第七章 免疫学基础知识
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Transcript of 第七章 免疫学基础知识
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1.2. T3.B
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1. B25% T75%
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2. T25% B65% :
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1. T
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2. B
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3. ADCC
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Kupffer A: -
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BCR/AbAntigen recognition and clearanceTCR Antigen recognition by T cellsMHC Antigen presentationCytokineImmunoregultation and effector functionComplementInnate immunity against pathogensCD moleculesImmune cell differentiation and function
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2::
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1 () 2 ()
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2 10000Da3 10DaAA 5734Da AA
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4.5.
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- - - - ,() - ( ,) Th -TD Ag -TI Ag
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(O)Ag 170 60,50 , AF (H)Ag 60 60,(a.b.c) , (1.2.3)Ag - , - (KAg) (Vi Ag) , 100,K88K99Ag -(,,,0.3-0.4%) -(,,)
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()
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A.heavy chainH 2 light chainL 2 B.variable region, V constant region, C
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Ig
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IgG (75%Ig) (2123) 35(8.017 mg/ml)
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ADCC
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IgM IgA IgE IgDIgM: IgA: IgE: IgD: B
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IgMIgG
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A. B. C. D. E. F.
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polyclonal antibody B :
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McAb B --- B --- --- HAT(H), (A)(T)
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DNAIg -(chimeric antibody) (reshaped humanized antibody) Fab Fc Fv (bispecific antibody)
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DNA DNA
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1. 2. TB3. T
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() () () ()
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IgE
.() -- --- --- ---
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() --- IgE Th2 IL-4 B IgEIgE(1000-10000)FcFcR ()IgE FcFcR FcR--- 112 () () FcR --- IgE
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(eosinophils) A. B.
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IgGIgMNK
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6h2448h