutyrate-

Aminotransferase -AminobutyricacidGABA

124

125

1 2~4 15mg/kg 5~10mg

30mg/kg

500mg

1. 2 Fibrinogen

2. Amylase

3. Thrombocytes 4. Ketones Falsepositive 5. 3 Phosphatase Transaminases

40 15~20mg/kg

1.VPA MAO

2. 3.

15 ~ 25

21404 MgSO4 IMAGS Magnesium Sulfate MgSO4 inj.10% 20ml. amp

1. 2.

3. Tendonreflex EndPlate

1~10mg.I.V I.M.

126

1 4gm 5ml 50100mg 12 5 1020 300mg 2mg4mg

Anilide

15 ~ 25

21405 Convulex

OCONV Valproic Acid Convulex 500mg. cap R.P. SCHERER GMBH-GERMANY , 500

Aminobutyrate-Aminotransferase -AminobutyricacidGABA

1 2~4 15mg/kg 5~10mg

30mg/kg

500mg

1. 2 Fibrinogen

2. Amylase

3. Thrombocytes 4. Ketones Falsepositive 5. 3 Phosphatase Transaminases

40 15~20mg/kg

1.VPA MAO

2. 3.

15 ~ 25

21406 Gatine OGATI Gabapentin Gatine 300mg cap , PU22

21407 Neurontin ONEUR100 Gabapentin Neurontin 100mg cap PFIZER-PUERTO RICO , NEURONTIN 100MG 1.

pentylenetetrazole

2. GABA(gamma-aminobutyric acid) GABA

3. GABA GABA GABA

1.

127

http://www.mims.com.tw/Page.aspx?menuid=html&name=23169.gif

128

2. 9001800mg/ 300 400mg () 1800mg 2400mg 12

3. gabapentin

4. 1

1.

2.2074 7(1.2)(0.8)(0.6)(0.6)(0.6)

1. 2.()

3.:(CNS)

C

1. gabapentin

(phenytoin,carbamazepine,valproic acid phenobarbital)

2.Cimetidine: cimetidine 300mgQID gabapentin 14 10 cimetidine gabapentin gabapentin cimetidine

3. AUC 2.5mg norethindrone acetate 50mcg ethinyl estradiol gabapentin (400mg TID),norethindrone,ethinyl estradiol gabapentin norethindrone Cmax 13

4.(Maalox)Maalox gabapentin 20

129

gabapentin Maalox 2 5 gabapentin Maalox 2

Gabapentin 50%-60% 1.5-4 L-amino acid 300mg 60% 1600mg 35%Gabapentin

130

2. Diazepam

3. 1 1

4.

5. 2

6.

7. 8. 9.

3 1.

2.Macrolide Antibiotics

ErythromycinLsoniazid Verapamil.DiatiazemDextropropoxypheneViloxazine Cimetidine

EEG ECG Diazepam

15 ~ 25

21409 Topamax

OTOPA Topiramate

131

Topamax 25mg Tab GILAG AG-SWITZERLAND , TOP, 25

21410 Topmax OTOPA1 Topiramate Topmax 100mg Tab GILAG AG-SWITZERLAND , 100 TOP

GABA GABA

1 2 25mg 50mg

200 400mg 2 1.

2.

3. 4.

1. 2. 3. 4. 5. 6. 7. 6 8 8.

9. 10. 11.

PHENTYTOIN VALPROATE

132

CARBAMAZEPINEPHENYTIONVALPROATE

topiramate topiramate 2030ml/minTopiramate

100400mg 48 100mgCmax 6.76g/ml topiramate 50mg 100mg 21

15 ~ 25

21411 Trileptal Film Coated OTRIL Oxcarbazepine 300mg Trileptal Film Coated Tab 300mg tab NOVARTIS-SWITZERLAND , TE CG

1.Trileptal oxcarbazepine MHD oxcarbazepine MHD

2.

