Update from the Division of

Epidemiology, Services and

Prevention Research

Wilson M. Compton, M.D., M.P.E.Director, Division of Epidemiology, Services and Prevention Research

National Institute on Drug AbuseDepartment of Health and Human Services

DESPR provides a foundation for NIDA’s Public Health Mission.

DESPR will improve the nation’s public health by promoting integrated approaches

to understand and address interactions between individuals and environments

that contribute to the continuum of problems

related to drug use.

Our goal is to develop scientific knowledge with clear application to practice and public policy.

DESPR Organization

OFFICE OF THE DIRECTOR

EPIDEMIOLOGY RESEARCH

BRANCH

ANALYTIC UNIT

WORKGROUPSAIDS/HIV

Health DisparitiesTranslational Research

Research TrainingPREVENTION RESEARCH

BRANCH

SERVICES RESEARCH

BRANCH

DESPR: Five Year Goals

1. Measurably impact public health prevention and treatment outcomes

2. Demonstrate the role of interactions between intrapersonal and environmental factors with each other and with genetic factors

3. Develop transdisciplinary research teams to better elucidate this chronic condition, its prevention and treatment

Priority Areas for NIDA

• Prevention Research (Children/Adolescents)

– Genetics– Development– Environment– Co-morbidity

• Treatment Interventions – New Targets & New Strategies

• HIV/AIDS Research

Preventing and Treating Drug Abuse and Addiction Require Multi-Pronged Approaches

DRUGS OF ABUSEgenome

protein expression

neuronal circuits

social

Behavior

Distribution of Selected Drug Abuse Related Variables by Race/Ethnicity

70 74 65

35 26

11 1116

4350

12 11 15 18 236 5 4 3 1

0%

20%

40%

60%

80%

100%

Popula

tion

Lifetim

e Use

Abuse

/Dep

ende

nt

Prisone

rs

IDUs

w/ HIV

-AID

S

White Black Hispanic Other

FY 2004 RFAs/Contracts

1. Prevention and Treatment of Drug Abuse in Primary Care Settings

FY04 $3.0m RFA with SAMHSA and AHRQ

2. Environment-Gene Interaction StudiesFY04 $2.0m RFA

3. Young Adult PreventionFY04 $1.5m RFA, meeting January 2004

4. HIV/AIDS Among Drug Users in Criminal JusticeFY04 $1.5m RFA

5. Studying CSAP’s Strategic Prevention PlanFY04 $2.5m IAA, meeting March 2004

Environmental Challenges/Opportunities

• New NIDA Organization

• Budget flattening

• NIH Roadmap

• Improved Collaborations with SAMHSA, DOJ and Education

• At Other ICs:– NIMH reduced support of longitudinal studies

– NIAAA re-organization of Services Research

Themes for DESPR in FY 2005

3. New Issues in the Emerging HIV/AIDS - Drug Abuse Nexus

2. Rethink the Social Environment

1. Maximize Return on Investment

4. Translational Research

What are we doing to develop and promote these

themes?

Workgroups, Meetings, Publications, etc.

Rethinking the Social Environment: IntegratingSocial and Genetic Epidemiology With Neuroscience

Future Initiative

Summer-Fall 2004:Identification of datasets/studies ripe for nestingDecember 2004:Special Supplement AJPMSpring 2005:Midsize meeting

Social Epi

Summer-Fall 2004: Portfolio & literature review Fall 2004:Small meetingSpring 2005: Phenotype Special Issue JSA

Genetic Epi

Social Epi Genetic Epi

Neuroscience

Transdisciplinary MeetingFall 2005

BenchBench

BedsideBedside

CommunityCommunity

Interagency Collaborations

are indispensable

BenchBench

BedsideBedside

CommunityCommunity

DHHSDHHS

NIDANIDA

SAMHSASAMHSA

NIHNIH

Collaborations to Translate Research Findings Into Relevant Clinical PracticeCollaborations to Translate Research

Findings Into Relevant Clinical Practice

NIDANIDA

Capacity-Building

Capacity-Building

Col

lab

orat

ion

Col

lab

orat

ion

Commitment

Commitment

Mon

itori

ng &

Feed

back

Research &

Developm

ent

Dissemination & Implementation

Science to Services CycleScience to Services CycleScience to Services CycleScience to Services Cycle

Working in “Real-World Settings”

is key.

BenchBench

BedsideBedside

CommunityCommunity

Research Centers Research Centers Coordinating Center Coordinating Center

Testing the Commuties That Care (CTC) Prevention System

Developing the Health Services Research

Program

BenchBench

BedsideBedside

CommunityCommunity

A multidisciplinary field that examines how:

Rec #1: Defining Health Services Research

access to and utilization of healthcare,

quality and cost of healthcare, and

our health and well-being.

Ultimately, the goals of health services research are to identify the most effective ways to organize, manage,

finance, and deliver high quality care.

social factors,

financing systems,

organizational structures and processes,

health technologies, and

personal beliefs and behaviors

affect

Division of Epidemiology, Services and Prevention Research

Providing a foundation for NIDA’s public health mission.