The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”

Jack Ealy WorkshopLa Jolla, CA July 2006

Professor Michael J. SailorUC San Diego

Dept. of Chemistry and Biochemistrymsailor@ucsd.edu

http://chem-faculty.ucsd.edu/sailor/

Death on the Danube

The Economist, 2/15/00The Economist, 2/15/00

Environmental sampling

Field

Lab

Smart DustKris Pister, UCB (1996)

Available:•wireless radios•data processing•networkingprotocols

Smart DustKris Pister, UCB (1996)

Need:•sensors•power sources

Silicon vapor sensors

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Making a silicon nanostructure

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Electrochemical machiningof nanopores

Silicon nanostructures mimic the beetle shell

a

chitinmultilayern = 1.73n = 1.40

Calloodes grayanus

2 mm

Chitin multilayer

Silicon nanostructures mimic the beetle shell

Silicon multilayer

Silicon Microsensors

William R. Freeman, M.D. and Lingyun Cheng, M.D.

Jacobs Retina CenterUCSD

Mother-Ships for Nanotherapies

color changes when particle releases drug

Porous silicon micro-particle in

the eye

Ruoslahti, Cancer Cell, 2002

UCSD Moores Cancer CenterNIH nanoTUMOR center

Erkki Ruoslahti, Burnham Inst.Sangeeta Bhatia, MITMichael Sailor, UCSD

Diagnostic

Therapeutic

Activation

Targeting Self-Destruct

Sensor

Targeted Nanomachines

Backup slides

As with any new technology, reasonable concerns about potential hazards are appropriate.

Hazards of nanotechnology

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University of Wisconsin, Madison Asbestos Management Program Heating/Chilling Plant: Furnace/Boiler Abatement (December 1997-

January 1998)

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Asbestos fibers (Nikon, inc)

Hazards of nanotechnology

Shvedova, A. A. et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 66, 1909-1926 (2003).

Derfus, A., Chan, W. & Bhatia, S. N. Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Lett. (2004).

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5 nm CdSe (A. Paul Alivisatos, UC

Berkeley)

Making a silicon nanostructure

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Encoded particles self-assemble

a

oxidizedalkylated

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Magnetic manipulation of microparticles

Nature Mater. 2004, 3, 896-899.

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30 nm magnetitenanoparticles[O]