حمل وادعيلي من هنــــــــــــــا
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Transcript of حمل وادعيلي من هنــــــــــــــا
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Lumpy Skin Disease
Pseudourticaria, Neethling Virus Disease, Exanthema Nodularis Bovis, Knopvelsiekte
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Center for Food Security and Public Health Iowa State University - 2004
OverviewOverview
• Organism• Economic impact• Epidemiology• Transmission• Clinical signs• Diagnosis and treatment• Prevention and control• Actions to take
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The Organism
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Center for Food Security and Public Health Iowa State University - 2004
Lumpy Skin Disease VirusLumpy Skin Disease Virus
• Family Poxviridae−Genus Capripoxvirus
• Closely related to sheep and goat pox
• Cannot be differentiated with routine serology
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Importance
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Center for Food Security and Public Health Iowa State University - 2004
History and Geographic Distribution
History and Geographic Distribution
• 1929: Southern and eastern Africa• Disease of cattle• Experimental
infection−Oryx, giraffe
and impala• Virus will replicate in sheep and goats• 1990’s: Resurgence in Africa
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Center for Food Security and Public Health Iowa State University - 2004
Economic ImpactEconomic Impact
• Major economic importance due to loss of production−Severe emaciation−Lowered milk production−Abortion−Secondary mastitis−Loss of fertility−Extensive damage to hides−Loss of draft from lameness
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Epidemiology
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Center for Food Security and Public Health Iowa State University - 2004
Morbidity/ MortalityMorbidity/ Mortality
• Morbidity−3% to 85%
• Mortality−1% to 2% usually−20% to 85% in
some cases
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Transmission
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Center for Food Security and Public Health Iowa State University - 2004
Animal TransmissionAnimal Transmission
• Primary route: Mosquitoes and flies• Minor route:
−Direct contact via cutaneous lesions, saliva, nasal discharge, milk, semen, muscles,
• Virus can survive up to 35 days in desiccated crusts
• No carrier state• Spread related to movement of cattle
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Center for Food Security and Public Health Iowa State University - 2004
Human TransmissionHuman Transmission
• There is no evidence that lumpy skin disease virus affects humans
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Animals andLumpy Skin Disease
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Center for Food Security and Public Health Iowa State University - 2004
Clinical SignsClinical Signs
• Incubation period−5 days to 5 weeks
• Inapparent to severe infection−worse in young
cattle• Fever• Decreased milk yield
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Center for Food Security and Public Health Iowa State University - 2004
Clinical SignsClinical Signs
• Raised, circular firm nodules coalescing into plaques− Anywhere on the body− May harden into “sitfast”
and be shed• Swollen/tender udder
or testicles• Tongue, gum and hard
palate lesions• Abortion and sterility
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Center for Food Security and Public Health Iowa State University - 2004
Post Mortem LesionsPost Mortem Lesions
• Characteristic skin nodules
• Lesions in the mucous membranes throughout the GI tract
• Nodules in lungs• Hemorrhages in
spleen, liver or rumen
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Center for Food Security and Public Health Iowa State University - 2004
Differential DiagnosisDifferential Diagnosis
• Pseudo-lumpy skin disease
• Bovine herpes mammillitis
• Dermatophilosis• Ringworm• Insect or tick bites• Rinderpest• Demodicosis
• Hypoderma bovis infection
• Photosensitization• Bovine papular
stomatitis• Urticaria• Cutaneous
tuberculosis• Onchocercosis
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Center for Food Security and Public Health Iowa State University - 2004
SamplingSampling
• Before collecting or sending any samples, the proper authorities should be contacted
• Samples should only be sent under secure conditions and to authorized laboratories to prevent the spread of the disease
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Center for Food Security and Public Health Iowa State University - 2004
DiagnosisDiagnosis
• Clinical−Suspect with characteristic skin nodules
(“sitfast”), fever and low mortality• Laboratory Tests
−Virus isolation and identification−Electron microscopy in combination with
history−Serology, cross reactions with other
poxviruses may occur
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Center for Food Security and Public Health Iowa State University - 2004
Treatment Treatment
• Animals generally recover with good nursing care
• Antibiotics for secondary infection• Up to 6 months for severely affected
animals to recover fully
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Lumpy Skin Disease in Humans
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Prevention and Control
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Center for Food Security and Public Health Iowa State University - 2004
Recommended ActionsRecommended Actions
• Notification of Authorities−Federal:
Area Veterinarian in Charge (AVIC) www.aphis.usda.gov/vs/area_offices.htm
−State veterinarian www.aphis.usda.gov/vs/sregs/official.htm
• Quarantine
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Center for Food Security and Public Health Iowa State University - 2004
DisinfectionDisinfection
• Susceptible to:−Ether (20%)−Chloroform−Formalin (1%) −Some detergents−Phenol (2% for 15 minutes)
• Can survive up to 35 days in the environment in desiccated scabs
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Center for Food Security and Public Health Iowa State University - 2004
Control and EradicationControl and Eradication
• Endemic areas−Vaccinate cattle
• Non-endemic areas−Keep free with import restrictions and
proper quarantine• Insect control
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Center for Food Security and Public Health Iowa State University - 2004
Control and EradicationControl and Eradication
• Outbreak in LSD free area: Small scale− Quarantine, slaughter infected and
exposed, clean and disinfect− Consider ring vaccination
• Outbreak in LSD free area: Large scale− Vaccination− Consider slaughter
• 1989: Israel− Quarantine, slaughter and ring vaccination
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Center for Food Security and Public Health Iowa State University - 2004
VaccinationVaccination
• Successful in endemic areas• Neethling strain vaccine confers
immunity up to 3 years• Sheep and goat pox vaccine is used
but may cause local, severe reaction
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Additional Resources
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Center for Food Security and Public Health Iowa State University - 2004
Additional ResourcesAdditional Resources
• World Organization for Animal Health (OIE) website−www.oie.int
• USAHA Foreign Animal Diseases – “The Gray Book”−www.vet.uga.edu/vpp/gray_book/index
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Acknowledgments
Development of this presentation was funded by a grant from the Centers for Disease Control and Prevention to the Center for Food Security and Public Health at Iowa State University.
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Author:
Co-authors:
Reviewer:
Katie Steneroden, DVM
Kristina August, DVMRadford Davis, DVM, MPH, DACVPM
Bindy Comito Sornsin, BA
Acknowledgments