6q13

1 2 320% 1 2 Wang L, et al. 2005

309 964 GSTT1 52 235 UGT1A7 365 379 NAT1 309 964 XRCC1 GWAS 3851 3934 ABO 163 337 MTHFR/TS 397 907 FasL/CASP8 393 786 COX2

copy number variation, CNV >1kb DNA > SNP copy number polymorphism, CNP >1%

SNP

* Two-sided 2 test.

6q13*Data were calculated by logistic regression, adjusted for sex, age and smoking status.

Copy number Patients (n=420)Controls (n=817)OR* (95% CI)PNo. (%)No. (%)2 copies 144 (34.28) 364 (44.55)1.00 (reference)1 copy 233 (55.48) 362 (44.31)1.75 (1.332.31)7.5610-5 0 copy 43 (10.24) 91 (11.14)1.07 (0.681.69)0.780 or 1 copy 276 (65.72) 453 (55.45) 1.61 (1.242.11) 4.4110-4

CNVchr6:74649185-74658419

9235bp

Feuk L, et al. 2006

P

6q13

chr6:74,648,791-74,659,169

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