Dementia

Dr nahed shehta

Definition: AEClinical pictureInvestigation treatment

DefinitionProgressive deterioration of memory

behavior personality

AE:DegenerativeNeurologicsystemic

Degenerative:AlzheimerFrontotemporalDementia with parkinsonism

SystemicEndocrine thyroidHeptic , renalNutritional B1, B6, B12, folatealchoholic

Neurological causesVascular dementiaTumers

FrontalTemporalCorpus callosum

NPHydrochephalusTrauma SDHInfection

AIDSHSimplex

Reading Speech

VisuospatialFunction

Speech motorcontrol

Alzheimer dementiaRisk factors1.Age2.Sex3.Education4.Alchol5.Repeated trauma6.Aluminum7.Family history

Famous people with alzheimer

Vascular dementiaRisk factors1.HPN2. DM3.Hyperlibidemia4.Recurrent strokes

Frontotemporal dementia selective frontal , temporal atrophy memory loss personality changes biopsy: picks cells in frontal,

Temporal lobes

investigation1.Lab

1. LFT, KFT , CBC (ANEMIA) , hormonal assay

2.Neuroimaging1. CT, MRI

1. Cortical atrophy2. Hippocampal atrophy3. lacunar infarct4. Frontotemporal atrophy5. NPH

NORMAL CT BRAIN

AXIAL CT for Alzheimer

CT for Alzhiemer

treatmentTarget: ↑ Ach

1. Cholinesterase inhibitors2. NMDA antagonists

glutamate tocicity3. Antidepressant4. Cerebral dilators5. Vitamins6. Estrogen replacement