Supplementary Material

Neuroinflammation Lab Learning Examples

Figure Legends

Figure 1 HIVE and NeuroInflammation Lab Exercise

By application of a focal mouse model of HIVE, where severe combined immunodeficiency (SCID) mice were intracranially injected with HIV+ human monocyte/macrophages and then transplanted with iron label mouse bone marrow macrophages intravenously provided the ability to track the transit of monocytes in vivo (Liu, et al., 2008). B, D, and F demonstrate prussian blue-stained monocytes labeled with SPIO and iv injected in the brain. D: increased astrocyte activation by staining with GFAP, and increased neuron cell loss by staining with NeuN (Liu, et al., 2008). A, C, and E show little or no evidence for an invasion of peripheral macrophages, astrocyte activation, or neuronal loss in the control sham injected mouse brain (Liu, et al., 2008).

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