Post on 02-Jan-2016
• 2. Activation: platelets change shape, turn on receptors and secrete chemical messages to other cells • “coagulation cascade”
• Coagulation cascade = combination of proteins activated by the chemical messages from the platelets. At the end of the coagulation cascade fibrinogens have become fibrin.
• Fibrin = product of fibrinogens which are blood clotting proteins
• 3. Aggregation: platelets continue to collect along with fibrin and develop into the platelet plug.
• What would be an example of a good blood clot?
• A bad one? • What might be the results of a bad blood
clot?
• Can be caused by: • Cancer, pregnancy, lupus, rheumatoid arthritis, certain medications• Damage to the inside of blood vessels
• Can lead to: • Heart attack, stroke, embolism