552

(BMD)

()

(WHO) BMD < 2.5 (25) T (T score)

(>75) ( 12) (GIOGIOP)

Genant

(Bone Mineral Density)

T score T < -2.5

-2.5 < T < -1

p 25

From Canalis et al, NEJM, 357: 905-916, 2007

From Canalis et al, NEJM, 357: 905-916, 2007

(1)

D

()

(2) () (Marfans syndrome)

( Ehlers-Danlos syndrome) (homocystinuria)

BMD (BMD)

Glucocorticoid-induced osteoporosis

Calcitonin Fluoride Strontium Thiazide Selective estrogen receptor

modulator (SERM) Bisphosphonate Salt restriction

D :

Actonel (Ladogal, danazol) (Livial, tibolone) (SERM): (Evista, raloxifene) D: () (onealfa) : (Forteo, teriparatide) : (Prolia, denosumab) (Miacalcic) :

(ONJosteonecrosisofthejaw)

Teriparatide

(3%), (3%) (8%), (4%), (4%) (5%) (4-6 11% 6%) (9%), (5%), (3%), (2%)

(3%) (10%), (9%), (3%),

(10%), (6%), (4%), (4%)

: ( 3%), (?)

Prolia

Prolia (34.7%) (11.7%)

(7.6%) (7.2%) (5.9%) (osteonecrosis of the jaw, ONJ)

Vertebroplasty

Morphopedics

Baloon Kyphoplasty

(!!)

()

D K &

D

D () 10-15 D

K

p K D ::

C

p C ::

&

p D : 5 5060

() 10 (240cc/) 7

http://www.shef.ac.uk/FRAX/tool.jsp?lang=cht