PENTAGRIT RESEARCH Quick End Points in Zebrafish Drug Discovery

Model: Developmental

ToxicityInduction: ChemicalEnd Point: HT Motor

Scan

Model: Brain TumorInduction: Surgery

End Point: Fluorescent Viability

Model: Muscular Dystrophy

Induction: Chemical End Point: Muscle

Pathology

Model: HepatocarcinomaInduction: SurgeryEnd Point: Tumor

Development

Model: HepatocarcinomaInduction: Surgery

End Point: Liver Pathology

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Model: Hepatomegaly with Liver Cirrhosis

Induction: Chemical + Elicitors

End Point: Liver Pathology

Model: Cardiovascular Hypertrophy

Induction: Chemical + Elicitors

End Point: Cardiovascular Pathology

Model: Dementia with Plaques

Induction: Surgery End Point: Brain Pathology

Model: Regeneration Model

Induction: Surgery End Point: Blastema cell

differentiation

Model: Parkinson’sInduction: Surgery

End Point: Altered Motor and Cognition

Model: Alzheimer’sInduction: Surgery +

ChemicalEnd Point: Anxiety &

Dementia

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