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第十二章 蛋白质降解和氨基酸代谢
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Transcript of 第十二章 蛋白质降解和氨基酸代谢
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60 1.
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Ubiquitin 76E1E2 E3
12
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(1):
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(2)4-10
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TRENDS in Plant Science Vol.8 No.3 March 2003Molecular Cell, Vol. 8, 499504, September, 2001,
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C-terminal side of Lys, Arg
C-term of Phe, Trp, Tyr
C-term of val, Ala, Ser, Lys
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()
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1.
,----
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- -
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GPT + -
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GOT -
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S-GPT S-GOT
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2. L-L- -
L-NAD+NADP+ GTPATP ADP
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3.
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PLP
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(NH3) - () CO2 - CO2
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1.(NH3)
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(1) GlnGln,NH3
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(2) --Ala
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-Ala
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2
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H2O
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Urea Biosynthesis -1 (carbamoyl phophate synthetase,CPS)
CPS-AGA(N-acetyl glutamatic acid,AGA)N--AGA
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Urea Biosynthesis -2
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Urea Biosynthesis -34
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Urea Biosynthesis -5
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NH4+ + CO2 + 3ATP + + 2H2O + 2ADP + 2Pi + AMP + PPi + 21CCO214NH3ITCA
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TCA
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5TCACoA-CoA
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TCA P3152.-1. CoA4. 3. CoACoA5. TCAA
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CoA,CoA- A
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() CO2CO2
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-ATCA
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TCA ACO2H2OATP-CO2TCA
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(one carbon unit, OCU) -CH3 -CH2--CH= CH=NH H-C0- -CH2OH- THF, FH4 S-50
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FH4FH4FH4FH4N5N10
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+ C
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S-SAMSAM Met SAM
SAHcy
N5-CH3-FH4 N5-CH3-FH4
N5-CH3-FH4Hcy
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S-ATP
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5-5-
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--(GABA)
-L-VB6
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(taurine)
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-NH2
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GluAspSerHis
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-1-
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-2TCA-5-CoA
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A