Week 3: Part 1 Sex Linked traits/Chromosomes

Warm Up 05/07: Dragon Genetics

1. Fill out Dragon Genetics Worksheet 1: “I’m all keyed up” by answering all the questions.

Dragon Genetics Continued

Complete Worksheet #2: Making Your Dragon”

DO NOT DEVIATE FROM YOUR ASSIGNED PARENT COMBO (1-4). YOU WILL RUIN THE EXPERIMENT FOR THE REST OF THE CLASS.

PLEASE FIND THE COMBO LISTED UNDER LAB AS UNDER Genetics as 3ai.

Video: Sex Linked Disorders

Take notes under your warm ups on the video.

Kahoot On Video

Why does this matter?

Chromosome Types:• Autosomes:

chromosomes that are not sex chromosomes.

• Sex-Linked: chromosomes on the X or Y chromosome.

Figure 1: Human Karyotype depicting all 23 chromosomes.

Location on the Chromosome:• Linked Genes: when 2 genes

are close together on the same chromosome it increases the likelihood they will be inherited together.

• Sex Linked Genes: the phenotypic expression of a gene is dependent upon the gender of the individual.

Inheritance:• Female offspring get an X chromosome from each parent

a. meaning females have 2 copies of every gene on the X chromosome

• Males get an X from their mother and a Y from their father

a. X chromosomes never pass from father to son

b. Y chromosomes always pass from father to son

• Certain genetic disorders will impact male offspring and not female because of this mode of inheritance

Warm Up 05/08

1. Explain what sex linked inheritance means. 2. Why are males more likely to inherit a genetic

disorder? 3. What is the difference between the Y chromosome

and the X chromosome?4. What traits does your baby dragon possess?

Dragon Genetics

Mate your dragon with a friend and determine what traits your baby dragon will possess.

Next, devise what kind of environment your baby dragon will best thrive in by creating a colorful background. Consider the traits your baby dragon has when designing their environment.

Turn in your baby dragon with both names on the front side of the paper to the bin with your period on it. You have 30 minutes go!

Exit Ticket:

1. Explain what traits your baby dragon received from each of its parents.

2. What traits is your baby dragon a carrier for? 3. What traits do you think are advantageous to

your baby dragon surviving? Why? 4. What traits do you think will hurt your baby

dragon’s chances of surviving? Why?

Week 3: Part 2 Pedigrees

Warm Up 05/09 or 05/10

1. Analyze the two maps below. Write down at least 5 observations in your warm ups about malaria and/or sickle cell disease.

Instructions: Next, write down 3 observations you can make from this graph on your warm ups.

Answer:

• Graph depicts children’s survival:

1. HbSS- Children who were homozygous for the Sickle Cell gene fared the worst.

2. HbAA- Children who were without the Sickle Cell gene had an advantage over those who were homozygous for the Sickle Cell gene.

3. HbAS- Those children who were heterozygous for the Sickle Cell gene had an advantage over those without the Sickle Cell gene.

Video: Sickle Cell Anemia

1. Take notes under your warm ups on the following video about the genetic disorder of sickle cell anemia.

Kahoot on Video

Discussion Question:

1. What generalizations can you make about genetics impact on a

population from this case study?

Answers:

1. Mutation developed out of an external pressure (disease).

2. Variation and distribution of traits are preserved through genetic and environmental pressures.

3. Traits that are advantageous tend to increase as traits that are deleterious tend to decrease.

Pedigrees Chalk Talk

Take notes on a seperate sheet of paper titled “ How To Solve A Pedigree” on the following….

Pedigree charts diagram the appearance of a trait through generationsA. squares = males

circles = femalesB. vertical lines connect parents and offspringC. horizontal lines connect male and female parentsD. Shade individuals who show the recessive traitE. Half shade individuals who are carriers (heterozygous)

for the trait

Ex 1: Albinism is a recessive trait. A non-albino man has three children with an

albino woman. Their first child, a daughter, is albino. Their second daughter and youngest child, a son, are not albino.

The albino daughter has two children (both boys) with an albino man. The son has children with a non-albino woman and has a non-albino daughter and an albino son.

Ex 2: Guinea Pigs In Guinea pigs, yellow fur coat (Y) is incompletely dominant over white fur

coat (y). The heterozygote is cream colored.Porky the cream colored Guinea pig met yellow Petunia, and they made

babies named Chubby and Miss Piggy. Chubby grew up and wandered into a new cage where he met Hanna. Hanna and Chubby had babies that were all the same color. Their little piggies were named Peter, Prince, Paula, and Prissy.

Miss Piggy met Oscar and they had three little piggies named Bessie, Bobby, and Beth. Each of these piggies was a different color. Bessie fell in love with Peter and made a lot of babies. These babies were always cream or white. Bobbie and Prissie found pig heaven and had babies of all three colors. Beth and Prince always had yellow or cream colored piggies. As for Paula, that little piggy had none.

Use the information above to complete a pedigree chart that includes the genotypes for each of the thirteen Guinea pigs named above.

Warm Up 05/11

1. How do you solve a pedigree? 2. How do you indicate someone is…

a. male b.female c. carrier

d. has the trait e. parents

Presentations 05/11

Audience take notes on the following:

a. Name of the disease they are presenting on. b. Identify and describe the type of mutation that occurred in

the specific affected gene.c. Describe why this mutation causes the disease of interest.d. Describe how the cure works and what will the cure do to

specifically decrease the symptoms of the disorder.

NOTE: THESE NOTES WILL BE COLLECTED WITH YOUR PACKET!

Pedigree Practice Quiz

1. Do your best to solve the pedigree problems presented in the handout, “ Pedigree Practice”.

2. When done flip your handout over. You have 12 minutes. Good Luck!