3.Oxcarbazepine MHD-

1. 2400 4200

2.Trileptal 600mg(810mg/Kg/day) 600mg2400mg 600mg

3. 810mg/Kg Trileptal 30mg/Kg 10mg/Kg/day

133

46mg/Kg/dayTrileptal 2

4.Trileptal

5.( 30ml/min)

1.

2. 3. 4. 5.

6.

7. 8.Stevens-Johnson syndrome

1. carbamazepine 25~30%Trileptal

2.

3. Oxcarbazepine (:)

4.Trileptal Trileptal

5.Trileptal

6.Trileptal

7. Trileptal Trileptal

8.

134

9.Stevens-Johnson syndrome(SJS)(TEN)

C

1.Trileptal CYP2C19

2.Oxcarbazepine MHD dihydropyridine calcium ( carbamazepine) CYP3A4 CYP3A5

3. Trileptal 1200 phenytoin 40% Trileptal 1200mg/day phenytoin

4.Phenobarbital Trileptal Phenobarbital 15%

5. P450 ( :carbamazepine, phenytoin phenobarbital) MHD 2940%

6.Trileptal ethinylestradiol(EE) levonorgestrel(LNG)EE LNG 4852% 3252% Trileptal

7. Trileptal felodipine (AUC) 25%

8. Trileptal

10%110% 0.1%1%0.010.1%0.01%

1. 600 Trileptal MHD 24.9 /(mol/L) 6 2. 40% MHD

3.Oxcarbazepine MHDMHD TrileptalMHD glucuronic acid

4.Oxcarbazepine 1.3 2.3 MHD 9.31.8

15 ~ 25

(Antiparkinsonism drugs)

22.1 22101 Akineton

OAKIN Biperiden Akineton 2mg. tab ABBOTT -GERMANY , /

22102 Biperin OBIPER Biperiden Biperin 2mg tab , UN407/UNION

22103 Bipiden IBIPI Biperiden Bipiden 5mg

, UN407/UNION amp (akinesia)

(seborrhea)(euphoria)

(incoordination) 1. 3~4 2mg

2.- 1~3 2mg-2mg 30 4

1.

135

136

2.

3.

4.

5.

6. 7.

AntiparkinsonQuinidine Tricyclic Antidepressant 15 ~ 25

22104 Artane (B.H.L)

OARTA Trihexyphenidyl Artane (B.H.L) 2mg. tab , BHL 2

1. 1mg 3~5 2mg

15mg 6~10mg 3~4 5mg

2. 1mg 12 1mg

C

15 ~ 25

22105 Norflex

ONORF Orphenadrine Hcl Norflex Tab 3M-AUSTRALIA , 3M N/X Antihistamine

2 100mg

1.

2.

3.

15 ~ 25

22.2 22201 Amantadine

OAMAN

137

138

Amantadine Amantadine 100mg Cap

Dopamine

A 100mg 2

Levodopa 100mg 1 1 100mg 2

15 ~ 25

22202 Parlodel

OPARL1 Bromocriptine Parlodel 2.5mg tab UBINOVARTISTW , X. C

Acetycoline

139

Ergot Alkaloids 15 ~ 25

22203 Celance

OCELA Pergolide Mesylate Celance 0.05mg/tab tab AEGIS-CYPRUS

D1 D2

D2 Levodopa/Carbidopa 3

1.

2.PERGOLIDE Levodopa Levodopa

3. 4.

PERGOLIDE PERGOLIDE Levodopa

HaloperidolPhenothiazines 15 ~ 25

22204 Parkryl

OPARK Selegiline Parkryl tab "M.S.

tab , LO/1 Levodopa

Levodopa 12 510mg

10mg Selegiline 10mg MAO C

Dopamine 1.Decarboxylase Levodopa

2. 15 ~ 25

22.3 22301 Madopar HBS

OMAH Levodopa 100mg/Benserazide 25mg Madopar HBS 125mg cap /, ROCHE

22302 Madopar OMAD Levodopa 200mg/Benserazide 50mg. Madopar 250mg.

tab , C. HE. Dopamine

140

141

dopamine dopamine - dopamine levodopa levodopa dopamine levodopa dopamine levodopa levodopa benserazide Madopar 41 levodopa Madopar HBS 3-6

