Rese

arch

Nee

ds fo

r Hig

h-th

roug

hput

As

sess

men

t of E

nviro

nmen

tal C

onta

min

ants

, an

d Su

stai

nabl

e M

olec

ular

Des

ign

and

Alte

rnat

ives

Anal

ysis

of C

hem

ical P

rodu

cts

Brya

n W

. Bro

oks

Bayl

or U

nive

rsity

Uni

ted

Nat

ions

Glo

bal G

oals

ww

w.gl

obal

goal

s.or

g

ww

w.gl

obal

goal

s.or

g

12.4

“By

2020

, ach

ieve

the

envi

ronm

enta

lly

soun

d m

anag

emen

t of c

hem

ical

s an

d al

l was

tes

thro

ugho

ut th

eir l

ife c

ycle

, in

acc

orda

nce

with

agr

eed

inte

rnat

iona

l fra

mew

orks

, and

sig

nific

antly

redu

ce

thei

r rel

ease

to a

ir, w

ater

and

soi

l in

orde

r to

min

imiz

e th

eir a

dver

se

impa

cts

on h

uman

hea

lth a

nd th

e en

viro

nmen

t”

12.5

“By

2030

, sub

stan

tially

redu

ce w

aste

ge

nera

tion

thro

ugh

prev

entio

n,

redu

ctio

n, re

cycl

ing

and

reus

e”

Why

now

?-O

ther

dis

cipl

ines

(e.g

., co

nser

vatio

n bi

olog

y,

agric

ultu

re) h

ave

bene

fited

from

hor

izon

sca

nnin

g ex

erci

ses

-Env

ironm

enta

l sci

ence

has

resp

onde

d to

man

y is

sues

, ye

t has

not

und

erta

ken

such

a p

rosp

ectiv

e ac

tivity

-Ans

wer

s to

env

ironm

enta

l que

stio

ns a

re n

eede

d…

But

whi

ch o

nes?

WHY

GLO

BAL

HORI

ZON

SCAN

NING

?

Inte

rest

from

fund

ers

and

gove

rnm

ents

in re

sults

from

big

que

stio

nex

erci

ses,

but

als

o in

the

proc

ess…

•

Ofte

n go

vern

men

t em

ploy

ees

prov

ide

inpu

t in

ques

tion

deve

lopm

ent p

roce

ss –

polic

y vo

ice

to h

elp

dire

ct a

nd s

hape

rese

arch

age

nda

Thes

e ex

erci

ses

can

have

mul

tiple

impa

cts

•U

K M

arin

e Sc

ienc

e St

rate

gy &

Agr

icul

tura

l po

licy

–ve

rbat

im u

se o

f Sut

herla

nd•

Thes

e ar

e in

here

ntly

bot

tom

-up

exer

cise

sR

udd

et a

l. 20

14. I

EA

M

KEY LESSON

S

Inte

rest

from

fund

ers

and

gove

rnm

ents

in re

sults

from

big

que

stio

nex

erci

ses,

but

als

o in

the

proc

ess…

•

Ofte

n go

vern

men

t em

ploy

ees

prov

ide

inpu

t in

ques

tion

deve

lopm

ent p

roce

ss –

polic

y vo

ice

to h

elp

dire

ct a

nd s

hape

rese

arch

age

nda

Thes

e ex

erci

ses

can

have

mul

tiple

impa

cts

•U

K M

arin

e Sc

ienc

e St

rate

gy &

Agr

icul

tura

l po

licy

–ve

rbat

im u

se o

f Sut

herla

nd•

Thes

e ar

e in

here

ntly

bot

tom

-up

exer

cise

s –

pote

ntia

lly m

ore

legi

timac

yR

udd

et a

l. 20

14. I

EA

M

KEY LESSON

S

-Nu

mer

ous

glob

al c

halle

nges

and

opp

ortu

nitie

s ex

ist to

ac

hiev

e su

stai

nabl

e en

viro

nmen

tal

qual

ity a

nd e

cosy

stem

inte

grity

-En

viro

nmen

tal s

cienc

e ha

s re

spon

ded

to m

any

issue

s, b

ut

has

not u

nder

take

n a

pros

pect

ive

activ

ity to

iden

tify

stra

tegi

c gl

obal

rese

arch

nee

ds

Broo

ks e

t al 2

013

WHY

GLO

BAL

HORI

ZON

SCAN

NING

?

-Th

e Gl

obal

Hor

izon

Scan

ning

Pro

ject

ai

ms

to id

entif

y im

porta

nt

envi

ronm

enta

l qua

lity

rese

arch

ne

eds

-Re

sear

ch q

uest

ions

iden

tifie

d in

th

is pr

ojec

t, if

answ

ered

, wou

ld

mar

kedl

y ad

vanc

e m

ore

sust

aina

ble

envi

ronm

enta

l qua

lity

over

the

next

dec

ade

Broo

ks e

t al 2

013

WHY

GLO

BAL

HORI

ZON

SCAN

NING

?

