By: Dasia Davis

Gabriella Mirenda

Lorena Sposato

Inherited blood disorder that affects red blood cells Red blood cells contain Hemoglobin S which is abnormal - Become sickle shape and makes it difficult fitting through

small blood vessels and less blood reaches body. Symptoms of sickle cell include

1. Abdominal Pain2. Delayed growth and puberty3. Bone Pain4. Breathlessness5. Fever6. Jaundice

7. Paleness8. Ulcer in the lower legs

Interesting facts: with each pregnancy, 2 people have sickle cell traits have: A 25% chance of having an unaffected child with normal

hemoglobin A 50% chance of having a child who also is a carrier. A 25% chance of having a child with sickle cell anemia

The HBB gene is found in the region 15.5 on the short (p) arm of human Chromosome 11.

Autosomal Recessive genetic disorder Two copies of the altered gene must be

present on the autosomes in order for the person to be affected by the trait.

2 alleles, one from each parent Alleles are represented by: -RR Rr rr Dominant- expressed in a person with

only one copy of that gene present. Recessive- expressed in a person with

two copies of the gene is present.

dd dd

dd dd

Ss ss

ss ss

s

s

Ss

d ddd

SS Ss

Ss ssS

S

s

sRatios:Homozygous dominant: Heterozygous dominant: Homozygous recessive

1 : 2 : 1 1SS : 2Ss : 1ss

Percentages:Homozygous dominant: Heterozygous dominant: Homozygous recessive

25% : 50% : 25% 25% SS : 50%Ss : 25% ss

SS represents the dominant allele SICKLE and s represents the recessive allele

Phenotype: SS= No disease Ss= Sickle cell anemia ss= Sickle cell anemia Genotype: SS=Homozygous dominant Ss=Heterozygous dominant Ss=Homozygous recessive

SS Ss

Ss ssS

S s

s

Phenotype -Ratios- 3SS: 1ss -Percentages: 75% SS: 25% ss Genotype -Ratio- 1SS: 2Ss: 1ss -Percentages- 25% SS: 50%Ss: 25%ss

SS SsSs ss

SSs

s

Father’s GenesM

O

T

H

E

R’

S

G

E

N

E

S

SS

s

sGenotype: Ratio: Percentage:

Phenotype: Ratio: Percentage:

SS

SsS

sss

3SS: 1ss75%SS: 25% ss

1SS: 2Ss: 1ss 25%SS: 50%Ss: 25%ss

SarahRicky Martin

CarlLizzie Alex Miranda

Bob Marley

Vanessa

Cashmere

Red= Person is Healthy, with a possible chance of carrying a “bad” gene.Yellow= Person is affected

Fergie

Zac

KEY Circle: Female

Square: Male

All Red: Person is healthy.

All Yellow: Person is affected.

Red/Yellow: Carrier.

Questions: Answers:

Kim Bob

Brian Lily

Gaby Kait Ana Ben Susan

Charlie Jen

2.) What does it mean, when a person is a “carrier” of the gene?

• It means the person carries one “bad” gene and one “healthy” gene, but is essentially healthy and has no symptoms of the disease.

1.) How many sickle cell genes are need to inherit the disease?

• It occurs when a person inherits two sickle cell genes.