Madopar

1 Madopar 62.5 1/2 Madopar 125 3-4 300-800 mg levodopa 75-200 mg benserazide 3 4-6 3-6 1 125 Madopar ( 3 )Madopar HBS Madopar

Madopar Madopar (on-off phenomena) Madopar HBS Madopar Madopar HBS Madopar 2-3 50% Madopar HBS Madopar HBS Madopar

Madopar HBS 2-3 Madopar HBS 250 mg

142

Madopar HBS () Madopar HBS Madopar Madopar Madopar HBS MadoparMadopar 30 1

L-dopa

1.

2.

3. 4. MADOPAR

5. 6. 7. 2~3

25

Cycloporpane Halothane trihexyphenidyl Madopar levodopa

trihexyphenidyl Madopar HBS levodopa Madopar HBS levodopa 32% levodopa AUC 30-50%

Metoclopramide levodopa Levodopa bromocriptineamantadineselegiline domperidone

Madopar HBS Madopar 3 levodopa 20-30%- Madopar HBS Madopar(

)Madopar HBS Madopar 50-70% levodopa Madopar HBS(5 ) Levodopa - 57 Levodopa AUC 12% levodopabenserazide - Levodopa (-)() Levodopa dopamine homovanillic acid dihydroxyphenylacetic acidLevodopa catechol-O-methyltransferase 3-O-methyldopa 15 Madopar benserazide levodopa levodopa 3-O-methyldopa catecholamines (dopaminenoradrenaline) phenolcarboxylic acids Benserazide trihydroxybenzylhydrazine levodopa levodopa 1.5 (65-78 )( 25%)levodopa 430 ml/min

15 ~ 25

(Drug for Migraine)

23.1 23101 Fluzine

143

144

OFLUZ Flunarizine Fluzine 5mg cap , STD/136

23102 Suzin OSUZI Flunarizine Suzin 10mg cap /, STD521

10mg/

()

(EPS) 1.

2.

15 ~ 25

23103 Seglor OSEGL Dihydroergotamine Seglor 5mg.

cap SANOFI--SYNTHELABO-FRANCE / 1.

2.

1.

2. 3. 4.

Troleandomycin, Erythromycin 15 ~ 25

(Dementia Therapeutics Agents)

24.1 24101 Aricept

OARIC Donepezil Aricept 5mg. tab , ARICEPT /5

10mg/

145

146

()

(EPS) 1.

2.

15 ~ 25

24102 Hodrin OHODR Dihydroergotoxine Hodrin 1.5mg tab , WD H/D

() 3 1.5mg

15 ~ 25

24103 Witgen OWITG Memantine Witgen 10mg

147

tab , LO/10 NMDA

GLUTAMATE , memantine NMDA

5mg, 5mg, 20mg PH ,

PH NMDA-antagonist memantine L-dopa, dopaminergicagonists,

anticholinergics barbiturates neuroleptics memantine antispasmodic agents, dantrolene baclofen memantine amantadine NMDA-antagonist ketamine dextromethorphan memantine phenytoin cimetidine, ranitidine, procainamide, quinidine, quinine nicotine amantadine (renal cationictransport system) memantine memantine hydrochlorothiazide(HCT) HCT Memantine CYP 1A2, 2A6, 2C9, 2D6, 2E1,3A monooxygenaseepoxide hydrolase

15 ~ 25

(Central Nervous System Stimulants)

25.1 25101 Ritalin

ORITA Methylphenidate ()Ritalin Tab 10mg tab ,A, B CG

25102 Concerta E.R OCONE Methylphenidate 18mg Concerta E.R Tab 18mg tab ALZA-USA , "ALZA 18"

1. 23 10mg 30~40

1 1 4 2.~6 6 2 5mg 1 510mg 60mg

1.

2. 3. 4. 5.

