GUMBORO FIELD EXPERIENCES IN SPAIN

¡ THINGS WE HAVE LEARNT !

JOSÉ LUIS VALLS GARCIA

Veterinario consultor avícola

Barcelona, 15th March 2016

GUMBORO is an Enzootic disease :

Challenge will come immediately after protection by MDA has reached unprotective level

IBDV will persist, cycle after cycle

IN OTHER WORDS : If a farm was with Gumboro IBDV yesterday,

then, it will have it again tomorrow

ACTIONS REQUIRED BUT NOT ENOUGH

CLEANING

DISINFECTION

DISINSECTION

RODENT CONTROL

BIOSECURITY

DANGER IBDV

WHICH IS THE OBJECTIVE OF GUMBORO VACCINATION ?

PROTECT THE CHICKENS

LOWER THE CHALLENGE

AVOID PRESSURE ON FARM OF IBDV POPULATION

INMUNE COMPLEX VACCINE

Following administration, the protection starts immediately after vaccine virus replication, which occurs after MDA have reached moderate level.

Vaccine adapts to the level of MAD

The protection against infection and re-excretion of the challenge virus most of the time reaches 100%.

DOUBTS OF VETERINARY

HATCHERY vs FIELD VACCINE APPLICATION

INJURIES IN THE BURSA: INMUNOSUPRESSION??

INMUNE COMPLEX: RETURN OF INVESTMENT

THIS PRESENTATION ATTEMPTS TO CLARIFY THESE QUESTIONS

CHICK PROGRAM – FIELD SERVICES SPAIN

CEVA

CONTINUOUS MONITORING AGAINST

GUMBORO

OBJECTIVE of CEVA SPAIN TEAM

CHECK THE HEALTH STATUS OF COMPANIES

AND ASSESS THE EFFECTIVENESS OF VACCINATION PLANS SET

THINGS WE HAVE LEARNT…

WORKING WITH INMUNO-COMPLEX VACCINE

SINCE 2009

WITH A LOT OF TRIALS AND INFORMATION

IT IS WORKING WITH DATA 62,4 MILLION CHICKENS / YEAR

C. CAZABAN

SAMPLES SEROLOGY SPANISH TEAM CEVA

COMPANY A

BIOCHEK TEST

COEFFICIENT OF VARIATION

Is the dispersión of titles of the flocks in the histogramMeasuring uniformity of titles Ideal; to present CV% lower in lots

Coefficient of variation Interpretation

< 40 % Excellent response to vaccination

< 40 – 60 % correct immune response

> 60 % There are birds without proper vaccine response

> 80 % Many non-uniformityRecent outbreak field

TRM: 34 FARMS; 17% CV between midpoints - Slaughter bloods

INTERMEDIATE VACCINE DW: 37 FARMS; 61% CV between midpoints - Slaughter bloods

FLOCKS VACCINATED :

BIOCHECK TEST

TRM: 58 FARMS; 26% CV between midpoints - Slaughter bloods

BIOCHECK TEST

2014

ELISA TESTING ( TRANSMUNE – VAXXITEK )

ELISA TESTING TRANSMUNE - VAXXITEK

BIOCHEK TEST

BIOCHEK TEST

BIOCHEK TEST

BIOCHEK TEST

IBD CEVA Biochek 2012 35d o more

CECAV - SPAIN

IBD CEVA Biochek 2015 35d o more

CECAV - SPAIN

INMUNO COMPLEX

INJURIES IN THE BURSA: INMUNOSUPRESSION ?

COMPANY B

All samples were taken fromhealthy chickens in routine visits

by the technical teamof CEVA Spain

PCR RESULTS & LYMPHOID DEPLETIONvs VACCINATION PLAN

SAMPLES TAKEN 2013 – 2015CRESA Y CECAV

VACCINATION PLAN:- DRINK OF WATER ( 71 samples )- INMUNO COMPLEX ( 248 samples )- HVT-VP2 ( 35 samples )

DRINKING WATER VACCINATION vs HATCHERY INMUNO COMPLEX

Average detectable vaccine replication (RT-PCR) after drinking water vaccination was delayed compared to that of the average hatchery vaccinated flocks

Average vaccine antibody response after drinking water vaccination was delayed compared to that of the average hatchery vaccinated flocks

Most likely due to the timing or quality of the application

INMUNO COMPLEX

RETURN INVESTMENT ?

PRODUCTION DATA 2013COMPANY C

WEIGHT FCR DAYS ADG MORT. IEE COST FINAL /

Kg

5,06% -1,47% 0,91% 3,98% 8,82% 5,66% -1,73%

1.115.660 chickens DW VACCINE

381.490 chickens TRM VACCINEVs

RETURN OF INVESTMENT

COMPANY CNº CHICKENS / YEAR = 18.500.000AVERAGE WEIGHT = 2,645 Kg / CHICKENCOST DIFFERENCE BETWEEN PLANS VACCINE = 0,018 EU/KG

TOTAL RETURN 1.000 CHICKENSRETURN OF INVESTMENT INMUNO COMPLEX

47,61 EUROS

PRODUCTION DATA 2014 - 2015COMPANY D

WEIGHT FCR DAYS ADG MORT. IEE COST FINAL /

Kg

+1,47 % -6,33 % -5,69 % +8,00 % +5,15 % +14,69 % -1,52 %

2.175.056 chickens DW VACCINE

2.674.487 chickens TRM VACCINEVs

RETURN OF INVESTMENT

COMPANY DCOST DECREASE 1,52 %AVERAGE WEIGHT = 2,701 Kg / CHICKENCOST DIFFERENCE BETWEEN PLANS VACCINE = 0,014 EU/KG

TOTAL RETURN 1.000 CHICKENSRETURN OF INVESTMENT INMUNO COMPLEX

37,80 EUROS

RETURN INVESTMENTINMUNO COMPLEX VACCINE

COMPANY RETURN euros / KG RETURN euros / 1.000 CHICKENS

RETURN euros / 20 MILLIONS YEAR

C 0,018 47,61 952.200

D 0,014 37,80 756.000

AVERAGE 0,016 42,71 854.000

CONCLUSIONSWHAT WE HAVE LEARNT ?

BETTER RESULTS (PCR AND SEROLOGY) WITH INMUNO COMPLEX VACCINE AND HATCHERY APPLICATION

INTERMEDIATE VACCINES vs INMUNO COMPLEX: THE LYMPHOID DEPLETION IS SIMILAR

THE INJURIES OF THE BURSA ARE REVERSIBLES

CONCLUSIONSWHAT WE HAVE LEARNT ?

ONCE BURSA IS COLONIZED BY INMUNO COMPLEX VACCINE, FIELD IBD VIRUS CANNOT INFECTED BIRDS

HOMOGENEUS BURSA COLONIZATION: ALL SAMPLES POSITIVE

SMOOTH TRANSTION FROM PASSIVE TOWARDS ACTIVE INMUNITY

RETURN OF INVESTMENT IS BETTER INMUNO COMPLEX

THANKS TO THE CEVA SPAIN TEAM ¡ WONDERFUL PEOPLE !

THANK YOU

VERY MUCH

FOR YOUR

ATTENTION