MRC/UCL Centre for Virology Division of Infection and Immunity

What is Science?

MRC/UCL Centre for Virology Division of Infection and Immunity

Virology

Viruses

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Viruses

Have you had!

Chicken Pox

Viruses

Have you had!

Herpes simplex

Viruses

Have you had!

Foot and Mouth

Three Broken Tulips (Nicolas Robert 1624-1685) Fitzwilliam museum, Cambridge

~10 viruses in the ocean 30

> 5,000 different viruses in 100 ml of seawater,

40 million viruses in one cubic metre of air

Electron Microscope

Electron Microscope Specimen Grid, 3 mm

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

890x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

1,200x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

5 !m

2,900x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

2 !m

4,800x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

2 !m

6,800x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

1 !m

11,000x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

1 !m

23,000x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

200 nm

49,000x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

200 nm

68,000x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

100 nm

98,000x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

100 nm

120,000x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

100 nm

150,000x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

100 nm

150,000x

Annegret Pelchen Matthews MRC Laboratory for Molecular Cell Biology

FMDV

Variola

Adeno

TMV

Ebola

All images from ICTV dB at http://phene.cpmc.columbia.edu/index.htm

Mimi

Phage T4

100nm HIV

Sneeze demo

H N H N H N

Reassortment of Influenza

H N H N H N

Reassortment of Influenza

H N H N H N

H N

Reassortment of Influenza

Reassortment demo

Virus Spread Demo

Viruses

Have you had!

BIOHAZARD

Ebola

BSL-4

Viruses

Have you had!

Small Pox

Ali Maow Maalim

October 1977 the last person on Earth to catch smallpox by natural transmission.

How do we prevent virus diseases?

Y

Y

Y Y

Y

Y

Antibodies Killer cells

Y Y

Y Y

Y Y

Antibodies Killer cells

Y Y

Y Y

Y Y

Antibodies Killer cells

Viruses are Small What about Big Pathogens?

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