148

6. 4~5 7. 1

8. 9. Tyramine

1. Phenylbutazone

2. MAO Furazolidone

3. Guanethidine

4. Phenothiazines Propoxyphene 15 ~ 25

(Brain Metabolism Strengtherner)

26.1 26101 Trental

OTRE4 Pentoxifylline Trental 400mg. tab

26102 Trental ITREN Pentoxifylline Trental inj. 20mg/cc 5cc Amp HOECHST MARION ROUSSEL-GERMANY

3 2

149

Pentoxifyllin

15 ~ 25

26.2 26201 Glycetose

IGLY3 Glycerin/Nacl/Fructose Glycetose inj.300ml.

Bot

1.

2. 3.

12 1 200500ml 500ml 23 12 500ml 30

1.

2. 3. 4. 5. Ketone

15 ~ 25

150

(Anesthetics)

(General Anesthetics)

27.1 27101 Anexate

IANEX Flumazenil Anexate inj 0.1mg/ml 5ml Amp CENEXI SAS-FRANCE 1. Benzodiazepine

2.- Benzodiazepine Benzodiazepine

3.- 5% Dextrose Nacl 0.9%

0.2mg 1.15 60 0.1mg

2. Benzodiazepine 3. 0.3mg 4. Benzodiazepine 5mg

Diazepam 5mg Midazolam

1.

2.

Anexate

1. 2. benzodiazepines ()

1. Benzodiazepine

151

152

2. Benzodiazepine Zopiclone, Triazolopyridazine

3.Benzodiazepine 15 ~ 25

27102 Anesvan

IANES1 Propofol Anesvan inj 200mg/20ml vial

55 2.0 2.5mgkg

1.

2.

1.()

2.Fresofol 1 16

15 ~ 25

27103 Etomidate IETOM Etomidate Etomidate Lipuro 20mg/10ml amp B.BRAUN MELSUNGEN -GERMANY

153

1. 0.2~0.3mgkg 2. 10 0.1mgkg 5

15 ~ 25

27104 Aerrane IISOF Isoflurane Aerrane(Isoflurane ) bot BAXTER-PUERTO RICO

Halothane

1.5~3%1~3.5% 1.

2. 3. 4.

1. 2.

1. Epinephrine

2. 15 ~ 25

27105 Ketalar

IKETA Ketamine Ketalar inj.50mg/cc.10cc. vial

1.

154

2.3. Nitrous Oxide 4. 5.

1. 2.(1)(2)(3)( NO)

InductionIV Route-1~4.5mgkg 0.5mgkg 1~2mgkg IM Route-6.5~13mgkg 3~6mgIb 15 ~25 Maintenance 0.1~0.5mgkg IV Diazepam 20mg

1. 2. 3.:,,,,

1.2.Postoperative Confusional States

1.

2. 1. Barbiturates Narcotics

2.

Analeptics 15 ~ 25

27106 Sevoflurane

ISEVO Sevoflurane Sevoflurane(Ultane) 250ml bot ABBOTT-UK

SEVOFLURANE

1.8-5% Nitrous Oxide

1. 2.

15 ~ 25

(Local Anesthetics )

28.1 28101 Cocaine

ECOCA Cocaine Cocaine bot 1.

2. 3.

1.1~5% 5~10%

2.Adrenaline

15 ~ 25

28102 Primalido cream

EPRIM Lidocaine /prilocaine Primalido cream tub lidocaine

600mg

155

156

1. 2gm

2.6 12 2 2

Prilocaine Metahemoglobin ()

1. 6 2.

( Sulphonamide)

15 ~ 25

28103 Xylocaine IXYL1 Lidocaine *Xylocaine 2% for IV 5ml 2% amp ASTRAZENECA-SWEDEN

lidocaine /

1. 1 1 50~100mg1~2mg/kg 1~2

2. 1 1~2mg 1

4mg () 10~20 1. Anilide

2.() IV 1020 IM 5

15 6090 12 (40%80%)(90%)

157

15 ~ 25

IXYLO Lidocaine Xylocaine inj.2% 20cc/vial 2% vial ASTRAZENECA-FRANCE

lidocaine (amide) (excitable membrane)

1.

