SIRRIS - QED · SIRRIS Bioprinting: markets and opportunities Grégory Nolens QED –AM in Medical...

SIRRIS

Bioprinting: markets and opportunities

Grégory Nolens

QED –AM in Medical – November 4th 2014

04/11/2014 © sirris 2014 Charleroi | www.sirris.be | info@sirris.be | 2

130 experts & high-tech infrastructure

Collective centre of the technology industry • Non profit organization • Industry owned

4,700 industrial interventions (advice, projects, services) •within 1,700 different companies •whose 75% are SME’s •24M EUR turnover

Mission

“Increase the competitiveness of companies of the Agoria sectors through technological innovations”

Additive Manufacturing technologies @ Sirris

SIRRIS – One of the largest machine park in EU

• 16 engineers and technicians

• Two locations: Liège (11 p.) and Charleroi (5 p.)

Rapid Prototyping / Tooling / Manufacturing

• Stereolithography (normal & hi-res)

• Paste polymerization for ceramics and metals (Optoform)

• 3D Printing of plaster and metal powder

• Laser sintering of polymeric powder (PA,…): P360 – P390

• Objet Connex 500: bi-material

• Laser sintering of metal powder (parts and mould inserts)

• Electron Beam Melting (Arcam A2)

• 3D Printing of wax (Thermojet)

• Vacuum Casting of Alu, Bronze, Zamak

• Laser Cladding (EasyClad)

• Selective Laser melting (MTT)

• Mcor - paper

• Bi-material FDM system

04/11/2014 4

CASE STUDIES @ SIRRIS

Leading applications of AM in biomedical:

• Personalized/complex devices

• Surgery tools

• In vitro Testing tools

• Communication tools

•Physician to Physician/Patient

•Student/education

Personalized implants

Poukens – Xilloc - Sirris

6 © sirris 2014 Charleroi | www.sirris.be | info@sirris.be | 04/11/2014

Newly designed implants – lattice porous structures

Finger prosthesis [UMons, Faculté Polytechnique] Cranial porous implant [SIRRIS-ADD]

04/11/2014 7

Complex implants – mass production

Spinal case studies in ceramic

• Porous scaffolds for Spine surgery

• In vivo testing for bone integration

• France - Belgium collaboration Tech transfer

[Sirris ADD]

04/11/2014 8

Surgery tools – custom cutting

[VISYOS] [VISYOS]

20-70% surgery time reduction

04/11/2014 9

Surgery tools – custom cutting

Surgical Cutting Templates – reimbursement problem

Surgical guides not reimbursed, but facts are:

- 1 min. in surgical theatre (estimated): 60€

- Mean of orthopedic surgery duration: 5-12h (18k-44k€)

- Surgical guide can reduce: 20-70% of the duration (TBC)

- Surgical guide cost: 50-300€

- Economy: estimated 3-30k€/surgery

Testing tools

Flexible device for in vitro studies (e.g. arteries)

04/11/2014

Communication/education tools

[Sirris ADD] [Sirris ADD] [Sirris ADD]

12 © sirris 2014 Charleroi | www.sirris.be | info@sirris.be | CENG 04/11/2014

The future of bio-manufacturing…not so far away!

13 © sirris 2014 Charleroi | www.sirris.be | info@sirris.be | CENG 04/11/2014

The future of bio-manufacturing…not so far away!

Anthony Atala – TED – March 2011

process of printing biologically relevant materials (such as cells,

tissues, and biodegradable biomaterials) that will accomplish

one or more biological functions

What’s Bioprinting

04/11/2014

Bio-glue

3D machine

Tissues Scaffolds

+ cells

04/11/2014 15

Bioprinting – an emerging technology

Bioprinting place in emerging technologies, from the Hype Cycle for Emerging

Technologies 2014- Gartner

Printing cells and biomaterials

EnvisionTech, RegenHU (CH), GESIM (DE), Regenovo

(China)…

3D Bioprinting solutions – customized machines

Printing Cells? Reality

Lot of barriers to raise

Technical, ethical, validation time, standards,…

Bioprinting strategy @ SIRRIS

Step by step approach:

Target most promising and nearest markets

Combine existing knowledge to succeed faster

Market approach interest for companies?

