Post on 17-Jan-2017
Clara FowlerResearch Services & Assessment MangerResearch Medical Library
Planning the Literature Search
Laurissa GannEducation & Outreach Services MangerResearch Medical Library
EXPE
RIEN
CE? What is your experience with
literature searching?
1. I search EMBASE or CINAHL or CENTRAL frequently
2. I search MEDLINE using the Ovid interface frequently
3. I search PubMed frequently4. I’ve searched one or more of these databases
infrequently5. I’ve heard of these databases, but never searched
them
1) Create a Searchable Question
2) Preliminary Searching Strategies
3) Search, Organize & Report ResultsA
GEN
DA
Systematic Reviews
High-quality systematic reviews seek to:
Identify all relevant published evidence through systematic searching of multiple literature databases
http://www.medicine.ox.ac.uk/bandolier/painres/download/whatis/syst-review.pdf
Create a
Searchable
Question
Use PICO format.
Create list of KEY CONCEPTS.
Identify SYNONYMS & ACRONYMS.
Approximately 5%-30% of the population age 50 and older suffers from dry eye disease impacting visual acuity, social and physical functioning, and workplace productivity. Patients incur medical costs through frequent visits to health care professionals, as well as from prescription and over-the-counter therapies.
The first line of treatment includes artificial tears and environmental coping strategies (frequent blinking and using humidifiers).
There are multiple secondary treatments including topical glucocorticoids, omega-3 fatty acids, acupuncture, and surgery. A new drug, Xiidra, was approved by the FDA in 2016 to treat dry eye disease.
Clinical Scenario
In patients with dry eye disease, does Xiidra improve patient-relevant outcomes over nonprescription artificial tears?
P (Patient): Dry Eye DiseaseI (Intervention): XiidraC (Comparison): artificial tearsO (Outcome(s)): improvement in ocular discomfort, eye dryness, and visual impairment
Create the PICO question
What are the most important elements of this search?
How can you make sure that your search is comprehensive?
.
P (Patient): Dry Eye DiseasesInclude conditions that would create dry eye disease as well as synonyms for dry eye
Dry eye disease: dry eye syndrome, dysfunctional tear syndrome, keratoconjunctivitis sicca, Sjögren's syndrome, aqueous tear-deficient dry eye, lacrimal dysfunction, lacrimal ductal obstruction, reduced reflex sensory tear secretion, decreased tear production, tear film evaporation, ocular surface irritation, chronic eye irritation, excessive tearing, blepharitis, blink rate
Identify SYNONYMS
I (Intervention): XiidraCreate a search for the drug using all name variants
Brand: XiidraScientific: LifitegrastExperimental: SAR 1118, SAR1118, SAR-1118Class: lymphocyte function-associated antigen 1 (LFA-1) antagonist
Identify SYNONYMS
Artificial tears
How many synonyms can you think of to use for this
concept?
Search
Experience
C (Comparison): artificial tears
Lubricant eye drops, artificial tear drops, lubricating eye-drops,
Nonprescription drugs, non-prescription, over the counter, OTC, over-the-counter
Identify SYNONYMS
Scoping Search
Is this a new question?
Is there enough data available to complete a systematic review?
How much time will it take to complete?
1. Search PubMed Clinical Queries & Cochrane Library to see if there are exisiting systematic reviews
2. Search PROSPERO for registered systematic reviews
Select DatabasesTo Search
Cochrane LibraryCampbell LibraryMEDLINEEMBASEWeb of ScienceCINAHLPsycINFOCENTRALOthers?
Create a comprehensive list of keywords with alternate
spellings
Use truncationdecreas* tear* irritat*
Use adjacencylacrimal adj3 (dysfunction* OR obstruct*)
Keywords
Most databases have a thesaurus or list of subject headings
MeSH – MEDLINEEMTREE – EMBASE
CINAHL Headlines
Look up all the relevant subject headings for each concept in your
search
Selectively explode terms
Subject
Headings
Draft
Strategy
Create MEDLINE Strategy and review line-by-line with co-authors
Use PRESS checklist to review all key search methods
PRESSCHECKLIST
REVIEW SEARCH
STRATEGIESSearch
Experience
Translate
Search
Strategy
into Other
Databases
Cochrane LibraryMEDLINEEMBASEWeb of ScienceCINAHLPsycINFOPubMedOthers?
EMBASE
Try translating the MEDLINE strategy into the EMBASE database
Search
Experience
IDENTIFICATION
Records identified through database searching
PRIS
MA
Unpublished
Literature
Hand SearchingGrey Literature DatabasesContacting ExpertsProceedingsClinicaltrials.govCited Reference Searchingpubstatusaheadofprint
IDENTIFICATION
Records identified through database searching
Additional records identified through other sourcesPRIS
MA
Tips
Run the final searches within 24 hours
Save search strategy in database as well as in a .txt file
Last update search should be done within 6-months of submission for publication
1. Exporting to EndNote
2. Organizing Search Results
3. De-duplication with EndNote
Citation
Management
Tracking Spreadsheet Includes:-Databases searched-Search parameters-Search Strategies-Number of results -Duplicates
PRISMA Flow Diagram-Track your methods as you work through the Systematic Review Process
Documentation
IDENTIFICATION
Records identified through database searching
Additional records identified through other sources
SCREENING
Records after duplicates removed
PRIS
MA
Writing the SearchMethodology
List databases and other resources searched and include date search ended
Describe search strategies and filters and number of results
Include other searching methods – hand searching, reference searching, requesting data and articles
Provide a copy of the MEDLINE search for the appendix Discussion Section: Include level of confidence that all
available studies were located. Address whether search limits may have blocked retrieval of results or if other sources could have been searched.
http://eahil.eu/wp-content/uploads/2015/09/3-7-Foster.pdf
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