2.2%a. epinethrine 7mg/kg(

158

IV 1020 IM 515 6090 12 (40%80%)(90%)

15 ~ 25

28105 Xylocaine Spray EXYL10 Lidocaine Xylocaine Spray 10% 50ml 10% bot ASTRAZENECA-SWEDEN

lidocaine (amide) (excitable membrane)

10mg xylocaine

3 3 20 20 400mg lidocaine 1-5

1. 2.

3.

Lidocaine ( tocainide)

lidocaine Xylocaine

10-15 1-5 15 ~ 25

159

28106 Xylocaine Jelly EXYLO Lidocaine Xylocaine Jelly 30gm. tub RECIP KARLSKOGA-SWEDEN

Xylocaine 2%

(20-30 )(5 ) Lidocaine

12

12 6 mg/kg 24 20ml(400mg) 5-10mg 10-20mg lidocaine 400mg 2ml

-

Adams-Stokes wolff-prkinson-white SAAV

15 ~ 25

28107 Marcaine Spinal

IMAR1 Bupivacaine Hydrochloride Marcaine Spinal inj. 0.5% 4ml.

160

amp ASTRAZENECA-SWEDEN

28108 Marcaine IMAR2 Bupivacaine Hydrochloride Marcaine inj. 0.5% 20cc. vial ASTRAZENICA-FRANCE

28109 Marcaine Spinal Heavy IMARC Bupivacaine Hydrochloride Marcaine Spinal Heavy inj. 0.5% 4ml. amp ASTRAZENECA-FRANCE

1. 2. 3. 2.5mg/ml 5mg/ml

1.2.5100mg 2.512.5mg 2550mg

2. 50mg 46 152540mg3.1025mg 4.75100150mg 5. 23 6.7. 2mg/kg

1.

2.

1.

2. 1.

2. BierBlock

15 ~ 25

(Drugs acting on the musculokeletal system)

('Addictive Analgesics )

29.1

161

Durogesic TTS 29101 EFENT25 Fentanyl * Durogesic TTS 25ug/hr LABORATORIOS BETA S.A

Fentanyl 29102 IFENT Fentanyl Fentanyl inj.0.05mg/ml.10ml. amp BODENE (PTY) Fentanyl u-

fentanyl 0.3-1.5 ng/ml 2 ng/ml

1. DUROGESIC

DUROGESIC 25mcg/h

2.a.2g/kg

162

b.2-20g/kg c.20-50g/kg 20-50g/kg

3. :

50-100g/kg

()()

1. DUROGESIC

2.Fentanyl

3.Fentanyl Durogesic fentanyl DUROGESIC fentanyl DUROGESIC

C

morphine DUROGESIC 72 fentanyl

Fentanyl (copolymer release membrane) fentanyl DUROGESIC fentanyl 12-24 72 Fentanyl DUROGESIC 72 DUROGESIC 24 fentanyl 17 ( 13-22 ) 50% DUROGESIC 72 20-25 DUROGESIC fentanyl DUROGESIC fentanyl (IV infusion) fentanyl 20%Fentanyl

163

75% fentanyl 10% 9% fentanyl 13-21%

15 ~ 25

29104 Pethidinae IDEME Pethidine(Meperidine) Pethidinae inj.50mg. amp

24 1/10

50100mg 1.

2. 3. 4. 5.

THIOPENTONE 1. MAO

2.AMPHETAMINE BARBITURATE CIMITIDINE MAO TRICYCLIEANTIDEPRESSANTS CNS

15 ~ 25

29105 Morphine OMORP Morphine Morphine 10mg. tab , M

164

29106 Morphine IMORP Morphine Morphine inj. 10mg/ml amp

10mg 20mg 50mg

1.

