LISTING OF SELECTED VERTEBRATE VIRUS FAMILIES BY MORPHOLOGY

Morphology of Particle

Icosahedral

Irregular

Morphology of Nucleocapsid

Poxviridae (ovoid) Yes

Enveloped

RoundCoronaviridae Yes Helical or tubularParamyxoviridae YesOrthomyxoviridae Yes

Rhabdoviridae (bacilliform)Yes

Filoviridae Yes

Bunyaviridae Yes HelicalArenaviridae Yes Helical

SphericalRetroviridae Yes

Togaviridae Yes T = 4

Flaviviridae Yes T = 3

Adenoviridae No T = 25

Papillomaviridae No P = 7d

Polyomaviridae No P = 7d Parvoviridae No T = 1

Reoviridae No T = 13l

Picornaviridae NoAstroviridae No Not applicable

T = 3

Caliciviridae No Not applicableT = 3

Triangulation Number

Herpesviridae Yes T = 16

Hepadnaviridae Yes Icosahedral T = 3 & 4

Table 2.1

?

Filamentous

Figure Numbers

Not applicable Figures 2.1, 2.5, 2.12Icosahedral Figures 2.1, 2.5, 2.11

Not applicable Figure 2.5

Not applicable Figures 2.5, 2.9Not applicable Figures 2.1, 2.5

Not applicable Figures 2.1, 2.5, 2.7, 2.8

Icosahedral Figures 2.1, 2.5, 2.16Icosahedral Figures 2.5, 2.14, 2.15

Icosahedral Figure 2.5

Dumbbell Figures 2.1, 2.20Coiled helix Figures 2.1, 2.19

Icosahedral? Figures 2.1, 2.17

Helical Figure 2.18Helical Figures 2.1, 2.18

Helical Figure 2.19

a

a,ba,b

c

c

aTwo mirror image structures can be formed using T = 13 or T = 7, a symmetry referred to as “d” or “l”.

cVirions are often pleiomorphic

P = 3 b

Because the subunits are not exactly equivalent, Papillomaviridae , Polyomaviridae, and as well as poliovirus have “pseudo-triangulation numbers” so are referred to as P = 7, P = 7, and P = 3 symmetries respectively.

b

DNA Viruses

Selected RNA Viruses

100 nm

Tobacco Mosaic Virus

HOOC

2

3

5F

D I BG

HC

NH

E

3

5

55 2

2 2A

A

A

Icosahedral Structure

A T=1 structure with 60 identical subunits Fold of the 8-stranded ß-sandwich

N(15)

C(361)N (1)C(238)

A. B.

C(349)

N(1)

C.

SV40 VP1 P = 7 Poliovirus 1 VP3 P = 3

Bluetongue virus VP7 T = 13

Capsid Proteins Having a Similar Fold

Reovirus (Lang) (850Å)

Rotavirus (1000Å)

Herpes Simplex (1250Å) 500Å

Ross River (700Å)

Human papilloma (600Å)Polyoma (495Å)

Poliovirus (320Å)

Human rhinovirus (320Å)

Flockhouse (330Å)

Cowpea mosaic (312Å)

B19 parvovirus (260Å)

Dengue 2 (490Å)

Figure 2.5

Structures

of Viruses

Determined

by Cryo EM

B.

C.

dsRNA

C C2

B5 A

AA5

B5

C5

C B

B2

A2

C2

5

55

3

ds RNAarm arm

5

A.

Flockhouse Virus (T=3)

T = 3 Poliovirus Cowpea Mosaic Virus

A

BC L

SVP1

VP2

VP3

Schematic of Three T=3 or P=3 Viruses

Human

Rhinovirus 14

VP1 = Blue

VP2 = Green

VP3 = Red

VP1

VP3

VP4

VP2

RNA

5-fold Axis

Drug-binding pocket

VP3-cylinder

D2

ICAM-1

“Canyon”D1

Five-fold Vertex of Rhinovirus Showing Binding of ICAM-1

Picornaviruses

Bound

To Receptors

PNAS 97:79 (2000)

Orbivirus Structure

Structure

of

Adenovirus

Structure

of

Ross River Virus

Sindbis Virus Capsid Protease

Herpesvirus

Schematic of Virion EM of Nucleocapsid

Retrovirus Structure

Rhabdoviruses

and

Filoviruses

Structure of Poxviruses

Budding

Viruses