1. Nu Skin NU SKIN 3 2011

2. 1984: Nutriol 3. NU SKIN ! 4. FDA (U.S. Food and Drug Administration) , , 5. CTFA (Cosmetic Toiletries and Fragrance Association) , . Cosmetic Ingredient Review (CIR) , 1976 . 6. NU SKIN FDA CTFA CIR NU SKIN 7. NU SKIN - / 8. ? ? 9. ? 10. ? 50-90% , , 11. : , , , , , 12. NU SKIN 13. .... 14. Nutricentials PCA Hypnea Mysciformis Gelidiella () (, , , , , ) 15. : Water, Isohexadecane, Cyclohexasiloxane, Dimethicone, lcohol denat., Dipropylene glycol, synthetic wax, PEG-10 dimethicone, Dimethicone PEG10/15- crosspolymer, Dimethycone/polyglycerin-3 crosspolymer, Caffeine, Sodium acrylates copolymer, Sodium hydroxide, Bifida ferment Lysat, Adenosine, Ascorbyl glucoside, Nylon-12, Limonene, Disodium EDTA, Propylene Carbonate, Hydroxyethylpiperasine Ethane Sulfonic acid, Caprylic/capric triglyceride, Disteardimonium hectorite, Ethylhexylglycerin, Polysilicone-8, Tocopheryl acetate, Methylparaben, Phenoxyethanol, Parfum/fragrance, Sodium benzoate : Water, Stearic acid, Aloe Barbadensis Leaf Juice, Propylene glycol, Safflower seed oil, Glyceryl Stearate, Tocopheryl Linoleate, Tocopheryl Acetate, Ethylhexyl methoxycinnamate, Sodium PCA, Bisabolol, Allantoin, Retinyl Palmitate, Royal Jelly, Sodium Hyaluronate, Fucus Vesiculosus Extract, Ceteareth-20, Butylene Glycol, Triethanolamine, Carbomer, Cetearyl Alcohol, Disodium EDTA, Fragrance, Phenoxyethanol, Methylparaben, Butylparaben, Isopropylparaben, Isobutylparaben, Iron Oxides L`Oreal 50 495 Nu Skin NaPCA 75 513 16. Water (AQUA), ALCOHOL, DIMETHICONE, AMMONIUM ACRYLOYLDIMETHILTAURATE/VP COPOLYMER, GLYCERETH-26, MACADAMIA TERNIFOLIA NUT OIL, PENTAERYTHRITYL TETRAETHYLHEXANOATE, PENTYLENE GLYCOL, HDI/TRIMETHYLOL HEXYLLACTONE CROSSPOLYMER, GLYCERIN, HEXYLENE GLYCOL, BUTYROSPERMUM PARKII EXTRACT, PARFUM (FRAGRANCE), TOCOPHERYL ACETATE, PORPHYRA UMBILICALIS EXTRACT, FRUCTOSE, GLUCOSE, CAPRYLYL GLYCOL, CASTANEA SATIVA (CHESNUT) SEED EXTRACT, GLYCERYL ACRYLATE/ACRYLIC ACID COPOLYMER, TRIHYDROLYZED PROTEIN, SODIUM EDTA, SILICA, OCTENYL SUCCINIC ANHYDRIDE, PROPYLENE GLYCOL, ALANINE, SODIUM HYALURONATE, UREA, PHENOXYETHANOL, METHYLPARABEN, ASPARTIC ACID, GLUTAMIC ACID, PROPYLPARABEN, BUTYLPARABEN, ETHYLPARABEN, LARIX EUROPEA WOOD EXTRACT, ISOBUTYLPARABEN WATER(AQUA), 12-15 ALKYL BENZOATE, CAPRYLIC/CAPRIC TRIGLYCERIDE, GLYCERYL STEARATE, CETEARYL ALCOHOL, BUTIROSPERMUM PARKII (SHEA BUTTER), BUTYLENE GLYCOL, ALOE BARBADENSIS LEAF JUICE, UREA, SODIUM