. Cardiovascular morbidity and mortality in patients with rheumatoid arthritis: vascular alterations...
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Transcript of . Cardiovascular morbidity and mortality in patients with rheumatoid arthritis: vascular alterations...
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PRESENTADO POR:Dr: Dairo Rey Residente II año medicina internaRuby Martinez RamirezJany Mazo Morales
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(1) Pieringer H, Pichler M. Cardiovascular morbidity and mortality in patients with rheumatoid arthritis: vascular alterations and possible
clinical implications. QJM 2011 Jan;104(1):13-26.
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(1) Pieringer H, Pichler M. Cardiovascular morbidity and mortality in patients with rheumatoid arthritis: vascular alterations and possible
clinical implications. QJM 2011 Jan;104(1):13-26.
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CONCLUSIÓN: Los resultados obtenidos en estos estudios soportan la suposición que los agentes bloqueantes anti TNF alfa, son capaces de reducir la incidencia de eventos cardiovasculares, especialmente en aquellos pacientes con responden clínicamente a la terapia.
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OTROS DMARDS
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(1) Pieringer H, Pichler M. Cardiovascular morbidity and mortality in patients with rheumatoid arthritis: vascular alterations and possible
clinical implications. QJM 2011 Jan;104(1):13-26.
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Las alteraciones cardiovasculares en pacientes con AR tienen mayor incidencia, por lo tanto la muerte cardiovascular en esta población es mayor en comparación con la población no afectada por AR. Los cambios morfológicos son evidentes, determinándose:
•Variaciones a nivel molecular •disfunción endotelial •rigidez arterial•Cambios en la morfología arterial
No solo los factores de riesgos comunes influyen en la aparición de enfermedades cardiovasculares sino que también la inflamación crónica contribuye con este proceso
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CONCLUSIONES• En la actualidad el uso de MTX y TNF parece
proporcionar una reducción de los eventos cardiovasculares.
• Drogas como la leflunomida, ciclosporina, AINES e inhibidores de la COX-2 pueden empeorar los eventos cardiovasculares
• La función del tratamiento con GC en AR activa aun queda por determinar, no hay estudios concluyentes, por lo tanto queda por determinar.
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BIBLIOGRAFÍA• (1) Pieringer H, Pichler M. Cardiovascular morbidity and mortality in
patients with rheumatoid arthritis: vascular alterations and possible clinical implications. QJM 2011 Jan;104(1):13-26.
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