Neuroimage Analysis CenterAn NCRR National Resource Center

http://nac.spl.harvard.edu

Viewing essentials

‡GE Research §Isomics¥Surgical Planning Laboratory, Brigham and Women’s Hospital

James Miller, Ph.D.‡. James Ross, M.Sc.‡, Xi Wang, Ph.D.‡, Steve Pieper, Ph.D.§, Wendy Plesniak, Ph.D.¥

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

Requisites, expectations and adaptations

Clinicians and researchers need and expect imaging platforms to provide stock capabilities

Window/level Pan/zoom Annotation Probe Measurement Oblique reformat Volume rendering Lightbox

How do we adapt these concepts to a Slicer experience?

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

Lightbox

http://www.brighamandwomens.org/excellence/neuroscience.aspx

?

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

Standard lightbox viewing

http://www.brighamandwomens.org/excellence/neuroscience.aspx

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with overlays

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with annotations

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with fiducials

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with multiple reformations

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with an editor

X

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

Oblique reformat

• Anatomy is rarely predominantly aligned axially, sagitally, or coronally

• Oblique reformation allows image display planes to be aligned to an anatomy’s principal axes

Axial

Oblique

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

Standard oblique reformat

CTRL-Right Button to manipulate reformation

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with lightbox

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

Comparing series and studies

• Longitudinal analysis• Cross-sectional analysis

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

Standard comparison of studies

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with overlays

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with annotations

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with fiducials

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… after registration

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with lightbox

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

… with oblique reformation

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

Applications

Atlas construction Manual delineation Quality control Cross-sectional comparison of atlas subjects before and after

aligning to common coordinate frame Cross-sectional comparison of atlas subjects to constructed

atlas Atlas application

Comparison of atlas to new subject Cross-sectional comparison of new subjects aligned with

atlas Longitudinal analysis

Response to therapy

Neuroimage Analysis Center http://nac.spl.harvard.eduAn NCRR National Resource Center

Image viewing is still predominantly 2D

Native format of acquisition Precision dimensional measurements Multiplanar reformat (axial, sagittal, coronal) provides a natural

(perhaps comfortable) navigation paradigm Lightbox provides a mechanism to display 3D relationships Oblique reformats provide a mechanism to mitigate 3D effects

(improve accuracy of dimensional measurements) Longitudinal and cross-sectional comparisons build on the same

framework of linked controls and coordinate frames Slicer3 allows all these capabilities to be layered due

incorporation of coordinate frames at a fundamental level of the viewing pipeline