BEHENOYL LACTYLATE, GLYCERIN, PISTACIA VERA SEED OIL, HELIANTHUS ANNUUS SED OIL, METHYL GLUCETH-10, PUNICA GRANATUM STEROLS, SODIUM PCA, GLYCINE, ALANINE, PROLINE, SERINE, THREONINE, LYSINE, ARGININE, GLUTAMIC ACID, SORBITOL, BETAINE, DIMETHICONE, TOCOPHERYL ACETATE, TOCOPHEROL, DISODIUM EDTA, FRAGRANCE, (Parfum), CHLORPHENESIN, METHYLPARABEN, PROPYLPARABEN Yves Saint Laurent, Hydra Feel Creme 1900-2100 10 18 Moisture Restore 919 17. 18. .... 19. 180 20. 180 Face Wash - 10% , , , , , - , HMW-, Fumos officinalis, Cell Renewal Fluid AHA facial Peel and Neutralizer 15% () 10% , , , , , , . . SPF 18 , , . , , , , 21. Product Name % AHA/PHA pH % Nu Skin 180 AHA Peel 10 3.50 7.0 Nu Skin 180 Cell Renewal - 15 3.75 6.2 Henderson-Hasselbalch equation: pKa = pH + log [Acid]/[Base] 180 pH 22. 180 ( , ) , 3 , , , , , 23. ... 24. Tru Face 25. Tru Face DMAE -7 26. 28 Tru Face Priming Solution - , - 16 . , DMAE . . : . 35 ( ) 35 + 27. : Tru Face Line Corrector -7 (-7) - -7 : I, III IV , 28. - , . TF Line Corrector 68% 47% 24% -7 35 , 58 , 6 : 29. TF Line Corrector 12- (42 ) 91% C 6 30. TF Line Corrector , / Face Gels : Galvanic Spa II 0,5-1 31. 33 32. 34 33. 34. () : 35. : () 36. ... 37. ... , 38. : Tru Face Essence Ultra 41 . 39. 42 40+ Tru Face Essence Ultra - , , : Q-10, , Tegreen97 - . 40. , , , ? 41. 44 2 5 ! 42. 45 CoQ10 C E Tegreen 97 43. (, 156 .) 44. 47 0% 5% 10% 15% 20% 25% 0 1 2 3 40-77 , 18-25 % 45. 45 TFE Ultra 46. 49 47. 50 40+ Tru Face Essence Ultra : 2 2-4- , 2-4 . 12 . 48. - 49. , 50. NU SKIN: , , , 51. TIMP1 COL7A1 AQP3 IL1B PPARG TNFA POMC IL1B IL6 SOD2 MT2A TXNRD1 20+ 35+ - 20+ 60+ 52. 53. 54. 11 55. , 56. 57. / 58. 1 3 50 : 2 3 50 59. ageLOC? ageLOC , 60. 2: , 2: , 2 5431 4 4 SalicinSalicin 61. 0,05% - 24 48 : , . : -2 (ADRB2), , (ADRP) , 2 (HAS2), Peroxisome Proliferator- activated receptor delta , - -5 (SCD5) : 3--3 - - 1 (HMGCS1), (HYAL1) , 62. 0,05% - 24 48 : , UV- : 2 (SOD2), FOXO1, 1 (TXNRD1), 2A (MT2A) , 63. 0,05% - 24 48 : , , : 1(TIMP1), 1(FN1), 4 -2 (COL4A2), (LOX) : 9 (MMP) , 64. 0,05% - 24 48 : , : - (KLK14), : 5 (KRT5), 14 (KRT14), AP 2- (TFAP2A) , 65. 8 ageLOC 66. , ageLOC: () IBR-dormin .. 