Pre-miR-191

α2α1 α3

β4β3β2β15’ 3’

-5kb +1kb0

Promoter analysis of miR-191

A

B

Name Estrogen Receptor Consensus Position Dissimilarity

α1 ER-α; CAGGTCAC GTGACCTT 874-881 0.21%

β1 ER-β; GCAAGGTCA TGACCTTGC 875-883 0.00%

α2 ER-α; GACCAGGTCA GACCAGGTCA 1707-1716 0.76%

β2 ER-β; GCAAGGTCA ACCAGGTCA 1708-1716 0.50%

α3 ER-αCAGGTCAC GTGACCTG 4964-4971 0.00%

β3 ER-β; GCAAGGTCA TGACCTGGG 4965-4973 0.50%

β4 ER-β; GCAAGGTCA TCCAGGTCA 5452-5460 0.42%