Scientists interested in:• Signal processing• Development of algorithm to automatically

analyze signals• Building gadgets to simulate biological/physical

phenomenon (eg. starling resistor)• Statistical models to analyze complex biological

interactions

• Improve monitoring techniques and support strategies during acute respiratory failure

• Understand patient-ventilator dyssynchrony and develop strategies to improve synchrony

• Understand ventilator induced lung injury and diaphragm dysfunction and develop strategies to decrease damage.

TYPE OF STUDIES METHODOLOGIES

Bench studiesSimulation of patients

breathing spontaneously or passively ventilated

Physiological studies (healthy subject, patients admitted to the general

ward and critically ill patients)

SEE DIAGRAM + data collection from chart

Large, multicenter epidemiological or randomized clinical

studies

Data collection from ventilators and clinical chart

More complex statisticalanalysis

Respiratory mechanics during passive mechanical ventilation

Expiratory flow limitation(EFL)

Respiratory drive / Inspiratory effort(Airway occlusion pressure – P0.1

and pressure-time product – PTPes)

Inspiratory effort / Patient ventilation dyssynchrony

(reverse triggering)

WHO ARE WE LOOKING FOR TO COLLABORATE?

• Respiratory physiology during acute respiratory failure and Mechanical Ventilation

• Acute respiratory distress syndrome (ARDS)• Patient-ventilation interaction during invasive and

non-invasive ventilation• Respiratory muscle function, control of breathing

and sleep during and after mechanical ventilation

RESEARCH AREAS

CLINICAL APPLICATION

Dr. Laurent Brochard's lab - The Keenan Research Centre for Biomedical Research of St. Michael's Hospital

Analysis

Lu Chen , Tài Pham , Martin Dres , Domenico Luca Grieco , Irene Telias , Detajin Junhasavasdikul , Luana Melo , Michael Sklar , Fabiana Madotto , Felipe Damiani , Louisa Matela , Thomas Piraino , Jenny Gu , Gyan Sandhu , Jennifer Hodder , Orla Smith , Laurent Brochard .

1st derivative of flow = 12 L/s2

Flow

Paw

Country of Origin: China, France, Italy, Argentina, Thailand, Brazil, Canada, Chile, Philippines, India