67. AGELOC - Nu skin ageLOC, ageLOC 14 , 68. - NU SKIN 69. - Radiant Day Transforming Night Future Serum 70. AGELOC - Gentle Cleanse & Tone ageLOC ageLOC 71. Nu Skin ageLOC ageLOC & 8 AGELOC Future Serum 72. AQUA, BIFIDA FERMENT LYSATE, GLYCERIN, ALCOHOL DENAT., DIMETHICONE, HYDROXYETHYLPIPERAZINE, ETHANE SULPHONIC ACID, SODIUM HYALORONATE, PHENOXYETHANOL, ADENOSINE, PEG-20 METHYL GLUCOSE SESQUISTEARARTE, PEG-60 HYDROGENATED CASTOR OIL, SALICYLOYL PHYTOSPHINGOSINE, AMMONIUM POLYACRYLOYLDIMETHYL TAURATE, LIMONENE, XANTHAN GUM, CAPRYLYL GLYCOL, DISODIUM EDTA, OCTYLDODECANOL, CITRIC ACID, CITRONELLOL, PARFUM/FRAGRANCE, SODIUM BENZOATE WATER, BYTILENE GLYCOL, CYCLOPENTASILOXANE, PENTYLENE GLYCOL, POLYMETHYLSILSESQUIOXANE, GLYCERIN, HDI/TRIMETHYOLHEXYLLACTONE CROSSPOLIMER, ISOTETETH-20, 1-METHYLHYDANTOIN- 2-IMIDE, DIMETHICONE, ETHYLHEXYLGLYCERIN, POLYSILICONE-11, SALICIN, GLUCOSAMINE HCL, POLYSORBATE 80, CITRUS MEDICA LIMONUM (LEMON) PEEL EXTRACT, SCLEROTIUM GUM, CETYL ALCOHOL, EQUIOL, AMMONIUM ACRYLOYLDIMETHYLTAURATE/BEHENETH-25 METHACRYLATE CROSSPOLYMER, AMMONIUM ACRYLOYLDIMETHILTAURATE/VP COPOLYMER, GLYCERYL STEARATE, PISUM SATIVUM (PEA) EXTRACT, NARCISSUS TAZETTA BULB EXTRACT, BAMBUSA VULGARIS LEAF/STEM EXTRACT, SODIUM HYALURONATE, HEXAPEPTIDE-2, SCHIZANDRA SHINENSIS FRUIT EXTRACT, PEG-75 STEARATE, ISOHEXADECADE, CETETH-20, DECYL GLUCOSIDE, STEARETH-20, AMMONIUM POLYACRYLOYLDIMETHYLTAURATE, CITRIC ACID, DISODIUM EDTA, FRAGRANCE, CHLORPHENESIN, POTASSIUM SORBATE, PHENOXYETHANOL 5499 Lancome Genifique. Youth Activating Concentrate (30ml) 3850 ageLOC Future Serum (30 ml) 73. AGELOC Radiant Day SPF 22 ageLOC : , 85% SPF 22 74. AGELOC Transforming Night ageLOC , 85% , 75. 60 ageLOC 90 ageLOC 76. 90 ageLOC Transformation 77. 100% ! 7 78. . 12 8 , Nu Skin 79. 80% ? 80. ! 81. : Agelo Galvanic Spa II ageloc Future Serum 80% 7 ageLOC Edition Galvanic Spa II Facial Gels ageLOC 3 , ageLOC Future Serum . 82. Galvanic Spa II Facial Gels : ageLOC 83. Galvanic Spa II? 1 2 84. AGELOC EDITION GALVANIC SPA 5 ageLOC!* * Galvanic Spa II 85. Pre-Treat Gel : , (, L- ) - - ( ) +=+H20 86. PRE-TREAT GEL : 1 , () ( , ) 87. TREATMENT GEL ageLOC , , 88. TREATMENT GEL : 2 pH ( ) ( ) 89. Galvanic Spa II ageLOC: : , , , , ( ) 90. Galvanic Spa II 24 Galvanic Spa Galvanic Spa , 91. : ( ) , , 92. : (, ) 93. Galvanic Spa II + + + + + + 94. 95. 96. AGELOC GALVANIC SPA II BODY SHAPING GEL * , * Cacao Theobroma 97. Galvanic Spa II 3 2020 4 ( ) 2 2-3- . : Dermatic Effect Glacial Marine Mud , + 98. 8 : 73% ( 50%) 34% 27 25 50 > 30% 99. , 31 . , 7 . . . 100. Nutriol : Nutriol ( ) Nutriol Hair Fitness Treatment - 101. . , . . 102. Nutriol . - : , , , , , , , , . , . ( ), - . , . Nutriol Hair Fitness Treatment - 103. 8 4 8 6 104. Galvanic Spa II ( . )