© 2014 HDR Architecture, Inc., all rights reserved.© 2014 HDR Architecture, Inc., all rights reserved.© 2014 HDR Architecture, Inc., all rights reserved.© 2014 HDR, Inc., all rights reserved.© 2014 HDR, Inc., all rights reserved.© 2014 HDR, Inc., all rights reserved.

STANDING ON THE SHOULDERS OF GIANTS:

February 1, 2016

EVOLUTION OF THE ARCHITECTURE AND ENGINEERING INDUSTRY’S INFLUENCE ON BIOSAFETY

HDR Architecture

Los Angeles, California Studied Architecture @ Auburn University Principal Laboratory Planner Director, Biological Containment Laboratory

Design Designing Science + Technology Facilities

Since 2001

MARK FITZGERALD

JIM ORZECHOWSKI

HARRY WIBER

SCOTT STIRTON

LES GARTNER

PAUL LANGEVIN

ROSS FERRIES

RANDY KRAY

JON CRANE

INDUSTRY LEADERS

WSP / CCRD(Smith Carter)

HOK Perkins & Will Merrick & Co. Hemisphere Engineering HDR (CUH2A) Flad Affiliated Engineers (AEI)

Geelong, Victoria, Australia

AUSTRALIAN ANIMAL HEALTH LABORATORY (AAHL)

Opened in 1985 Construction Cost $185M Diagnostic Testing for

Agricultural Pathogens Large Animal Containment

Geelong, Victoria, Australia

AUSTRALIAN ANIMAL HEALTH LABORATORY

CONTROLS

BARRIER

Opened in 1997 Construction Cost $96M 29,600m2 Combined Human &

Agricultural Focus

Atlanta, Georgia, United States

CENTERS FOR DISEASE CONTROL & PREVENTION (CDC) – BUILDING 18

EMERGING INFECTIOUS DISEASE LABORATORY

METRICS

Atlanta, GA 39,500m2 790m2 (A)BSL-4 700m2 BSL-3E Complete in 2005 $135M

FUNCTIONS

BSL-2, BSL-3, BSL 3EBSL-4 Laboratories

ABSL-3, ABSL-4 & ABSL-3E

Centralized Glassware Washing for the Campus

FlexibilityBIG IDEA

BIG IDEA

Diagnostic Focus Each BSL 4 lab has

Adjacent Supporting BSL-3E

Animal Holding & Procedure spaces Swing From BSL-3E to BSL 4

EMERGING INFECTIOUS DISEASE LABORATORY

Frederick, Maryland, United States

NATIONAL INSTITUTES OF HEALTH (NIH) – INTEGRATED RESEARCH FACILITY (IRF)

METRICS

Frederick, MD 13,000m2 1,460m2 BSL-4 Complete in 2009 $73M

FUNCTIONS

BSL-3 & BSL-4 Laboratories

ABSL-3 & ABSL-4 Containment Imaging

Suites

BIG IDEA

High Containment Imaging CT/PET CT/Spectroscopy Magnetic Resonance Xray/Fluoroscopy Equipment Straddles

Barrier Animals Inside

Containment - Equipment Outside

INTEGRATED RESEARCH FACILITYNIH

Pirbright, Surrey, United Kingdom

PIRBRIGHT INSTITUTE – PLOWRIGHTBUILDING

• Design for SOP’s• Appropriate Storage• Sufficient Area• Key Elements

• Decontamination• Personnel Flow• Waste Flow

PROTOCOL MAPPINGEntry & Exit Protocols

Work Room

Laboratory

“Outside” R-SC

A-UC

A-SB

A-FW

A-BT

A-OP

A-RP

A-EP

A-HC

D-BS

R-UC

R-SB

R-FW

A-FW

R-GL

R-OP

R-CT

R-RP

R-EP

R-HC

A-SC

Contained Corridor

A-CT

R-BT

*

**

*

*

*

D-DR

A-GL

D-HW

R-FW

* where required by RA

1

2

3

4

5

8

7

6

LegendA- Add

C- Change

D- Decontamination Procedure

R- Remove

T- Test

-SC Street Clothes

-FW Footwear

-GL Gloves

-EP Eye Protection

-UC Under Clothes

-BT Boots

-OP Over Pants

-VG Virus Gown

-HC Hair Covering

-SB Scrubs

-LC Lab Coat

-RP Respiratory Protection

-CT Hooded Coat

-CS Chemical Shower

-AS Air Pressure Resistant Suit

-BS Body Shower

-HW Hand Wash

-DR Disinfectant Rinse

Pirbright, Surrey, United KingdomPIRBRIGHT INSTITUTE – PLOWRIGHT BUILDING

FUTURE CONSIDERATIONS

© 2014 HDR Architecture, Inc., all rights reserved.© 2014 HDR Architecture, Inc., all rights reserved.© 2014 HDR Architecture, Inc., all rights reserved.© 2014 HDR, Inc., all rights reserved.© 2014 HDR, Inc., all rights reserved.© 2014 HDR, Inc., all rights reserved.