04/11/2014

• Applications:

1. Drug/Cosmetic discovery & Assays

2. Cell therapy + Tissue Engineering

3. Bioproduction

4. In vitro diagnostic & research

5. Food

Drug/Cosmetic Discovery and Assays

04/11/2014

• Facts: Drug Discovery and Assays

• 90-95% of drugs approved on animal (mouse, rabbit, etc.), was not

for human lot of money lost, ethic problem

• Animal use: 10-100 Mio in US/year

• European Comission banning: FULL on cosmetic (2013), next

pharma ?

Drug Discovery and Assays

04/11/2014

• Applications:

• Drug screening w/o animal

& less deviations

Drug X

Disease tissue

Treated tissue

Organovo’s targeted market

Pharmaceutical and

Cosmetic area

(Big companies and

subcontractors)

Drug Discovery and Assays

04/11/2014

• Applications:

• Biocompatibility assays w/o animals (ISO)

• Improvement of existing models

Artificial skin Irritation testing

Cell Therapy & Tissue engineering

04/11/2014

• Facts: Cell Therapy

Cell therapy industry market

(autologous)

[Markets and Markets]

04/11/2014

• Facts: Cell Therapy

High potential for

Small defect repair

But spatial limitations

04/11/2014

• Raise cell therapy barrier of Large defect repairing

(= scaffold)

04/11/2014

Repairing large defects by combining

Stem Cells + Biomaterial Scaffold

= 1st step to bioprinting

Biotechnolgies & Bioprocess

04/11/2014

• Facts:

• More and more treatments using biomolecules instead of small

drugs: BioPharma / Biological Therapy (protein, peptide, antibody,

etc.) Produced with cells

• Very expensive products: cost reduction through production

[PharmPro]

Biotechnolgies & Bioprocess (Bioproduction)

04/11/2014

Application

• Biomolecule production: 2D 3D

• Pure and higher production

• Cost reduction, bigger productions

• Enlarge areas

[university of Virginia]

In vitro diagnostic and Research

04/11/2014

• Biomarker

• Biosensors

• Drug kinetic

• Pathogen reaction

biosensor

Blood brain barrier

Food & Agriculture

04/11/2014

• New food process?

Focus on food player with Life Science approach:

biomaterial ( e.g. Tissue engineering)

Standards

Medical Device (MD)

MD Directive Regulation proposal

General MD standards (ISO 13485, 10993, …)

Specific standards for applications/material (e.g. ISO

13175 bone filling with Ca-P)

Faster and easier to label than Drugs

Magic Scaffold ------

Synthetic non-active

implant scaffold

Standards

Advanced therapy medicinal products – ATMP

Regulation 1394/2007

Drug like procedure

long clinical procedure (6-10 years, +post market)

heavy process constrains

Magic Cells

------

Standards

Magic Tissue

------

? ATMP Incubating cells

+ scaffold

Standards

Magic Cells

------

Magic Scaffold ------

Combined

during

surgery

Conclusion

Print biomaterial add cells

Print « exotic » biomaterial

validate it add cells

Print biomaterial and cells

Suggested steps to Bioprinting

innovation

Time to market

Bioprinting R&D players in Europe – few

…and others…

Sirris Additive Manufacturing: Contact

Grégory NOLENS, PhD

Department of Additive Manufacturing

Mail: gregory.nolens@sirris.be

Mobile: +32 498 91 94 75

Skype: gnolens

SIRRIS

Rue Auguste Piccard, 20

B-6041 GOSSELIES BELGIUM

http://www.sirris.be

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SIRRIS - QED · SIRRIS Bioprinting: markets and opportunities Grégory Nolens QED –AM in Medical...

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