2. 3. 3672

4. NALOXONE 400ug kg 510ug

15 ~ 25

29107 Tramal

OTRAM Tramadol Tramal 50mg cap FARMACENTICI FORMENTI SPA-ITALY /

165

29108 Tramal ITRAM Tramadol Tramal inj. 50mg/ml 2ml amp GRUNENTHAL-GERMANY

100mg PethidineHCI 100mg Onset15~20 Duration4~5 ( 400mg)

1.1~2Amp(50~100mg)

1~2Amp(50~100mg) 2. 400mg 1 3~4 1

3. 1.

2. 3.

4.

()

(MAO)

15 ~ 25

29.2 29201 Naloxone

INALO1 Naloxone Hcl Naloxone inj 0.4mg/ml

amp 1.PIOID RECEPTOR

2. 12 35

SCIMIV IV (1)IV 2 (1~4

) (2)IV 2~3 0.4~2mg 10mg (3) 0.1~0.2mg (4)IV 0.9%NaCl 5%Glucose500ml 2mg(4g/ml)0.4mg/hr0.005mg/kg 2.5g/kg/hr(5)Challenge test 0.2mg0.5ml 30 0.6mg 20

1. Opioids Opioid

2. 15 ~ 25

166

(Non-Addictive Analgesics and Anti-inflammatory Drugs)

30.1 Cox-2 NSAID 30101 Celebrex 100mg

OCEL1 Celecoxib Celebrex 100mg cap

30102 Celebrex 200mg OCELE Celecoxib Celebrex 200mg cap Cox-2 Cox-1

100200mg 200mg 1.2.3.

4.5.

1. 2. 3.4. 5. 6. 7.

C 1. 2. 3. 4. ACE

5. 6. ACE fluconazole

167

97%11.2 3

57%27% 15 ~ 25

30103 Bodopine

OBODO Etodolac Bodopine 200mg cap 1. pyranocarboxylic acid (NSAIDs)

2. inducible cyclooxygenase(COX2:

cyclooxygenase ) consititutive cyclooxygenase(COX1:cyclooxygenase ) prostaglandin biosynthesis antiinflammtory, analgestic antipyretic

3. threshold

4.Onset 30 5.

1. 200~400mg

2. 200~400mg 3. 1200mg

1.

2.

3. D

1.aspirin NSAIDs asthmarhinitis

urticaria 2.15

1.( warfarin)

168

2. aspirin 3. cyclosporin cyclosporin 4. methotrexate methotrexate methotrexate 5. digoxin digoxin 6.Etodolac ACEIs loop diuretics

15 ~ 25

30104 Mesulid

OMESU Nimesulide Mesulid 100mg Tab HELSINN BIREX-IRELAND 1.

cyclooxygenase-2(COX-2) cyclooxygenase-1(COX-1)2.: cytokine()

interleukin-6,urokinase

1. 2. 3. 4. 5.

100mg400mg 30~80mL 30mL

(

3. (: )

1. 2. 1 2 B 3 D 3.: nimesulide

(30mL) 12

1. NSAIDs Salicylates: NSAID

2.Haparin Ticlopidine:

3.:

4.: 5.:

6.Methotrexate: NSAIDs methotrexate

7.Pentoxifylline:8. GlibendamideWarfarinDigoxin Cimetidine

30105 Meloxin

OMELO Meloxicam Meloxin 7.5mg Tab , YSP/75 1. enolic acid NSAIDs

2.

170

171

COX-2( COX-1) 3. COX-2 NSAIDs COX-1 meloxicam NSAIDs

1. 15mg 7.5mg

2. 7.5mg 15mg 3. 7.5mg 4. 7.5mg 5. 15mg 6. 5mg 7. 15mg()

D

C

(aspirin) 1. NSAIDs Salicylates: NSAID

2.Haparin Ticlopidine: 3.: 4.: 5.: 6.Methotrexate: NSAIDs methotrexate 7. GlibendamideWarfarinDigoxin Cimetidine

15 ~ 25

30.2 NSAID 30201 Flur Difen Patch

EFLUR Flurbiprofen Flur Difen Patch

(Prostaglandin)

1.

2.

3. 4.

1.

2. 3.

