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P.BALABANInstitute of Higher Nervous Activity and Neurophysiology,Russian Academy of Sciences

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+Cellular mechanisms of learning and memory have been highly conserved during evolution2PKmProtein Kinase M zeta

Constitutively active isoform of Protein Kinase C (PKC)

Functions in the storage of memory.

Protein nitrosylation

Nitrosylation is a protein modification in which a nitrosyl group is post-translationally added to a protein.S-nitrosylation, discovered by Joseph Loscalzo, is an important biological reaction of nitric oxide; it refers to the conversion of thiol groups, including cysteine residues in proteins, to form S-nitrosothiols (RSNOs). S-Nitrosylation is a mechanism for dynamic, post-translational regulation of most or all major classes of protein.Known:Nitric oxide is necessary for synaptic plasticityNO in small concentrations activates protein synthesis via G-pathways, while in big concentrations LOCALLY impairs proteins functioning via S-nitrosylation mechanism.Question:? NO is necessary both for memory formation and local memory plastification in synapses?