Supplementary table 1. The corresponding values of each marker with respect to endoscopic Mayo score in ulcerative colitis

Mayo 0(N=14)

Mayo 1(N=9)

Mayo 2(N=11)

Mayo 3(N=6)

P value (between groups)

P value (within groups)

FCT (ug/g) 74 ±18

114 ±31

626 ±132

755 ±116

<0.001 all <0.001 except 0.726 (0 vs 1) and 0.342 (2 vs 3)

FIT (ug/g) 16 ±1 35 ±20 57 ±20 112 ±31

0.007 0 vs 1: 0.4060 vs 2: 0.0640 vs 3: 0.0011 vs 2: 0.3671 vs 3: 0.0112 vs 3: 0.055

CRP (mg/dL)

0.38 ±0.04

0.42 ±0.08

0.74 ±0.17

1.38 ±0.46

0.003 0 vs 1: 0.8580 vs 2: 0.1090 vs 3: 0.0011 vs 2: 0.2011 vs 3: 0.0022 vs 3: 0.023

ESR (mm/hour)

12 ±1 30 ±5 46 ±8 41 ±13 0.001 0 vs 1: 0.0010 vs 2: <0.0010 vs 3: 0.0021 vs 2: 0.1371 vs 3: 0.4002 vs 3: 0.737

Albumin (g/L)

44 ±1 45 ±1 40 ±2 36 ±3 0.005 0 vs 1: 0.5260 vs 2: 0.0930 vs 3: 0.0031 vs 2: 0.0381 vs 3: 0.0012 vs 3: 0.094

Platelet count ( x109/L)

250 ±13

260 ±29

555 ±84 484 ±52

<0.001 0 vs 1: 0.7230 vs 2: <0.0010 vs 3: <0.0011 vs 2: 0.0071 vs 3: 0.0012 vs 3: 0.565

Hemoblogbin (g/L)

13.7 ±0.4

13.3 ±0.4

12.1 ±0.6

11.5 ±0.8

0.026 0 vs 1: 0.5420 vs 2: 0.0250 vs 3: 0.0091 vs 2: 0.1391 vs 3: 0.0492 vs 3: 0.440

CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, FCT: fecal calprotectin test, FIT: fecal immunochemical test

Supplementary table 2. The corresponding values of each marker with respect to SES-CD in Crohn’s disease

SES-CD 0-3 (remission)(N=17)

SES-CD 4-6(mild activity)(N=1)

SES-CD ≥7(moderate to severe activity)(N=8)

P value (between groups)

P value (within groups)

FCT (ug/g) 307 ±96 1000 ±N/A

930 ±69 0.001 remission vs mild: 0.108remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.747

FIT (ug/g) 23 ±3 69 ±N/A 98 ±21 <0.001 remission vs mild: 0.04remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.669

CRP (mg/dL) 0.50 ±0.09 0.35 ±N/A

2.73 ±0.76 0.001 remission vs mild: 0.712remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.330

ESR (mm/hour)

18 ±3 7 ±N/A 37 ±7 0.021 remission vs mild: 0.325remission vs moderate/ severe: 0.011mild vs moderate/ severe: 0.208

Albumin (g/L) 45 ±1 48 ±N/A 39 ±2 0.008 remission vs mild: 0.530remission vs moderate/ severe: 0.003mild vs moderate/ severe: 0.216

Platelet count ( x109/L)

255 ±13 139 ±N/A 394 ±30 <0.001 remission vs mild: 0.051remission vs moderate/ severe: <0.001mild vs moderate/ severe: 0.026

Haemoblogbin (g/dL)

13.9 ±0.2 13.7 ±N/A

12.8 ±0.6 0.183 remission vs mild: 0.847remission vs moderate/ severe: 0.069mild vs moderate/ severe: 0.658

CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, FCT: fecal calprotectin test, FIT: fecal immunochemical test, SES-CD: simple endoscopic score for Crohn’s disease

Supplementary table 3. Clinical parameters of patients in endoscopic remission and non-

remission

Parameters PatientsEndoscopic

remission

Endoscopic non-

remissionP value

FCT (ug/g)

All patients* 182 ± 282 764 ± 352 <0.001

UC** 90 ± 81 672 ± 388 <0.001

CD*** 307 ± 96 938 ± 185 <0.001

FIT (ug/g)

All patients 23 ± 30 83 ± 68 <0.001

UC 24 ± 38 77 ± 73 0.005

CD 23 ± 14 95 ± 59 <0.001

CRP (mg/dL)

All patients 0.44 ± 0.28 1.48 ± 1.56 0.002

UC 0.40 ± 0.18 0.97 ± 0.84 0.003

CD 0.50 ± 0.38 2.47 ± 2.16 0.001

ESR (mm/hour)

All patients 19 ±13 41 ± 25 <0.001

UC 19 ± 14 44 ± 27 <0.001

CD 18 ± 11 34 ± 21 0.034

Albumin (g/L)

All patients 45 ± 3 39 ± 6 <0.001

UC 44 ± 2 39 ± 7 0.002

CD 46 ± 3 41 ± 6 0.010

Platelet count (x

109/L)

All patients 254 ± 59 473 ± 213 <0.001

UC 254 ± 65 529 ± 234 <0.001

CD 255 ± 54 366 ± 117 0.003

Haemoglobin

(g/dL)

All patients 13.7 ± 1.2 12.7 ± 1.9 0.002

UC 13.6 ± 1.3 11.9 ± 1.9 0.004

CD 13.9 ± 1.1 12.9 ± 1.7 0.079

CD: Crohn’s disease, CRP: C-reactive protein, ESR: erythrocyte sedimentation rate, FCT: fecal calprotectin test, FIT: fecal immunochemical test, UC: ulcerative colitis

*All patients: Total number = 66. Endoscopic remission = 40; Endoscopic non-remission = 26**UC: Total number = 40. Endoscopic remission = 23; Endoscopic non-remission = 17***CD: Total number = 26. Endoscopic remission = 17; Endoscopic non-remission = 9

Supplementary figure 1. AUROC values of each marker in UC vs. CD patients

Supplementary figure 2. Sensitivity and specificity of blood indices in all IBD patients

Supplementary figure 3. Sensitivity and specificity of different biomarkers in UC

Supplementary figure 4. Sensitivity of combinations of fecal and blood biomarkers for endoscopically active UC

Supplementary figure 5. Specificity of combinations of fecal and blood biomarkers for

endoscopically active UC

Supplementary figure 6. Sensitivity and specificity of different biomarkers in CD

Supplementary figure 7. Sensitivity of combinations of fecal and blood biomarkers for endoscopically active CD

Supplementary figure 8. Specificity of combinations of fecal and blood biomarkers for endoscopically active CD