B 1. aspirin NSAIDs NSAIDs

2.NSAID methotrexateMTX MTX

3. Warfarin

30202 Focus gel EFOCU Piroxicam Focus gel 10mg/gm 40gm Tube

172

1.(Cyclooxygenase) (Prostaglandin) 2. 1% Piroxicam

24 13gm

1.

2. 3.()

1. aspirin NSAIDs NSAIDs

2.NSAID methotrexateMTX MTX

3. Warfarin

30203 Meitan F.C.

OMEIT Diclofenac Potassium Meitan F.C. 25mg Tab , ME

30204 Voren OVORE Diclofenac sodium Voren 50mg Cap

173

http://www.mims.com.tw/Page.aspx?menuid=identaresult&ID=3708&name=Meitan+F.C.+tab

174

/, YSP VRCP

30205 Diclofenac Supp EVOR1 Diclofenac Diclofenac Supp 12.5mg EA

Meitan Vottaren

50150mg 200mgday

100150mgday 23 3 1/2 3~5 1/2~1 6~8 1 9~11 1~2 1 150mg

1. 2. 3. 4. 5.

1. 2.

a.

b.

3.

a.

b.

c.

4.

5.

6.

7.

a.

b.

c.

8.

9.

10.

3 / FDA Pregnancy CategoryC

1. 2. 3. 4. 5. 6.Aspirin

7.

1.(Li)

2.(Aspirin)

30206 Keto E.M. OKET2 Ketorolac Keto E.M. 10mg

175

Cap

30207 Keto inj. IKETO Ketorolac Keto inj. 30mg/ml Amp 1.

2. 3. 4.

10mg 4-6

15 : 1.65

1. 2. 3. 4. 5.

1.

2. aspinin NSAIDs 3. 4.

1.Protein-bound Drugs: ketorolac 2.Nonsteroidal Anti-inflammatory Agents: aspirin NSAIDs NSAIDs 3.Anticoagulants and Thrombolytic Agents:ketorolac ( haparinwarfarin dextrans) 4.Diuretics: ketorolac prostaglandin 5.Methothrexate: ketorolac methothrexate methothrexate 6.Lithium: lithium lithium 7.Probenecid: probenecid 8.ACE inhibitors: ACEIs

(15~30)

30208 Ketoprofen

OKETP Ketoprofen Ketoprofen 50mg

177

Cap , 30408

30209 Ketoprofen IALON Ketoprofen Ketoprofen inj. 25mg/ml 2ml

Amp NSAIDs aspirin

1.-1 3 50mg 1 4 2

-1 2 50mg 2. 150-300mg 3-4 300mg

3. 1/2-1/3 1.-

2.- 3.-

1. 2. 3.

D- Ketoprofen 1. aspirin NSAIDs NSAIDs

2.NSAID methotrexateMTX MTX

3. Warfarin

30210 Depyretin OSCAN Acetaminophen

178

Depyretin 500mg Tab , 867 VPC

30211 Anti-Phen Syr. OANTS

Acetaminophen Anti-Phen Syr.24mg/ml(1Bot=60ml.)

Bot

CNS

1 1~2 (7~12 )1 1/2~1 7 3~4 12 10ml6~12 5ml3~6 2.5ml3 38.5 4~6 5

1. 2. 3.

1. 2. 3. 4. 150mg/kg

179

B Acetaminophen 1.

2.

30212 Bokey OBOKE Aspirin Bokey 100mg Cap /, YSP.BKCP 1. (Cyclo-oxygenase)

Thromboxane2.3.Thromboxane () Salicylate Acetyl Salicylic Acid Prostacyclin

4.Acetyl Salicylic Acid

1

1.

2. Acetyl Salicylic Acid 3. 4.()

1.

2.

aminoslicylic acid aspirin 2g/d

180

(15-30)

30213 Indalgin(Indocin) OINDO Indomethacin Indalgin(Indocin) 25mg

Cap

/ 1.

2.

25mg 23 50mg 3

1.