Afric

aLa

ngeb

aan,

Sou

th A

frica

Asia

Sing

apor

e, S

inga

pore

Aust

ralas

iaNe

lson,

New

Zea

land

Euro

peBa

rcel

ona,

Spa

inLa

tin A

mer

icaBu

enos

Aire

s, A

rgen

tina

North

Am

erica

Salt

Lake

City

, USA

Each

wor

ksho

p tri

chai

red

by e

xper

ts fr

om a

cade

mia

, go

vern

men

t and

bus

ines

s

THE

GLOB

AL W

ORKS

HOPS

Coup

led

Hum

an a

nd E

colo

gica

l Fra

mew

orks

Inte

grat

ive N

eeds

for P

ublic

Hea

lth a

nd th

e En

viron

men

t

Whi

ch c

hem

icals,

nat

ural

or s

ynth

etic,

par

ent

com

poun

ds o

r met

abol

ites,

are

the

mai

n dr

iver

s of

m

ixtur

e to

xicity

in h

uman

s an

d th

e en

viro

nmen

t?

Inhe

rent

Con

nect

ions

am

ong

Hum

an H

ealth

, Eco

syst

ems

and

Envi

ronm

enta

l Qua

lity

Urba

niza

tion

and

Conc

entra

tion

of C

hem

ical U

seUn

ders

tand

and

Man

age

Cum

ulat

ive S

tress

ors,

Mixt

ures

Whe

n an

d un

der w

hat c

ircum

stan

ces

do

inte

ract

ions

(e.g

., ec

olog

ical,

chem

ical,

phys

iolo

gica

l) oc

cur t

hat

are

not c

aptu

red

by c

urre

ntly

ac

cept

ed m

ixtur

e to

xicity

mod

els?

Glob

al M

egat

rend

s an

d En

viro

nmen

tal Q

ualit

y

S.R

. Bur

ket

ww

w.gl

obal

goal

s.or

g

11.6

“B

y 20

30, r

educ

e th

e ad

vers

e pe

r cap

ita

envi

ronm

enta

l im

pact

of c

ities

, inc

ludi

ng

by p

ayin

g sp

ecia

l atte

ntio

n to

air

qual

ity

and

mun

icip

al a

nd o

ther

was

te

man

agem

ent”

Adva

ncin

g hi

stor

ically

des

crip

tive

effo

rtsCo

mpa

rativ

e To

xicol

ogy,

Mol

ecul

ar In

itiat

ion

Even

ts,

Ecol

ogica

l Gen

omics

, Beh

avio

r, Hi

gh T

hrou

ghpu

t Tes

ting

How

do

we

crea

te h

igh-

thro

ughp

ut s

trate

gies

for

pred

ictin

g hu

man

and

eco

logi

cally

rele

vant

effe

cts

and

proc

esse

s (e

.g.,

beha

vior

, mul

tigen

erat

iona

l, de

laye

d an

d in

dire

ct e

ffect

s)?

Ecot

oxico

logy

and

Env

ironm

enta

l To

xicol

ogy

-Mat

ured

to

Mec

hani

stic

Scie

nces

Curre

nt E

nviro

nmen

tal A

sses

smen

t Con

cern

sNe

w m

odels

, ana

lytica

l too

ls ne

eded

to u

nder

stan

ding

fate

an

d ex

posu

re o

f hist

orica

l and

em

ergi

ng c

onta

min

ants

How

can

dat

a on

the

occu

rrenc

e of

con

tam

inan

ts o

f em

ergi

ng c

once

rn in

the

envi

ronm

ent a

nd q

ualit

y of

ec

osys

tem

s ex

pose

d to

thes

e co

ntam

inan

ts b

e us

ed

to d

eter

min

e w

heth

er c

urre

nt re

gula

tory

risk

as

sess

men

t sch

emes

are

effe

ctiv

e?

Envi

ronm

enta

l Ass

essm

ent a

nd

Effe

ctiv

e M

anag

emen

t

Adva

ncin

g su

stai

nabi

lity

thro

ugh

desig

nSu

bstit

utio

ns, a

ltern

ative

s and

the

ratio

nal d

esig

n of

less

ha

zard

ous c

hem

icals

How

can

we

bette

r man

age,

us

e an

d sh

are

data

gen

erat

ed

from

exis

ting

test

ing

stra

tegi

es

in o

rder

to d

evel

op m

ore

sust

aina

ble

and

safe

r pro

duct

s?

Gree

n Ch

emist

ry &

Eng

inee

ring

and

Envi

ronm

enta

l Qua

lity

Coi

shet

al 2

016.

AC

S S

usC

hem

Eng

Cor

rale

s et

al 2

017.

Che

mR

es T

oxic

ol

Adva

ncin

g su

stai

nabi

lity

thro

ugh

desig

nSu

bstit

utio

ns, a

ltern

ative

s and

the

ratio

nal d

esig

n of

less

ha

zard

ous c

hem

icals

How

can

we

impl

emen

t co

mpa

rativ

e ris

k as

sess

men

t, lif

e cy

cle a

naly

sis, a

nd ri

sk

bene

fit a

naly

sis in

ord

er to

id

entif

y an

d de

sign

mor

e su

stai

nabl

e al

tern

ativ

es?

Gree

n Ch

emist

ry &

Eng

inee

ring

and

Envi

ronm

enta

l Qua

lity

THA

NK

YO

U!