3D-Printed heart saves the life

of baby John

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John Doe Jr JOHN Doe Sr* *JOHN Doe Sr is a fictitious person with a fictitious disease and a fictitious clinical outcome, any resemblance to a real person, living or dead, is purely coincidental

*Clinical images from Prof Dr Peter de Jaegere, EMC, Rotterdam

Which device size would be the best for JOHN?

26 mm 29 mm

JOHN had a severe complication …

* Kodali et al., 2012, N Engl J Med

Months after implantation

Death

s (

%)

Low leakage

High leakage

chance of dying 100% higher

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Virtual heart saves the life of John Doe Sr

Bigger size decreases leakage with 70%

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Validation

The model can predict the valve morphology

In silico In vivo

0

5

10

15

20

25

Sellers 0, 1 Sellers > 2

Clinically observed leakage

29 pts included, further enrolling

p < 0.05

Pre

dic

ted leakage

The model can predict the valve function

Integration

What have we learned today? ‘

“

’ - P. Huysentruyt

SIZE matters