2. 1. aspirin NSAIDs NSAIDs

2.NSAID methotrexateMTX MTX

3. Warfarin (15-30)

30214 Napton S.R

ONAPT Naproxen Napton S.R 750mg Tab , NAPTON (Cyclo-Oxygenase)(Prostanlandins)

Thromboxan 1

181

14

2 250mg

1. 2.

Sodium Bicarbonate 13

30215 Norgesic

ONORG Orphenadrine citrate/Paracetamol Norgesic 450mg Tab 3M-AUSTRALIA , 3M N/C Orphenadrin

Paracetamol

1. Orphenadrine

2. 3. Orphenadrine

Orphenadrine

182

1. Amantadine, , Butyrophenones,Phenothia Tricyclic antidepressants. 2.

30216 Sconin solution OSCON Ibuprofen Sconin solution 20mg/ml 60ml Bot (Prostaglandin)

6 12 102.5( 39.2) 0.25ml 102.5( 39.2) 0.5ml 6~8 2.0ml 6 12 6~8 0.5ml 2.0ml 1.5ml 2.0ml 3 4 1.0ml 4 6 20ml 400mg 4 20ml 60ml-160ml (15ml 4 20ml30ml 40ml3 4 ) Ibuprofen

183

184

1.

2. STEVENS-JOHNSON ( )LYELL () 3. 4.(TRANSAMINASE) 5. 6. 7. 8.

1. 2.() () 3. 4. 5. 6. 7.

1. 2. 3. 4.

5. 6. 7.(ASPIRIN)

1. aspirin NSAIDs NSAIDs 2.NSAID methotrexateMTX MTX 3. Warfarin

1. 2.

30217 Suloril (Clinoril) OSULI Sulindac Suloril (Clinoril) 200mg Tab , WD 200 1.

2. 90% 2-4 7.8 Sulfide 15.4 3. Sulfone Sulfide 4. 50% 25% 5.

()

2 400mg

1.

185

186

2. 3.() 4. 5. 6.

1. 2. Aspirin

1. Aspirin Sulfide Metabolite 2. Probenecid Probenecid

30218 Synotec

OSYNO Tiaprofenic Acid Synotec 200mg Tab UC 04

(Prostaglandin)

3 200mg

Aspirin

30.3 30301 Metalcaptase

OMETA D-Penicillamine 300mg Metalcaptase Tab HAUPT-GERMANY Penicillamine

T- 1Gm

Wilson (Cystinuria)

300~600 mg 5~10 mg 900~1.8g

1.

2. 3 3 7~10 1 1

3. 1 6 1 4. Pyridoxine25 mg

Wilson

5. 6

1. Wilson 1mg 2.(Cystinuria)

187

30302 Peitil

OPEIT Glucosamine Sulfate 250mg Peitil Cap

/, PEILI CO4 1.

2.Mucopolys Accharides

1. 2 2 6

15 2. 8 3 2 15 3~4 2 2 15

1. Causaltherapy 1

2. 3.()

30303 Plaquenil OPLAQ Hydroxychloroquin 200mg Plaquenil

188

Tab , 200 HCQ DNA S

1.20mg/kg

2.80mg/kg 3

1.

2.(G-6-PD ) 3. 3

C HYDROXYCHLOROQUINE

HYDROXYCHLOROQUINE

30.4 ( Antigout Agents) 30401 Allopurinol

OALLO Allopurinol 100mg. Allopurinol Tab , SHIN/YUNG Hypoxanthine

Xanthine Oxidase(Xanthine Oxidase Hypoxanthine XanthineUric Acid )

1 200mg~300mg 2~3

1.

2.

189

3. 4. 5.

1. 1 1 (100mg/Tab) 2. 3.() ()

1. Oxipurinol Allopurinol 2. Allopurinol

Dicumarol,Sulfinpyrazone,Mercaptopurine,Azathioprine,Ampicllin, Amoxicillin Thiazide Diuretics

15~30

30402 Beenrone OBEEN Benzbromarone50mg Beenrone Tab , Y/S 1.

2.